GREMLIN Database
GLRX4 - Glutaredoxin-4
UniProt: P0AC69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12181
Length: 115 (99)
Sequences: 1988 (966)
Seq/√Len: 97.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_P77_D3.3991.00
9_Q13_A3.3021.00
19_L74_L3.1271.00
11_Q20_Y2.8651.00
51_D54_Q2.8481.00
25_P49_Y2.7561.00
35_Q88_I2.5221.00
62_L71_F2.5201.00
36_A87_V2.4631.00
41_A47_F2.4061.00
9_Q65_Y2.2511.00
60_A64_K2.2221.00
56_P60_A1.9391.00
66_A75_W1.8721.00
36_A84_C1.8551.00
10_R14_E1.8201.00
18_L48_A1.8121.00
43_C91_Y1.6491.00
24_S51_D1.6241.00
29_S51_D1.6061.00
7_K55_N1.5271.00
18_L50_V1.4971.00
52_I71_F1.4341.00
5_I9_Q1.4241.00
76_V99_L1.4221.00
7_K11_Q1.4090.99
84_C88_I1.3420.99
74_L87_V1.2990.99
15_N48_A1.2800.99
11_Q48_A1.2450.99
71_F80_L1.2430.99
19_L36_A1.2380.99
90_M99_L1.2350.99
42_A91_Y1.2290.99
97_Q101_K1.2250.99
98_Q102_E1.1970.98
39_A87_V1.1870.98
6_E10_R1.1820.98
35_Q84_C1.1000.97
5_I64_K1.0910.97
52_I62_L1.0820.97
36_A74_L1.0740.97
66_A80_L1.0690.97
38_Q42_A1.0630.96
4_T8_I1.0570.96
21_M33_S1.0280.96
4_T7_K1.0230.96
65_Y75_W0.9820.95
91_Y97_Q0.9790.94
17_I45_E0.9710.94
11_Q50_V0.9670.94
88_I92_Q0.9620.94
25_P47_F0.9340.93
21_M36_A0.9320.93
39_A88_I0.9290.93
15_N50_V0.9100.92
81_V99_L0.9090.92
5_I61_E0.9080.92
43_C97_Q0.9030.92
89_E93_R0.9000.92
34_A38_Q0.8560.89
8_I12_I0.8440.89
66_A73_Q0.8310.88
45_E100_I0.8290.88
39_A84_C0.8260.88
14_E48_A0.8240.88
76_V100_I0.8230.87
11_Q18_L0.8130.87
24_S27_L0.8100.87
6_E9_Q0.8050.86
59_R68_W0.7930.85
91_Y96_L0.7890.85
22_K30_C0.7800.85
23_G28_P0.7660.83
77_D102_E0.7630.83
24_S49_Y0.7490.82
12_I78_G0.7450.82
40_L74_L0.7390.81
60_A89_E0.7100.79
55_N75_W0.7030.78
61_E64_K0.7020.78
39_A91_Y0.6980.77
65_Y73_Q0.6900.77
22_K59_R0.6810.76
99_L102_E0.6740.75
81_V90_M0.6740.75
34_A84_C0.6730.75
50_V58_I0.6700.74
54_Q57_D0.6670.74
24_S54_Q0.6650.74
76_V81_V0.6540.73
17_I100_I0.6540.73
45_E101_K0.6500.72
69_P86_I0.6490.72
12_I65_Y0.6490.72
39_A43_C0.6310.70
35_Q91_Y0.6300.70
29_S56_P0.6260.69
90_M96_L0.6260.69
97_Q102_E0.6240.69
26_K41_A0.6200.69
9_Q12_I0.6180.68
57_D61_E0.6100.67
34_A50_V0.6050.67
22_K32_F0.6040.67
25_P41_A0.5990.66
70_T85_D0.5970.66
5_I12_I0.5950.65
84_C87_V0.5940.65
4_T61_E0.5930.65
63_P75_W0.5890.65
25_P48_A0.5890.65
95_E99_L0.5870.64
7_K20_Y0.5850.64
90_M95_E0.5830.64
42_A92_Q0.5790.63
22_K33_S0.5780.63
34_A43_C0.5750.63
34_A37_V0.5680.62
53_L59_R0.5680.62
35_Q39_A0.5630.61
93_R98_Q0.5610.61
48_A58_I0.5590.61
27_L34_A0.5580.61
34_A88_I0.5570.60
73_Q83_G0.5550.60
11_Q58_I0.5530.60
38_Q41_A0.5520.60
98_Q101_K0.5500.59
21_M59_R0.5450.59
37_V41_A0.5450.59
32_F85_D0.5440.59
60_A63_P0.5380.58
86_I96_L0.5360.58
64_K67_N0.5280.56
23_G30_C0.5270.56
82_G85_D0.5260.56
35_Q42_A0.5260.56
60_A71_F0.5230.56
81_V102_E0.5230.56
32_F44_G0.5190.55
6_E86_I0.5180.55
12_I66_A0.5090.54
10_R24_S0.5080.54
20_Y89_E0.5020.53
9_Q78_G0.5010.53
63_P71_F0.5000.52
32_F69_P0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wciA 3 0.9826 99.9 0.445 Contact Map
2jadA 1 0.8609 99.9 0.496 Contact Map
2wulA 3 0.9304 99.8 0.519 Contact Map
3gx8A 1 0.9391 99.8 0.524 Contact Map
1wikA 1 0.9478 99.8 0.535 Contact Map
2yanA 1 0.8957 99.8 0.537 Contact Map
3ipzA 3 0.9217 99.8 0.538 Contact Map
3zywA 1 0.9565 99.8 0.55 Contact Map
2ltkA 1 0.9565 99.7 0.582 Contact Map
1u6tA 1 0.8261 99.7 0.585 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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