WECA - ECOLI - GREMLIN Contacts

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WECA - Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase

UniProt:	P0AC78	Sequences: MNLLTVSTDLISIFLFTTLFLFFARKVAKKVGLVDKPNFRKRHQGLIPLVGGISVYAGICFTFGIVDYYIPHASLYLACAGVLVFIGALDDRFDISVKIRATIQAAVGIVMMVFGKLYLSSLGYIFGSWEMVLGPFGYFLTLFAVWAAINAFNMVDGIDGLLGGLSCVSFAAIGMILWFDGQTSLAIWCFAMIAAILPYIMLNLGILGRRYKVFMGDAGSTLIGFTVIWILLETTQGKTHPISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLASIGVLAEYSHFVPEWVMLVLFLLAFFLYGYCIKRAWKVARFIKRVKRRLRRNRGGSPNLTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10840
Length:	367 (300)
Sequences:	6706 (4418)
Seq/√Len:	255.1

ECOLI - WECA MRAY
BACSU - TAGO MRAY
SULSO - GPT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
259_V	272_P	4.317	1.00
172_A	306_A	4.035	1.00
164_G	299_T	3.863	1.00
174_G	190_F	3.401	1.00
274_S	287_A	3.383	1.00
189_C	230_I	3.307	1.00
96_S	99_I	3.200	1.00
82_V	107_V	2.700	1.00
167_C	193_I	2.676	1.00
38_N	41_K	2.542	1.00
111_M	229_W	2.531	1.00
55_V	215_M	2.512	1.00
80_A	222_L	2.414	1.00
277_R	286_R	2.412	1.00
56_Y	84_V	2.382	1.00
263_Y	267_R	2.375	1.00
145_V	228_I	2.365	1.00
171_A	193_I	2.351	1.00
17_T	198_P	2.298	1.00
89_L	93_F	2.295	1.00
17_T	58_G	2.228	1.00
290_T	293_Q	2.144	1.00
56_Y	81_G	2.112	1.00
248_L	305_L	2.066	1.00
58_G	62_T	2.015	1.00
163_G	196_I	2.015	1.00
79_C	225_F	2.012	1.00
263_Y	266_L	1.989	1.00
60_C	81_G	1.960	1.00
152_F	166_S	1.884	1.00
192_M	226_T	1.876	1.00
86_I	103_I	1.864	1.00
188_W	226_T	1.842	1.00
163_G	200_I	1.841	1.00
6_V	190_F	1.827	1.00
112_M	142_L	1.821	1.00
25_R	29_K	1.808	1.00
124_Y	127_G	1.799	1.00
21_L	54_S	1.777	1.00
109_I	113_V	1.767	1.00
166_S	170_F	1.764	1.00
262_M	266_L	1.756	1.00
192_M	223_I	1.721	1.00
14_F	201_M	1.707	1.00
59_I	192_M	1.706	1.00
100_R	104_Q	1.705	1.00
266_L	272_P	1.698	1.00
105_A	142_L	1.671	1.00
16_F	58_G	1.638	1.00
177_L	234_T	1.631	1.00
18_T	201_M	1.627	1.00
167_C	197_L	1.620	1.00
109_I	142_L	1.595	1.00
79_C	111_M	1.593	1.00
12_S	66_V	1.584	1.00
88_A	92_R	1.580	1.00
27_V	30_K	1.580	1.00
174_G	189_C	1.565	1.00
204_L	296_V	1.558	1.00
24_A	54_S	1.543	1.00
170_F	192_M	1.535	1.00
165_L	302_A	1.521	1.00
264_R	269_G	1.515	1.00
112_M	141_T	1.502	1.00
135_P	139_F	1.501	1.00
105_A	146_W	1.492	1.00
55_V	195_A	1.475	1.00
255_L	259_V	1.453	1.00
