GLO2 - ECOLI - GREMLIN Contacts

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GLO2 - Hydroxyacylglutathione hydrolase

UniProt:	P0AC84	Sequences: MNLNSIPAFDDNYIWVLNDEAGRCLIVDPGDAEPVLNAIAANNWQPEAIFLTHHHHDHVGGVKELVEKFPQIVVYGPQETQDKGTTQVVKDGETAFVLGHEFSVIATPGHTLGHICYFSKPYLFCGDTLFSGGCGRLFEGTASQMYQSLKKLSALPDDTLVCCAHEYTLSNMKFALSILPHDLSINDYYRKVKELRAKNQITLPVILKNERQINVFLRTEDIDLINVINEETLLQQPEERFAWLRSKKDRF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13330
Length:	251 (206)
Sequences:	7203 (4785)
Seq/√Len:	333.4

ECOLI - GLO2 YCBL
BACSU - PKSB YRKH YQGX YQJP YYBB YFLN YOBT
HALSA - O54647 O54661 Q9HS22 Q9HNJ2 Q9HQ50 Q9HRG5 Q9HSD1 Q9HNJ9 Q9HSH2
SULSO - Q7LYK3 Q97U88 Q97VU4 Q97UV2 Q97VU0 Q97YZ2 Q97XZ1 Q97UR2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
107_T	116_C	4.358	1.00
91_D	151_K	3.966	1.00
23_R	47_E	3.579	1.00
104_V	115_I	3.073	1.00
94_T	101_E	2.881	1.00
96_F	101_E	2.836	1.00
157_D	211_R	2.825	1.00
39_I	46_P	2.800	1.00
94_T	103_S	2.743	1.00
51_L	62_V	2.589	1.00
75_Y	89_V	2.492	1.00
78_Q	90_K	2.429	1.00
23_R	45_Q	2.426	1.00
50_F	117_Y	2.422	1.00
69_F	72_I	2.249	1.00
73_V	87_Q	2.182	1.00
188_Y	191_K	2.158	1.00
25_L	48_A	2.134	1.00
48_A	75_Y	2.026	1.00
27_V	124_F	1.943	1.00
147_Q	189_Y	1.864	1.00
121_P	158_D	1.836	1.00
122_Y	162_C	1.818	1.00
80_T	113_G	1.805	1.00
137_L	142_A	1.794	1.00
37_N	41_A	1.778	1.00
194_E	198_K	1.768	1.00
48_A	73_V	1.755	1.00
36_L	69_F	1.724	1.00
66_V	86_T	1.709	1.00
38_A	42_N	1.689	1.00
36_L	68_K	1.689	1.00
33_E	37_N	1.642	1.00
16_V	38_A	1.618	1.00
116_C	123_L	1.617	1.00
18_N	24_C	1.610	1.00
90_K	93_E	1.609	1.00
75_Y	87_Q	1.607	1.00
143_S	189_Y	1.595	1.00
64_E	68_K	1.591	1.00
24_C	44_W	1.569	1.00
104_V	117_Y	1.563	1.00
184_S	212_Q	1.561	1.00
188_Y	213_I	1.551	1.00
37_N	40_A	1.546	1.00
87_Q	93_E	1.542	1.00
18_N	44_W	1.512	1.00
132_G	172_M	1.500	1.00
109_G	148_S	1.495	1.00
105_I	151_K	1.494	1.00
27_V	52_T	1.490	1.00
40_A	68_K	1.482	1.00
146_Y	150_K	1.480	1.00
169_L	193_K	1.477	1.00
91_D	106_A	1.442	1.00
52_T	126_G	1.423	1.00
20_E	99_G	1.410	1.00
95_A	102_F	1.400	1.00
107_T	148_S	1.396	1.00
14_I	35_V	1.392	1.00
190_R	194_E	1.388	1.00
179_L	182_D	1.348	1.00
62_V	74_V	1.320	1.00
103_S	118_F	1.316	1.00
38_A	41_A	1.284	1.00
118_F	123_L	1.251	1.00
147_Q	150_K	1.247	1.00
141_T	144_Q	1.227	1.00
176_L	189_Y	1.226	1.00
64_E	67_E	1.217	1.00
123_L	155_L	1.205	1.00
36_L	40_A	1.205	1.00
153_S	175_A	1.200	1.00
17_L	27_V	1.187	1.00
191_K	195_L	1.180	1.00
118_F	121_P	1.175	1.00
89_V	104_V	1.174	1.00
50_F	102_F	1.161	1.00
26_I	46_P	1.160	1.00
123_L	161_V	1.154	1.00
77_P	106_A	1.139	1.00
173_K	177_S	1.137	1.00
25_L	97_V	1.136	1.00
92_G	103_S	1.135	1.00
116_C	128_T	1.135	1.00
189_Y	193_K	1.125	1.00
25_L	50_F	1.123	1.00
157_D	179_L	1.105	1.00
