GREMLIN Database
G6PD - Glucose-6-phosphate 1-dehydrogenase
UniProt: P0AC53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11221
Length: 491 (468)
Sequences: 3122 (1762)
Seq/√Len: 81.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_R324_D5.1321.00
263_E266_K4.7861.00
54_D57_A4.1331.00
225_Y229_A3.8851.00
464_K475_A3.6271.00
119_M127_I3.6081.00
271_L448_W3.4591.00
262_D438_R3.3771.00
248_A333_F3.3721.00
207_D485_R3.3651.00
209_V333_F3.3471.00
63_R67_E3.1581.00
450_D454_E3.1191.00
152_S155_T3.0731.00
79_W83_S3.0251.00
226_F231_Q2.9181.00
17_A58_Y2.9121.00
444_E447_K2.9081.00
285_R456_W2.8961.00
55_K59_T2.8941.00
55_K87_D2.8051.00
163_V172_V2.7951.00
168_E171_Q2.5541.00
144_V428_T2.4851.00
227_D313_T2.3731.00
272_R322_D2.3471.00
95_D98_A2.3241.00
342_P471_W2.3161.00
114_I428_T2.3061.00
262_D440_D2.2951.00
300_G303_E2.2831.00
289_T465_P2.2591.00
286_G465_P2.2581.00
52_D90_N2.2511.00
231_Q337_T2.2361.00
151_T155_T2.1881.00
145_M163_V2.1871.00
286_G463_P2.1861.00
60_K64_E2.1591.00
275_D278_N2.1361.00
256_S259_S2.1341.00
143_V167_F2.1301.00
62_V86_L2.0931.00
129_K165_E2.0761.00
347_E375_R2.0741.00
349_V371_K2.0571.00
320_R483_D2.0251.00
157_Q443_E2.0101.00
63_R80_D2.0011.00
120_P123_T1.9961.00
53_W57_A1.9871.00
153_L157_Q1.9361.00
27_L62_V1.9251.00
201_W206_I1.9091.00
103_G107_D1.8811.00
128_C163_V1.8761.00
149_L159_I1.8361.00
87_D105_M1.8301.00
352_F372_L1.8091.00
254_D259_S1.7951.00
22_A62_V1.7911.00
243_I348_V1.7881.00
34_E85_R1.7721.00
189_A399_L1.7681.00
283_T452_I1.7631.00
17_A47_G1.7611.00
291_G298_V1.7581.00
450_D453_T1.7281.00
76_E80_D1.7251.00
128_C143_V1.7211.00
231_Q314_E1.7121.00
262_D269_K1.7121.00
46_I105_M1.7011.00
11_D44_R1.6951.00
236_I337_T1.6781.00
20_D24_R1.6631.00
218_G340_R1.6601.00
200_N352_F1.6581.00
129_K162_Q1.6551.00
334_Y483_D1.6491.00
22_A27_L1.6421.00
132_G166_Y1.6171.00
236_I317_V1.6171.00
55_K105_M1.6161.00
250_S327_R1.6151.00
326_W356_E1.6131.00
210_E351_Y1.6091.00
209_V248_A1.6051.00
271_L321_V1.5841.00
129_K133_E1.5801.00
283_T319_I1.5731.00
478_A481_T1.5721.00
298_V340_R1.5641.00
235_M337_T1.5511.00
208_H485_R1.5481.00
125_G162_Q1.5380.99
53_W61_V1.5370.99
158_E162_Q1.5330.99
213_V346_S1.5280.99
34_E81_T1.5250.99
251_P326_W1.5110.99
91_L98_A1.4990.99
161_D165_E1.4900.99
389_K392_G1.4860.99
96_T133_E1.4860.99
89_C105_M1.4850.99
190_L382_V1.4850.99
14_I22_A1.4840.99
137_N167_F1.4730.99
66_L79_W1.4670.99
57_A60_K1.4590.99
