GREMLIN Database
KDTA - 3-deoxy-D-manno-octulosonic acid transferase
UniProt: P0AC75 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10520
Length: 425 (410)
Sequences: 2325 (1844)
Seq/√Len: 91.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_R100_D4.1201.00
119_N144_R4.0401.00
324_V339_A3.4281.00
323_F328_L3.3081.00
291_R311_E3.0001.00
373_D376_T2.9311.00
281_V288_Y2.9201.00
184_N187_D2.8671.00
150_I177_I2.8261.00
249_I281_V2.7511.00
348_M368_L2.7171.00
237_A240_T2.7001.00
179_L202_T2.6881.00
70_A410_Q2.6651.00
235_W252_H2.6351.00
267_V306_G2.6251.00
322_A344_I2.5411.00
384_L394_Y2.5131.00
232_R263_L2.4621.00
81_T121_V2.4431.00
138_I148_L2.4401.00
252_H264_L2.4331.00
372_T376_T2.4331.00
64_A129_M2.3741.00
126_V141_L2.3411.00
185_E189_A2.3051.00
115_N140_A2.2541.00
74_R417_E2.2361.00
275_P290_T2.2171.00
388_A391_R2.2011.00
391_R395_G2.1521.00
336_P359_C2.1391.00
210_D407_G2.1261.00
281_V305_V2.1111.00
340_A346_V2.0931.00
306_G315_L2.0501.00
147_P178_T2.0461.00
348_M363_E2.0381.00
348_M359_C2.0361.00
158_R162_G2.0021.00
142_H176_R1.9161.00
142_H178_T1.9021.00
181_A415_L1.8691.00
133_L173_L1.8541.00
297_P301_T1.8531.00
363_E368_L1.8471.00
67_L151_A1.8351.00
250_A284_A1.8231.00
118_L144_R1.8121.00
255_L262_L1.7971.00
90_S103_H1.7961.00
387_D390_Y1.7771.00
278_I290_T1.7711.00
106_L137_L1.7591.00
83_T104_V1.7591.00
141_L148_L1.7581.00
61_T93_V1.7481.00
308_T311_E1.7451.00
138_I177_I1.7311.00
92_R95_S1.7301.00
331_R334_H1.7181.00
118_L141_L1.7121.00
290_T305_V1.7001.00
274_F277_A1.6981.00
383_S390_Y1.6591.00
352_T370_T1.6531.00
177_I180_I1.6401.00
312_L316_Y1.6391.00
393_F397_H1.6291.00
22_W25_G1.6261.00
188_G203_V1.6151.00
237_A264_L1.6041.00
317_G342_H1.6001.00
149_V416_L1.5831.00
245_E273_R1.5731.00
153_A182_A1.5701.00
125_L149_V1.5671.00
140_A143_K1.5621.00
153_A180_I1.5541.00
291_R308_T1.5481.00
129_M151_A1.5451.00
321_L347_L1.5431.00
234_V265_I1.5401.00
246_S280_L1.5261.00
343_A399_V1.5191.00
250_A374_A1.5091.00
15_P19_I1.4981.00
352_T359_C1.4961.00
148_L177_I1.4931.00
236_I319_A1.4921.00
78_L124_K1.4891.00
392_S396_R1.4881.00
237_A252_H1.4741.00
312_L315_L1.4741.00
70_A74_R1.4711.00
348_M370_T1.4681.00
403_Y406_Q1.4671.00
410_Q414_Q1.4571.00
127_L151_A1.4540.99
34_R90_S1.4510.99
126_V148_L1.4480.99
188_G201_V1.4460.99
240_T245_E1.4430.99
82_V93_V1.4430.99
34_R103_H1.4420.99
390_Y394_Y1.4410.99
65_I96_A1.4380.99
359_C368_L1.4370.99
277_A280_L1.4270.99
288_Y305_V1.4210.99
348_M352_T1.4150.99
70_A413_L1.4140.99
64_A68_V1.4110.99
84_T103_H1.4070.99
356_K360_A1.4060.99
138_I176_R1.3940.99
51_I125_L1.3940.99
