SATP - ECOLI - GREMLIN Contacts

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SATP - Succinate-acetate/proton symporter SatP

UniProt:	P0AC98	Sequences: MGNTKLANPAPLGLMGFGMTTILLNLHNVGYFALDGIILAMGIFYGGIAQIFAGLLEYKKGNTFGLTAFTSYGSFWLTLVAILLMPKLGLTDAPNAQFLGVYLGLWGVFTLFMFFGTLKGARVLQFVFFSLTVLFALLAIGNIAGNAAIIHFAGWIGLICGASAIYLAMGEVLNEQFGRTVLPIGESH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11512
Length:	188 (180)
Sequences:	1223 (869)
Seq/√Len:	64.8

ECOLI - SATP
SULSO - Q97UX7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
54_G	70_T	3.199	1.00
57_E	62_N	3.180	1.00
72_Y	110_T	3.099	1.00
78_T	102_Y	2.991	1.00
126_F	163_S	2.771	1.00
107_G	136_A	2.736	1.00
136_A	140_I	2.676	1.00
109_F	113_M	2.545	1.00
141_G	150_I	2.495	1.00
25_N	157_G	2.412	1.00
137_L	156_I	2.391	1.00
104_G	139_A	2.381	1.00
114_F	125_Q	2.371	1.00
45_Y	71_S	2.369	1.00
44_F	81_A	2.361	1.00
23_L	41_M	2.196	1.00
15_M	168_A	2.194	1.00
114_F	129_F	2.172	1.00
133_V	137_L	2.168	1.00
44_F	77_L	2.162	1.00
18_G	164_A	2.145	1.00
111_L	132_T	2.062	1.00
123_V	167_L	2.045	1.00
107_G	139_A	2.000	1.00
52_F	55_L	1.942	1.00
155_W	159_I	1.919	1.00
134_L	157_G	1.790	1.00
111_L	115_F	1.737	1.00
19_M	165_I	1.733	1.00
104_G	143_I	1.687	0.99
29_V	155_W	1.678	0.99
148_A	152_F	1.656	0.99
114_F	132_T	1.588	0.99
118_L	125_Q	1.582	0.99
55_L	70_T	1.577	0.99
130_S	159_I	1.561	0.99
68_A	128_F	1.539	0.99
18_G	161_G	1.493	0.98
26_L	31_Y	1.482	0.98
134_L	160_C	1.453	0.98
22_I	165_I	1.430	0.98
100_G	143_I	1.427	0.98
96_A	142_N	1.418	0.98
47_G	73_G	1.406	0.98
142_N	150_I	1.401	0.98
147_A	151_H	1.389	0.98
133_V	156_I	1.383	0.97
56_L	66_L	1.379	0.97
13_G	53_A	1.372	0.97
102_Y	106_W	1.368	0.97
130_S	160_C	1.359	0.97
58_Y	66_L	1.331	0.97
114_F	118_L	1.330	0.97
51_I	74_S	1.322	0.97
130_S	163_S	1.300	0.96
117_T	128_F	1.297	0.96
125_Q	129_F	1.284	0.96
41_M	78_T	1.284	0.96
85_M	88_L	1.283	0.96
43_I	85_M	1.274	0.96
75_F	135_F	1.264	0.96
126_F	130_S	1.240	0.95
121_A	184_I	1.236	0.95
89_G	92_D	1.226	0.95
127_V	163_S	1.217	0.95
51_I	70_T	1.214	0.95
114_F	117_T	1.213	0.95
103_L	153_A	1.204	0.94
137_L	152_F	1.191	0.94
139_A	143_I	1.184	0.94
112_F	169_M	1.174	0.94
140_I	149_I	1.171	0.94
100_G	104_G	1.110	0.92
117_T	125_Q	1.100	0.91
146_N	149_I	1.094	0.91
122_R	125_Q	1.091	0.91
159_I	163_S	1.078	0.90
69_F	124_L	1.059	0.90
131_L	160_C	1.044	0.89
63_T	67_T	1.035	0.88
