GREMLIN Database
GNTU - Low-affinity gluconate transporter
UniProt: P0AC96 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12631
Length: 446 (420)
Sequences: 4928 (3205)
Seq/√Len: 156.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_L276_V3.8081.00
16_L38_G3.5201.00
184_C188_P3.4721.00
13_S316_F3.4681.00
318_Q322_D3.2141.00
91_K226_F3.2091.00
13_S39_A3.1761.00
298_H301_Q3.1531.00
232_L236_P3.1361.00
91_K95_S3.0801.00
327_P331_E3.0641.00
53_T322_D3.0491.00
81_E295_I2.9271.00
288_P291_K2.9151.00
342_I435_A2.9031.00
15_L19_F2.8211.00
415_T418_E2.8181.00
226_F230_L2.6021.00
349_A396_V2.5971.00
175_F179_I2.5431.00
345_F431_G2.5421.00
236_P240_V2.5011.00
91_K94_K2.4601.00
52_A56_K2.4121.00
331_E334_T2.3871.00
86_D90_V2.3431.00
171_M390_I2.2631.00
46_P49_K2.2551.00
19_F23_K2.2531.00
436_I440_I2.2221.00
200_F204_Y2.1971.00
180_L184_C2.1881.00
192_I196_L2.1801.00
182_G185_A2.1561.00
197_W201_I2.1561.00
428_T432_T2.1411.00
432_T436_I2.1361.00
229_S232_L2.1361.00
175_F180_L2.1321.00
46_P50_I2.1111.00
56_K60_G2.1011.00
348_A365_A2.0621.00
186_A189_G2.0491.00
16_L35_V2.0471.00
353_I397_V2.0181.00
225_S228_F1.9881.00
344_C390_I1.9591.00
328_A332_A1.9261.00
266_P270_I1.9181.00
229_S236_P1.9011.00
167_L362_C1.8981.00
232_L240_V1.8851.00
49_K52_A1.8671.00
103_Y195_P1.8631.00
239_L243_K1.8511.00
425_M429_I1.8401.00
181_I184_C1.8371.00
421_K425_M1.8301.00
98_H135_H1.8061.00
9_T42_F1.7731.00
227_G231_S1.7621.00
185_A441_A1.7611.00
176_G179_I1.7511.00
78_I277_A1.7301.00
276_V280_G1.7301.00
204_Y208_H1.7271.00
17_L35_V1.7211.00
74_M296_C1.7171.00
317_K321_V1.7031.00
182_G188_P1.6911.00
170_Q366_V1.6881.00
178_M387_S1.6721.00
174_D177_W1.6651.00
205_V209_I1.6641.00
279_Y284_R1.6351.00
196_L200_F1.6211.00
87_Q91_K1.6201.00
119_E403_A1.6131.00
180_L183_L1.6051.00
208_H211_D1.6011.00
206_E209_I1.5971.00
239_L272_V1.5861.00
156_A395_I1.5841.00
58_M66_A1.5821.00
228_F232_L1.5801.00
233_I236_P1.5681.00
203_R207_L1.5621.00
398_S402_D1.5611.00
77_K81_E1.5571.00
409_G419_T1.5491.00
16_L20_L1.5451.00
38_G42_F1.5441.00
392_G438_G1.5341.00
439_M442_F1.5221.00
396_V431_G1.5211.00
144_V412_T1.4981.00
196_L199_N1.4761.00
392_G434_G1.4651.00
119_E310_I1.4621.00
176_G180_L1.4531.00
137_G208_H1.4451.00
275_L279_Y1.4411.00
433_V437_V1.4311.00
227_G232_L1.4301.00
26_M31_A1.4271.00
85_V89_A1.4251.00
118_F404_G1.4061.00
106_G190_M1.4051.00
183_L186_A1.3941.00
57_G318_Q1.3931.00
397_V424_T1.3921.00
294_E298_H1.3861.00
379_S384_A1.3811.00
231_S235_L1.3711.00
437_V441_A1.3711.00
409_G416_E1.3631.00
179_I184_C1.3561.00
232_L248_R1.3541.00
236_P248_R1.3441.00
82_T281_L1.3411.00
227_G236_P1.3411.00
202_S206_E1.3351.00