138_F	141_T	1.087	1.00
175_A	179_L	1.082	1.00
19_D	98_L	1.077	1.00
77_P	115_I	1.055	1.00
112_L	144_Q	1.040	1.00
32_A	61_G	1.040	1.00
131_S	213_I	1.040	1.00
77_P	80_T	1.012	1.00
76_G	85_T	1.009	1.00
66_V	74_V	1.008	1.00
97_V	100_H	1.004	1.00
173_K	178_I	1.001	1.00
116_C	152_L	0.996	1.00
169_L	192_V	0.994	1.00
137_L	145_M	0.994	1.00
50_F	95_A	0.991	1.00
190_R	193_K	0.988	1.00
31_D	34_P	0.985	1.00
176_L	186_N	0.983	1.00
96_F	99_G	0.983	1.00
128_T	152_L	0.974	1.00
122_Y	160_L	0.971	1.00
151_K	154_A	0.970	1.00
174_F	177_S	0.966	1.00
56_H	60_G	0.959	1.00
157_D	208_K	0.949	1.00
176_L	180_P	0.938	1.00
102_F	117_Y	0.923	1.00
16_V	26_I	0.923	1.00
118_F	159_T	0.922	1.00
26_I	29_P	0.920	1.00
157_D	176_L	0.918	1.00
178_I	182_D	0.911	1.00
73_V	86_T	0.905	1.00
177_S	181_H	0.896	1.00
35_V	38_A	0.883	1.00
187_D	191_K	0.879	1.00
34_P	38_A	0.876	1.00
49_I	72_I	0.873	1.00
193_K	197_A	0.865	1.00
143_S	147_Q	0.864	1.00
107_T	114_H	0.863	1.00
63_K	66_V	0.863	1.00
134_C	168_T	0.851	1.00
143_S	193_K	0.851	1.00
79_E	82_D	0.846	1.00
184_S	187_D	0.837	1.00
15_W	162_C	0.830	1.00
106_A	115_I	0.829	1.00
78_Q	81_Q	0.829	1.00
196_R	199_N	0.820	1.00
144_Q	147_Q	0.817	1.00
18_N	22_G	0.816	1.00
128_T	145_M	0.812	1.00
186_N	190_R	0.810	1.00
19_D	22_G	0.807	1.00
85_T	88_V	0.804	1.00
209_N	213_I	0.803	1.00
32_A	35_V	0.798	1.00
112_L	139_E	0.792	1.00
123_L	152_L	0.790	1.00
105_I	118_F	0.786	1.00
18_N	38_A	0.786	1.00
198_K	201_I	0.778	1.00
121_P	160_L	0.775	1.00
114_H	128_T	0.773	1.00
149_L	185_I	0.773	1.00
191_K	194_E	0.772	1.00
196_R	200_Q	0.772	1.00
152_L	161_V	0.768	1.00
55_H	58_H	0.765	1.00
59_V	62_V	0.754	1.00
208_K	212_Q	0.754	1.00
46_P	69_F	0.751	0.99
26_I	35_V	0.750	0.99
47_E	73_V	0.743	0.99
148_S	152_L	0.741	0.99
156_P	159_T	0.739	0.99
133_G	136_R	0.738	0.99
91_D	104_V	0.738	0.99
49_I	74_V	0.737	0.99
195_L	200_Q	0.736	0.99
23_R	48_A	0.731	0.99
128_T	148_S	0.730	0.99
26_I	39_I	0.730	0.99
63_K	67_E	0.729	0.99
150_K	154_A	0.728	0.99
97_V	102_F	0.724	0.99
76_G	80_T	0.723	0.99
176_L	185_I	0.720	0.99
54_H	215_V	0.718	0.99
108_P	148_S	0.718	0.99
54_H	80_T	0.718	0.99
89_V	95_A	0.717	0.99
107_T	152_L	0.717	0.99
188_Y	192_V	0.716	0.99
131_S	188_Y	0.716	0.99
175_A	215_V	0.714	0.99
70_P	73_V	0.712	0.99
146_Y	153_S	0.710	0.99
30_G	34_P	0.708	0.99
14_I	30_G	0.702	0.99
34_P	37_N	0.701	0.99
109_G	137_L	0.699	0.99
49_I	65_L	0.697	0.99
24_C	46_P	0.696	0.99
209_N	212_Q	0.696	0.99
174_F	182_D	0.691	0.99
114_H	126_G	0.691	0.99
161_V	175_A	0.687	0.99
79_E	106_A	0.684	0.99
46_P	72_I	0.684	0.99
208_K	211_R	0.684	0.99
188_Y	209_N	0.680	0.99
142_A	145_M	0.676	0.99
33_E	64_E	0.672	0.99
100_H	120_K	0.668	0.99
66_V	70_P	0.667	0.99
107_T	128_T	0.663	0.99
143_S	190_R	0.660	0.99
182_D	186_N	0.659	0.99
127_D	165_H	0.659	0.99
