GREMLIN Database
PHSG - Glycogen phosphorylase
UniProt: P0AC86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10380
Length: 815 (794)
Sequences: 2221 (1257)
Seq/√Len: 44.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
302_Y339_H5.4351.00
543_A584_V4.5551.00
504_Q790_N4.2681.00
487_E515_A4.2541.00
316_A432_H4.1031.00
691_F773_L4.0961.00
531_I539_V4.0751.00
573_K617_Q3.9451.00
513_N785_M3.9321.00
717_D761_R3.8711.00
779_E783_K3.8201.00
517_H781_T3.8171.00
433_K462_T3.7721.00
562_V608_V3.7461.00
291_S295_Q3.7301.00
532_A538_V3.6891.00
387_E391_Y3.6641.00
565_V585_N3.5871.00
574_A722_Q3.4831.00
521_L542_K3.3921.00
213_G292_S3.3701.00
684_H793_Y3.3661.00
552_I589_G3.3631.00
499_L502_E3.2631.00
513_N778_E3.0951.00
501_N790_N3.0731.00
714_Y725_T3.0161.00
309_D345_D2.9731.00
348_E352_Q2.9421.00
464_V806_H2.8981.00
567_T760_Y2.8371.00
409_R452_D2.8131.00
508_D782_A2.7851.00
516_V788_I2.7201.00
674_L696_T2.7081.00
480_S526_R2.7061.00
682_L687_A2.6921.00
443_N447_Q2.6421.00
762_S765_D2.6191.00
133_F799_T2.6011.00
721_H725_T2.5641.00
308_Y341_F2.4871.00
451_A455_K2.4811.00
298_L334_L2.4611.00
570_N726_Q2.4401.00
644_L671_I2.4351.00
464_V799_T2.4211.00
496_D499_L2.3981.00
501_N504_Q2.3761.00
516_V784_A2.3661.00
644_L770_V2.3461.00
480_S522_E2.3451.00
562_V565_V2.3421.00
310_N313_D2.3401.00
108_N111_E2.3301.00
149_I266_S2.3221.00
776_L779_E2.3201.00
492_N499_L2.3161.00
468_V665_L2.2951.00
572_I618_I2.2851.00
517_H777_Q2.2831.00
523_N526_R2.2731.00
361_L444_L2.2671.00
488_H506_H2.2571.00
486_D494_R2.2551.00
342_S345_D2.2301.00
454_A459_G2.2271.00
164_S603_H2.2271.00
488_H512_V2.2161.00
711_R715_E2.2021.00
482_S493_W2.1951.00
307_T310_N2.1901.00
297_I317_I2.1761.00
549_I638_I2.1761.00
665_L791_M2.1751.00
510_P778_E2.1751.00
188_Y215_A2.1481.00
374_L385_I2.1471.00
25_L36_A2.1261.00
521_L525_K2.0971.00
702_E706_Q2.0950.99
516_V785_M2.0950.99
197_Q206_I2.0860.99
294_I334_L2.0810.99
801_K805_D2.0520.99
531_I586_I2.0440.99
773_L783_K2.0320.99
480_S523_N2.0190.99
434_V460_R2.0120.99
301_H310_N2.0120.99
575_D578_A1.9840.99
709_K712_E1.9580.99
355_S432_H1.9570.99
761_R765_D1.9510.99
406_L455_K1.9410.99
486_D493_W1.9280.99
681_M685_V1.9190.99
343_W347_F1.9170.99
406_L410_A1.9130.99
298_L311_L1.9070.99
669_L691_F1.9050.99
389_N393_L1.8870.99
57_W230_T1.8760.99
280_E376_K1.8630.99
643_D781_T1.8610.99
579_K775_E1.8600.99
802_E806_H1.8440.99
195_R207_E1.8430.99
714_Y721_H1.8210.99
547_V642_A1.8100.99
583_R767_Q1.8060.98
24_K28_T1.8040.98
502_E505_Q1.7930.98
627_I634_L1.7930.98
31_K40_E1.7840.98
674_L682_L1.7710.98
682_L690_I1.7710.98
362_M653_T1.7650.98
664_A791_M1.7480.98
