GREMLIN Database
GLNK - Nitrogen regulatory protein P-II 2
UniProt: P0AC55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12191
Length: 112 (112)
Sequences: 2942 (1589)
Seq/√Len: 150.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_R107_A4.4761.00
64_A96_L3.6731.00
98_R108_D3.6071.00
65_I73_V3.0911.00
66_A109_E2.6591.00
12_K15_D2.5241.00
69_Q72_E2.4401.00
16_V81_A2.2861.00
78_S82_Y2.2601.00
6_V77_V2.2361.00
23_I76_I2.1681.00
29_T33_V2.1371.00
5_T94_A1.9871.00
76_I80_A1.9191.00
75_D79_K1.9011.00
66_A69_Q1.8001.00
74_I93_V1.7971.00
3_L64_A1.6771.00
8_I16_V1.6511.00
71_D75_D1.6421.00
13_L30_V1.5591.00
31_T62_D1.5231.00
16_V61_I1.3831.00
72_E76_I1.3751.00
4_V73_V1.3321.00
31_T60_K1.3071.00
67_D109_E1.2931.00
2_K67_D1.2661.00
75_D78_S1.2611.00
74_I91_I1.2531.00
78_S107_A1.2321.00
78_S91_I1.2291.00
3_L94_A1.2151.00
18_E22_S1.2071.00
8_I61_I1.1941.00
4_V65_I1.1931.00
19_A22_S1.1861.00
5_T60_K1.1611.00
64_A92_F1.1581.00
72_E79_K1.1541.00
7_I29_T1.1230.99
101_R106_E1.1220.99
30_V55_F1.1090.99
2_K95_E1.1020.99
19_A79_K1.0960.99
2_K70_L1.0900.99
65_I70_L1.0900.99
82_Y105_G1.0900.99
39_Q56_L1.0870.99
71_D107_A1.0850.99
8_I13_L1.0840.99
70_L74_I1.0830.99
9_K86_I1.0800.99
17_R28_L1.0790.99
78_S100_I1.0730.99
2_K93_V1.0710.99
71_D98_R1.0630.99
19_A80_A1.0550.99
5_T64_A1.0460.99
92_F102_I1.0220.99
2_K97_Q1.0140.99
39_Q58_K1.0140.99
103_R106_E0.9830.99
20_L63_V0.9730.99
13_L59_V0.9660.98
72_E75_D0.9530.98
21_S36_F0.9470.98
83_T88_D0.9380.98
84_G88_D0.9330.98
42_H54_N0.9310.98
36_F42_H0.9080.98
9_K33_V0.9050.98
25_I63_V0.9040.98
4_V77_V0.8980.97
99_V111_A0.8780.97
36_F54_N0.8770.97
19_A76_I0.8730.97
63_V73_V0.8680.97
69_Q73_V0.8620.97
23_I72_E0.8590.97
27_G36_F0.8290.96
43_A50_E0.8070.95
45_L49_A0.7850.95
100_I107_A0.7700.94
46_Y49_A0.7700.94
16_V80_A0.7670.94
74_I100_I0.7630.94
41_G58_K0.7620.94
36_F55_F0.7490.93
6_V81_A0.7430.93
42_H49_A0.7400.93
7_I92_F0.7360.92
60_K92_F0.7280.92
6_V63_V0.7230.92
13_L54_N0.7210.92
3_L96_L0.7210.92
20_L77_V0.7200.92
28_L61_I0.7000.90
48_G51_Y0.6960.90
42_H45_L0.6960.90
25_I73_V0.6950.90
11_F15_D0.6900.90
47_R51_Y0.6760.89
37_G90_K0.6760.89
5_T62_D0.6710.89
33_V60_K0.6640.88
11_F56_L0.6620.88
8_I77_V0.6540.87
20_L73_V0.6530.87
45_L85_K0.6530.87
13_L55_F0.6530.87
45_L50_E0.6490.87
66_A73_V0.6400.86
21_S40_K0.6390.86
15_D80_A0.6340.86
8_I12_K0.6340.86
92_F99_V0.6340.86
43_A52_S0.6280.85
41_G44_E0.6180.84
42_H50_E0.6140.84
70_L95_E0.6110.83
71_D78_S0.6110.83
67_D70_L0.6070.83
3_L92_F0.6040.83
79_K82_Y0.5990.82
30_V61_I0.5940.82
32_E59_V0.5900.81
5_T99_V0.5880.81
34_K46_Y0.5880.81
17_R54_N0.5850.81
22_S79_K0.5840.81
1_M67_D0.5820.80
20_L61_I0.5810.80
27_G99_V0.5790.80
38_R102_I0.5730.79
9_K82_Y0.5730.79
36_F102_I0.5670.79
57_P85_K0.5640.78
91_I100_I0.5640.78
11_F49_A0.5610.78
27_G56_L0.5590.78
76_I79_K0.5560.77
17_R21_S0.5530.77
25_I42_H0.5530.77
70_L98_R0.5510.77
11_F55_F0.5430.76
45_L54_N0.5420.76
20_L72_E0.5410.75
77_V81_A0.5350.75
11_F32_E0.5340.74
96_L99_V0.5320.74
39_Q86_I0.5300.74
38_R44_E0.5300.74
53_V112_L0.5300.74
28_L52_S0.5290.74
41_G56_L0.5220.73
100_I106_E0.5220.73
13_L61_I0.5190.72
50_E85_K0.5190.72
100_I111_A0.5170.72
44_E49_A0.5170.72
2_K8_I0.5120.71
28_L62_D0.5080.71
70_L93_V0.5080.71
13_L52_S0.5060.71
20_L23_I0.5050.70
42_H85_K0.5010.70
85_K102_I0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ozjA 3 0.875 100 0.177 Contact Map
3t9zA 3 0.875 100 0.188 Contact Map
2o66A 5 0.8661 100 0.189 Contact Map
3ncqA 4 1 100 0.196 Contact Map
1hwuA 6 0.9554 100 0.206 Contact Map
1vfjA 3 1 100 0.209 Contact Map
4r25A 3 1 100 0.21 Contact Map
3bzqA 3 0.8661 100 0.211 Contact Map
3l7pA 4 0.8125 100 0.212 Contact Map
2ns1B 3 1 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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