48_V91_L1.4570.99
208_H351_Y1.4540.99
34_E82_L1.4470.99
264_K441_E1.4450.99
372_L384_I1.4390.99
203_N353_K1.4330.99
182_E389_K1.4330.99
211_I244_L1.4310.99
342_P470_T1.4310.99
96_T130_G1.4300.99
78_L81_T1.4220.99
340_R468_A1.4170.99
25_K419_D1.4110.99
195_S205_T1.4070.99
474_V478_A1.4000.99
290_A303_E1.3920.99
240_L335_L1.3830.99
13_V106_L1.3650.99
290_A300_G1.3620.99
31_Y75_D1.3500.99
80_D84_A1.3380.99
204_R353_K1.3360.99
81_T84_A1.3220.98
265_V438_R1.3150.98
190_L374_I1.3140.98
351_Y371_K1.3050.98
207_D353_K1.2990.98
283_T456_W1.2970.98
386_V404_L1.2960.98
101_R104_A1.2930.98
292_F295_G1.2920.98
321_V448_W1.2860.98
316_F477_V1.2830.98
160_N443_E1.2740.98
302_L465_P1.2720.98
62_V66_L1.2630.98
241_L449_V1.2590.98
241_L268_L1.2580.98
301_Y307_A1.2450.98
195_S199_N1.2400.98
261_R438_R1.2390.98
223_W306_G1.2390.98
292_F297_K1.2380.98
122_S228_K1.2310.98
349_V373_T1.2270.97
227_D308_N1.2270.97
93_V123_T1.2230.97
112_I140_P1.2220.97
64_E68_T1.2220.97
236_I319_I1.2140.97
97_A100_S1.2100.97
285_R314_E1.2070.97
153_L443_E1.1980.97
284_V479_M1.1970.97
478_A482_R1.1940.97
182_E392_G1.1920.97
245_C268_L1.1870.97
154_A157_Q1.1850.97
48_V98_A1.1810.97
197_F386_V1.1790.97
60_K63_R1.1780.97
49_G88_F1.1660.97
474_V477_V1.1570.96
106_L113_T1.1560.96
312_N463_P1.1550.96
407_S410_E1.1420.96
41_P81_T1.1380.96
46_I87_D1.1380.96
157_Q447_K1.1360.96
25_K178_Y1.1320.96
247_I348_V1.1320.96
31_Y82_L1.1270.96
24_R217_V1.1210.96
316_F476_S1.1200.96
45_I86_L1.1190.96
100_S133_E1.1180.96
10_C429_M1.1120.95
12_L114_I1.1120.95
302_L310_S1.1100.95
284_V475_A1.1080.95
14_I26_L1.1080.95
169_E174_R1.1010.95
382_V386_V1.0980.95
291_G295_G1.0950.95
289_T467_Q1.0930.95
477_V481_T1.0880.95
44_R87_D1.0870.95
154_A158_E1.0870.95
232_M456_W1.0830.95
125_G158_E1.0820.95
59_T83_S1.0810.95
202_D205_T1.0780.95
75_D78_L1.0760.95
377_Q380_E1.0750.95
390_V400_Q1.0740.95
326_W329_A1.0740.95
274_I278_N1.0690.94
59_T87_D1.0530.94
203_N331_V1.0510.94
56_A60_K1.0500.94
51_A93_V1.0360.93
23_R61_V1.0350.93
93_V127_I1.0290.93
46_I89_C1.0260.93
13_V115_N1.0250.93
18_K51_A1.0230.93
321_V335_L1.0230.93
223_W304_E1.0200.93
27_L58_Y1.0180.93
212_T336_R1.0180.93
124_F149_L1.0160.93
287_Q311_S1.0150.93
199_N205_T1.0140.93
247_I350_V1.0120.93
198_V327_R1.0120.93
291_G468_A1.0110.93
236_I335_L1.0030.92
31_Y78_L1.0010.92
318_A476_S1.0000.92
408_Y412_F1.0000.92
114_I429_M0.9950.92
98_A101_R0.9940.92
265_V440_D0.9930.92
347_E373_T0.9850.92