396_V428_T1.3341.00
201_I204_Y1.3231.00
81_E291_K1.3211.00
54_M315_V1.3121.00
184_C189_G1.3111.00
174_D179_I1.3091.00
177_W180_L1.2991.00
228_F231_S1.2851.00
53_T318_Q1.2821.00
290_D294_E1.2711.00
134_R140_L1.2631.00
201_I205_V1.2501.00
194_G198_G1.2421.00
122_I411_F1.2421.00
257_Y260_F1.2401.00
233_I240_V1.2391.00
224_P229_S1.2301.00
353_I396_V1.2291.00
379_S383_M1.2251.00
278_I296_C1.2231.00
324_G327_P1.2131.00
310_I403_A1.2001.00
398_S423_W1.1991.00
182_G186_A1.1941.00
179_I182_G1.1941.00
188_P192_I1.1871.00
266_P269_A1.1861.00
246_A250_V1.1841.00
199_N203_R1.1831.00
202_S205_V1.1721.00
418_E421_K1.1701.00
185_A189_G1.1671.00
183_L187_I1.1651.00
185_A188_P1.1571.00
109_G112_C1.1561.00
90_V135_H1.1511.00
45_M53_T1.1501.00
175_F184_C1.1471.00
197_W200_F1.1391.00
357_S360_V1.1331.00
13_S38_G1.1311.00
108_A112_C1.1271.00
10_A14_V1.1211.00
105_I109_G1.1201.00
197_W425_M1.1161.00
154_A161_G1.1131.00
352_R402_D1.1061.00
185_A437_V1.1061.00
370_M374_E1.1030.99
273_A277_A1.1010.99
77_K295_I1.0920.99
48_D52_A1.0900.99
182_G189_G1.0870.99
86_D221_G1.0800.99
120_V123_V1.0800.99
166_L363_L1.0790.99
209_I212_D1.0770.99
90_V94_K1.0770.99
149_A194_G1.0750.99
247_A261_E1.0740.99
43_S323_S1.0730.99
152_A427_E1.0720.99
291_K294_E1.0700.99
417_A421_K1.0670.99
257_Y261_E1.0660.99
204_Y207_L1.0590.99
175_F178_M1.0530.99
236_P247_A1.0510.99
164_P168_A1.0500.99
61_T314_G1.0480.99
206_E210_P1.0470.99
31_A35_V1.0470.99
51_A55_E1.0420.99
39_A316_F1.0400.99
195_P198_G1.0400.99
239_L276_V1.0390.99
84_A229_S1.0370.99
192_I433_V1.0360.99
318_Q321_V1.0320.99
361_A402_D1.0310.99
56_K59_G1.0290.99
183_L188_P1.0200.99
73_A296_C1.0150.99
397_V401_N1.0120.99
218_L222_K1.0080.99
165_M168_A1.0040.99
427_E430_L1.0030.99
225_S229_S1.0030.99
203_R206_E1.0020.99
240_V244_T1.0000.99
439_M443_Q0.9990.99
7_V11_V0.9990.99
173_A178_M0.9970.99
426_M430_L0.9910.99
145_I149_A0.9890.99
220_E223_M0.9880.99
229_S233_I0.9870.99
303_A307_L0.9870.99
49_K53_T0.9790.99
35_V38_G0.9770.99
29_F308_L0.9760.99
419_T423_W0.9740.99
107_L111_V0.9710.99
194_G199_N0.9670.99
88_I229_S0.9610.99
218_L221_G0.9590.99
52_A55_E0.9510.98
434_G438_G0.9500.98
229_S240_V0.9480.98
228_F236_P0.9470.98
345_F435_A0.9450.98
243_K247_A0.9390.98
435_A439_M0.9380.98
120_V163_A0.9370.98
219_G222_K0.9360.98
340_I376_L0.9340.98
349_A353_I0.9290.98
194_G197_W0.9270.98
138_T142_K0.9260.98
20_L34_V0.9260.98
194_G200_F0.9250.98
383_M386_L0.9240.98
112_C125_L0.9210.98
205_V208_H0.9170.98
207_L210_P0.9170.98
192_I200_F0.9150.98
440_I443_Q0.9150.98
262_F265_H0.9140.98
398_S401_N0.9110.98
235_L273_A0.9100.98
201_I429_I0.9080.98
258_E261_E0.9070.98
342_I439_M0.9060.98