133_F800_I1.7440.98
529_E533_Q1.7290.98
714_Y748_I1.7270.98
562_V604_L1.7220.98
507_C513_N1.7220.98
312_A352_Q1.7030.98
720_L760_Y1.7010.98
137_L144_G1.7010.98
765_D769_K1.6780.98
540_N620_D1.6780.98
525_K529_E1.6590.97
696_T699_E1.6580.97
585_N622_L1.6560.97
484_V512_V1.6550.97
486_D491_R1.6470.97
406_L409_R1.6440.97
390_D394_K1.6420.97
488_H515_A1.6360.97
535_L628_P1.6350.97
669_L783_K1.6350.97
572_I578_A1.6250.97
439_E443_N1.6150.97
387_E390_D1.6130.97
773_L779_E1.6120.97
301_H312_A1.6040.97
571_R768_D1.6010.97
685_V690_I1.5950.97
549_I663_F1.5950.97
766_C769_K1.5860.97
530_Y534_Q1.5820.96
38_K111_E1.5780.96
597_M743_L1.5720.96
336_I342_S1.5690.96
489_L502_E1.5580.96
186_T215_A1.5560.96
544_L644_L1.5500.96
539_V584_V1.5460.96
18_K104_A1.5450.96
728_G744_V1.5430.96
485_L489_L1.5420.96
81_I131_A1.5390.96
389_N411_S1.5320.96
68_E305_H1.5270.96
579_K621_K1.5250.96
311_L353_V1.5190.96
328_I354_F1.5140.95
72_V810_I1.5140.95
137_L142_L1.5100.95
295_Q334_L1.5070.95
600_H742_D1.5040.95
526_R637_L1.4920.95
327_S354_F1.4900.95
141_G225_T1.4900.95
251_D254_A1.4890.95
177_N218_Q1.4820.95
13_S16_A1.4760.95
480_S519_A1.4750.95
75_L293_T1.4740.95
142_L810_I1.4700.95
326_L374_L1.4660.95
325_V427_A1.4660.95
375_G386_F1.4610.94
485_L503_L1.4600.94
745_D749_N1.4560.94
507_C786_L1.4540.94
796_S800_I1.4440.94
347_F388_I1.4420.94
703_L707_G1.4400.94
457_F460_R1.4360.94
712_E715_E1.4340.94
741_R745_D1.4290.94
332_M347_F1.4270.94
368_T420_R1.4120.93
769_K772_E1.4110.93
443_N446_V1.4100.93
485_L488_H1.4090.93
802_E805_D1.4060.93
540_N623_K1.4040.93
311_L315_I1.4010.93
528_A541_P1.4000.93
150_R180_E1.3920.93
382_L421_V1.3910.93
14_V100_G1.3850.93
136_S796_S1.3800.93
325_V426_L1.3770.92
24_K51_D1.3770.92
603_H607_D1.3690.92
587_F624_V1.3690.92
254_A257_E1.3670.92
564_H568_R1.3640.92
714_Y757_L1.3630.92
341_F349_V1.3630.92
515_A518_Q1.3630.92
454_A461_F1.3620.92
570_N722_Q1.3600.92
99_Q103_E1.3590.92
343_W387_E1.3510.92
567_T571_R1.3460.92
313_D352_Q1.3460.92
512_V785_M1.3450.92
507_C785_M1.3370.91
798_R802_E1.3360.91
84_T119_P1.3270.91
804_A810_I1.3260.91
587_F605_I1.3210.91
462_T806_H1.3180.91
301_H305_H1.3130.91
141_G227_A1.3100.90
711_R749_N1.3080.90
326_L329_P1.3050.90
397_Q404_T1.3030.90
719_E761_R1.3020.90
403_D406_L1.3010.90
630_Y639_I1.2990.90
302_Y308_Y1.2970.90
700_V755_Q1.2970.90
760_Y764_V1.2940.90
189_K210_E1.2920.90
718_E721_H1.2900.90
81_I84_T1.2870.90
374_L382_L1.2860.90
316_A355_S1.2840.90
433_K464_V1.2840.90
518_Q522_E1.2820.89
484_V519_A1.2820.89
301_H306_K1.2810.89
610_K614_N1.2810.89
301_H308_Y1.2780.89
405_D408_G1.2770.89
674_L692_I1.2740.89
