GREMLIN Database
GLRX2 - Glutaredoxin-2
UniProt: P0AC59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12688
Length: 215 (198)
Sequences: 433 (328)
Seq/√Len: 23.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_M58_Y4.2871.00
19_F69_V4.0261.00
116_P120_K3.7351.00
22_K70_D3.5421.00
14_K174_Q3.3501.00
140_S144_I3.1941.00
130_A136_L2.8540.99
52_Q58_Y2.7540.99
163_A166_G2.7510.99
127_E132_N2.6790.99
120_K124_D2.6500.99
43_V47_Q2.5990.99
155_D192_S2.5970.99
155_D193_R2.5580.99
139_H142_G2.4370.98
31_L38_T2.3840.98
126_K133_F2.3560.98
11_Y14_K2.3090.97
24_I69_V2.2910.97
96_Y150_D2.2290.97
36_A121_Y2.1610.96
53_K73_D2.1330.96
89_W93_V2.0310.94
183_T186_A2.0310.94
164_V175_L2.0180.94
22_K73_D2.0000.94
70_D76_P1.8970.92
195_A199_D1.8900.92
116_P119_R1.8340.91
36_A125_K1.8220.90
188_I194_V1.7970.90
108_S184_L1.7960.90
166_G201_M1.7100.87
183_T198_R1.6790.86
38_T46_K1.6500.85
177_P181_N1.6430.85
131_G151_L1.5940.83
135_D138_A1.5430.81
14_K80_G1.5330.80
6_Y9_C1.5310.80
39_P50_I1.5180.80
140_S180_R1.4950.79
6_Y46_K1.4750.78
53_K68_Y1.4490.76
97_A102_L1.4440.76
92_K153_A1.4290.75
84_P87_E1.4050.74
146_N150_D1.3930.73
23_N75_K1.3910.73
27_E97_A1.3880.73
63_M170_E1.3880.73
34_D117_A1.3840.73
157_L188_I1.3770.73
80_G83_S1.3770.73
141_D149_D1.3230.70
126_K130_A1.3100.69
66_V170_E1.3030.68
21_L173_I1.2980.68
117_A120_K1.2900.68
76_P79_T1.2560.65
39_P46_K1.2510.65
27_E114_S1.2230.63
195_A198_R1.2220.63
33_N126_K1.1850.61
22_K76_P1.1790.60
103_P112_E1.1590.59
89_W100_L1.1560.59
88_E93_V1.1510.58
28_L147_I1.1490.58
177_P182_L1.1470.58
21_L204_Q1.1400.58
144_I148_S1.1360.57
6_Y16_R1.1060.55
64_D112_E1.1040.55
122_F166_G1.0990.55
29_H160_K1.0970.55
53_K57_R1.0970.55
139_H195_A1.0970.55
67_H71_K1.0930.54
53_K56_S1.0790.54
15_A66_V1.0710.53
200_N203_K1.0570.52
36_A40_T1.0400.51
15_A65_I1.0280.50
167_E196_D1.0260.50
24_I75_K1.0250.50
33_N121_Y1.0220.50
22_K77_L1.0130.49
7_D176_F1.0120.49
61_E194_V0.9870.47
14_K194_V0.9850.47
124_D149_D0.9820.47
18_I163_A0.9750.46
89_W97_A0.9670.46
14_K156_K0.9610.45
34_D113_F0.9480.44
8_H13_L0.9440.44
200_N204_Q0.9430.44
90_L93_V0.9370.44
29_H107_K0.9350.43
164_V201_M0.9310.43
121_Y125_K0.9300.43
35_D112_E0.9260.43
183_T190_W0.9230.43
31_L36_A0.9160.42
62_S65_I0.9140.42
22_K68_Y0.9140.42
124_D128_A0.9130.42
61_E64_D0.9130.42
146_N149_D0.9000.41
113_F126_K0.8990.41
23_N109_A0.8990.41
78_L173_I0.8810.40
36_A50_I0.8800.40
142_G189_N0.8770.40
123_V134_A0.8750.39
43_V60_P0.8740.39
142_G152_R0.8720.39
134_A138_A0.8720.39
63_M179_L0.8710.39
123_V127_E0.8680.39
21_L66_V0.8670.39
87_E90_L0.8550.38
122_F131_G0.8550.38
59_M164_V0.8530.38
138_A196_D0.8460.37
18_I69_V0.8420.37
57_R88_E0.8350.37
29_H189_N0.8330.37
96_Y115_T0.8330.37
43_V46_K0.8270.36
179_L198_R0.8210.36
154_L172_D0.8180.36
14_K171_D0.8140.35
22_K87_E0.8110.35
127_E199_D0.8070.35
176_F202_A0.8050.35
41_R44_G0.8030.35
14_K169_S0.8030.35
38_T42_M0.8000.35
38_T179_L0.7980.34
31_L47_Q0.7960.34
166_G200_N0.7950.34
187_G191_P0.7940.34
22_K69_V0.7850.34
52_Q57_R0.7830.33
142_G146_N0.7830.33
40_T44_G0.7820.33
152_R155_D0.7810.33
23_N146_N0.7770.33
149_D152_R0.7730.33
48_V65_I0.7730.33
130_A133_F0.7700.33
192_S200_N0.7700.33
109_A203_K0.7640.32
191_P194_V0.7590.32