9_D	191_A	1.440	1.00
289_F	297_L	1.426	1.00
100_R	221_T	1.418	1.00
169_S	227_V	1.418	1.00
101_A	104_Q	1.416	1.00
178_W	186_A	1.412	1.00
136_F	139_F	1.405	1.00
159_D	210_R	1.396	1.00
261_I	264_R	1.390	1.00
166_S	223_I	1.388	1.00
163_G	167_C	1.382	1.00
170_F	193_I	1.382	1.00
112_M	138_Y	1.379	1.00
169_S	302_A	1.370	1.00
22_F	26_K	1.367	1.00
56_Y	222_L	1.365	1.00
154_M	254_P	1.335	1.00
141_T	232_L	1.321	1.00
26_K	30_K	1.295	1.00
27_V	31_V	1.294	1.00
21_L	213_V	1.282	1.00
170_F	227_V	1.277	1.00
293_Q	297_L	1.270	1.00
85_F	89_L	1.266	1.00
168_V	299_T	1.263	1.00
13_I	194_A	1.255	1.00
263_Y	272_P	1.254	1.00
153_N	217_D	1.254	1.00
105_A	109_I	1.246	1.00
280_I	284_I	1.238	1.00
168_V	306_A	1.232	1.00
296_V	300_L	1.231	1.00
108_G	142_L	1.230	1.00
62_T	191_A	1.228	1.00
78_A	110_V	1.216	1.00
108_G	145_V	1.206	1.00
196_I	223_I	1.196	1.00
111_M	145_V	1.176	1.00
14_F	198_P	1.175	1.00
86_I	107_V	1.175	1.00
60_C	77_L	1.174	1.00
84_V	218_A	1.168	1.00
55_V	196_I	1.162	1.00
26_K	29_K	1.156	1.00
145_V	229_W	1.155	1.00
205_G	292_R	1.153	1.00
253_I	298_I	1.145	1.00
152_F	162_L	1.131	1.00
144_A	148_A	1.131	1.00
34_V	37_P	1.122	1.00
83_L	108_G	1.114	1.00
141_T	145_V	1.114	1.00
101_A	146_W	1.108	1.00
170_F	189_C	1.107	1.00
149_I	221_T	1.106	1.00
150_N	153_N	1.101	1.00
16_F	62_T	1.100	1.00
157_G	281_H	1.094	1.00
147_A	258_M	1.091	1.00
302_A	306_A	1.090	1.00
174_G	193_I	1.075	1.00
191_A	194_A	1.073	1.00
137_G	141_T	1.072	1.00
198_P	202_L	1.070	1.00
82_V	103_I	1.069	1.00
18_T	198_P	1.068	1.00
58_G	61_F	1.057	1.00
35_D	41_K	1.044	1.00
257_D	261_I	1.044	1.00
25_R	212_K	1.043	1.00
154_M	258_M	1.038	1.00
118_Y	137_G	1.035	1.00
108_G	146_W	1.033	1.00
10_L	190_F	1.029	1.00
43_H	214_F	1.027	1.00
47_I	214_F	1.024	1.00
174_G	177_L	1.023	1.00
222_L	226_T	1.022	1.00
40_R	43_H	1.020	1.00
144_A	231_L	1.019	1.00
163_G	215_M	1.016	1.00
168_V	302_A	1.012	1.00
17_T	21_L	1.010	1.00
16_F	61_F	1.009	1.00
21_L	198_P	1.008	1.00
78_A	82_V	1.007	1.00
83_L	225_F	1.005	1.00
177_L	185_L	1.001	1.00
194_A	198_P	1.001	1.00
104_Q	221_T	0.999	1.00
166_S	196_I	0.998	1.00
59_I	195_A	0.997	1.00
47_I	211_Y	0.997	1.00
171_A	175_M	0.991	1.00
10_L	194_A	0.987	1.00
83_L	107_V	0.985	1.00
155_V	165_L	0.979	1.00
252_A	280_I	0.978	1.00
87_G	221_T	0.970	1.00
34_V	46_L	0.968	1.00
80_A	226_T	0.964	1.00
