GREMLIN Database
GM4D - GDP-mannose 4,6-dehydratase
UniProt: P0AC88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11787
Length: 373 (300)
Sequences: 43871 (30575)
Seq/√Len: 1765.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_V31_G3.2831.00
265_M340_R2.9391.00
4_V28_E2.8151.00
247_E326_K2.6971.00
21_F235_K2.6261.00
249_F330_K2.6081.00
72_T119_F2.5581.00
236_M251_I2.5351.00
338_T341_E2.3961.00
104_D108_M2.3321.00
82_E241_L2.3071.00
32_I63_G2.2561.00
235_K336_E2.2401.00
63_G70_N2.2371.00
268_A340_R2.2141.00
98_S101_Y2.1881.00
21_F25_K2.1461.00
328_H334_K2.1361.00
188_E342_M2.1211.00
127_R178_Y2.1111.00
131_A237_Q2.0781.00
184_L237_Q2.0281.00
84_Y241_L2.0271.00
269_Q344_S2.0241.00
67_D70_N2.0121.00
182_G240_M1.9841.00
325_T329_E1.9581.00
235_K239_M1.9571.00
260_R264_E1.9471.00
7_I19_A1.9351.00
21_F238_W1.9151.00
231_K345_E1.9141.00
30_H59_H1.8731.00
8_T85_N1.8721.00
66_S104_D1.8191.00
25_K242_Q1.8021.00
258_S261_Q1.7711.00
18_L234_V1.7711.00
168_T179_A1.7561.00
229_H345_E1.7541.00
85_N130_Q1.7421.00
4_V30_H1.7381.00
30_H78_V1.7061.00
30_H61_H1.7031.00
18_L84_Y1.6991.00
18_L86_L1.6521.00
72_T116_A1.6511.00
265_M268_A1.6491.00
28_E59_H1.6491.00
35_R60_L1.6301.00
20_E191_R1.6221.00
327_A331_L1.6151.00
254_G328_H1.5961.00
348_A352_E1.5771.00
68_T115_E1.5731.00
344_S348_A1.5531.00
110_T164_A1.5481.00
21_F24_E1.5311.00
324_P328_H1.5231.00
207_N212_L1.4911.00
5_A27_Y1.4881.00
111_L167_I1.4491.00
206_A210_Q1.4491.00
59_H78_V1.4481.00
260_R278_G1.4471.00
25_K238_W1.4351.00
73_R77_E1.4291.00
146_K149_T1.4031.00
111_L115_E1.4021.00
72_T120_L1.4021.00
229_H342_M1.4011.00
81_D123_E1.3961.00
185_F322_G1.3901.00
238_W242_Q1.3841.00
162_L166_W1.3721.00
14_D187_H1.3691.00
132_S136_L1.3691.00
70_N73_R1.3671.00
84_Y237_Q1.3591.00
108_M111_L1.3551.00
68_T112_R1.3501.00
261_Q264_E1.3481.00
224_L256_Q1.3481.00
130_Q164_A1.3261.00
341_E344_S1.3251.00
19_A31_G1.3231.00
147_E326_K1.3231.00
85_N110_T1.3181.00
137_Y250_V1.3051.00
182_G237_Q1.3051.00
31_G58_F1.3021.00
86_L131_A1.2991.00
83_V117_I1.2981.00
106_D160_A1.2971.00
142_E146_K1.2931.00
341_E345_E1.2921.00
265_M269_Q1.2911.00
151_F162_L1.2881.00
247_E330_K1.2831.00
27_Y242_Q1.2771.00
117_I128_F1.2741.00
21_F234_V1.2721.00
100_E104_D1.2691.00
157_Y161_K1.2661.00
239_M243_Q1.2661.00
115_E118_R1.2641.00
127_R180_C1.2611.00
68_T72_T1.2561.00
226_D254_G1.2511.00
230_A234_V1.2501.00
