GREMLIN Database
WECA - Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
UniProt: P0AC78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10840
Length: 367 (300)
Sequences: 6706 (4418)
Seq/√Len: 255.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
259_V272_P4.3171.00
172_A306_A4.0351.00
164_G299_T3.8631.00
174_G190_F3.4011.00
274_S287_A3.3831.00
189_C230_I3.3071.00
96_S99_I3.2001.00
82_V107_V2.7001.00
167_C193_I2.6761.00
38_N41_K2.5421.00
111_M229_W2.5311.00
55_V215_M2.5121.00
80_A222_L2.4141.00
277_R286_R2.4121.00
56_Y84_V2.3821.00
263_Y267_R2.3751.00
145_V228_I2.3651.00
171_A193_I2.3511.00
17_T198_P2.2981.00
89_L93_F2.2951.00
17_T58_G2.2281.00
290_T293_Q2.1441.00
56_Y81_G2.1121.00
248_L305_L2.0661.00
58_G62_T2.0151.00
163_G196_I2.0151.00
79_C225_F2.0121.00
263_Y266_L1.9891.00
60_C81_G1.9601.00
152_F166_S1.8841.00
192_M226_T1.8761.00
86_I103_I1.8641.00
188_W226_T1.8421.00
163_G200_I1.8411.00
6_V190_F1.8271.00
112_M142_L1.8211.00
25_R29_K1.8081.00
124_Y127_G1.7991.00
21_L54_S1.7771.00
109_I113_V1.7671.00
166_S170_F1.7641.00
262_M266_L1.7561.00
192_M223_I1.7211.00
14_F201_M1.7071.00
59_I192_M1.7061.00
100_R104_Q1.7051.00
266_L272_P1.6981.00
105_A142_L1.6711.00
16_F58_G1.6381.00
177_L234_T1.6311.00
18_T201_M1.6271.00
167_C197_L1.6201.00
109_I142_L1.5951.00
79_C111_M1.5931.00
12_S66_V1.5841.00
88_A92_R1.5801.00
27_V30_K1.5801.00
174_G189_C1.5651.00
204_L296_V1.5581.00
24_A54_S1.5431.00
170_F192_M1.5351.00
165_L302_A1.5211.00
264_R269_G1.5151.00
112_M141_T1.5021.00
135_P139_F1.5011.00
105_A146_W1.4921.00
55_V195_A1.4751.00
255_L259_V1.4531.00
9_D191_A1.4401.00
289_F297_L1.4261.00
100_R221_T1.4181.00
169_S227_V1.4181.00
101_A104_Q1.4161.00
178_W186_A1.4121.00
136_F139_F1.4051.00
159_D210_R1.3961.00
261_I264_R1.3901.00
166_S223_I1.3881.00
163_G167_C1.3821.00
170_F193_I1.3821.00
112_M138_Y1.3791.00
169_S302_A1.3701.00
22_F26_K1.3671.00
56_Y222_L1.3651.00
154_M254_P1.3351.00
141_T232_L1.3211.00
26_K30_K1.2951.00
27_V31_V1.2941.00
21_L213_V1.2821.00
170_F227_V1.2771.00
293_Q297_L1.2701.00
85_F89_L1.2661.00
168_V299_T1.2631.00
13_I194_A1.2551.00
263_Y272_P1.2541.00
153_N217_D1.2541.00
105_A109_I1.2461.00
280_I284_I1.2381.00
168_V306_A1.2321.00
296_V300_L1.2311.00
108_G142_L1.2301.00
62_T191_A1.2281.00
78_A110_V1.2161.00
108_G145_V1.2061.00
196_I223_I1.1961.00
111_M145_V1.1761.00
14_F198_P1.1751.00
86_I107_V1.1751.00
60_C77_L1.1741.00