70_A73_H1.3910.99
241_H334_H1.3890.99
251_A378_A1.3800.99
196_A201_V1.3640.99
56_V85_M1.3620.99
53_L127_L1.3550.99
336_P362_L1.3520.99
363_E370_T1.3510.99
7_T136_N1.3500.99
115_N144_R1.3480.99
278_I282_R1.3420.99
369_I394_Y1.3350.99
390_Y393_F1.3290.99
81_T104_V1.3200.99
367_G398_A1.3070.99
366_S397_H1.3070.99
237_A248_V1.3030.99
160_A193_A1.2950.99
11_Y112_D1.2940.99
383_S387_D1.2940.99
278_I288_Y1.2930.99
253_Q286_L1.2880.99
236_I315_L1.2780.99
188_G192_V1.2730.99
180_I196_A1.2720.99
68_V82_V1.2690.99
238_T316_Y1.2690.99
42_Y121_V1.2650.99
340_A395_G1.2600.99
160_A164_A1.2580.99
292_S307_D1.2570.99
170_V174_L1.2520.98
399_V403_Y1.2490.98
287_S302_Q1.2450.98
396_R400_E1.2430.98
253_Q284_A1.2340.98
151_A412_L1.2330.98
254_A257_Q1.2230.98
114_L118_L1.2200.98
362_L401_V1.2040.98
220_K314_L1.2040.98
347_L380_E1.2020.98
255_L382_S1.1990.98
181_A204_T1.1930.98
225_R320_D1.1850.98
53_L71_L1.1830.98
262_L385_L1.1770.98
235_W381_V1.1720.98
258_Q382_S1.1720.98
394_Y397_H1.1680.98
51_I78_L1.1660.98
110_L113_A1.1560.97
388_A392_S1.1550.97
91_E95_S1.1520.97
52_M81_T1.1420.97
31_Y87_P1.1360.97
401_V405_N1.1320.97
167_G171_R1.1310.97
83_T117_F1.1300.97
274_F278_I1.1270.97
365_A397_H1.1240.97
340_A362_L1.1210.97
118_L146_I1.1200.97
337_L402_L1.1140.97
278_I305_V1.1090.97
347_L371_V1.1060.97
210_D408_A1.1020.97
84_T93_V1.1020.97
241_H331_R1.1010.97
34_R37_E1.1000.97
55_S61_T1.0930.96
75_Y78_L1.0880.96
30_A34_R1.0880.96
252_H262_L1.0850.96
88_T271_P1.0850.96
371_V377_L1.0680.96
93_V103_H1.0660.96
131_T163_Y1.0620.96
409_L413_L1.0550.96
87_P105_Y1.0550.96
55_S129_M1.0540.96
316_Y324_V1.0470.95
259_F382_S1.0460.95
169_F173_L1.0390.95
242_E246_S1.0380.95
298_S301_T1.0270.95
204_T412_L1.0230.95
192_V201_V1.0220.95
323_F371_V1.0210.95
42_Y120_K1.0190.95
236_I265_I1.0180.95
369_I380_E1.0170.95
240_T273_R1.0160.95
279_N282_R1.0160.95
128_I148_L1.0130.94
290_T293_S1.0100.94
336_P352_T1.0060.94
382_S386_T1.0050.94
65_I97_F1.0000.94
25_G32_R1.0000.94
51_I75_Y0.9970.94
153_A191_F0.9940.94
273_R277_A0.9920.94
141_L146_I0.9910.94
61_T84_T0.9840.94
287_S300_S0.9840.94
248_V377_L0.9800.93
267_V312_L0.9800.93
365_A404_Q0.9790.93
242_E276_D0.9670.93
24_R31_Y0.9630.93
150_I191_F0.9620.93
334_H355_F0.9570.93
380_E383_S0.9550.93
146_I178_T0.9460.92
267_V309_M0.9430.92
179_L415_L0.9420.92
265_I304_V0.9380.92
42_Y104_V0.9370.92
182_A191_F0.9320.92
278_I293_S0.9260.91
259_F386_T0.9240.91
7_T111_P0.9240.91
65_I69_R0.9190.91
181_A412_L0.9170.91
19_I23_V0.9130.91
69_R100_D0.9100.91
75_Y417_E0.9090.91
395_G398_A0.9090.91
238_T312_L0.9080.91
233_P391_R0.9060.90
