GREMLIN Database
GNTP - High-affinity gluconate transporter
UniProt: P0AC94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12563
Length: 447 (424)
Sequences: 4538 (3036)
Seq/√Len: 147.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_L207_T3.5881.00
234_I275_V3.4961.00
231_V235_P3.2331.00
178_Y181_G3.2061.00
90_T225_F3.0251.00
12_G38_V2.8651.00
183_L187_P2.8271.00
52_T321_D2.8121.00
203_L206_P2.7521.00
317_Q321_D2.7411.00
12_G315_L2.7411.00
15_L37_S2.7281.00
228_S231_V2.6851.00
326_D330_M2.5801.00
193_G197_P2.5761.00
265_S269_M2.5621.00
287_D290_W2.4741.00
225_F229_I2.4181.00
235_P239_M2.4081.00
228_S235_P2.3991.00
231_V239_M2.3931.00
90_T94_R2.3861.00
344_W433_S2.3561.00
178_Y182_V2.3461.00
417_S420_D2.3401.00
297_S300_K2.3381.00
174_M178_Y2.2861.00
80_D294_A2.2821.00
45_D48_S2.2811.00
185_T188_S2.2701.00
14_G18_V2.2661.00
18_V22_K2.2641.00
55_A59_N2.2391.00
196_L200_L2.2121.00
180_Y183_L2.1591.00
173_D176_M2.1351.00
90_T93_A2.1091.00
198_K202_N2.0791.00
51_H55_A2.0511.00
224_S227_V2.0491.00
180_Y184_V2.0401.00
256_W260_N2.0291.00
204_E207_T2.0241.00
176_M180_Y2.0091.00
15_L34_A1.9631.00
199_F202_N1.9631.00
48_S51_H1.9431.00
348_V398_T1.9431.00
175_G180_Y1.9411.00
175_G178_Y1.9291.00
170_Y392_T1.9211.00
45_D49_L1.8691.00
179_I182_V1.8551.00
438_I442_I1.8421.00
330_M333_S1.8361.00
223_P228_S1.7971.00
179_I183_L1.7851.00
352_L399_L1.7791.00
227_V231_V1.7791.00
85_H89_H1.7761.00
176_M179_I1.7571.00
341_I437_L1.7491.00
238_I271_I1.7391.00
200_L203_L1.7291.00
343_A392_T1.7211.00
430_L434_V1.7111.00
196_L199_F1.6951.00
166_L361_A1.6941.00
275_V279_L1.6871.00
335_G340_Y1.6811.00
423_K427_L1.6771.00
327_T331_L1.6741.00
258_V261_F1.6561.00
186_I190_I1.6501.00
204_E208_P1.6391.00
181_G184_V1.6351.00
20_N24_K1.6311.00
434_V438_I1.6281.00
172_A177_V1.6261.00
226_G230_L1.6121.00
97_L134_E1.5971.00
195_I199_F1.5941.00
347_T364_A1.5921.00
178_Y183_L1.5911.00
382_G385_P1.5811.00
258_V262_I1.5761.00
177_V389_V1.5691.00
205_R208_P1.5571.00
15_L19_L1.5281.00
118_E405_A1.5191.00
274_V278_V1.5071.00
25_I30_A1.5001.00
177_V180_Y1.4981.00
191_C435_V1.4901.00
184_V188_S1.4831.00
427_L431_V1.4761.00
14_G17_L1.4671.00
178_Y185_T1.4561.00
197_P200_L1.4491.00
185_T189_V1.4411.00
169_A365_A1.4401.00
228_S239_M1.4381.00
336_N339_P1.4361.00
173_D178_Y1.4311.00
247_I250_V1.4241.00
175_G179_I1.4161.00
225_F228_S1.4131.00
56_G317_Q1.4101.00
316_K320_I1.4031.00
224_S228_S1.3961.00
227_V235_P1.3911.00
228_S232_P1.3911.00
226_G235_P1.3841.00
155_S397_N1.3791.00
176_M182_V1.3771.00
256_W259_V1.3711.00
108_G111_F1.3701.00
411_K421_T1.3701.00
193_G196_L1.3671.00
178_Y184_V1.3641.00
256_W261_F1.3641.00
232_P239_M1.3541.00