157_Q161_D0.9840.91
298_V468_A0.9830.91
74_I79_W0.9810.91
63_R79_W0.9810.91
467_Q470_T0.9770.91
346_S376_L0.9770.91
290_A297_K0.9760.91
96_T134_A0.9730.91
92_D95_D0.9730.91
390_V398_N0.9660.91
99_F130_G0.9660.91
178_Y377_Q0.9620.91
24_R235_M0.9600.90
12_L26_L0.9580.90
185_L427_E0.9510.90
295_G298_V0.9510.90
52_D57_A0.9490.90
117_F128_C0.9460.90
31_Y70_M0.9450.90
63_R83_S0.9440.90
289_T464_K0.9430.90
269_K444_E0.9420.90
388_N402_T0.9400.90
319_I452_I0.9340.89
223_W307_A0.9340.89
56_A59_T0.9300.89
225_Y228_K0.9280.89
218_G304_E0.9250.89
453_T457_A0.9250.89
322_D330_G0.9240.89
455_A459_D0.9230.89
244_L271_L0.9170.88
320_R334_Y0.9090.88
89_C101_R0.9050.88
386_V406_L0.9040.88
182_E423_R0.9040.88
373_T385_Q0.9020.87
33_L43_T0.8990.87
480_I485_R0.8980.87
454_E457_A0.8880.87
260_I434_A0.8870.87
33_L39_L0.8860.87
227_D302_L0.8840.86
449_V452_I0.8840.86
262_D265_V0.8830.86
25_K29_S0.8830.86
375_R381_G0.8790.86
226_F337_T0.8780.86
283_T317_V0.8780.86
22_A58_Y0.8730.86
217_V344_K0.8730.86
428_T437_V0.8700.86
48_V124_F0.8670.85
199_N202_D0.8670.85
57_A61_V0.8670.85
196_L200_N0.8660.85
476_S479_M0.8650.85
312_N465_P0.8640.85
114_I140_P0.8620.85
213_V235_M0.8610.85
37_G41_P0.8580.85
261_R440_D0.8560.85
302_L462_A0.8540.84
126_A129_K0.8540.84
210_E318_A0.8530.84
125_G129_K0.8520.84
35_K78_L0.8520.84
268_L271_L0.8520.84
399_L435_L0.8510.84
351_Y369_Q0.8490.84
462_A465_P0.8490.84
23_R68_T0.8490.84
27_L86_L0.8480.84
236_I240_L0.8440.84
217_V235_M0.8440.84
268_L441_E0.8420.84
169_E440_D0.8400.83
197_F384_I0.8380.83
145_M159_I0.8370.83
224_G228_K0.8370.83
18_K49_G0.8350.83
345_C375_R0.8320.83
291_G297_K0.8280.83
444_E448_W0.8280.83
221_G305_E0.8270.83
11_D106_L0.8260.82
198_V250_S0.8240.82
250_S325_N0.8220.82
78_L82_L0.8190.82
38_Q426_L0.8180.82
312_N459_D0.8170.82
213_V335_L0.8150.82
129_K166_Y0.8150.82
251_P356_E0.8130.81
33_L426_L0.8120.81
144_V175_I0.8120.81
273_R444_E0.8120.81
96_T100_S0.8110.81
209_V350_V0.8080.81
77_G81_T0.8060.81
33_L429_M0.8050.81
385_Q403_K0.8050.81
314_E457_A0.8040.81
169_E261_R0.8020.81
39_L429_M0.8020.81
219_I226_F0.8010.80
67_E74_I0.8000.80
296_K299_P0.7960.80
258_D438_R0.7960.80
104_A108_Q0.7960.80
173_Y258_D0.7960.80
11_D46_I0.7940.80
244_L321_V0.7940.80
58_Y65_A0.7940.80
289_T463_P0.7930.80
180_G424_L0.7910.80
158_E161_D0.7880.79
249_M260_I0.7840.79
66_L83_S0.7830.79
33_L38_Q0.7830.79
299_P305_E0.7820.79
375_R379_D0.7820.79
16_G19_G0.7810.79
232_M314_E0.7810.79