10_V19_A1.2441.00
113_L128_F1.2411.00
6_L78_V1.2241.00
337_I345_E1.2231.00
228_G233_Y1.2221.00
75_L83_V1.2191.00
216_L277_E1.2171.00
65_L109_G1.2071.00
103_A163_Y1.2031.00
172_R179_A1.1981.00
114_L171_Y1.1921.00
73_R76_R1.1851.00
183_I248_D1.1761.00
131_A184_L1.1641.00
222_D260_R1.1611.00
166_W169_V1.1581.00
21_F231_K1.1571.00
115_E119_F1.1491.00
184_L233_Y1.1471.00
118_R175_Y1.1451.00
324_P335_P1.1411.00
86_L237_Q1.1331.00
222_D258_S1.1221.00
11_T33_K1.1171.00
257_Y339_L1.1161.00
326_K330_K1.1131.00
267_A273_K1.1121.00
5_A22_L1.1121.00
76_R120_L1.1111.00
130_Q181_N1.1091.00
32_I71_L1.1041.00
142_E149_T1.0991.00
16_S191_R1.0841.00
229_H337_I1.0831.00
264_E267_A1.0831.00
169_V181_N1.0781.00
20_E24_E1.0781.00
269_Q347_V1.0671.00
23_L58_F1.0661.00
17_Y231_K1.0611.00
128_F168_T1.0591.00
165_Y183_I1.0571.00
252_A322_G1.0561.00
146_K323_D1.0491.00
340_R344_S1.0451.00
6_L32_I1.0401.00
4_V78_V1.0401.00
72_T76_R1.0361.00
61_H74_I1.0341.00
32_I70_N1.0321.00
23_L57_K1.0321.00
61_H78_V1.0271.00
114_L128_F1.0211.00
117_I122_L1.0161.00
345_E348_A1.0151.00
148_T326_K1.0071.00
130_Q168_T1.0071.00
183_I250_V1.0021.00
200_K204_A0.9971.00
270_L347_V0.9961.00
71_L116_A0.9941.00
180_C240_M0.9891.00
118_R177_M0.9891.00
61_H77_E0.9861.00
199_R202_T0.9851.00
32_I74_I0.9781.00
70_N74_I0.9761.00
65_L87_G0.9761.00
236_M327_A0.9711.00
231_K337_I0.9671.00
68_T119_F0.9641.00
89_M105_V0.9631.00
235_K337_I0.9591.00
75_L120_L0.9591.00
348_A351_L0.9581.00
4_V81_D0.9511.00
214_S275_R0.9501.00
105_V109_G0.9491.00
22_L238_W0.9461.00
116_A120_L0.9441.00
188_E229_H0.9341.00
190_P345_E0.9321.00
169_V248_D0.9301.00
240_M327_A0.9301.00
169_V173_E0.9291.00
239_M242_Q0.9281.00
232_D253_T0.9271.00
69_S73_R0.9241.00
170_N174_S0.9191.00
34_R64_D0.9181.00
159_V163_Y0.9161.00
123_E178_Y0.9081.00
187_H233_Y0.9071.00
69_S72_T0.9071.00
129_Y182_G0.9021.00
5_A82_E0.8931.00
280_G283_E0.8881.00
75_L78_V0.8831.00
18_L22_L0.8821.00
167_I170_N0.8821.00
249_F326_K0.8811.00
23_L29_V0.8811.00
114_L167_I0.8801.00
337_I341_E0.8791.00
13_Q230_A0.8781.00
203_R206_A0.8771.00
132_S165_Y0.8771.00
269_Q343_V0.8711.00
108_M112_R0.8681.00
35_R62_Y0.8601.00
267_A274_L0.8591.00
114_L168_T0.8581.00
116_A119_F0.8511.00
269_Q340_R0.8461.00
325_T328_H0.8451.00
107_A163_Y0.8441.00
5_A84_Y0.8421.00
251_I327_A0.8411.00
74_I78_V0.8331.00
4_V27_Y0.8311.00
54_C58_F0.8281.00
252_A324_P0.8251.00
245_Q330_K0.8231.00
