GREMLIN Database
SATP - Succinate-acetate/proton symporter SatP
UniProt: P0AC98 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11512
Length: 188 (180)
Sequences: 1223 (869)
Seq/√Len: 64.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_G70_T3.1991.00
57_E62_N3.1801.00
72_Y110_T3.0991.00
78_T102_Y2.9911.00
126_F163_S2.7711.00
107_G136_A2.7361.00
136_A140_I2.6761.00
109_F113_M2.5451.00
141_G150_I2.4951.00
25_N157_G2.4121.00
137_L156_I2.3911.00
104_G139_A2.3811.00
114_F125_Q2.3711.00
45_Y71_S2.3691.00
44_F81_A2.3611.00
23_L41_M2.1961.00
15_M168_A2.1941.00
114_F129_F2.1721.00
133_V137_L2.1681.00
44_F77_L2.1621.00
18_G164_A2.1451.00
111_L132_T2.0621.00
123_V167_L2.0451.00
107_G139_A2.0001.00
52_F55_L1.9421.00
155_W159_I1.9191.00
134_L157_G1.7901.00
111_L115_F1.7371.00
19_M165_I1.7331.00
104_G143_I1.6870.99
29_V155_W1.6780.99
148_A152_F1.6560.99
114_F132_T1.5880.99
118_L125_Q1.5820.99
55_L70_T1.5770.99
130_S159_I1.5610.99
68_A128_F1.5390.99
18_G161_G1.4930.98
26_L31_Y1.4820.98
134_L160_C1.4530.98
22_I165_I1.4300.98
100_G143_I1.4270.98
96_A142_N1.4180.98
47_G73_G1.4060.98
142_N150_I1.4010.98
147_A151_H1.3890.98
133_V156_I1.3830.97
56_L66_L1.3790.97
13_G53_A1.3720.97
102_Y106_W1.3680.97
130_S160_C1.3590.97
58_Y66_L1.3310.97
114_F118_L1.3300.97
51_I74_S1.3220.97
130_S163_S1.3000.96
117_T128_F1.2970.96
125_Q129_F1.2840.96
41_M78_T1.2840.96
85_M88_L1.2830.96
43_I85_M1.2740.96
75_F135_F1.2640.96
126_F130_S1.2400.95
121_A184_I1.2360.95
89_G92_D1.2260.95
127_V163_S1.2170.95
51_I70_T1.2140.95
114_F117_T1.2130.95
103_L153_A1.2040.94
137_L152_F1.1910.94
139_A143_I1.1840.94
112_F169_M1.1740.94
140_I149_I1.1710.94
100_G104_G1.1100.92
117_T125_Q1.1000.91
146_N149_I1.0940.91
122_R125_Q1.0910.91
159_I163_S1.0780.90
69_F124_L1.0590.90
131_L160_C1.0440.89
63_T67_T1.0350.88
123_V127_V1.0340.88
49_A74_S1.0310.88
128_F135_F1.0290.88
15_M165_I1.0240.88
111_L114_F1.0170.88
138_L153_A1.0100.87
112_F168_A1.0080.87
116_G173_L1.0010.87
22_I161_G0.9980.87
29_V158_L0.9980.87
64_F68_A0.9960.86
6_L58_Y0.9950.86
16_G49_A0.9910.86
107_G132_T0.9830.86
89_G93_A0.9820.86
76_W131_L0.9820.86
6_L60_K0.9820.86
113_M172_V0.9810.86
79_L142_N0.9760.85
26_L158_L0.9760.85
22_I105_L0.9750.85
62_N65_G0.9550.84
25_N134_L0.9520.84
28_N68_A0.9450.83
22_I26_L0.9450.83
24_L75_F0.9440.83
123_V185_G0.9380.83
120_G124_L0.9320.83
141_G153_A0.9250.82
126_F159_I0.9230.82
19_M105_L0.9160.81
101_V143_I0.9140.81
23_L105_L0.9110.81
110_T132_T0.8930.80
134_L156_I0.8910.80
108_V112_F0.8900.80
30_G147_A0.8890.80
110_T131_L0.8810.79
120_G176_Q0.8750.78
24_L103_L0.8620.77
73_G77_L0.8390.75
10_A57_E0.8360.75
77_L81_A0.8350.75
147_A150_I0.8340.75
6_L56_L0.8330.75
130_S156_I0.8330.75
132_T136_A0.8310.75
68_A138_L0.8160.73
137_L149_I0.8150.73
173_L182_L0.8130.73
82_I88_L0.8080.73
27_H34_L0.7950.71
54_G73_G0.7900.71
43_I80_V0.7840.70
115_F118_L0.7810.70
7_A12_L0.7800.70
10_A121_A0.7760.70
76_W166_Y0.7750.70
160_C163_S0.7650.69
50_Q164_A0.7650.69