332_M343_W1.2730.89
571_R719_E1.2680.89
17_L21_I1.2610.89
410_A452_D1.2600.89
88_A221_P1.2570.89
777_Q781_T1.2560.88
583_R771_D1.2550.88
567_T719_E1.2500.88
484_V488_H1.2440.88
149_I289_L1.2410.88
530_Y637_L1.2370.88
635_A639_I1.2300.87
691_F770_V1.2290.87
767_Q770_V1.2290.87
371_V413_I1.2280.87
563_L723_V1.2230.87
522_E525_K1.2210.87
464_V802_E1.2200.87
147_Y296_D1.2200.87
403_D409_R1.2190.87
301_H307_T1.2180.87
70_R316_A1.2170.87
566_I732_F1.2160.87
568_R771_D1.2110.87
799_T806_H1.2060.86
779_E782_A1.2010.86
470_P497_L1.1990.86
442_S462_T1.1970.86
347_F430_V1.1950.86
197_Q204_R1.1870.85
568_R585_N1.1870.85
674_L687_A1.1870.85
188_Y299_S1.1770.85
698_E702_E1.1760.85
566_I604_L1.1760.85
276_Y372_D1.1750.85
504_Q786_L1.1740.85
713_Y720_L1.1690.85
482_S486_D1.1680.85
514_H518_Q1.1670.84
514_H778_E1.1660.84
22_A105_M1.1660.84
120_G155_M1.1580.84
192_F284_R1.1560.84
73_Y315_I1.1550.84
371_V382_L1.1540.84
500_L503_L1.1520.84
337_D380_R1.1500.84
14_V104_A1.1500.84
167_E599_K1.1470.83
21_I45_T1.1440.83
513_N516_V1.1430.83
428_V434_V1.1380.83
375_G382_L1.1360.83
410_A456_I1.1350.83
549_I639_I1.1320.83
521_L541_P1.1310.83
537_V625_V1.1310.83
548_Q561_N1.1300.83
351_C460_R1.1300.83
485_L512_V1.1250.82
681_M690_I1.1210.82
689_N783_K1.1200.82
28_T47_F1.1180.82
99_Q110_E1.1180.82
77_M286_E1.1140.82
393_L411_S1.1130.82
581_V775_E1.1130.82
259_K263_E1.1120.81
214_V237_Q1.1120.81
224_D495_T1.1110.81
196_I383_Q1.1080.81
539_V545_F1.1050.81
137_L810_I1.1040.81
724_L744_V1.1040.81
505_Q513_N1.1030.81
572_I621_K1.1000.81
397_Q407_L1.0980.81
70_R312_A1.0950.80
742_D745_D1.0950.80
312_A349_V1.0930.80
603_H740_Y1.0920.80
325_V328_I1.0920.80
161_V166_K1.0910.80
351_C395_T1.0890.80
498_S801_K1.0890.80
489_L499_L1.0890.80
70_R432_H1.0830.80
374_L421_V1.0820.80
363_S589_G1.0810.80
334_L339_H1.0800.80
695_N758_A1.0800.80
608_V612_I1.0770.79
547_V638_I1.0770.79
306_K310_N1.0770.79
683_D793_Y1.0730.79
627_I638_I1.0730.79
682_L692_I1.0720.79
510_P513_N1.0700.79
344_D391_Y1.0680.79
408_G415_E1.0670.79
191_R207_E1.0670.79
17_L98_V1.0640.79
505_Q508_D1.0640.79
177_N180_E1.0630.78
531_I535_L1.0630.78
475_A494_R1.0630.78
189_K212_L1.0620.78
513_N781_T1.0600.78
142_L804_A1.0550.78
474_L665_L1.0490.78
393_L396_L1.0480.77
503_L512_V1.0450.77
704_R753_H1.0440.77
728_G748_I1.0440.77
312_A348_E1.0420.77
75_L327_S1.0410.77
405_D409_R1.0390.77
566_I727_I1.0310.76
332_M350_C1.0290.76
513_N782_A1.0280.76
334_L338_E1.0270.76
394_K397_Q1.0250.76
195_R206_I1.0250.76
703_L755_Q1.0250.76
769_K773_L1.0220.76
36_A40_E1.0170.75
68_E314_K1.0150.75
618_I623_K1.0150.75
445_M449_L1.0140.75
412_I429_V1.0120.75