459_D463_P0.7770.78
276_R458_M0.7760.78
67_E76_E0.7750.78
302_L308_N0.7740.78
479_M483_D0.7740.78
24_R69_F0.7730.78
341_L476_S0.7730.78
137_N141_A0.7720.78
113_T141_A0.7700.78
15_F119_M0.7700.78
49_G90_N0.7690.78
91_L99_F0.7660.77
245_C445_A0.7660.77
160_N439_R0.7650.77
15_F127_I0.7640.77
10_C33_L0.7590.77
16_G21_L0.7580.77
219_I223_W0.7550.76
93_V119_M0.7530.76
341_L411_T0.7530.76
265_V441_E0.7510.76
14_I17_A0.7500.76
178_Y220_E0.7490.76
481_T486_S0.7480.76
268_L448_W0.7470.76
173_Y392_G0.7460.76
154_A454_E0.7460.76
144_V425_L0.7410.75
274_I283_T0.7370.75
22_A118_A0.7340.74
478_A486_S0.7340.74
105_M108_Q0.7340.74
178_Y181_K0.7340.74
301_Y311_S0.7320.74
77_G80_D0.7320.74
97_A101_R0.7320.74
346_S437_V0.7310.74
69_F217_V0.7300.74
210_E336_R0.7300.74
12_L45_I0.7290.74
198_V202_D0.7290.74
462_A475_A0.7270.74
61_V64_E0.7270.74
153_L447_K0.7270.74
261_R433_Q0.7260.74
284_V476_S0.7250.73
274_I452_I0.7250.73
219_I304_E0.7240.73
199_N203_N0.7230.73
130_G133_E0.7230.73
170_C258_D0.7220.73
350_V374_I0.7200.73
260_I264_K0.7200.73
34_E78_L0.7190.73
135_K143_V0.7190.73
402_T406_L0.7190.73
48_V89_C0.7180.73
210_E334_Y0.7160.73
14_I156_S0.7160.73
418_A422_E0.7160.73
270_S325_N0.7140.72
189_A267_V0.7130.72
99_F127_I0.7100.72
291_G296_K0.7090.72
195_S355_P0.7070.72
324_D329_A0.7060.72
149_L163_V0.7060.72
314_E456_W0.7040.71
100_S103_G0.7040.71
186_N389_K0.7040.71
345_C471_W0.7030.71
191_R327_R0.7020.71
385_Q401_I0.7020.71
42_D85_R0.7010.71
338_G341_L0.7010.71
163_V322_D0.6980.71
304_E340_R0.6930.70
267_V271_L0.6920.70
320_R479_M0.6920.70
115_N124_F0.6900.70
244_L335_L0.6900.70
199_N356_E0.6880.70
449_V453_T0.6870.69
151_T457_A0.6870.69
285_R452_I0.6850.69
283_T455_A0.6810.69
240_L244_L0.6780.68
143_V163_V0.6750.68
381_G408_Y0.6740.68
193_A265_V0.6740.68
207_D351_Y0.6740.68
402_T405_D0.6730.68
25_K175_I0.6730.68
290_A296_K0.6720.68
164_G439_R0.6690.67
173_Y342_P0.6690.67
91_L448_W0.6660.67
40_N43_T0.6630.67
70_M73_T0.6610.66
46_I106_L0.6610.66
225_Y235_M0.6590.66
173_Y431_G0.6590.66
32_Q36_A0.6580.66
266_K423_R0.6570.66
300_G465_P0.6570.66
287_Q465_P0.6560.66
132_G137_N0.6530.66
36_A351_Y0.6490.65
291_G469_G0.6490.65
192_F249_M0.6490.65
302_L307_A0.6470.65
100_S104_A0.6470.65
267_V323_I0.6460.65
233_R453_T0.6460.65
463_P475_A0.6430.64
265_V269_K0.6420.64
32_Q422_E0.6420.64
11_D109_K0.6400.64
160_N167_F0.6400.64
232_M236_I0.6400.64
346_S442_V0.6350.63
219_I231_Q0.6350.63
83_S86_L0.6340.63