56_Y	80_A	0.963	1.00
22_F	202_L	0.962	1.00
263_Y	268_K	0.958	1.00
174_G	178_W	0.957	1.00
173_I	231_L	0.954	1.00
200_I	204_L	0.952	1.00
104_Q	149_I	0.948	1.00
169_S	246_T	0.944	1.00
124_Y	129_W	0.943	1.00
170_F	196_I	0.942	1.00
23_F	26_K	0.939	1.00
124_Y	128_S	0.934	1.00
59_I	80_A	0.931	1.00
104_Q	146_W	0.926	1.00
76_Y	229_W	0.921	1.00
101_A	105_A	0.920	1.00
166_S	227_V	0.920	1.00
125_I	128_S	0.919	1.00
19_L	23_F	0.917	1.00
79_C	107_V	0.915	1.00
158_I	295_F	0.914	1.00
205_G	210_R	0.905	1.00
104_Q	150_N	0.904	1.00
201_M	297_L	0.901	1.00
37_P	40_R	0.901	1.00
253_I	281_H	0.897	1.00
167_C	196_I	0.894	1.00
100_R	149_I	0.892	1.00
172_A	310_V	0.886	1.00
143_F	147_A	0.882	1.00
289_F	293_Q	0.881	1.00
79_C	229_W	0.873	1.00
108_G	112_M	0.873	1.00
100_R	154_M	0.870	1.00
136_F	140_L	0.866	1.00
49_L	218_A	0.863	1.00
122_L	125_I	0.863	1.00
83_L	149_I	0.863	1.00
151_A	254_P	0.860	0.99
13_I	195_A	0.858	0.99
121_S	125_I	0.856	0.99
301_A	305_L	0.855	0.99
312_A	315_S	0.855	0.99
162_L	223_I	0.854	0.99
98_K	102_T	0.853	0.99
197_L	201_M	0.851	0.99
121_S	132_V	0.850	0.99
20_F	54_S	0.847	0.99
35_D	38_N	0.847	0.99
93_F	96_S	0.846	0.99
132_V	136_F	0.843	0.99
204_L	292_R	0.842	0.99
14_F	18_T	0.841	0.99
59_I	222_L	0.837	0.99
154_M	261_I	0.834	0.99
23_F	27_V	0.824	0.99
271_S	274_S	0.823	0.99
168_V	303_A	0.822	0.99
174_G	186_A	0.820	0.99
15_L	19_L	0.819	0.99
169_S	250_I	0.816	0.99
169_S	306_A	0.813	0.99
152_F	169_S	0.808	0.99
177_L	186_A	0.802	0.99
274_S	286_R	0.799	0.99
262_M	265_R	0.798	0.99
205_G	291_S	0.798	0.99
188_W	230_I	0.796	0.99
175_M	179_F	0.794	0.99
284_I	298_I	0.791	0.99
12_S	62_T	0.789	0.99
305_L	309_G	0.781	0.99
214_F	217_D	0.776	0.99
83_L	103_I	0.771	0.99
300_L	304_L	0.769	0.99
172_A	246_T	0.767	0.99
14_F	197_L	0.766	0.99
18_T	202_L	0.766	0.99
9_D	187_I	0.766	0.99
270_M	274_S	0.763	0.99
82_V	86_I	0.763	0.99
10_L	193_I	0.760	0.99
8_T	12_S	0.753	0.99
76_Y	226_T	0.747	0.99
17_T	55_V	0.746	0.99
84_V	222_L	0.744	0.99
89_L	92_R	0.744	0.99
153_N	214_F	0.741	0.98
100_R	103_I	0.740	0.98
121_S	130_E	0.740	0.98
35_D	49_L	0.736	0.98
205_G	295_F	0.734	0.98
7_S	11_I	0.729	0.98
307_S	311_L	0.728	0.98
59_I	63_F	0.726	0.98
111_M	115_G	0.723	0.98
148_A	228_I	0.723	0.98
140_L	144_A	0.722	0.98
75_L	114_F	0.721	0.98
25_R	213_V	0.720	0.98
134_G	139_F	0.719	0.98