252_H302_Q0.9050.90
149_V179_L0.9040.90
240_T328_L0.9030.90
367_G395_G0.9020.90
369_I390_Y0.9000.90
408_A412_L0.8990.90
357_D361_R0.8970.90
306_G312_L0.8940.90
72_R80_I0.8930.90
281_V286_L0.8910.90
133_L150_I0.8900.90
104_V121_V0.8900.90
359_C363_E0.8890.90
126_V146_I0.8880.90
277_A305_V0.8880.90
235_W264_L0.8880.90
361_R401_V0.8860.89
209_F358_I0.8840.89
271_P309_M0.8830.89
168_K171_R0.8810.89
185_E192_V0.8800.89
182_A187_D0.8770.89
53_L64_A0.8740.89
251_A262_L0.8730.89
327_S333_G0.8700.89
319_A322_A0.8690.89
330_E351_H0.8650.88
340_A402_L0.8630.88
271_P274_F0.8610.88
261_N302_Q0.8590.88
90_S94_Q0.8590.88
255_L378_A0.8560.88
289_I301_T0.8490.87
208_K269_R0.8460.87
56_V132_E0.8450.87
347_L381_V0.8450.87
31_Y38_R0.8420.87
132_E154_R0.8390.87
62_L92_R0.8380.87
67_L207_L0.8360.87
32_R38_R0.8300.86
84_T90_S0.8300.86
72_R97_F0.8300.86
233_P385_L0.8300.86
326_G334_H0.8290.86
249_I284_A0.8260.86
66_P70_A0.8260.86
392_S395_G0.8250.86
396_R399_V0.8230.86
32_R35_W0.8210.86
98_G101_V0.8190.85
306_G311_E0.8190.85
186_E189_A0.8170.85
140_A144_R0.8150.85
75_Y413_L0.8130.85
154_R354_N0.8120.85
157_A190_R0.8090.85
133_L174_L0.8080.85
343_A395_G0.8060.84
7_T10_L0.8060.84
182_A201_V0.8050.84
155_L191_F0.8050.84
206_S358_I0.8000.84
150_I153_A0.7960.84
369_I384_L0.7950.84
71_L80_I0.7940.84
255_L381_V0.7910.83
235_W262_L0.7900.83
130_E269_R0.7890.83
360_A364_Q0.7880.83
24_R30_A0.7870.83
128_I177_I0.7850.83
233_P261_N0.7850.83
97_F101_V0.7840.83
70_A175_R0.7830.83
221_A318_I0.7820.83
62_L96_A0.7810.83
384_L391_R0.7810.83
126_V137_L0.7780.82
320_D391_R0.7770.82
274_F290_T0.7760.82
269_R333_G0.7710.82
279_N283_Q0.7700.82
130_E208_K0.7700.82
236_I312_L0.7690.82
10_L14_Q0.7690.82
208_K333_G0.7690.82
337_L358_I0.7680.82
400_E404_Q0.7650.81
204_T207_L0.7650.81
111_P136_N0.7620.81
220_K223_T0.7620.81
267_V315_L0.7600.81
164_A167_G0.7580.81
413_L417_E0.7550.80
53_L80_I0.7530.80
118_L140_A0.7530.80
90_S104_V0.7530.80
380_E384_L0.7490.80
183_Q206_S0.7470.80
237_A323_F0.7450.80
263_L302_Q0.7450.80
409_L412_L0.7450.80
154_R355_F0.7450.80
340_A367_G0.7410.79
328_L350_P0.7380.79
50_G79_P0.7380.79
240_T323_F0.7350.79
79_P124_K0.7340.79
237_A377_L0.7320.78
30_A87_P0.7280.78
23_V26_R0.7260.78
157_A161_A0.7240.78
321_L391_R0.7240.78
93_V101_V0.7230.77
50_G81_T0.7230.77
74_R410_Q0.7230.77
4_L8_A0.7210.77
306_G309_M0.7170.77
275_P278_I0.7160.77
347_L377_L0.7160.77
321_L385_L0.7150.77
154_R208_K0.7140.77
180_I191_F0.7080.76
376_T379_K0.7080.76
106_L316_Y0.7070.76
346_V368_L0.7060.76
347_L394_Y0.7050.76
241_H333_G0.7050.76
326_G331_R0.7030.75
167_G172_R0.7010.75