60_S64_Q1.0110.75
17_L101_A1.0080.75
371_V386_F1.0060.74
209_E284_R1.0060.74
786_L790_N1.0050.74
372_D375_G1.0020.74
311_L335_L1.0000.74
432_H809_H0.9990.74
563_L727_I0.9990.74
332_M384_I0.9970.74
567_T764_V0.9950.74
192_F211_I0.9930.74
308_Y311_L0.9930.74
53_L221_P0.9890.73
90_L475_A0.9880.73
712_E716_K0.9870.73
527_L531_I0.9870.73
613_N623_K0.9860.73
468_V474_L0.9860.73
768_D772_E0.9840.73
525_K541_P0.9840.73
442_S445_M0.9830.73
196_I203_T0.9820.73
475_A482_S0.9820.73
446_V454_A0.9810.73
17_L97_D0.9810.73
274_S594_A0.9800.73
508_D776_L0.9790.72
726_Q731_V0.9790.72
695_N700_V0.9760.72
695_N703_L0.9740.72
83_R118_D0.9730.72
799_T802_E0.9730.72
153_Y170_D0.9720.72
534_Q631_S0.9710.72
72_V144_G0.9680.72
45_T98_V0.9670.72
95_Y99_Q0.9650.71
386_F389_N0.9650.71
89_M109_L0.9630.71
719_E760_Y0.9630.71
49_V85_L0.9630.71
442_S464_V0.9620.71
159_N168_S0.9590.71
297_I315_I0.9570.71
713_Y758_A0.9570.71
413_I421_V0.9540.70
627_I637_L0.9530.70
695_N755_Q0.9510.70
671_I766_C0.9490.70
86_S113_I0.9480.70
310_N341_F0.9460.70
38_K115_E0.9450.70
21_I102_L0.9440.70
724_L757_L0.9440.70
247_F255_A0.9420.70
147_Y293_T0.9390.69
482_S485_L0.9370.69
762_S766_C0.9350.69
560_M760_Y0.9350.69
748_I757_L0.9350.69
100_G104_A0.9290.68
382_L386_F0.9290.68
566_I611_V0.9280.68
642_A663_F0.9230.68
619_G623_K0.9230.68
607_D610_K0.9220.68
396_L456_I0.9210.68
289_L326_L0.9190.68
41_W107_L0.9150.67
203_T383_Q0.9140.67
744_V748_I0.9110.67
511_M514_H0.9100.67
396_L407_L0.9100.67
738_G741_R0.9090.67
164_S739_R0.9080.67
84_T218_Q0.9040.66
571_R575_D0.9020.66
157_K629_N0.9020.66
501_N684_H0.9010.66
781_T785_M0.9000.66
205_W208_T0.9000.66
765_D768_D0.9000.66
150_R216_Y0.8990.66
86_S476_V0.8980.66
291_S334_L0.8970.66
691_F766_C0.8970.66
442_S697_A0.8960.66
687_A690_I0.8950.66
462_T799_T0.8940.65
21_I48_A0.8940.65
355_S433_K0.8930.65
32_D35_V0.8910.65
618_I621_K0.8900.65
198_Q201_K0.8890.65
559_L743_L0.8890.65
36_A41_W0.8880.65
504_Q507_C0.8870.65
669_L784_A0.8850.65
309_D341_F0.8840.65
131_A231_L0.8830.64
286_E326_L0.8830.64
242_I247_F0.8830.64
559_L756_V0.8830.64
508_D513_N0.8810.64
351_C432_H0.8780.64
604_L727_I0.8730.64
543_A623_K0.8730.64
311_L331_M0.8720.63
439_E683_D0.8710.63
544_L581_V0.8680.63
396_L401_P0.8680.63
535_L539_V0.8670.63
191_R210_E0.8660.63
782_A786_L0.8640.63
652_G701_E0.8630.63
290_V326_L0.8630.63
133_F464_V0.8620.63
329_P336_I0.8590.62
296_D299_S0.8580.62
46_L178_P0.8580.62
317_I353_V0.8570.62
90_L95_Y0.8570.62
301_H341_F0.8560.62
492_N496_D0.8550.62
605_I624_V0.8550.62
607_D740_Y0.8530.62
617_Q620_D0.8530.62
37_N519_A0.8530.62
96_E99_Q0.8530.62
671_I681_M0.8500.61
699_E702_E0.8500.61