121_P	159_T	0.659	0.99
150_K	153_S	0.657	0.99
89_V	115_I	0.656	0.99
91_D	105_I	0.656	0.99
76_G	84_G	0.656	0.99
118_F	155_L	0.655	0.99
185_I	189_Y	0.648	0.99
105_I	152_L	0.644	0.98
19_D	99_G	0.643	0.98
177_S	180_P	0.640	0.98
192_V	196_R	0.638	0.98
116_C	125_C	0.636	0.98
36_L	65_L	0.636	0.98
26_I	65_L	0.636	0.98
207_L	211_R	0.634	0.98
9_F	60_G	0.634	0.98
102_F	119_S	0.633	0.98
48_A	87_Q	0.630	0.98
54_H	113_G	0.628	0.98
16_V	44_W	0.627	0.98
174_F	178_I	0.624	0.98
183_L	186_N	0.623	0.98
173_K	189_Y	0.622	0.98
125_C	164_A	0.621	0.98
147_Q	151_K	0.621	0.98
100_H	119_S	0.620	0.98
108_P	128_T	0.618	0.98
32_A	64_E	0.618	0.98
35_V	39_I	0.618	0.98
163_C	203_L	0.616	0.98
183_L	187_D	0.616	0.98
15_W	164_A	0.613	0.98
131_S	163_C	0.611	0.98
199_N	202_T	0.609	0.98
25_L	102_F	0.608	0.98
16_V	46_P	0.605	0.98
29_P	60_G	0.600	0.98
180_P	185_I	0.596	0.97
194_E	197_A	0.595	0.97
111_T	128_T	0.594	0.97
15_W	203_L	0.591	0.97
93_E	104_V	0.589	0.97
150_K	182_D	0.587	0.97
129_L	161_V	0.587	0.97
19_D	100_H	0.586	0.97
22_G	45_Q	0.585	0.97
40_A	43_N	0.583	0.97
78_Q	88_V	0.583	0.97
103_S	151_K	0.582	0.97
182_D	185_I	0.582	0.97
31_D	35_V	0.580	0.97
127_D	130_F	0.576	0.97
17_L	25_L	0.574	0.97
92_G	151_K	0.573	0.97
111_T	114_H	0.573	0.97
9_F	30_G	0.573	0.97
173_K	193_K	0.571	0.97
23_R	99_G	0.570	0.97
125_C	163_C	0.569	0.97
24_C	45_Q	0.565	0.97
114_H	125_C	0.565	0.97
195_L	198_K	0.563	0.96
180_P	184_S	0.562	0.96
12_N	164_A	0.555	0.96
205_V	210_E	0.555	0.96
19_D	23_R	0.553	0.96
139_E	145_M	0.552	0.96
16_V	24_C	0.552	0.96
46_P	65_L	0.549	0.96
16_V	39_I	0.545	0.96
137_L	141_T	0.544	0.96
176_L	179_L	0.541	0.96
130_F	135_G	0.539	0.95
130_F	163_C	0.538	0.95
155_L	159_T	0.537	0.95
80_T	83_K	0.537	0.95
196_R	201_I	0.533	0.95
106_A	151_K	0.530	0.95
204_P	214_N	0.526	0.95
192_V	202_T	0.526	0.95
132_G	185_I	0.524	0.95
59_V	76_G	0.522	0.95
18_N	42_N	0.521	0.95
103_S	155_L	0.521	0.95
12_N	210_E	0.521	0.95
142_A	197_A	0.520	0.95
50_F	97_V	0.518	0.94
20_E	23_R	0.518	0.94
173_K	176_L	0.517	0.94
14_I	26_I	0.516	0.94
195_L	202_T	0.516	0.94
54_H	139_E	0.512	0.94
98_L	102_F	0.512	0.94
131_S	192_V	0.510	0.94
90_K	106_A	0.509	0.94
131_S	134_C	0.507	0.94
67_E	70_P	0.502	0.93
174_F	180_P	0.502	0.93
207_L	210_E	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1qh5A	1	0.9801	100	0.243	Contact Map
2qedA	1	1	100	0.247	Contact Map
1xm8A	1	0.992	100	0.263	Contact Map
2p18A	1	0.9602	100	0.312	Contact Map
4yslA	2	0.8287	100	0.424	Contact Map
3r2uA	4	0.9721	100	0.428	Contact Map
3tp9A	2	0.9721	100	0.433	Contact Map
4efzA	2	0.9442	100	0.436	Contact Map
4ysbA	2	0.8645	100	0.452	Contact Map
2gcuA	3	0.8884	100	0.461	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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