84_V218_A1.1681.00
55_V196_I1.1621.00
26_K29_K1.1561.00
145_V229_W1.1551.00
205_G292_R1.1531.00
253_I298_I1.1451.00
152_F162_L1.1311.00
144_A148_A1.1311.00
34_V37_P1.1221.00
83_L108_G1.1141.00
141_T145_V1.1141.00
101_A146_W1.1081.00
170_F189_C1.1071.00
149_I221_T1.1061.00
150_N153_N1.1011.00
16_F62_T1.1001.00
157_G281_H1.0941.00
147_A258_M1.0911.00
302_A306_A1.0901.00
174_G193_I1.0751.00
191_A194_A1.0731.00
137_G141_T1.0721.00
198_P202_L1.0701.00
82_V103_I1.0691.00
18_T198_P1.0681.00
58_G61_F1.0571.00
35_D41_K1.0441.00
257_D261_I1.0441.00
25_R212_K1.0431.00
154_M258_M1.0381.00
118_Y137_G1.0351.00
108_G146_W1.0331.00
10_L190_F1.0291.00
43_H214_F1.0271.00
47_I214_F1.0241.00
174_G177_L1.0231.00
222_L226_T1.0221.00
40_R43_H1.0201.00
144_A231_L1.0191.00
163_G215_M1.0161.00
168_V302_A1.0121.00
17_T21_L1.0101.00
16_F61_F1.0091.00
21_L198_P1.0081.00
78_A82_V1.0071.00
83_L225_F1.0051.00
177_L185_L1.0011.00
194_A198_P1.0011.00
104_Q221_T0.9991.00
166_S196_I0.9981.00
59_I195_A0.9971.00
47_I211_Y0.9971.00
171_A175_M0.9911.00
10_L194_A0.9871.00
83_L107_V0.9851.00
155_V165_L0.9791.00
252_A280_I0.9781.00
87_G221_T0.9701.00
34_V46_L0.9681.00
80_A226_T0.9641.00
56_Y80_A0.9631.00
22_F202_L0.9621.00
263_Y268_K0.9581.00
174_G178_W0.9571.00
173_I231_L0.9541.00
200_I204_L0.9521.00
104_Q149_I0.9481.00
169_S246_T0.9441.00
124_Y129_W0.9431.00
170_F196_I0.9421.00
23_F26_K0.9391.00
124_Y128_S0.9341.00
59_I80_A0.9311.00
104_Q146_W0.9261.00
76_Y229_W0.9211.00
101_A105_A0.9201.00
166_S227_V0.9201.00
125_I128_S0.9191.00
19_L23_F0.9171.00
79_C107_V0.9151.00
158_I295_F0.9141.00
205_G210_R0.9051.00
104_Q150_N0.9041.00
201_M297_L0.9011.00
37_P40_R0.9011.00
253_I281_H0.8971.00
167_C196_I0.8941.00
100_R149_I0.8921.00
172_A310_V0.8861.00
143_F147_A0.8821.00
289_F293_Q0.8811.00
79_C229_W0.8731.00
108_G112_M0.8731.00
100_R154_M0.8701.00
136_F140_L0.8661.00
49_L218_A0.8631.00
122_L125_I0.8631.00
83_L149_I0.8631.00
151_A254_P0.8600.99
13_I195_A0.8580.99
121_S125_I0.8560.99
301_A305_L0.8550.99
312_A315_S0.8550.99
162_L223_I0.8540.99
98_K102_T0.8530.99
197_L201_M0.8510.99
121_S132_V0.8500.99
20_F54_S0.8470.99
35_D38_N0.8470.99
93_F96_S0.8460.99
132_V136_F0.8430.99
204_L292_R0.8420.99
14_F18_T0.8410.99
59_I222_L0.8370.99
154_M261_I0.8340.99
23_F27_V0.8240.99
271_S274_S0.8230.99
168_V303_A0.8220.99
174_G186_A0.8200.99
15_L19_L0.8190.99
169_S250_I0.8160.99
169_S306_A0.8130.99
