GREMLIN Database
LGUL - Lactoylglutathione lyase
UniProt: P0AC81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13421
Length: 135 (123)
Sequences: 2739 (1302)
Seq/√Len: 117.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_D22_K5.5591.00
87_E91_Q4.4521.00
81_N84_E2.9831.00
78_S126_E2.5851.00
28_L31_T2.5451.00
13_L42_A2.4741.00
95_N114_E2.3571.00
12_D15_R2.2431.00
38_K62_G2.0841.00
90_R99_E2.0321.00
89_I94_G1.9001.00
21_T27_K1.8361.00
88_K92_N1.8171.00
33_E40_S1.7651.00
11_G63_V1.7501.00
114_E120_K1.6671.00
23_V92_N1.5871.00
63_V70_T1.5841.00
26_M46_Y1.5831.00
80_D126_E1.5821.00
28_L42_A1.5701.00
29_L45_G1.5641.00
112_F122_E1.5221.00
6_T53_A1.4171.00
17_I44_V1.4041.00
35_P38_K1.3871.00
97_T114_E1.3851.00
40_S61_W1.3721.00
14_Q18_D1.3691.00
27_K47_G1.3351.00
16_S57_L1.3351.00
10_V13_L1.3181.00
26_M77_L1.2981.00
34_N39_Y1.2911.00
11_G64_D1.2851.00
18_D23_V1.2790.99
47_G52_E1.2650.99
15_R18_D1.2390.99
4_L78_S1.2370.99
29_L54_V1.2340.99
33_E61_W1.2270.99
23_V89_I1.2250.99
16_S20_Y1.2170.99
11_G65_K1.2130.99
24_L113_V1.2050.99
87_E90_R1.1930.99
31_T42_A1.1860.99
47_G51_E1.1520.99
85_A88_K1.1180.99
77_L121_I1.1020.98
72_Y75_I1.0830.98
97_T120_K1.0790.98
110_I124_I1.0620.98
49_E54_V1.0610.98
86_C90_R1.0520.98
66_Y69_G1.0510.98
74_H122_E1.0470.98
84_E88_K1.0450.98
86_C111_A1.0420.98
55_I75_I1.0350.98
15_R117_D1.0280.98
4_L124_I1.0250.98
89_I111_A1.0250.98
75_I121_I1.0190.97
38_K61_W1.0090.97
16_S117_D1.0070.97
22_K92_N1.0020.97
11_G15_R0.9980.97
89_I123_L0.9920.97
46_Y77_L0.9890.97
41_L58_T0.9800.97
74_H112_F0.9780.97
20_Y115_D0.9580.96
5_H76_A0.9430.96
13_L59_Y0.9380.96
31_T40_S0.9380.96
34_N37_Y0.9130.95
30_R49_E0.9120.95
42_A59_Y0.9050.95
35_P61_W0.8980.95
46_Y51_E0.8820.94
2_R78_S0.8820.94
83_A87_E0.8820.94
114_E118_G0.8660.94
6_T75_I0.8560.93
24_L123_L0.8550.93
14_Q31_T0.8530.93
39_Y103_V0.8390.93
28_L40_S0.8300.92
88_K91_Q0.8280.92
8_L20_Y0.8260.92
40_S59_Y0.8250.92
45_G54_V0.8220.92
68_L118_G0.8130.91
7_M60_N0.8080.91
30_R54_V0.7960.91
4_L54_V0.7960.91
34_N38_K0.7870.90
56_E60_N0.7840.90
10_V18_D0.7810.90
67_E70_T0.7770.89
39_Y60_N0.7750.89
3_L75_I0.7640.89
33_E59_Y0.7610.88
98_R104_K0.7530.88
98_R102_P0.7410.87
7_M73_G0.7360.87
83_A102_P0.7310.86
8_L75_I0.7300.86
46_Y50_T0.7240.86
32_S41_L0.7190.85
68_L71_A0.7180.85
79_V85_A0.7180.85
99_E104_K0.7170.85
99_E102_P0.7170.85
47_G50_T0.7150.85
37_Y61_W0.7150.85
7_M58_T0.7120.85
16_S116_P0.7060.84
86_C95_N0.6890.83
109_V125_E0.6860.83
111_A123_L0.6840.83
68_L72_Y0.6790.82
5_H74_H0.6700.81
49_E53_A0.6670.81
16_S115_D0.6650.81
53_A75_I0.6650.81
34_N41_L0.6640.81
18_D21_T0.6590.80
82_A109_V0.6590.80
96_V114_E0.6530.80
84_E87_E0.6520.79
21_T44_V0.6490.79
22_K88_K0.6460.79
44_V55_I0.6460.79
9_R60_N0.6380.78
5_H56_E0.6370.78
39_Y58_T0.6360.78
82_A125_E0.6360.78
9_R119_Y0.6300.77
60_N66_Y0.6270.77
43_F56_E0.6200.76
24_L77_L0.6180.76
94_G113_V0.6150.75
102_P108_T0.6110.75
27_K30_R0.6100.75
90_R96_V0.6010.74
17_I21_T0.5870.72
73_G112_F0.5780.71
31_T61_W0.5750.70
3_L46_Y0.5750.70
23_V94_G0.5740.70
85_A89_I0.5740.70
18_D92_N0.5740.70
80_D127_K0.5730.70
2_R50_T0.5710.70
69_G118_G0.5690.70
83_A109_V0.5660.69
111_A122_E0.5630.69
78_S82_A0.5580.68
32_S35_P0.5560.68
4_L76_A0.5550.68
76_A112_F0.5540.68
99_E103_V0.5520.67
2_R54_V0.5510.67
6_T71_A0.5460.66
96_V99_E0.5430.66
96_V120_K0.5320.65
60_N72_Y0.5310.64
6_T43_F0.5270.64
19_F113_V0.5200.63
50_T54_V0.5190.63
82_A110_I0.5140.62
41_L60_N0.5120.62
34_N103_V0.5110.61
58_T66_Y0.5100.61
39_Y105_G0.5100.61
49_E52_E0.5070.61
98_R111_A0.5070.61
88_K95_N0.5060.61
44_V54_V0.5030.60
9_R72_Y0.5030.60
8_L72_Y0.5010.60
32_S37_Y0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f9zA 2 0.9481 99.9 0.445 Contact Map
4mtsA 2 0.9556 99.9 0.459 Contact Map
2c21A 2 0.963 99.9 0.477 Contact Map
3w0tA 2 0.9704 99.9 0.479 Contact Map
4ro6A 1 1 99.8 0.495 Contact Map
3zi1A 1 0.9259 99.8 0.505 Contact Map
1ss4A 4 0.9185 99.8 0.515 Contact Map
3hdpA 2 0.8963 99.8 0.517 Contact Map
3rmuA 4 0.9037 99.8 0.522 Contact Map
2p25A 2 0.8889 99.8 0.53 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.