344_I395_G0.7010.75
347_L384_L0.6990.75
126_V177_I0.6970.75
329_V351_H0.6930.74
216_Q317_G0.6930.74
11_Y111_P0.6930.74
37_E90_S0.6920.74
53_L68_V0.6890.74
221_A317_G0.6880.74
139_A176_R0.6860.74
235_W266_L0.6860.74
251_A374_A0.6860.74
61_T65_I0.6860.74
242_E245_E0.6860.74
273_R276_D0.6830.73
219_A223_T0.6830.73
17_I20_R0.6830.73
84_T105_Y0.6820.73
274_F305_V0.6820.73
208_K241_H0.6800.73
52_M336_P0.6770.73
387_D391_R0.6760.73
290_T307_D0.6720.72
37_E40_G0.6720.72
85_M106_L0.6700.72
291_R306_G0.6700.72
18_W39_Y0.6690.72
309_M334_H0.6680.72
86_T269_R0.6670.72
248_V323_F0.6660.72
164_A193_A0.6660.72
223_T227_Q0.6660.72
183_Q195_G0.6650.71
133_L177_I0.6650.71
35_W38_R0.6650.71
10_L110_L0.6650.71
319_A344_I0.6640.71
171_R175_R0.6630.71
254_A378_A0.6630.71
81_T102_Q0.6600.71
183_Q332_G0.6590.71
245_E277_A0.6580.71
280_L284_A0.6580.71
56_V129_M0.6570.70
412_L415_L0.6560.70
221_A225_R0.6540.70
89_G163_Y0.6510.70
374_A378_A0.6510.70
53_L151_A0.6500.70
53_L129_M0.6490.70
320_D345_P0.6470.69
208_K270_H0.6470.69
205_G408_A0.6470.69
362_L367_G0.6460.69
21_L35_W0.6450.69
255_L259_F0.6440.69
156_S355_F0.6420.69
58_V309_M0.6410.69
59_G239_S0.6410.69
264_L303_V0.6410.69
220_K224_L0.6400.68
209_F337_L0.6380.68
184_N336_P0.6370.68
22_W32_R0.6360.68
14_Q18_W0.6330.68
235_W255_L0.6320.68
184_N315_L0.6310.67
132_E355_F0.6310.67
139_A173_L0.6290.67
97_F100_D0.6230.66
393_F400_E0.6220.66
233_P262_L0.6220.66
60_E310_G0.6210.66
286_L302_Q0.6190.66
247_V250_A0.6190.66
320_D344_I0.6180.66
52_M55_S0.6170.66
400_E403_Y0.6170.66
367_G394_Y0.6160.66
20_R23_V0.6160.66
377_L381_V0.6150.65
240_T277_A0.6150.65
254_A375_T0.6140.65
249_I286_L0.6130.65
218_A221_A0.6130.65
25_G31_Y0.6110.65
86_T208_K0.6090.65
271_P277_A0.6090.65
133_L153_A0.6090.65
132_E270_H0.6080.65
61_T89_G0.6050.64
62_L241_H0.6030.64
6_Y10_L0.6030.64
156_S208_K0.6030.64
244_E328_L0.6020.64
304_V315_L0.6020.64
57_S239_S0.6020.64
246_S250_A0.6010.64
414_Q417_E0.6000.64
336_P368_L0.5990.63
162_G165_K0.5990.63
205_G210_D0.5980.63
51_I80_I0.5980.63
68_V80_I0.5970.63
104_V117_F0.5960.63
128_I138_I0.5950.63
85_M108_Y0.5950.63
15_P232_R0.5940.63
340_A398_A0.5920.62
189_A193_A0.5890.62
24_R27_K0.5890.62
187_D315_L0.5870.62
150_I180_I0.5860.62
183_Q187_D0.5850.62
339_A342_H0.5840.61
289_I295_E0.5830.61
127_L416_L0.5820.61
207_L409_L0.5820.61
183_Q191_F0.5820.61
224_L314_L0.5800.61
330_E353_F0.5780.61
240_T248_V0.5770.61
132_E174_L0.5770.61
166_L170_V0.5770.61
182_A190_R0.5710.60
249_I264_L0.5710.60
327_S355_F0.5700.60
161_A165_K0.5700.60
154_R269_R0.5670.59
72_R101_V0.5670.59
