GREMLIN Database
GLO2 - Hydroxyacylglutathione hydrolase
UniProt: P0AC84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13330
Length: 251 (206)
Sequences: 7203 (4785)
Seq/√Len: 333.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_T116_C4.3581.00
91_D151_K3.9661.00
23_R47_E3.5791.00
104_V115_I3.0731.00
94_T101_E2.8811.00
96_F101_E2.8361.00
157_D211_R2.8251.00
39_I46_P2.8001.00
94_T103_S2.7431.00
51_L62_V2.5891.00
75_Y89_V2.4921.00
78_Q90_K2.4291.00
23_R45_Q2.4261.00
50_F117_Y2.4221.00
69_F72_I2.2491.00
73_V87_Q2.1821.00
188_Y191_K2.1581.00
25_L48_A2.1341.00
48_A75_Y2.0261.00
27_V124_F1.9431.00
147_Q189_Y1.8641.00
121_P158_D1.8361.00
122_Y162_C1.8181.00
80_T113_G1.8051.00
137_L142_A1.7941.00
37_N41_A1.7781.00
194_E198_K1.7681.00
48_A73_V1.7551.00
36_L69_F1.7241.00
66_V86_T1.7091.00
38_A42_N1.6891.00
36_L68_K1.6891.00
33_E37_N1.6421.00
16_V38_A1.6181.00
116_C123_L1.6171.00
18_N24_C1.6101.00
90_K93_E1.6091.00
75_Y87_Q1.6071.00
143_S189_Y1.5951.00
64_E68_K1.5911.00
24_C44_W1.5691.00
104_V117_Y1.5631.00
184_S212_Q1.5611.00
188_Y213_I1.5511.00
37_N40_A1.5461.00
87_Q93_E1.5421.00
18_N44_W1.5121.00
132_G172_M1.5001.00
109_G148_S1.4951.00
105_I151_K1.4941.00
27_V52_T1.4901.00
40_A68_K1.4821.00
146_Y150_K1.4801.00
169_L193_K1.4771.00
91_D106_A1.4421.00
52_T126_G1.4231.00
20_E99_G1.4101.00
95_A102_F1.4001.00
107_T148_S1.3961.00
14_I35_V1.3921.00
190_R194_E1.3881.00
179_L182_D1.3481.00
62_V74_V1.3201.00
103_S118_F1.3161.00
38_A41_A1.2841.00
118_F123_L1.2511.00
147_Q150_K1.2471.00
141_T144_Q1.2271.00
176_L189_Y1.2261.00
64_E67_E1.2171.00
123_L155_L1.2051.00
36_L40_A1.2051.00
153_S175_A1.2001.00
17_L27_V1.1871.00
191_K195_L1.1801.00
118_F121_P1.1751.00
89_V104_V1.1741.00
50_F102_F1.1611.00
26_I46_P1.1601.00
123_L161_V1.1541.00
77_P106_A1.1391.00
173_K177_S1.1371.00
25_L97_V1.1361.00
92_G103_S1.1351.00
116_C128_T1.1351.00
189_Y193_K1.1251.00
25_L50_F1.1231.00
157_D179_L1.1051.00
138_F141_T1.0871.00
175_A179_L1.0821.00
19_D98_L1.0771.00
77_P115_I1.0551.00
112_L144_Q1.0401.00
32_A61_G1.0401.00
131_S213_I1.0401.00
77_P80_T1.0121.00
76_G85_T1.0091.00
66_V74_V1.0081.00
97_V100_H1.0041.00
173_K178_I1.0011.00
116_C152_L0.9961.00
169_L192_V0.9941.00
137_L145_M0.9941.00
50_F95_A0.9911.00
190_R193_K0.9881.00
31_D34_P0.9851.00
176_L186_N0.9831.00
96_F99_G0.9831.00
128_T152_L0.9741.00
122_Y160_L0.9711.00
151_K154_A0.9701.00
174_F177_S0.9661.00
56_H60_G0.9591.00
157_D208_K0.9491.00
176_L180_P0.9381.00
102_F117_Y0.9231.00
16_V26_I0.9231.00
118_F159_T0.9221.00
26_I29_P0.9201.00
157_D176_L0.9181.00
178_I182_D0.9111.00
73_V86_T0.9051.00
177_S181_H0.8961.00
35_V38_A0.8831.00
187_D191_K0.8791.00
34_P38_A0.8761.00
49_I72_I0.8731.00
193_K197_A0.8651.00
143_S147_Q0.8641.00
107_T114_H0.8631.00
63_K66_V0.8631.00
134_C168_T0.8511.00
143_S193_K0.8511.00
79_E82_D0.8461.00
184_S187_D0.8371.00
15_W162_C0.8301.00
106_A115_I0.8291.00
78_Q81_Q0.8291.00
196_R199_N0.8201.00
144_Q147_Q0.8171.00
18_N22_G0.8161.00
128_T145_M0.8121.00
186_N190_R0.8101.00
19_D22_G0.8071.00
85_T88_V0.8041.00
209_N213_I0.8031.00
32_A35_V0.7981.00
112_L139_E0.7921.00
123_L152_L0.7901.00
105_I118_F0.7861.00
18_N38_A0.7861.00
198_K201_I0.7781.00
121_P160_L0.7751.00
114_H128_T0.7731.00
149_L185_I0.7731.00
191_K194_E0.7721.00
196_R200_Q0.7721.00
152_L161_V0.7681.00
55_H58_H0.7651.00
59_V62_V0.7541.00
208_K212_Q0.7541.00
46_P69_F0.7510.99