232_P235_P1.3541.00
398_T433_S1.3501.00
178_Y187_P1.3461.00
183_L186_I1.3441.00
118_E309_I1.3421.00
143_A414_F1.3411.00
180_Y186_I1.3391.00
37_S41_L1.3321.00
242_T246_N1.3231.00
8_W41_L1.3201.00
399_L426_G1.3091.00
264_S269_M1.3061.00
172_A176_M1.2901.00
117_Y406_S1.2841.00
180_Y185_T1.2781.00
309_I405_A1.2771.00
173_D182_V1.2761.00
173_D177_V1.2721.00
77_L276_A1.2691.00
179_I184_V1.2681.00
76_K80_D1.2681.00
223_P231_V1.2671.00
372_I388_L1.2561.00
184_V187_P1.2541.00
225_F235_P1.2541.00
381_V385_P1.2531.00
223_P235_P1.2491.00
119_V122_I1.2451.00
195_I198_K1.2341.00
181_G187_P1.2211.00
85_H220_N1.2181.00
87_I228_S1.2151.00
182_V186_I1.2141.00
441_L444_S1.2141.00
289_Q293_N1.2111.00
244_I247_I1.2031.00
394_A436_G1.1991.00
184_V443_I1.1911.00
174_M181_G1.1901.00
198_K201_G1.1881.00
181_G185_T1.1861.00
177_V181_G1.1851.00
86_Q90_T1.1851.00
227_V239_M1.1781.00
199_F203_L1.1761.00
400_T404_D1.1761.00
14_G22_K1.1731.00
352_L398_T1.1701.00
112_G153_A1.1701.00
338_S341_I1.1631.00
52_T317_Q1.1571.00
193_G199_F1.1571.00
194_L197_P1.1551.00
380_L385_P1.1501.00
335_G338_S1.1471.00
230_L234_I1.1401.00
394_A440_V1.1350.99
187_P191_C1.1340.99
21_L24_K1.1330.99
183_L188_S1.1270.99
51_H54_K1.1080.99
384_N387_L1.1080.99
177_V183_L1.1060.99
16_M34_A1.1000.99
186_I189_V1.0980.99
257_E260_N1.0950.99
17_L21_L1.0950.99
30_A34_A1.0940.99
107_I111_F1.0920.99
174_M182_V1.0910.99
108_G112_G1.0910.99
257_E261_F1.0860.99
231_V236_A1.0820.99
121_F413_Y1.0800.99
177_V182_V1.0750.99
265_S268_A1.0740.99
227_V230_L1.0710.99
83_A228_S1.0710.99
264_S267_I1.0690.99
194_L199_F1.0500.99
174_M177_V1.0460.99
15_L22_K1.0460.99
34_A38_V1.0440.99
419_K423_K1.0420.99
421_T425_W1.0400.99
302_I306_I1.0400.99
176_M181_G1.0370.99
57_F65_A1.0300.99
81_S280_F1.0260.99
176_M184_V1.0250.99
176_M183_L1.0240.99
105_I189_V1.0220.99
213_A216_P1.0160.99
74_I273_M1.0080.99
226_G231_V1.0030.99
369_S373_L1.0010.99
411_K418_V1.0000.99
405_A408_W0.9960.99
246_N249_L0.9940.99
245_A249_L0.9920.99
272_A276_A0.9910.99
188_S192_A0.9910.99
34_A37_S0.9890.99
258_V263_G0.9870.99
137_I141_K0.9790.98
175_G182_V0.9720.98
259_V262_I0.9690.98
117_Y120_A0.9680.98
384_N388_L0.9660.98
55_A58_G0.9650.98
420_D423_K0.9630.98
172_A178_Y0.9620.98
17_L25_I0.9610.98
400_T425_W0.9580.98
200_L204_E0.9570.98
398_T430_L0.9550.98
183_L190_I0.9490.98
235_P247_I0.9470.98
197_P202_N0.9410.98
223_P227_V0.9410.98
184_V439_I0.9400.98
13_I17_L0.9380.98
89_H222_L0.9330.98
61_L310_G0.9310.98
437_L441_L0.9310.98
173_D180_Y0.9300.98
246_N250_V0.9290.98
235_P240_I0.9260.98
173_D179_I0.9250.98
80_D290_W0.9240.98
38_V315_L0.9180.98
234_I238_I0.9170.98
172_A181_G0.9170.98
193_G200_L0.9160.98
317_Q320_I0.9150.98