424_L444_E0.6330.63
203_N326_W0.6320.63
183_T380_E0.6320.63
54_D60_K0.6320.63
64_E67_E0.6320.63
31_Y74_I0.6300.63
211_I353_K0.6290.63
444_E451_S0.6260.62
62_V65_A0.6260.62
17_A22_A0.6230.62
66_L308_N0.6190.61
258_D269_K0.6180.61
13_V120_P0.6170.61
47_G86_L0.6170.61
214_A342_P0.6170.61
126_A130_G0.6160.61
162_Q165_E0.6150.61
373_T383_D0.6140.61
77_G297_K0.6130.61
231_Q285_R0.6110.60
253_S269_K0.6110.60
292_F467_Q0.6110.60
66_L70_M0.6090.60
23_R65_A0.6090.60
50_R224_G0.6080.60
317_V320_R0.6080.60
317_V337_T0.6080.60
33_L225_Y0.6070.60
326_W360_F0.6070.60
388_N417_L0.6060.60
14_I118_A0.6050.60
380_E420_A0.6050.60
381_G418_A0.6050.60
114_I144_V0.6050.60
104_A107_D0.6050.60
181_K377_Q0.6050.60
243_I376_L0.6040.60
58_Y118_A0.6040.60
84_A454_E0.6040.60
350_V353_K0.6030.59
77_G316_F0.6030.59
220_E296_K0.6020.59
454_E458_M0.6020.59
120_P347_E0.6020.59
74_I78_L0.6010.59
291_G340_R0.6000.59
144_V433_Q0.6000.59
29_S418_A0.6000.59
387_L401_I0.5990.59
269_K440_D0.5980.59
268_L445_A0.5970.59
54_D95_D0.5960.59
355_P358_N0.5950.58
75_D104_A0.5950.58
100_S134_A0.5950.58
125_G128_C0.5950.58
216_E343_T0.5940.58
482_R485_R0.5920.58
326_W357_L0.5910.58
87_D196_L0.5900.58
159_I163_V0.5900.58
351_Y373_T0.5880.57
185_L435_L0.5880.57
107_D111_R0.5860.57
124_F286_G0.5860.57
203_N329_A0.5850.57
287_Q302_L0.5840.57
187_L376_L0.5840.57
62_V79_W0.5840.57
149_L156_S0.5830.57
56_A63_R0.5820.57
56_A104_A0.5820.57
93_V120_P0.5810.57
227_D307_A0.5810.57
51_A90_N0.5800.56
433_Q437_V0.5780.56
248_A323_I0.5780.56
104_A323_I0.5780.56
387_L399_L0.5770.56
317_V321_V0.5750.56
115_N131_L0.5750.56
18_K442_V0.5750.56
480_I483_D0.5720.55
249_M252_P0.5720.55
312_N462_A0.5710.55
14_I183_T0.5710.55
81_T87_D0.5710.55
34_E43_T0.5710.55
117_F355_P0.5680.55
24_R220_E0.5670.55
14_I30_L0.5660.55
209_V300_G0.5660.55
18_K93_V0.5660.55
91_L349_V0.5650.55
334_Y485_R0.5650.55
61_V382_V0.5640.54
48_V347_E0.5640.54
391_P406_L0.5630.54
191_R249_M0.5630.54
82_L86_L0.5630.54
259_S269_K0.5620.54
31_Y34_E0.5600.54
236_I449_V0.5600.54
195_S198_V0.5600.54
124_F238_N0.5590.54
128_C167_F0.5590.54
131_L141_A0.5590.54
328_W333_F0.5580.54
255_L359_L0.5580.54
189_A255_L0.5560.53
199_N391_P0.5550.53
151_T229_A0.5550.53
183_T326_W0.5550.53
114_I173_Y0.5550.53
191_R250_S0.5540.53
334_Y480_I0.5540.53
25_K50_R0.5530.53
203_N356_E0.5520.53
227_D301_Y0.5510.53
206_I212_T0.5510.53
269_K303_E0.5500.53
437_V445_A0.5490.52
48_V93_V0.5490.52