358_A394_S0.9040.98
154_A158_L0.9010.98
179_I183_L0.9000.98
373_I385_A0.8970.98
219_G223_M0.8970.98
37_M268_T0.8960.98
195_P199_N0.8950.98
236_P244_T0.8920.98
100_R104_A0.8920.98
186_A190_M0.8900.98
374_E383_M0.8890.98
43_S46_P0.8890.98
332_A336_M0.8880.98
20_L31_A0.8880.98
149_A426_M0.8840.98
203_R209_I0.8830.98
9_T43_S0.8780.97
226_F233_I0.8780.97
388_I438_G0.8780.97
39_A319_V0.8760.97
352_R398_S0.8750.97
113_A154_A0.8730.97
358_A403_A0.8690.97
181_I384_A0.8670.97
90_V223_M0.8620.97
118_F121_A0.8570.97
45_M323_S0.8560.97
203_R208_H0.8550.97
110_L114_L0.8530.97
175_F183_L0.8530.97
203_R211_D0.8510.97
371_P375_Q0.8500.97
153_A186_A0.8440.97
178_M384_A0.8420.97
57_G60_G0.8400.97
179_I188_P0.8400.97
333_L347_L0.8380.97
14_V17_L0.8360.97
244_T247_A0.8300.96
204_Y211_D0.8300.96
397_V420_L0.8270.96
229_S248_R0.8250.96
228_F280_G0.8250.96
178_M181_I0.8220.96
81_E298_H0.8200.96
279_Y283_M0.8200.96
41_L47_L0.8190.96
67_V71_L0.8190.96
166_L170_Q0.8180.96
92_M96_F0.8170.96
30_L274_C0.8160.96
87_Q223_M0.8150.96
278_I292_V0.8100.96
202_S208_H0.8070.96
12_G16_L0.8060.96
133_A138_T0.8040.96
245_I249_F0.7950.95
98_H136_T0.7950.95
87_Q226_F0.7940.95
226_F232_L0.7930.95
232_L280_G0.7910.95
329_L333_L0.7880.95
245_I248_R0.7870.95
157_F434_G0.7870.95
360_V364_T0.7850.95
9_T13_S0.7840.95
260_F265_H0.7830.95
278_I282_A0.7820.95
400_V420_L0.7820.95
129_A147_L0.7810.95
234_L238_V0.7800.95
344_C386_L0.7790.95
338_L342_I0.7780.95
106_G110_L0.7780.95
362_C394_S0.7780.95
95_S99_S0.7770.95
247_A250_V0.7760.95
152_A395_I0.7700.95
200_F203_R0.7670.94
147_L150_G0.7660.94
333_L336_M0.7650.94
362_C365_A0.7650.94
197_W429_I0.7640.94
287_M292_V0.7640.94
121_A161_G0.7640.94
102_H105_I0.7630.94
147_L412_T0.7620.94
142_K146_P0.7620.94
11_V15_L0.7600.94
388_I392_G0.7600.94
424_T431_G0.7600.94
53_T56_K0.7580.94
240_V248_R0.7550.94
181_I187_I0.7540.94
148_F405_F0.7500.94
355_Q360_V0.7450.94
79_L84_A0.7450.94
208_H212_D0.7450.94
180_L188_P0.7440.94
202_S207_L0.7420.93
344_C348_A0.7420.93
326_G330_G0.7410.93
99_S212_D0.7390.93
422_T425_M0.7390.93
178_M182_G0.7370.93
139_N202_S0.7270.93
352_R358_A0.7270.93
175_F186_A0.7270.93
170_Q367_G0.7250.93
45_M50_I0.7240.93
341_A378_Y0.7240.93
177_W183_L0.7240.93
71_L162_P0.7240.93
20_L26_M0.7230.93
297_G301_Q0.7220.93
358_A398_S0.7220.93
329_L354_I0.7220.93
268_T272_V0.7210.92
343_T373_I0.7210.92
183_L189_G0.7200.92
54_M60_G0.7180.92
114_L154_A0.7170.92
110_L153_A0.7160.92
319_V322_D0.7110.92
259_W263_I0.7100.92
373_I386_L0.7100.92
371_P376_L0.7090.92
250_V257_Y0.7080.92
341_A443_Q0.7020.91
141_V207_L0.7010.91
213_I217_H0.7000.91
430_L434_G0.7000.91
224_P232_L0.7000.91