123_V	127_V	1.034	0.88
49_A	74_S	1.031	0.88
128_F	135_F	1.029	0.88
15_M	165_I	1.024	0.88
111_L	114_F	1.017	0.88
138_L	153_A	1.010	0.87
112_F	168_A	1.008	0.87
116_G	173_L	1.001	0.87
22_I	161_G	0.998	0.87
29_V	158_L	0.998	0.87
64_F	68_A	0.996	0.86
6_L	58_Y	0.995	0.86
16_G	49_A	0.991	0.86
107_G	132_T	0.983	0.86
89_G	93_A	0.982	0.86
76_W	131_L	0.982	0.86
6_L	60_K	0.982	0.86
113_M	172_V	0.981	0.86
79_L	142_N	0.976	0.85
26_L	158_L	0.976	0.85
22_I	105_L	0.975	0.85
62_N	65_G	0.955	0.84
25_N	134_L	0.952	0.84
28_N	68_A	0.945	0.83
22_I	26_L	0.945	0.83
24_L	75_F	0.944	0.83
123_V	185_G	0.938	0.83
120_G	124_L	0.932	0.83
141_G	153_A	0.925	0.82
126_F	159_I	0.923	0.82
19_M	105_L	0.916	0.81
101_V	143_I	0.914	0.81
23_L	105_L	0.911	0.81
110_T	132_T	0.893	0.80
134_L	156_I	0.891	0.80
108_V	112_F	0.890	0.80
30_G	147_A	0.889	0.80
110_T	131_L	0.881	0.79
120_G	176_Q	0.875	0.78
24_L	103_L	0.862	0.77
73_G	77_L	0.839	0.75
10_A	57_E	0.836	0.75
77_L	81_A	0.835	0.75
147_A	150_I	0.834	0.75
6_L	56_L	0.833	0.75
130_S	156_I	0.833	0.75
132_T	136_A	0.831	0.75
68_A	138_L	0.816	0.73
137_L	149_I	0.815	0.73
173_L	182_L	0.813	0.73
82_I	88_L	0.808	0.73
27_H	34_L	0.795	0.71
54_G	73_G	0.790	0.71
43_I	80_V	0.784	0.70
115_F	118_L	0.781	0.70
7_A	12_L	0.780	0.70
10_A	121_A	0.776	0.70
76_W	166_Y	0.775	0.70
160_C	163_S	0.765	0.69
50_Q	164_A	0.765	0.69
92_D	95_N	0.764	0.68
129_F	132_T	0.762	0.68
34_L	97_Q	0.761	0.68
107_G	140_I	0.760	0.68
97_Q	143_I	0.750	0.67
27_H	98_F	0.747	0.67
9_P	65_G	0.744	0.66
167_L	184_I	0.742	0.66
71_S	109_F	0.742	0.66
151_H	155_W	0.738	0.66
51_I	73_G	0.726	0.64
71_S	106_W	0.725	0.64
174_N	181_V	0.722	0.64
7_A	175_E	0.717	0.63
120_G	171_E	0.714	0.63
110_T	135_F	0.712	0.63
174_N	180_T	0.708	0.63
167_L	171_E	0.707	0.62
50_Q	110_T	0.707	0.62
28_N	157_G	0.704	0.62
52_F	66_L	0.699	0.62
29_V	32_F	0.699	0.62
14_L	21_T	0.698	0.61
24_L	154_G	0.698	0.61
121_A	185_G	0.696	0.61
28_N	65_G	0.695	0.61
64_F	117_T	0.692	0.61
104_G	136_A	0.690	0.61
45_Y	74_S	0.688	0.60
156_I	159_I	0.686	0.60
87_K	90_L	0.682	0.60
104_G	124_L	0.681	0.60
91_T	95_N	0.674	0.59
28_N	164_A	0.673	0.59
77_L	132_T	0.669	0.58
127_V	167_L	0.669	0.58
124_L	167_L	0.667	0.58
40_A	80_V	0.666	0.58
69_F	182_L	0.663	0.57
7_A	60_K	0.661	0.57
21_T	50_Q	0.660	0.57
155_W	158_L	0.654	0.56
122_R	185_G	0.653	0.56
11_P	63_T	0.652	0.56
103_L	138_L	0.652	0.56
105_L	161_G	0.648	0.56