94_V98_S0.8211.00
221_M260_R0.8171.00
30_H77_E0.8161.00
75_L116_A0.8141.00
181_N248_D0.8131.00
75_L117_I0.8111.00
103_A107_A0.8091.00
257_Y261_Q0.8091.00
35_R38_S0.8071.00
200_K203_R0.8071.00
187_H228_G0.8061.00
171_Y175_Y0.8061.00
66_S105_V0.8021.00
19_A29_V0.7991.00
110_T168_T0.7991.00
145_Q149_T0.7981.00
115_E171_Y0.7961.00
33_K60_L0.7951.00
17_Y230_A0.7911.00
282_E285_G0.7911.00
229_H232_D0.7891.00
134_S185_F0.7881.00
203_R207_N0.7881.00
5_A241_L0.7861.00
182_G251_I0.7761.00
96_F156_P0.7761.00
103_A108_M0.7761.00
13_Q189_S0.7691.00
8_T113_L0.7661.00
85_N113_L0.7651.00
264_E268_A0.7601.00
236_M333_W0.7601.00
262_F339_L0.7601.00
235_K333_W0.7591.00
8_T87_G0.7571.00
18_L237_Q0.7561.00
326_K329_E0.7561.00
239_M332_G0.7551.00
267_A272_I0.7541.00
214_S277_E0.7511.00
136_L165_Y0.7441.00
257_Y262_F0.7431.00
36_A62_Y0.7411.00
269_Q348_A0.7371.00
169_V179_A0.7371.00
135_E158_A0.7371.00
27_Y81_D0.7351.00
118_R171_Y0.7261.00
118_R176_G0.7241.00
337_I342_M0.7241.00
224_L258_S0.7231.00
166_W170_N0.7151.00
232_D336_E0.7141.00
235_K238_W0.7131.00
239_M331_L0.7111.00
265_M339_L0.7091.00
14_D233_Y0.7071.00
206_A209_A0.7071.00
201_I204_A0.7061.00
136_L151_F0.7051.00
164_A168_T0.7051.00
26_G29_V0.7041.00
101_Y104_D0.7021.00
17_Y234_V0.7011.00
6_L83_V0.7001.00
159_V166_W0.7001.00
256_Q321_L0.6971.00
261_Q265_M0.6971.00
22_L241_L0.6961.00
255_V338_T0.6951.00
44_V47_I0.6941.00
83_V128_F0.6921.00
110_T114_L0.6911.00
194_E197_V0.6901.00
134_S322_G0.6881.00
182_G236_M0.6861.00
83_V113_L0.6851.00
101_Y105_V0.6831.00
55_N58_F0.6831.00
159_V170_N0.6801.00
254_G324_P0.6791.00
179_A246_P0.6781.00
25_K235_K0.6781.00
103_A160_A0.6781.00
190_P229_H0.6771.00
240_M331_L0.6731.00
27_Y82_E0.6681.00
17_Y20_E0.6671.00
95_S102_T0.6671.00
127_R244_E0.6651.00
129_Y241_L0.6651.00
59_H77_E0.6631.00
346_M349_N0.6611.00
184_L187_H0.6611.00
17_Y21_F0.6601.00
11_T35_R0.6571.00
28_E57_K0.6551.00
140_V145_Q0.6541.00
112_R116_A0.6521.00
20_E46_H0.6511.00
112_R115_E0.6511.00
226_D253_T0.6511.00
89_M102_T0.6501.00
129_Y237_Q0.6501.00
151_F166_W0.6461.00
102_T160_A0.6451.00
20_E231_K0.6431.00
109_G112_R0.6431.00
147_E327_A0.6431.00
7_I22_L0.6421.00
239_M333_W0.6421.00
223_S259_V0.6391.00
234_V238_W0.6371.00
153_P158_A0.6351.00
267_A276_F0.6341.00
88_A106_D0.6331.00
67_D71_L0.6301.00
202_T206_A0.6291.00
163_Y167_I0.6281.00
71_L112_R0.6281.00
99_P159_V0.6261.00