92_D95_N0.7640.68
129_F132_T0.7620.68
34_L97_Q0.7610.68
107_G140_I0.7600.68
97_Q143_I0.7500.67
27_H98_F0.7470.67
9_P65_G0.7440.66
167_L184_I0.7420.66
71_S109_F0.7420.66
151_H155_W0.7380.66
51_I73_G0.7260.64
71_S106_W0.7250.64
174_N181_V0.7220.64
7_A175_E0.7170.63
120_G171_E0.7140.63
110_T135_F0.7120.63
174_N180_T0.7080.63
167_L171_E0.7070.62
50_Q110_T0.7070.62
28_N157_G0.7040.62
52_F66_L0.6990.62
29_V32_F0.6990.62
14_L21_T0.6980.61
24_L154_G0.6980.61
121_A185_G0.6960.61
28_N65_G0.6950.61
64_F117_T0.6920.61
104_G136_A0.6900.61
45_Y74_S0.6880.60
156_I159_I0.6860.60
87_K90_L0.6820.60
104_G124_L0.6810.60
91_T95_N0.6740.59
28_N164_A0.6730.59
77_L132_T0.6690.58
127_V167_L0.6690.58
124_L167_L0.6670.58
40_A80_V0.6660.58
69_F182_L0.6630.57
7_A60_K0.6610.57
21_T50_Q0.6600.57
155_W158_L0.6540.56
122_R185_G0.6530.56
11_P63_T0.6520.56
103_L138_L0.6520.56
105_L161_G0.6480.56
21_T76_W0.6460.56
42_G80_V0.6430.55
53_A110_T0.6400.55
29_V154_G0.6380.55
30_G79_L0.6360.54
119_K177_F0.6320.54
35_D38_I0.6280.53
171_E184_I0.6270.53
170_G184_I0.6260.53
180_T184_I0.6250.53
18_G22_I0.6230.53
24_L138_L0.6220.53
7_A63_T0.6220.53
24_L135_F0.6180.52
81_A88_L0.6170.52
7_A11_P0.6170.52
49_A53_A0.6160.52
169_M182_L0.6110.51
174_N179_R0.6100.51
81_A85_M0.6080.51
79_L99_L0.6080.51
21_T157_G0.6070.51
47_G77_L0.6050.51
15_M19_M0.6040.51
34_L98_F0.6030.51
68_A134_L0.5990.50
156_I160_C0.5970.50
21_T25_N0.5960.50
134_L153_A0.5940.49
18_G70_T0.5930.49
14_L17_F0.5920.49
105_L108_V0.5870.49
82_I90_L0.5830.48
170_G182_L0.5820.48
38_I52_F0.5820.48
40_A81_A0.5810.48
12_L70_T0.5750.47
117_T120_G0.5740.47
52_F56_L0.5740.47
41_M45_Y0.5720.47
131_L164_A0.5710.47
23_L38_I0.5690.47
57_E65_G0.5620.46
154_G160_C0.5610.46
120_G167_L0.5610.46
167_L182_L0.5600.46
68_A113_M0.5550.45
33_A94_P0.5550.45
51_I72_Y0.5480.44
18_G165_I0.5480.44
158_L162_A0.5470.44
107_G144_A0.5450.44
8_N171_E0.5430.44
32_F98_F0.5420.43
21_T75_F0.5400.43
14_L171_E0.5390.43
37_I40_A0.5380.43
26_L102_Y0.5380.43
123_V162_A0.5370.43
170_G181_V0.5360.43
90_L94_P0.5290.42
169_M173_L0.5280.42
94_P152_F0.5240.41
116_G169_M0.5230.41
170_G174_N0.5230.41
152_F156_I0.5200.41
33_A79_L0.5180.41
25_N28_N0.5140.40
94_P98_F0.5140.40
47_G74_S0.5130.40
142_N149_I0.5130.40
88_L91_T0.5110.40
108_V162_A0.5100.40
19_M135_F0.5100.40
67_T84_L0.5100.40
128_F172_V0.5090.40
28_N154_G0.5090.40
9_P28_N0.5070.39
5_K182_L0.5070.39
126_F140_I0.5050.39
36_G82_I0.5020.39
6_L59_K0.5020.39
173_L177_F0.5020.39
18_G72_Y0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ux4A 3 0.8564 3 0.96 Contact Map
2h88D 1 0.2394 2.5 0.962 Contact Map
1ckkB 1 0.0532 2.5 0.962 Contact Map
4gveA 1 0.2074 1.6 0.966 Contact Map
1iq5B 1 0.0585 1.3 0.968 Contact Map
2lp1A 1 0 1.1 0.969 Contact Map
4k7eA 2 0.1436 1 0.97 Contact Map
4g59C 1 0.0266 1 0.97 Contact Map
1colA 1 0.3298 0.9 0.97 Contact Map
4ogqG 1 0.1968 0.9 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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