292_F298_V0.5480.52
382_V390_V0.5480.52
94_N126_A0.5470.52
170_C206_I0.5460.52
143_V479_M0.5450.52
35_K70_M0.5450.52
182_E191_R0.5450.52
394_D398_N0.5450.52
202_D325_N0.5450.52
375_R423_R0.5440.52
258_D440_D0.5440.52
248_A327_R0.5430.52
78_L101_R0.5430.52
17_A114_I0.5400.51
285_R317_V0.5400.51
258_D261_R0.5400.51
261_R442_V0.5400.51
23_R69_F0.5400.51
253_S259_S0.5390.51
11_D111_R0.5380.51
220_E304_E0.5380.51
290_A299_P0.5370.51
63_R76_E0.5370.51
263_E356_E0.5370.51
27_L391_P0.5350.51
166_Y173_Y0.5350.51
248_A267_V0.5340.50
65_A69_F0.5330.50
118_A441_E0.5330.50
286_G459_D0.5330.50
210_E487_W0.5330.50
284_V317_V0.5330.50
66_L442_V0.5330.50
187_L247_I0.5320.50
184_V261_R0.5320.50
326_W355_P0.5320.50
217_V337_T0.5320.50
213_V443_E0.5310.50
103_G108_Q0.5300.50
159_I432_I0.5290.50
60_K84_A0.5290.50
445_A449_V0.5290.50
266_K380_E0.5280.50
57_A90_N0.5280.50
121_P210_E0.5270.50
203_N330_G0.5270.50
141_A171_Q0.5260.49
103_G256_S0.5260.49
245_C267_V0.5250.49
141_A225_Y0.5250.49
323_I328_W0.5240.49
371_K385_Q0.5240.49
92_D98_A0.5240.49
216_E344_K0.5230.49
128_C166_Y0.5230.49
48_V92_D0.5220.49
35_K75_D0.5220.49
420_A426_L0.5210.49
346_S428_T0.5210.49
47_G121_P0.5210.49
241_L441_E0.5200.49
231_Q456_W0.5200.49
441_E445_A0.5200.49
30_L45_I0.5190.49
237_Q445_A0.5180.48
253_S326_W0.5180.48
289_T310_S0.5180.48
256_S325_N0.5170.48
77_G165_E0.5160.48
199_N326_W0.5150.48
49_G301_Y0.5140.48
437_V448_W0.5140.48
334_Y487_W0.5140.48
136_L171_Q0.5130.48
474_V481_T0.5120.48
232_M453_T0.5110.47
217_V246_M0.5110.47
130_G134_A0.5100.47
114_I253_S0.5100.47
232_M285_R0.5100.47
320_R428_T0.5100.47
203_N357_L0.5090.47
292_F478_A0.5080.47
251_P327_R0.5080.47
22_A106_L0.5080.47
376_L406_L0.5060.47
459_D462_A0.5060.47
348_V376_L0.5060.47
49_G103_G0.5050.47
182_E391_P0.5040.47
24_R372_L0.5040.47
47_G65_A0.5030.46
427_E434_A0.5020.46
266_K377_Q0.5020.46
72_E76_E0.5010.46
221_G344_K0.5010.46
104_A276_R0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dpgA 2 0.9715 100 -0.003 Contact Map
2bh9A 2 0.9674 100 0.005 Contact Map
4e9iA 3 0.9552 100 0.02 Contact Map
4lgvA 4 0.9267 100 0.039 Contact Map
3u3xA 2 0.6375 97.1 0.959 Contact Map
3rc1A 1 0.6375 96.7 0.961 Contact Map
3f4lA 2 0.6721 96.6 0.962 Contact Map
3i23A 2 0.6884 96.4 0.962 Contact Map
3uuwA 4 0.6029 95.8 0.964 Contact Map
4koaA 2 0.6436 95.8 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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