282_H	285_M	0.719	0.98
173_I	234_T	0.719	0.98
259_V	262_M	0.718	0.98
269_G	272_P	0.715	0.98
165_L	249_W	0.714	0.98
28_A	213_V	0.712	0.98
9_D	62_T	0.708	0.98
155_V	281_H	0.705	0.98
81_G	85_F	0.705	0.98
163_G	199_Y	0.704	0.98
252_A	305_L	0.701	0.98
304_L	308_I	0.701	0.98
80_A	188_W	0.699	0.98
11_I	15_L	0.695	0.98
99_I	102_T	0.695	0.98
117_L	120_S	0.695	0.98
173_I	189_C	0.688	0.98
280_I	298_I	0.688	0.98
294_A	298_I	0.687	0.98
13_I	58_G	0.686	0.98
42_R	291_S	0.686	0.98
20_F	58_G	0.683	0.97
16_F	20_F	0.682	0.97
246_T	309_G	0.682	0.97
176_I	313_E	0.682	0.97
168_V	172_A	0.677	0.97
262_M	267_R	0.674	0.97
88_A	218_A	0.673	0.97
150_N	217_D	0.672	0.97
83_L	104_Q	0.671	0.97
41_K	47_I	0.671	0.97
164_G	168_V	0.669	0.97
36_K	46_L	0.667	0.97
162_L	215_M	0.664	0.97
261_I	278_Q	0.664	0.97
148_A	243_S	0.662	0.97
170_F	226_T	0.662	0.97
256_M	260_A	0.661	0.97
268_K	278_Q	0.660	0.97
50_V	88_A	0.659	0.97
84_V	88_A	0.658	0.97
225_F	229_W	0.657	0.97
36_K	39_F	0.656	0.97
100_R	217_D	0.654	0.97
289_F	294_A	0.654	0.97
147_A	151_A	0.652	0.97
185_L	233_E	0.645	0.96
53_I	218_A	0.643	0.96
31_V	92_R	0.642	0.96
148_A	231_L	0.642	0.96
258_M	262_M	0.639	0.96
37_P	41_K	0.636	0.96
257_D	279_H	0.636	0.96
158_I	294_A	0.631	0.96
175_M	310_V	0.630	0.96
10_L	14_F	0.629	0.96
295_F	299_T	0.629	0.96
258_M	261_I	0.628	0.96
167_C	171_A	0.624	0.96
176_I	234_T	0.624	0.96
291_S	295_F	0.623	0.96
63_F	188_W	0.622	0.96
149_I	220_S	0.622	0.96
111_M	225_F	0.621	0.96
267_R	270_M	0.620	0.96
28_A	48_P	0.619	0.95
113_V	138_Y	0.619	0.95
28_A	33_L	0.617	0.95
176_I	236_Q	0.616	0.95
147_A	255_L	0.615	0.95
139_F	142_L	0.614	0.95
254_P	281_H	0.613	0.95
169_S	247_A	0.610	0.95
59_I	188_W	0.610	0.95
247_A	250_I	0.608	0.95
59_I	170_F	0.608	0.95
55_V	59_I	0.607	0.95
24_A	28_A	0.607	0.95
96_S	100_R	0.606	0.95
262_M	278_Q	0.606	0.95
24_A	33_L	0.605	0.95
290_T	294_A	0.604	0.95
215_M	223_I	0.603	0.95
164_G	295_F	0.602	0.95
148_A	251_I	0.600	0.95
284_I	289_F	0.598	0.95
173_I	246_T	0.598	0.95
110_V	114_F	0.596	0.94
133_L	137_G	0.596	0.94
151_A	258_M	0.594	0.94
264_R	267_R	0.593	0.94
62_T	66_V	0.593	0.94
97_V	101_A	0.592	0.94
252_A	255_L	0.592	0.94
111_M	232_L	0.592	0.94
180_D	183_T	0.591	0.94
123_G	128_S	0.590	0.94
86_I	221_T	0.589	0.94
129_W	132_V	0.587	0.94
108_G	228_I	0.587	0.94
285_M	294_A	0.587	0.94