68_T116_A0.6241.00
86_L184_L0.6211.00
328_H335_P0.6191.00
89_M106_D0.6171.00
267_A270_L0.6171.00
6_L74_I0.6171.00
89_M101_Y0.6171.00
347_V351_L0.6161.00
163_Y166_W0.6141.00
82_E127_R0.6111.00
30_H74_I0.6101.00
324_P333_W0.6101.00
6_L63_G0.6071.00
16_S20_E0.6061.00
18_L238_W0.6041.00
106_D157_Y0.6011.00
178_Y245_Q0.6011.00
17_Y191_R0.5991.00
153_P162_L0.5951.00
22_L27_Y0.5951.00
204_A207_N0.5911.00
168_T181_N0.5901.00
144_P323_D0.5901.00
257_Y265_M0.5891.00
265_M343_V0.5891.00
209_A212_L0.5841.00
279_T282_E0.5821.00
61_H70_N0.5811.00
190_P231_K0.5801.00
141_Q149_T0.5791.00
103_A159_V0.5791.00
211_G272_I0.5771.00
266_A343_V0.5741.00
63_G74_I0.5731.00
274_L277_E0.5691.00
65_L105_V0.5681.00
22_L84_Y0.5661.00
84_Y238_W0.5641.00
74_I77_E0.5641.00
285_G288_V0.5641.00
185_F252_A0.5631.00
133_T161_K0.5631.00
186_N225_R0.5601.00
19_A58_F0.5591.00
100_E111_L0.5591.00
232_D235_K0.5581.00
82_E123_E0.5551.00
75_L113_L0.5551.00
54_C57_K0.5551.00
147_E250_V0.5541.00
167_I171_Y0.5521.00
85_N128_F0.5491.00
6_L75_L0.5491.00
13_Q17_Y0.5481.00
64_D67_D0.5481.00
82_E129_Y0.5471.00
117_I120_L0.5451.00
31_G60_L0.5441.00
151_F248_D0.5441.00
202_T205_I0.5421.00
133_T136_L0.5411.00
266_A347_V0.5411.00
155_S158_A0.5401.00
327_A330_K0.5381.00
170_N173_E0.5381.00
23_L55_N0.5381.00
261_Q340_R0.5351.00
216_L279_T0.5331.00
256_Q319_T0.5331.00
255_V340_R0.5311.00
279_T284_K0.5301.00
273_K276_F0.5291.00
143_I149_T0.5281.00
214_S217_Y0.5231.00
188_E253_T0.5231.00
139_L154_R0.5221.00
156_P160_A0.5181.00
117_I177_M0.5181.00
113_L117_I0.5161.00
172_R178_Y0.5151.00
249_F327_A0.5151.00
193_G197_V0.5151.00
284_K287_V0.5131.00
172_R246_P0.5131.00
33_K37_S0.5111.00
275_R278_G0.5111.00
243_Q249_F0.5101.00
228_G232_D0.5071.00
165_Y181_N0.5061.00
186_N227_W0.5041.00
284_K288_V0.5041.00
82_E242_Q0.5041.00
172_R177_M0.5031.00
238_W241_L0.5011.00
71_L75_L0.5011.00
132_S181_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1db3A 2 0.8981 100 0.234 Contact Map
1rpnA 4 0.8579 100 0.246 Contact Map
1t2aA 4 0.9062 100 0.251 Contact Map
2z1mA 4 0.9169 100 0.254 Contact Map
1orrA 3 0.8338 100 0.267 Contact Map
3rufA 2 0.8499 100 0.267 Contact Map
1sb8A 2 0.8633 100 0.268 Contact Map
1n7hA 4 0.882 100 0.268 Contact Map
1rkxA 3 0.8686 100 0.272 Contact Map
2c20A 2 0.8365 100 0.274 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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