182_V185_T0.9130.98
360_S404_D0.9110.98
15_L20_N0.9110.98
89_H134_E0.9090.98
27_S38_V0.9070.97
246_N260_N0.9060.97
13_I20_N0.9060.97
17_L22_K0.9010.97
202_N206_P0.8990.97
53_M314_V0.8990.97
9_V13_I0.8940.97
193_G198_K0.8910.97
180_Y386_A0.8890.97
163_P167_V0.8870.97
325_G329_G0.8870.97
240_I244_I0.8850.97
174_M179_I0.8850.97
153_A160_Q0.8830.97
293_N297_S0.8830.97
10_V14_G0.8790.97
6_I10_V0.8740.97
239_M243_T0.8720.97
12_G37_S0.8710.97
47_M51_H0.8700.97
44_M49_L0.8690.97
290_W293_N0.8690.97
399_L422_L0.8640.97
178_Y186_I0.8630.97
410_F413_Y0.8620.97
18_V21_L0.8620.97
101_Q104_V0.8580.96
196_L201_G0.8570.96
234_I239_M0.8570.96
243_T247_I0.8550.96
230_L237_I0.8550.96
226_G232_P0.8510.96
28_M307_L0.8490.96
203_L208_P0.8470.96
436_G440_V0.8460.96
175_G181_G0.8460.96
20_N25_I0.8440.96
243_T246_N0.8400.96
348_V352_L0.8370.96
86_Q225_F0.8370.96
429_E432_N0.8350.96
266_P269_M0.8340.96
405_A411_K0.8330.96
211_L214_D0.8330.96
202_N205_R0.8320.96
229_I232_P0.8320.96
183_L189_V0.8300.96
224_S231_V0.8290.96
344_W437_L0.8270.96
231_V234_I0.8250.96
194_L201_G0.8240.96
89_H93_A0.8230.96
181_G189_V0.8230.96
225_F232_P0.8210.96
151_T429_E0.8200.95
104_V108_G0.8190.95
351_R404_D0.8190.95
15_L18_V0.8160.95
14_G24_K0.8140.95
148_A428_L0.8130.95
44_M52_T0.8120.95
182_V187_P0.8100.95
19_L22_K0.8080.95
175_G184_V0.8070.95
200_L206_P0.8070.95
164_V167_V0.8050.95
16_M20_N0.8040.95
60_T313_G0.8030.95
40_M46_L0.8020.95
72_A295_F0.8000.95
323_G326_D0.7990.95
359_V363_T0.7990.95
112_G120_A0.7960.95
390_L440_V0.7950.95
381_V384_N0.7930.95
424_T427_L0.7930.95
386_A390_L0.7920.95
361_A396_S0.7910.95
44_M47_M0.7890.94
42_A322_T0.7870.94
187_P190_I0.7790.94
336_N341_I0.7770.94
235_P243_T0.7760.94
422_L426_G0.7750.94
39_G49_L0.7740.94
220_N228_S0.7730.94
225_F231_V0.7730.94
328_I332_M0.7730.94
117_Y121_F0.7730.94
226_G239_M0.7720.94
115_M269_M0.7710.94
335_G339_P0.7690.94
36_L267_I0.7660.94
13_I16_M0.7660.94
357_G396_S0.7630.93
231_V247_I0.7620.93
16_M24_K0.7620.93
66_I70_F0.7610.93
230_L235_P0.7600.93
17_L20_N0.7590.93
194_L198_K0.7590.93
337_I340_Y0.7570.93
269_M273_M0.7550.93
387_L444_S0.7520.93
250_V256_W0.7510.93
189_V193_G0.7500.93
148_A193_G0.7480.93
439_I442_I0.7460.93
268_A273_M0.7440.93
191_C195_I0.7400.92
225_F239_M0.7390.92
340_Y383_V0.7380.92
217_V221_N0.7360.92
222_L228_S0.7330.92
356_Q359_V0.7310.92
63_E66_I0.7310.92
11_F15_L0.7310.92
16_M21_L0.7310.92
52_T56_G0.7310.92
257_E262_I0.7290.92
22_K25_I0.7270.92
165_A362_M0.7260.92
84_A88_A0.7240.91
235_P238_I0.7240.91
212_K215_Q0.7230.91
175_G183_L0.7220.91
108_G124_L0.7200.91
201_G207_T0.7170.91
49_L318_T0.7150.91
245_A259_V0.7140.91
428_L432_N0.7130.91
244_I248_W0.7120.91