152_F169_S0.8080.99
177_L186_A0.8020.99
274_S286_R0.7990.99
262_M265_R0.7980.99
205_G291_S0.7980.99
188_W230_I0.7960.99
175_M179_F0.7940.99
284_I298_I0.7910.99
12_S62_T0.7890.99
305_L309_G0.7810.99
214_F217_D0.7760.99
83_L103_I0.7710.99
300_L304_L0.7690.99
172_A246_T0.7670.99
14_F197_L0.7660.99
18_T202_L0.7660.99
9_D187_I0.7660.99
270_M274_S0.7630.99
82_V86_I0.7630.99
10_L193_I0.7600.99
8_T12_S0.7530.99
76_Y226_T0.7470.99
17_T55_V0.7460.99
84_V222_L0.7440.99
89_L92_R0.7440.99
153_N214_F0.7410.98
100_R103_I0.7400.98
121_S130_E0.7400.98
35_D49_L0.7360.98
205_G295_F0.7340.98
7_S11_I0.7290.98
307_S311_L0.7280.98
59_I63_F0.7260.98
111_M115_G0.7230.98
148_A228_I0.7230.98
140_L144_A0.7220.98
75_L114_F0.7210.98
25_R213_V0.7200.98
134_G139_F0.7190.98
282_H285_M0.7190.98
173_I234_T0.7190.98
259_V262_M0.7180.98
269_G272_P0.7150.98
165_L249_W0.7140.98
28_A213_V0.7120.98
9_D62_T0.7080.98
155_V281_H0.7050.98
81_G85_F0.7050.98
163_G199_Y0.7040.98
252_A305_L0.7010.98
304_L308_I0.7010.98
80_A188_W0.6990.98
11_I15_L0.6950.98
99_I102_T0.6950.98
117_L120_S0.6950.98
173_I189_C0.6880.98
280_I298_I0.6880.98
294_A298_I0.6870.98
13_I58_G0.6860.98
42_R291_S0.6860.98
20_F58_G0.6830.97
16_F20_F0.6820.97
246_T309_G0.6820.97
176_I313_E0.6820.97
168_V172_A0.6770.97
262_M267_R0.6740.97
88_A218_A0.6730.97
150_N217_D0.6720.97
83_L104_Q0.6710.97
41_K47_I0.6710.97
164_G168_V0.6690.97
36_K46_L0.6670.97
162_L215_M0.6640.97
261_I278_Q0.6640.97
148_A243_S0.6620.97
170_F226_T0.6620.97
256_M260_A0.6610.97
268_K278_Q0.6600.97
50_V88_A0.6590.97
84_V88_A0.6580.97
225_F229_W0.6570.97
36_K39_F0.6560.97
100_R217_D0.6540.97
289_F294_A0.6540.97
147_A151_A0.6520.97
185_L233_E0.6450.96
53_I218_A0.6430.96
31_V92_R0.6420.96
148_A231_L0.6420.96
258_M262_M0.6390.96
37_P41_K0.6360.96
257_D279_H0.6360.96
158_I294_A0.6310.96
175_M310_V0.6300.96
10_L14_F0.6290.96
295_F299_T0.6290.96
258_M261_I0.6280.96
167_C171_A0.6240.96
176_I234_T0.6240.96
291_S295_F0.6230.96
63_F188_W0.6220.96
149_I220_S0.6220.96
111_M225_F0.6210.96
267_R270_M0.6200.96
28_A48_P0.6190.95
113_V138_Y0.6190.95
28_A33_L0.6170.95
176_I236_Q0.6160.95
147_A255_L0.6150.95
139_F142_L0.6140.95
254_P281_H0.6130.95
169_S247_A0.6100.95
59_I188_W0.6100.95
247_A250_I0.6080.95
59_I170_F0.6080.95
55_V59_I0.6070.95
24_A28_A0.6070.95
96_S100_R0.6060.95
262_M278_Q0.6060.95
24_A33_L0.6050.95
290_T294_A0.6040.95
215_M223_I0.6030.95
164_G295_F0.6020.95