428_V449_L0.8500.61
198_Q203_T0.8500.61
691_F783_K0.8490.61
411_S415_E0.8480.61
411_S414_D0.8480.61
611_V732_F0.8470.61
182_K237_Q0.8450.61
613_N619_G0.8440.61
301_H311_L0.8430.61
733_S740_Y0.8430.61
483_A487_E0.8420.61
544_L770_V0.8420.61
440_L565_V0.8400.61
150_R173_L0.8400.61
295_Q338_E0.8380.60
545_F586_I0.8370.60
597_M742_D0.8360.60
597_M601_I0.8310.60
539_V586_I0.8290.60
99_Q108_N0.8290.60
541_P545_F0.8280.59
539_V627_I0.8280.59
187_R214_V0.8280.59
26_M55_E0.8280.59
520_K774_Y0.8270.59
720_L757_L0.8270.59
64_Q227_A0.8240.59
647_Q668_A0.8230.59
645_S670_T0.8230.59
581_V771_D0.8220.59
205_W381_H0.8200.59
215_A228_T0.8200.59
19_H23_Y0.8160.58
653_T753_H0.8160.58
14_V18_K0.8140.58
771_D775_E0.8140.58
89_M95_Y0.8140.58
492_N495_T0.8120.58
245_G249_Q0.8100.58
119_P636_Q0.8100.58
386_F415_E0.8090.58
325_V430_V0.8090.58
140_L801_K0.8090.58
506_H512_V0.8070.57
31_K185_N0.8070.57
630_Y635_A0.8070.57
393_L415_E0.8040.57
152_D267_R0.8030.57
703_L706_Q0.8010.57
290_V325_V0.8000.57
247_F250_G0.8000.57
540_N582_P0.7970.57
70_R73_Y0.7960.56
73_Y300_R0.7950.56
597_M746_S0.7940.56
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671_I767_Q0.5100.30
70_R313_D0.5100.30
709_K715_E0.5100.30
434_V638_I0.5100.30
697_A701_E0.5100.30
352_Q432_H0.5090.30
588_G638_I0.5080.30
669_L718_E0.5080.30
564_H567_T0.5080.30
134_L220_I0.5070.30
17_L23_Y0.5070.30
700_V703_L0.5070.30
697_A700_V0.5070.30
15_E19_H0.5070.30
504_Q789_A0.5060.30
279_R588_G0.5050.30
95_Y109_L0.5050.30
407_L422_R0.5050.30
473_W630_Y0.5040.29
287_Y549_I0.5040.29
87_N392_F0.5040.29
544_L568_R0.5040.29
69_T314_K0.5040.29
592_A602_I0.5040.29
575_D579_K0.5040.29
484_V516_V0.5030.29
345_D348_E0.5030.29
68_E304_L0.5030.29
611_V733_S0.5030.29
272_D753_H0.5030.29
671_I691_F0.5020.29
71_Q300_R0.5020.29
93_G224_D0.5020.29
286_E351_C0.5020.29
75_L147_Y0.5020.29
484_V593_S0.5020.29
189_K208_T0.5020.29
313_D339_H0.5020.29
120_G755_Q0.5010.29
105_M108_N0.5010.29
342_S391_Y0.5010.29
479_P483_A0.5010.29
528_A538_V0.5000.29
669_L791_M0.5000.29
32_D65_L0.5000.29
382_L415_E0.5000.29
571_R578_A0.5000.29
257_E587_F0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ygpA 2 0.989 100 0.302 Contact Map
4bqeA 2 0.9914 100 0.32 Contact Map
2gj4A 2 0.9816 100 0.341 Contact Map
1l5wA 2 0.9742 100 0.354 Contact Map
2c4mA 4 0.9583 100 0.381 Contact Map
4l22A 1 0.9215 100 0.45 Contact Map
3vueA 1 0.5755 98.5 0.974 Contact Map
4qlbA 3 0.6528 97.8 0.978 Contact Map
3nb0A 4 0.6515 97.7 0.979 Contact Map
2qzsA 1 0.519 87.8 0.987 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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