128_V146_A0.7080.91
262_I266_P0.7080.91
101_Q105_I0.7070.90
332_M346_I0.7060.90
231_V279_L0.7060.90
151_T397_N0.7030.90
259_V263_G0.7010.90
102_L193_G0.7000.90
400_T429_E0.6990.90
30_A36_L0.6990.90
172_A175_G0.6980.90
273_M276_A0.6980.90
14_G21_L0.6930.90
172_A187_P0.6910.89
177_V184_V0.6910.89
357_G400_T0.6870.89
74_I272_A0.6860.89
136_K207_T0.6840.89
19_L25_I0.6800.89
201_G204_E0.6790.89
228_S247_I0.6780.89
409_L412_G0.6760.88
56_G59_N0.6760.88
16_M19_L0.6750.88
373_L385_P0.6740.88
217_V220_N0.6740.88
114_A118_E0.6730.88
277_F295_F0.6730.88
188_S439_I0.6730.88
181_G186_I0.6700.88
192_A196_L0.6670.88
153_A157_F0.6650.88
174_M180_Y0.6630.87
173_D181_G0.6610.87
155_S166_L0.6590.87
407_F410_F0.6590.87
31_L34_A0.6560.87
21_L25_I0.6550.87
249_L256_W0.6540.87
44_M322_T0.6540.87
269_M272_A0.6530.87
17_L24_K0.6520.87
387_L440_V0.6520.87
8_W42_A0.6510.87
8_W12_G0.6510.87
146_A414_F0.6500.86
231_V243_T0.6500.86
120_A150_A0.6490.86
226_G229_I0.6470.86
212_K216_P0.6460.86
416_L420_D0.6460.86
42_A49_L0.6440.86
144_I148_A0.6440.86
242_T245_A0.6430.86
118_E122_I0.6400.86
121_F125_A0.6390.85
383_V388_L0.6390.85
351_R400_T0.6390.85
260_N265_S0.6380.85
234_I272_A0.6370.85
12_G42_A0.6370.85
195_I200_L0.6360.85
154_H160_Q0.6350.85
410_F414_F0.6350.85
277_F291_V0.6340.85
401_H429_E0.6320.85
102_L194_L0.6320.85
308_I362_M0.6320.85
418_V422_L0.6310.85
156_L394_A0.6280.85
174_M184_V0.6270.84
238_I242_T0.6270.84
76_K294_A0.6260.84
156_L436_G0.6260.84
133_A139_F0.6250.84
78_M83_A0.6250.84
197_P201_G0.6250.84
357_G405_A0.6240.84
26_N29_V0.6230.84
342_M372_I0.6220.84
132_A137_I0.6210.84
264_S272_A0.6200.84
262_I265_S0.6190.84
386_A389_V0.6190.84
424_T428_L0.6160.83
154_H358_V0.6140.83
38_V41_L0.6120.83
228_S234_I0.6120.83
120_A124_L0.6110.83
86_Q222_L0.6110.83
183_L192_A0.6110.83
405_A409_L0.6100.83
31_L38_V0.6090.83
233_L237_I0.6090.83
169_A366_G0.6080.83
86_Q224_S0.6070.82
201_G206_P0.6060.82
354_T360_S0.6060.82
188_S435_V0.6050.82
83_A280_F0.6040.82
439_I443_I0.6030.82
361_A364_A0.6030.82
230_L279_L0.6030.82
227_V236_A0.6010.82
214_D217_V0.6000.82
341_I441_L0.5980.82
184_V390_L0.5980.82
97_L135_A0.5980.82
180_Y390_L0.5970.81
13_I24_K0.5970.81
141_K145_P0.5970.81
182_V188_S0.5930.81
407_F413_Y0.5920.81
177_V187_P0.5900.81
149_A153_A0.5860.80
15_L21_L0.5840.80
76_K297_S0.5830.80
232_P243_T0.5810.80
177_V386_A0.5780.79
343_A347_T0.5770.79
399_L430_L0.5750.79
112_G160_Q0.5750.79
177_V186_I0.5740.79
152_T432_N0.5730.79
63_E67_I0.5720.79
217_V224_S0.5720.79
116_F119_V0.5720.79
231_V240_I0.5710.79
157_F160_Q0.5700.78
186_I191_C0.5690.78
351_R357_G0.5670.78
146_A149_A0.5660.78
37_S40_M0.5660.78
401_H424_T0.5650.78