162_L	199_Y	0.586	0.94
62_T	65_I	0.586	0.94
138_Y	142_L	0.586	0.94
29_K	33_L	0.585	0.94
241_P	244_P	0.583	0.94
83_L	221_T	0.583	0.94
156_D	219_G	0.581	0.94
132_V	135_P	0.581	0.94
263_Y	270_M	0.580	0.94
51_G	199_Y	0.579	0.94
284_I	294_A	0.578	0.94
28_A	34_V	0.577	0.93
149_I	228_I	0.577	0.93
186_A	190_F	0.576	0.93
306_A	309_G	0.576	0.93
156_D	215_M	0.572	0.93
24_A	27_V	0.572	0.93
251_I	254_P	0.572	0.93
201_M	212_K	0.571	0.93
37_P	42_R	0.568	0.93
101_A	142_L	0.568	0.93
50_V	92_R	0.568	0.93
306_A	310_V	0.567	0.93
42_R	285_M	0.567	0.93
148_A	244_P	0.567	0.93
22_F	25_R	0.565	0.93
149_I	225_F	0.564	0.93
58_G	195_A	0.563	0.93
104_Q	220_S	0.562	0.93
67_D	70_I	0.560	0.92
158_I	299_T	0.560	0.92
187_I	191_A	0.560	0.92
13_I	62_T	0.558	0.92
189_C	226_T	0.558	0.92
264_R	271_S	0.556	0.92
256_M	283_L	0.552	0.92
199_Y	215_M	0.550	0.92
297_L	300_L	0.547	0.92
261_I	282_H	0.546	0.91
94_D	273_F	0.543	0.91
261_I	281_H	0.542	0.91
20_F	23_F	0.542	0.91
128_S	131_M	0.538	0.91
285_M	288_G	0.536	0.91
270_M	278_Q	0.536	0.91
265_R	282_H	0.536	0.91
53_I	84_V	0.535	0.91
253_I	280_I	0.534	0.91
161_L	298_I	0.534	0.91
36_K	45_G	0.531	0.90
218_A	221_T	0.531	0.90
159_D	282_H	0.529	0.90
277_R	282_H	0.529	0.90
152_F	247_A	0.529	0.90
28_A	50_V	0.528	0.90
251_I	255_L	0.528	0.90
56_Y	59_I	0.526	0.90
148_A	258_M	0.526	0.90
79_C	82_V	0.525	0.90
159_D	215_M	0.524	0.90
34_V	49_L	0.524	0.90
308_I	312_A	0.522	0.90
97_V	261_I	0.522	0.90
264_R	268_K	0.516	0.89
260_A	264_R	0.515	0.89
79_C	145_V	0.515	0.89
120_S	132_V	0.515	0.89
155_V	261_I	0.514	0.89
49_L	291_S	0.514	0.89
6_V	9_D	0.514	0.89
253_I	257_D	0.511	0.89
69_Y	74_S	0.511	0.89
6_V	174_G	0.510	0.89
40_R	286_R	0.509	0.88
109_I	138_Y	0.506	0.88
148_A	255_L	0.504	0.88
41_K	282_H	0.502	0.88
35_D	39_F	0.502	0.88
199_Y	214_F	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4j72A	2	0.7793	100	0.293	Contact Map
3emlA	1	0.5177	16.5	0.965	Contact Map
3vw7A	1	0.5259	16	0.966	Contact Map
2z73A	2	0.5395	15.2	0.966	Contact Map
4od4A	1	0.1826	11.3	0.968	Contact Map
2r4rA	1	0.3869	10.3	0.969	Contact Map
3rkoA	1	0.2098	7.5	0.97	Contact Map
3ukxC	1	0.03	7.3	0.971	Contact Map
2kluA	1	0.1417	6.7	0.971	Contact Map
2ls4A	1	0.0654	6.7	0.971	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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