26_I35_V0.7500.99
47_E73_V0.7430.99
148_S152_L0.7410.99
156_P159_T0.7390.99
133_G136_R0.7380.99
91_D104_V0.7380.99
49_I74_V0.7370.99
195_L200_Q0.7360.99
23_R48_A0.7310.99
128_T148_S0.7300.99
26_I39_I0.7300.99
63_K67_E0.7290.99
150_K154_A0.7280.99
97_V102_F0.7240.99
76_G80_T0.7230.99
176_L185_I0.7200.99
54_H215_V0.7180.99
108_P148_S0.7180.99
54_H80_T0.7180.99
89_V95_A0.7170.99
107_T152_L0.7170.99
188_Y192_V0.7160.99
131_S188_Y0.7160.99
175_A215_V0.7140.99
70_P73_V0.7120.99
146_Y153_S0.7100.99
30_G34_P0.7080.99
14_I30_G0.7020.99
34_P37_N0.7010.99
109_G137_L0.6990.99
49_I65_L0.6970.99
24_C46_P0.6960.99
209_N212_Q0.6960.99
174_F182_D0.6910.99
114_H126_G0.6910.99
161_V175_A0.6870.99
79_E106_A0.6840.99
46_P72_I0.6840.99
208_K211_R0.6840.99
188_Y209_N0.6800.99
142_A145_M0.6760.99
33_E64_E0.6720.99
100_H120_K0.6680.99
66_V70_P0.6670.99
107_T128_T0.6630.99
143_S190_R0.6600.99
182_D186_N0.6590.99
127_D165_H0.6590.99
121_P159_T0.6590.99
150_K153_S0.6570.99
89_V115_I0.6560.99
91_D105_I0.6560.99
76_G84_G0.6560.99
118_F155_L0.6550.99
185_I189_Y0.6480.99
105_I152_L0.6440.98
19_D99_G0.6430.98
177_S180_P0.6400.98
192_V196_R0.6380.98
116_C125_C0.6360.98
36_L65_L0.6360.98
26_I65_L0.6360.98
207_L211_R0.6340.98
9_F60_G0.6340.98
102_F119_S0.6330.98
48_A87_Q0.6300.98
54_H113_G0.6280.98
16_V44_W0.6270.98
174_F178_I0.6240.98
183_L186_N0.6230.98
173_K189_Y0.6220.98
125_C164_A0.6210.98
147_Q151_K0.6210.98
100_H119_S0.6200.98
108_P128_T0.6180.98
32_A64_E0.6180.98
35_V39_I0.6180.98
163_C203_L0.6160.98
183_L187_D0.6160.98
15_W164_A0.6130.98
131_S163_C0.6110.98
199_N202_T0.6090.98
25_L102_F0.6080.98
16_V46_P0.6050.98
29_P60_G0.6000.98
180_P185_I0.5960.97
194_E197_A0.5950.97
111_T128_T0.5940.97
15_W203_L0.5910.97
93_E104_V0.5890.97
150_K182_D0.5870.97
129_L161_V0.5870.97
19_D100_H0.5860.97
22_G45_Q0.5850.97
40_A43_N0.5830.97
78_Q88_V0.5830.97
103_S151_K0.5820.97
182_D185_I0.5820.97
31_D35_V0.5800.97
127_D130_F0.5760.97
17_L25_L0.5740.97
92_G151_K0.5730.97
111_T114_H0.5730.97
9_F30_G0.5730.97
173_K193_K0.5710.97
23_R99_G0.5700.97
125_C163_C0.5690.97
24_C45_Q0.5650.97
114_H125_C0.5650.97
195_L198_K0.5630.96
180_P184_S0.5620.96
12_N164_A0.5550.96
205_V210_E0.5550.96
19_D23_R0.5530.96
139_E145_M0.5520.96
16_V24_C0.5520.96
46_P65_L0.5490.96
16_V39_I0.5450.96
137_L141_T0.5440.96
176_L179_L0.5410.96
130_F135_G0.5390.95
130_F163_C0.5380.95
155_L159_T0.5370.95
80_T83_K0.5370.95
196_R201_I0.5330.95
106_A151_K0.5300.95
204_P214_N0.5260.95
192_V202_T0.5260.95
132_G185_I0.5240.95
59_V76_G0.5220.95
18_N42_N0.5210.95
103_S155_L0.5210.95
12_N210_E0.5210.95
142_A197_A0.5200.95
50_F97_V0.5180.94
20_E23_R0.5180.94
173_K176_L0.5170.94
14_I26_I0.5160.94
195_L202_T0.5160.94
54_H139_E0.5120.94
98_L102_F0.5120.94
131_S192_V0.5100.94
90_K106_A0.5090.94
131_S134_C0.5070.94
67_E70_P0.5020.93
174_F180_P0.5020.93
207_L210_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qh5A 1 0.9801 100 0.243 Contact Map
2qedA 1 1 100 0.247 Contact Map
1xm8A 1 0.992 100 0.263 Contact Map
2p18A 1 0.9602 100 0.312 Contact Map
4yslA 2 0.8287 100 0.424 Contact Map
3r2uA 4 0.9721 100 0.428 Contact Map
3tp9A 2 0.9721 100 0.433 Contact Map
4efzA 2 0.9442 100 0.436 Contact Map
4ysbA 2 0.8645 100 0.452 Contact Map
2gcuA 3 0.8884 100 0.461 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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