11_V436_I0.6980.91
121_A125_L0.6960.91
156_A167_L0.6940.91
175_F182_G0.6930.91
226_F229_S0.6930.91
225_S232_L0.6920.91
116_L123_V0.6910.91
198_G202_S0.6890.91
280_G284_R0.6880.91
222_K291_K0.6870.91
395_I398_S0.6860.91
77_K298_H0.6850.90
189_G433_V0.6810.90
84_A87_Q0.6800.90
33_M71_L0.6780.90
414_A418_E0.6780.90
38_G41_L0.6780.90
437_V440_I0.6770.90
270_I273_A0.6760.90
122_I126_I0.6730.90
236_P241_G0.6720.90
193_A197_W0.6720.90
11_V35_V0.6720.90
416_E420_L0.6700.89
433_V436_I0.6680.89
184_C192_I0.6670.89
74_M273_A0.6660.89
155_A161_G0.6660.89
139_N205_V0.6640.89
192_I198_G0.6640.89
399_H427_E0.6630.89
54_M312_A0.6620.89
94_K203_R0.6620.89
121_A151_V0.6620.89
232_L284_R0.6590.89
361_A365_A0.6570.89
9_T35_V0.6570.89
246_A260_F0.6560.88
95_S279_Y0.6540.88
397_V428_T0.6510.88
56_K322_D0.6500.88
309_V363_L0.6490.88
181_I388_I0.6480.88
45_M49_K0.6480.88
355_Q361_A0.6470.88
175_F188_P0.6460.88
152_A394_S0.6430.87
423_W427_E0.6410.87
222_K228_F0.6410.87
226_F231_S0.6390.87
192_I195_P0.6390.87
228_F276_V0.6380.87
397_V402_D0.6380.87
150_G154_A0.6370.87
97_G100_R0.6370.87
361_A398_S0.6350.87
172_N331_E0.6340.87
16_L19_F0.6330.87
17_L31_A0.6310.86
227_G230_L0.6290.86
140_L144_V0.6290.86
113_A116_L0.6280.86
116_L270_I0.6280.86
71_L404_G0.6280.86
9_T12_G0.6270.86
179_I186_A0.6270.86
399_H422_T0.6260.86
36_S312_A0.6240.86
195_P200_F0.6230.86
177_W181_I0.6210.86
153_A156_A0.6200.86
51_A268_T0.6190.85
399_H406_W0.6190.85
246_A257_Y0.6180.85
77_K80_H0.6170.85
205_V210_P0.6150.85
40_G50_I0.6140.85
34_V38_G0.6110.85
142_K202_S0.6110.85
420_L424_T0.6110.85
205_V212_D0.6110.85
241_G245_I0.6090.84
62_L311_G0.6080.84
177_W384_A0.6080.84
27_H30_L0.6070.84
110_L154_A0.6070.84
25_R134_R0.6060.84
56_K318_Q0.6060.84
261_E264_G0.6050.84
228_F240_V0.6050.84
105_I108_A0.6050.84
149_A153_A0.6030.84
174_D178_M0.6020.84
158_L161_G0.6020.84
113_A161_G0.6020.84
15_L284_R0.6020.84
236_P250_V0.6010.84
36_S315_V0.6000.84
73_A194_G0.6000.84
31_A37_M0.5980.83
199_N202_S0.5970.83
157_F183_L0.5970.83
385_A442_F0.5960.83
349_A431_G0.5950.83
339_P342_I0.5930.83
202_S209_I0.5930.83
9_T39_A0.5910.83
119_E123_V0.5900.83
145_I426_M0.5900.83
178_M184_C0.5900.83
352_R361_A0.5890.82
9_T38_G0.5850.82
126_I412_T0.5850.82
176_G182_G0.5850.82
365_A390_I0.5840.82
348_A394_S0.5840.82
357_S361_A0.5830.82
87_Q225_S0.5830.82
13_S43_S0.5790.81
398_S427_E0.5750.81
74_M292_V0.5750.81
237_L241_G0.5740.81
356_G361_A0.5740.81
277_A280_G0.5740.81
225_S233_I0.5730.81
281_L284_R0.5730.81
119_E162_P0.5720.81
389_C393_G0.5720.81
161_G310_I0.5710.81
90_V219_G0.5710.81
207_L418_E0.5700.80
226_F240_V0.5700.80
201_I211_D0.5690.80
378_Y383_M0.5690.80