68_Y71_K0.7580.32
60_P185_V0.7580.32
128_A158_I0.7570.32
73_D76_P0.7560.32
162_N166_G0.7520.32
44_G96_Y0.7450.31
100_L103_P0.7440.31
19_F26_V0.7430.31
37_E145_K0.7410.31
24_I153_A0.7360.31
13_L18_I0.7360.31
15_A57_R0.7350.31
24_I174_Q0.7300.30
123_V132_N0.7250.30
31_L48_V0.7230.30
8_H36_A0.7090.29
61_E153_A0.7090.29
139_H203_K0.7050.29
122_F172_D0.7040.29
49_P62_S0.7020.29
110_F160_K0.6990.28
16_R52_Q0.6970.28
75_K133_F0.6940.28
39_P42_M0.6930.28
166_G172_D0.6900.28
47_Q106_A0.6890.28
149_D169_S0.6890.28
122_F126_K0.6890.28
34_D110_F0.6860.28
100_L197_Y0.6830.28
61_E173_I0.6770.27
48_V68_Y0.6750.27
87_E102_L0.6750.27
180_R183_T0.6660.27
198_R202_A0.6660.27
170_E177_P0.6650.27
49_P65_I0.6640.26
90_L99_K0.6570.26
148_S189_N0.6550.26
40_T43_V0.6510.26
94_N97_A0.6460.26
84_P96_Y0.6420.25
18_I168_L0.6400.25
11_Y97_A0.6400.25
161_P194_V0.6390.25
192_S203_K0.6380.25
68_Y177_P0.6370.25
115_T118_A0.6370.25
53_K177_P0.6350.25
56_S103_P0.6340.25
34_D126_K0.6340.25
85_A128_A0.6320.25
82_R149_D0.6320.25
115_T156_K0.6320.25
81_K142_G0.6260.24
90_L97_A0.6240.24
87_E147_I0.6220.24
148_S152_R0.6200.24
71_K156_K0.6190.24
8_H12_C0.6160.24
33_N177_P0.6150.24
167_E182_L0.6120.24
17_M176_F0.6120.24
97_A101_L0.6070.23
164_V200_N0.6050.23
160_K201_M0.6010.23
105_F184_L0.5980.23
31_L171_D0.5970.23
51_L68_Y0.5950.23
84_P169_S0.5950.23
113_F133_F0.5940.23
101_L105_F0.5930.23
19_F22_K0.5890.23
88_E91_R0.5890.23
93_V153_A0.5880.23
83_S87_E0.5880.23
45_Q132_N0.5880.23
6_Y39_P0.5860.22
56_S139_H0.5860.22
78_L169_S0.5840.22
83_S98_N0.5840.22
154_L185_V0.5820.22
120_K127_E0.5810.22
77_L146_N0.5780.22
16_R97_A0.5750.22
82_R174_Q0.5700.22
12_C104_R0.5680.22
85_A88_E0.5660.21
13_L19_F0.5640.21
116_P142_G0.5620.21
47_Q60_P0.5620.21
49_P172_D0.5600.21
84_P88_E0.5590.21
8_H126_K0.5590.21
91_R175_L0.5570.21
87_E94_N0.5570.21
117_A189_N0.5560.21
7_D180_R0.5540.21
48_V62_S0.5530.21
135_D189_N0.5500.21
56_S64_D0.5500.21
139_H145_K0.5470.21
91_R198_R0.5470.21
139_H152_R0.5460.21
142_G159_V0.5450.21
121_Y126_K0.5430.20
80_G86_I0.5400.20
134_A195_A0.5400.20
22_K75_K0.5370.20
70_D78_L0.5370.20
13_L21_L0.5350.20
109_A176_F0.5350.20
144_I190_W0.5340.20
8_H33_N0.5340.20
27_E124_D0.5340.20
97_A148_S0.5330.20
160_K164_V0.5330.20
107_K177_P0.5330.20
100_L143_L0.5270.20
60_P132_N0.5260.20
95_G98_N0.5250.20
89_W195_A0.5250.20
182_L202_A0.5250.20
116_P146_N0.5240.20
46_K169_S0.5220.19
59_M197_Y0.5220.19
16_R65_I0.5200.19
70_D84_P0.5200.19
24_I199_D0.5190.19
138_A142_G0.5160.19
158_I163_A0.5140.19
189_N196_D0.5120.19
145_K167_E0.5120.19
87_E91_R0.5110.19
21_L155_D0.5100.19
12_C125_K0.5060.19
190_W196_D0.5050.19
59_M110_F0.5040.19
152_R196_D0.5030.19
60_P105_F0.5020.19
71_K84_P0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ir4A 1 1 100 0.398 Contact Map
4mdcA 2 0.9488 100 0.541 Contact Map
3m0fA 2 0.8977 100 0.545 Contact Map
4kf9A 2 0.9907 100 0.546 Contact Map
1k0dA 2 0.9581 100 0.547 Contact Map
4mp4A 2 0.8558 100 0.547 Contact Map
1gnwA 2 0.893 100 0.549 Contact Map
4w66A 2 0.8977 100 0.55 Contact Map
1b8xA 2 0.8605 100 0.55 Contact Map
3ic8A 3 0.8465 100 0.55 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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