148_A251_I0.6000.95
284_I289_F0.5980.95
173_I246_T0.5980.95
110_V114_F0.5960.94
133_L137_G0.5960.94
151_A258_M0.5940.94
264_R267_R0.5930.94
62_T66_V0.5930.94
97_V101_A0.5920.94
252_A255_L0.5920.94
111_M232_L0.5920.94
180_D183_T0.5910.94
123_G128_S0.5900.94
86_I221_T0.5890.94
129_W132_V0.5870.94
108_G228_I0.5870.94
285_M294_A0.5870.94
162_L199_Y0.5860.94
62_T65_I0.5860.94
138_Y142_L0.5860.94
29_K33_L0.5850.94
241_P244_P0.5830.94
83_L221_T0.5830.94
156_D219_G0.5810.94
132_V135_P0.5810.94
263_Y270_M0.5800.94
51_G199_Y0.5790.94
284_I294_A0.5780.94
28_A34_V0.5770.93
149_I228_I0.5770.93
186_A190_F0.5760.93
306_A309_G0.5760.93
156_D215_M0.5720.93
24_A27_V0.5720.93
251_I254_P0.5720.93
201_M212_K0.5710.93
37_P42_R0.5680.93
101_A142_L0.5680.93
50_V92_R0.5680.93
306_A310_V0.5670.93
42_R285_M0.5670.93
148_A244_P0.5670.93
22_F25_R0.5650.93
149_I225_F0.5640.93
58_G195_A0.5630.93
104_Q220_S0.5620.93
67_D70_I0.5600.92
158_I299_T0.5600.92
187_I191_A0.5600.92
13_I62_T0.5580.92
189_C226_T0.5580.92
264_R271_S0.5560.92
256_M283_L0.5520.92
199_Y215_M0.5500.92
297_L300_L0.5470.92
261_I282_H0.5460.91
94_D273_F0.5430.91
261_I281_H0.5420.91
20_F23_F0.5420.91
128_S131_M0.5380.91
285_M288_G0.5360.91
270_M278_Q0.5360.91
265_R282_H0.5360.91
53_I84_V0.5350.91
253_I280_I0.5340.91
161_L298_I0.5340.91
36_K45_G0.5310.90
218_A221_T0.5310.90
159_D282_H0.5290.90
277_R282_H0.5290.90
152_F247_A0.5290.90
28_A50_V0.5280.90
251_I255_L0.5280.90
56_Y59_I0.5260.90
148_A258_M0.5260.90
79_C82_V0.5250.90
159_D215_M0.5240.90
34_V49_L0.5240.90
308_I312_A0.5220.90
97_V261_I0.5220.90
264_R268_K0.5160.89
260_A264_R0.5150.89
79_C145_V0.5150.89
120_S132_V0.5150.89
155_V261_I0.5140.89
49_L291_S0.5140.89
6_V9_D0.5140.89
253_I257_D0.5110.89
69_Y74_S0.5110.89
6_V174_G0.5100.89
40_R286_R0.5090.88
109_I138_Y0.5060.88
148_A255_L0.5040.88
41_K282_H0.5020.88
35_D39_F0.5020.88
199_Y214_F0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j72A 2 0.7793 100 0.293 Contact Map
3emlA 1 0.5177 16.5 0.965 Contact Map
3vw7A 1 0.5259 16 0.966 Contact Map
2z73A 2 0.5395 15.2 0.966 Contact Map
4od4A 1 0.1826 11.3 0.968 Contact Map
2r4rA 1 0.3869 10.3 0.969 Contact Map
3rkoA 1 0.2098 7.5 0.97 Contact Map
3ukxC 1 0.03 7.3 0.971 Contact Map
2kluA 1 0.1417 6.7 0.971 Contact Map
2ls4A 1 0.0654 6.7 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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