333_G350_P0.5660.59
248_V328_L0.5650.59
131_T156_S0.5630.59
233_P388_A0.5630.59
180_I195_G0.5620.59
90_S93_V0.5610.58
27_K169_F0.5610.58
236_I344_I0.5610.58
10_L136_N0.5590.58
253_Q257_Q0.5580.58
333_G351_H0.5580.58
134_W239_S0.5560.58
336_P348_M0.5560.58
156_S159_S0.5550.58
361_R405_N0.5550.58
9_L406_Q0.5540.57
58_V240_T0.5540.57
54_H57_S0.5540.57
170_V173_L0.5530.57
206_S316_Y0.5530.57
157_A356_K0.5530.57
347_L385_L0.5530.57
60_E134_W0.5500.57
34_R105_Y0.5490.57
379_K382_S0.5470.57
46_L121_V0.5460.56
75_Y125_L0.5460.56
276_D279_N0.5450.56
112_D119_N0.5450.56
55_S327_S0.5450.56
57_S60_E0.5450.56
237_A251_A0.5440.56
276_D280_L0.5440.56
172_R175_R0.5440.56
59_G310_G0.5440.56
131_T241_H0.5430.56
328_L371_V0.5430.56
52_M126_V0.5420.56
241_H269_R0.5400.56
272_E276_D0.5390.55
160_A190_R0.5380.55
89_G93_V0.5380.55
217_L220_K0.5370.55
86_T156_S0.5370.55
31_Y34_R0.5370.55
63_A131_T0.5370.55
262_L382_S0.5370.55
152_N269_R0.5340.55
60_E239_S0.5340.55
156_S269_R0.5330.55
326_G330_E0.5320.54
247_V329_V0.5300.54
281_V303_V0.5300.54
263_L304_V0.5300.54
89_G92_R0.5300.54
285_G289_I0.5290.54
172_R176_R0.5280.54
156_S327_S0.5260.54
61_T96_A0.5250.53
32_R36_G0.5250.53
59_G134_W0.5240.53
119_N146_I0.5240.53
133_L194_L0.5240.53
202_T411_R0.5230.53
352_T368_L0.5230.53
231_H261_N0.5210.53
55_S114_L0.5210.53
366_S394_Y0.5200.53
237_A328_L0.5200.53
154_R333_G0.5200.53
106_L182_A0.5200.53
289_I292_S0.5190.53
14_Q110_L0.5190.53
106_L114_L0.5170.52
58_V92_R0.5150.52
111_P140_A0.5150.52
191_F206_S0.5150.52
398_A404_Q0.5150.52
14_Q17_I0.5140.52
84_T241_H0.5120.52
323_F377_L0.5120.52
52_M245_E0.5110.52
145_K416_L0.5110.52
112_D115_N0.5110.52
185_E188_G0.5110.52
31_Y35_W0.5110.52
47_K230_P0.5100.51
188_G196_A0.5100.51
82_V103_H0.5090.51
130_E154_R0.5090.51
152_N208_K0.5080.51
185_E203_V0.5080.51
249_I280_L0.5070.51
157_A193_A0.5060.51
247_V374_A0.5050.51
14_Q112_D0.5050.51
365_A401_V0.5040.51
20_R31_Y0.5040.51
54_H326_G0.5030.50
34_R84_T0.5030.50
96_A131_T0.5030.50
386_T389_D0.5020.50
310_G338_E0.5020.50
249_I303_V0.5010.50
131_T355_F0.5010.50
29_P32_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xciA 3 0.8306 100 0.515 Contact Map
1v4vA 2 0.8118 100 0.745 Contact Map
1vgvA 2 0.8071 100 0.75 Contact Map
3dzcA 2 0.7976 100 0.776 Contact Map
4hwgA 5 0.8094 100 0.78 Contact Map
3ot5A 2 0.8141 100 0.793 Contact Map
4nesA 2 0.7859 99.9 0.806 Contact Map
2vsyA 1 0.9059 99.9 0.823 Contact Map
4bfcA 3 0.4494 99.9 0.824 Contact Map
4fkzA 2 0.8165 99.9 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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