21_T	76_W	0.646	0.56
42_G	80_V	0.643	0.55
53_A	110_T	0.640	0.55
29_V	154_G	0.638	0.55
30_G	79_L	0.636	0.54
119_K	177_F	0.632	0.54
35_D	38_I	0.628	0.53
171_E	184_I	0.627	0.53
170_G	184_I	0.626	0.53
180_T	184_I	0.625	0.53
18_G	22_I	0.623	0.53
24_L	138_L	0.622	0.53
7_A	63_T	0.622	0.53
24_L	135_F	0.618	0.52
81_A	88_L	0.617	0.52
7_A	11_P	0.617	0.52
49_A	53_A	0.616	0.52
169_M	182_L	0.611	0.51
174_N	179_R	0.610	0.51
81_A	85_M	0.608	0.51
79_L	99_L	0.608	0.51
21_T	157_G	0.607	0.51
47_G	77_L	0.605	0.51
15_M	19_M	0.604	0.51
34_L	98_F	0.603	0.51
68_A	134_L	0.599	0.50
156_I	160_C	0.597	0.50
21_T	25_N	0.596	0.50
134_L	153_A	0.594	0.49
18_G	70_T	0.593	0.49
14_L	17_F	0.592	0.49
105_L	108_V	0.587	0.49
82_I	90_L	0.583	0.48
170_G	182_L	0.582	0.48
38_I	52_F	0.582	0.48
40_A	81_A	0.581	0.48
12_L	70_T	0.575	0.47
117_T	120_G	0.574	0.47
52_F	56_L	0.574	0.47
41_M	45_Y	0.572	0.47
131_L	164_A	0.571	0.47
23_L	38_I	0.569	0.47
57_E	65_G	0.562	0.46
154_G	160_C	0.561	0.46
120_G	167_L	0.561	0.46
167_L	182_L	0.560	0.46
68_A	113_M	0.555	0.45
33_A	94_P	0.555	0.45
51_I	72_Y	0.548	0.44
18_G	165_I	0.548	0.44
158_L	162_A	0.547	0.44
107_G	144_A	0.545	0.44
8_N	171_E	0.543	0.44
32_F	98_F	0.542	0.43
21_T	75_F	0.540	0.43
14_L	171_E	0.539	0.43
37_I	40_A	0.538	0.43
26_L	102_Y	0.538	0.43
123_V	162_A	0.537	0.43
170_G	181_V	0.536	0.43
90_L	94_P	0.529	0.42
169_M	173_L	0.528	0.42
94_P	152_F	0.524	0.41
116_G	169_M	0.523	0.41
170_G	174_N	0.523	0.41
152_F	156_I	0.520	0.41
33_A	79_L	0.518	0.41
25_N	28_N	0.514	0.40
94_P	98_F	0.514	0.40
47_G	74_S	0.513	0.40
142_N	149_I	0.513	0.40
88_L	91_T	0.511	0.40
108_V	162_A	0.510	0.40
19_M	135_F	0.510	0.40
67_T	84_L	0.510	0.40
128_F	172_V	0.509	0.40
28_N	154_G	0.509	0.40
9_P	28_N	0.507	0.39
5_K	182_L	0.507	0.39
126_F	140_I	0.505	0.39
36_G	82_I	0.502	0.39
6_L	59_K	0.502	0.39
173_L	177_F	0.502	0.39
18_G	72_Y	0.500	0.39

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ux4A	3	0.8564	3	0.96	Contact Map
2h88D	1	0.2394	2.5	0.962	Contact Map
1ckkB	1	0.0532	2.5	0.962	Contact Map
4gveA	1	0.2074	1.6	0.966	Contact Map
1iq5B	1	0.0585	1.3	0.968	Contact Map
2lp1A	1	0	1.1	0.969	Contact Map
4k7eA	2	0.1436	1	0.97	Contact Map
4g59C	1	0.0266	1	0.97	Contact Map
1colA	1	0.3298	0.9	0.97	Contact Map
4ogqG	1	0.1968	0.9	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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