227_G249_F0.5680.80
39_A325_V0.5680.80
344_C369_V0.5680.80
50_I54_M0.5680.80
358_A395_I0.5650.80
181_I185_A0.5650.80
406_W419_T0.5650.80
155_A359_T0.5640.80
116_L317_K0.5640.80
86_D108_A0.5640.80
373_I377_N0.5630.80
408_F414_A0.5630.80
148_F404_G0.5620.79
328_A331_E0.5620.79
105_I112_C0.5610.79
385_A441_A0.5610.79
79_L164_P0.5600.79
202_S430_L0.5600.79
148_F426_M0.5590.79
16_L23_K0.5590.79
196_L204_Y0.5580.79
170_Q351_V0.5580.79
84_A281_L0.5580.79
185_A438_G0.5570.79
153_A427_E0.5570.79
235_L240_V0.5560.79
109_G125_L0.5510.78
164_P167_L0.5510.78
130_F140_L0.5500.78
17_L354_I0.5500.78
357_S405_F0.5500.78
12_G38_G0.5490.78
263_I268_T0.5480.78
201_I208_H0.5480.78
231_S238_V0.5470.78
122_I159_V0.5470.78
226_F236_P0.5470.78
156_A392_G0.5460.78
193_A196_L0.5450.77
259_W265_H0.5450.77
294_E297_G0.5440.77
154_A164_P0.5420.77
142_K153_A0.5420.77
8_L12_G0.5410.77
284_R288_P0.5400.77
97_G104_A0.5400.77
58_M67_V0.5390.77
171_M174_D0.5370.76
227_G233_I0.5370.76
70_A308_L0.5370.76
438_G442_F0.5370.76
218_L225_S0.5370.76
56_K327_P0.5360.76
73_A278_I0.5360.76
422_T426_M0.5340.76
232_L235_L0.5330.76
293_M296_C0.5330.76
105_I143_L0.5330.76
231_S280_G0.5320.76
188_P437_V0.5320.76
402_D423_W0.5290.75
152_A358_A0.5280.75
347_L368_L0.5280.75
269_A274_C0.5260.75
189_G437_V0.5250.75
113_A150_G0.5250.75
193_A198_G0.5240.75
283_M291_K0.5240.75
402_D405_F0.5240.75
29_F33_M0.5230.74
36_S40_G0.5220.74
79_L281_L0.5220.74
153_A430_L0.5210.74
227_G234_L0.5210.74
58_M62_L0.5210.74
157_F392_G0.5200.74
55_E64_F0.5190.74
16_L374_E0.5180.74
53_T57_G0.5170.74
50_I319_V0.5170.74
263_I267_F0.5160.74
17_L21_V0.5150.73
338_L440_I0.5150.73
93_L136_T0.5140.73
131_S329_L0.5140.73
281_L292_V0.5130.73
161_G164_P0.5130.73
161_G362_C0.5120.73
242_L246_A0.5120.73
213_I222_K0.5120.73
87_Q229_S0.5120.73
10_A325_V0.5120.73
377_N383_M0.5120.73
353_I424_T0.5120.73
351_V395_I0.5100.73
39_A42_F0.5090.73
291_K295_I0.5090.73
372_V376_L0.5080.72
348_A361_A0.5080.72
355_Q398_S0.5060.72
25_R31_A0.5050.72
274_C278_I0.5040.72
278_I281_L0.5040.72
185_A388_I0.5040.72
121_A391_A0.5030.72
156_A358_A0.5020.71
414_A419_T0.5020.71
49_K331_E0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9709 100 0.606 Contact Map
4r0cA 3 0.9664 100 0.619 Contact Map
4f35D 2 0.8924 100 0.66 Contact Map
4pd6A 3 0.7556 63.2 0.952 Contact Map
4dx5A 3 0.3632 59.7 0.953 Contact Map
2a65A 2 0.5605 49.3 0.956 Contact Map
2cfqA 1 0.8117 49.1 0.956 Contact Map
3qe7A 2 0.4484 41.3 0.958 Contact Map
3giaA 1 0.4484 36.9 0.959 Contact Map
3aqpA 1 0.3363 33.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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