GREMLIN Database
GLRX3 - Glutaredoxin-3
UniProt: P0AC62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12294
Length: 83 (81)
Sequences: 2405 (1409)
Seq/√Len: 156.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_C70_Y3.7101.00
23_S29_F3.0401.00
19_K31_E2.1951.00
25_K79_D2.1271.00
25_K73_D2.0991.00
10_E33_P2.0181.00
3_N59_D1.9561.00
40_K43_E1.9551.00
50_R55_Q1.8931.00
56_I69_L1.7641.00
20_A24_S1.6631.00
4_V27_V1.6601.00
10_E35_D1.6281.00
17_R66_C1.5681.00
5_E47_R1.5681.00
55_Q62_H1.5571.00
43_E47_R1.4751.00
50_R62_H1.4731.00
5_E32_L1.4561.00
8_T31_E1.4501.00
6_I56_I1.4161.00
17_R70_Y1.4131.00
18_A66_C1.3911.00
8_T19_K1.3791.00
18_A69_L1.3261.00
33_P36_G1.3021.00
45_I51_T1.2471.00
21_L66_C1.2241.00
61_Q81_L1.2161.00
9_K53_V1.1861.00
17_R67_D1.1841.00
34_I53_V1.1811.00
58_I63_I1.1631.00
77_G80_P1.1521.00
9_K34_I1.1471.00
5_E30_Q1.1131.00
18_A56_I1.0920.99
61_Q77_G1.0750.99
58_I81_L1.0540.99
16_H20_A1.0220.99
42_E45_I1.0090.99
17_R20_A1.0090.99
20_A23_S1.0070.99
75_R80_P0.9890.99
42_E51_T0.9850.99
72_L77_G0.9750.99
3_N30_Q0.9740.99
44_M53_V0.9720.99
21_L70_Y0.9560.99
50_R68_D0.9290.98
21_L73_D0.9210.98
43_E46_K0.9160.98
73_D78_L0.9120.98
6_I18_A0.9080.98
71_A75_R0.9070.98
21_L25_K0.8890.98
42_E46_K0.8840.98
7_Y60_A0.8780.97
73_D79_D0.8710.97
37_N40_K0.8480.97
50_R67_D0.8380.97
63_I81_L0.8320.96
24_S73_D0.8270.96
9_K52_T0.8190.96
48_S55_Q0.8140.96
63_I72_L0.8120.96
48_S57_F0.8060.96
9_K13_P0.7750.95
6_I22_L0.7700.95
38_A42_E0.7660.94
70_Y74_A0.7660.94
6_I31_E0.7600.94
5_E60_A0.7550.94
13_P16_H0.7450.94
22_L27_V0.7300.93
68_D71_A0.7280.93
37_N44_M0.7170.92
9_K41_R0.7070.92
9_K33_P0.7060.92
78_L82_L0.7010.91
39_A42_E0.6990.91
67_D70_Y0.6970.91
3_N60_A0.6960.91
11_T16_H0.6940.91
8_T11_T0.6860.91
21_L69_L0.6840.90
15_C53_V0.6770.90
69_L72_L0.6770.90
41_R44_M0.6720.90
36_G40_K0.6660.89
39_A43_E0.6620.89
72_L80_P0.6580.89
9_K35_D0.6340.87
59_D80_P0.6340.87
44_M48_S0.6330.87
6_I29_F0.6320.87
41_R51_T0.6270.86
7_Y40_K0.6200.86
38_A51_T0.6130.85
23_S28_S0.6030.84
44_M47_R0.6000.84
4_V82_L0.5890.83
73_D80_P0.5870.82
48_S62_H0.5850.82
40_K48_S0.5770.81
41_R45_I0.5760.81
19_K33_P0.5730.81
34_I44_M0.5730.81
8_T33_P0.5710.81
14_Y67_D0.5700.80
21_L27_V0.5670.80
69_L73_D0.5580.79
10_E40_K0.5490.78
7_Y32_L0.5410.77
58_I61_Q0.5400.77
65_G69_L0.5330.76
10_E34_I0.5300.75
62_H72_L0.5300.75
11_T36_G0.5270.75
15_C49_G0.5060.72
62_H67_D0.5060.72
22_L59_D0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jadA 1 1 99.9 0.235 Contact Map
1u6tA 1 0.9759 99.9 0.285 Contact Map
2wciA 3 1 99.9 0.32 Contact Map
1t1vA 2 1 99.9 0.335 Contact Map
2ct6A 1 0.988 99.9 0.344 Contact Map
2wulA 3 1 99.9 0.362 Contact Map
3gx8A 1 1 99.9 0.365 Contact Map
1wikA 1 1 99.8 0.381 Contact Map
2yanA 1 1 99.8 0.383 Contact Map
3zywA 1 1 99.8 0.384 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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