109_L113_L0.5650.78
50_L54_K0.5640.78
7_L11_F0.5640.78
337_I341_I0.5630.78
227_V279_L0.5610.77
113_L153_A0.5610.77
350_I354_T0.5600.77
261_F264_S0.5600.77
267_I271_I0.5590.77
212_K221_N0.5580.77
55_A317_Q0.5580.77
273_M279_L0.5570.77
195_I201_G0.5570.77
54_K63_E0.5570.77
167_V171_G0.5560.77
38_V324_I0.5560.77
219_M223_P0.5560.77
109_L152_T0.5560.77
440_V444_S0.5560.77
259_V265_S0.5560.77
86_Q228_S0.5550.77
218_D221_N0.5550.77
407_F411_K0.5540.76
102_L105_I0.5520.76
165_A170_Y0.5520.76
236_A239_M0.5520.76
400_T403_N0.5510.76
287_D291_V0.5500.76
228_S244_I0.5500.76
276_A279_L0.5480.76
245_A250_V0.5470.76
185_T190_I0.5470.76
116_F120_A0.5470.76
227_V232_P0.5460.75
179_I186_I0.5460.75
260_N263_G0.5460.75
179_I187_P0.5450.75
199_F207_T0.5450.75
286_H291_V0.5430.75
8_W34_A0.5420.75
435_V439_I0.5420.75
35_A314_V0.5410.75
120_A160_Q0.5410.75
409_L416_L0.5410.75
226_G248_W0.5390.74
425_W428_L0.5390.74
406_S411_K0.5390.74
402_I422_L0.5380.74
335_G341_I0.5380.74
242_T248_W0.5380.74
178_Y189_V0.5380.74
239_M247_I0.5380.74
87_I117_Y0.5380.74
91_L95_L0.5370.74
224_S232_P0.5370.74
262_I269_M0.5360.74
32_L70_F0.5340.74
52_T55_A0.5340.74
152_T185_T0.5340.74
209_S212_K0.5330.74
8_W37_S0.5330.74
426_G430_L0.5330.74
265_S276_A0.5310.73
198_K206_P0.5310.73
27_S31_L0.5300.73
373_L388_L0.5290.73
245_A248_W0.5280.73
223_P239_M0.5280.73
172_A179_I0.5270.73
160_Q309_I0.5270.73
42_A47_M0.5240.72
357_G429_E0.5240.72
214_D218_D0.5240.72
219_M222_L0.5230.72
226_G247_I0.5230.72
196_L431_V0.5220.72
199_F205_R0.5220.72
280_F291_V0.5220.72
238_I275_V0.5220.72
210_F215_Q0.5220.72
112_G116_F0.5210.72
94_R278_V0.5200.72
331_L334_H0.5200.72
193_G203_L0.5200.72
8_W38_V0.5200.72
119_V162_G0.5190.72
304_M308_I0.5180.72
419_K422_L0.5180.72
425_W429_E0.5170.71
421_T428_L0.5170.71
211_L217_V0.5170.71
209_S215_Q0.5170.71
409_L413_Y0.5160.71
147_V428_L0.5150.71
404_D425_W0.5120.71
19_L33_V0.5110.71
343_A368_I0.5110.71
100_V104_V0.5110.71
42_A45_D0.5110.71
180_Y187_P0.5100.70
141_K201_G0.5100.70
181_G190_I0.5090.70
192_A198_K0.5060.70
173_D183_L0.5060.70
256_W262_I0.5020.69
229_I239_M0.5020.69
406_S409_L0.5020.69
224_S239_M0.5010.69
93_A290_W0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r1iA 2 0.9664 100 0.665 Contact Map
4r0cA 3 0.9642 100 0.67 Contact Map
4f35D 2 0.8904 100 0.699 Contact Map
3qe7A 2 0.4452 82.8 0.95 Contact Map
4dx5A 3 0.3602 77.5 0.953 Contact Map
3aqpA 1 0.3333 65.5 0.957 Contact Map
3w9iA 3 0.3378 60.6 0.958 Contact Map
2cfqA 1 0.8166 59.4 0.958 Contact Map
3giaA 1 0.4474 58.3 0.959 Contact Map
3qnqA 2 0.4609 44.4 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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