ZUR - ECOLI - GREMLIN Contacts

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ZUR - Zinc uptake regulation protein

UniProt:	P0AC51	Sequences: MEKTTTQELLAQAEKICAQRNVRLTPQRLEVLRLMSLQDGAISAYDLLDLLREAEPQAKPPTVYRALDFLLEQGFVHKVESTNSYVLCHLFDQPTHTSAMFICDRCGAVKEECAEGVEDIMHTLAAKMGFALRHNVIEAHGLCAACVEVEACRHPEQCQHDHSVQVKKKPR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11929
Length:	171 (136)
Sequences:	5802 (3747)
Seq/√Len:	321.3

ECOLI - ZUR FUR
BACSU - FUR PERR ZUR
SULSO - Q97WH5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
104_D	133_R	4.042	1.00
105_R	142_L	3.954	1.00
108_A	145_A	3.477	1.00
131_A	147_V	3.081	1.00
35_M	76_V	2.877	1.00
132_L	139_A	2.471	1.00
14_E	29_L	2.253	1.00
129_G	144_A	2.126	1.00
34_L	50_L	2.114	1.00
104_D	142_L	2.078	1.00
44_A	67_L	2.035	1.00
104_D	140_H	2.031	1.00
71_L	78_K	1.981	1.00
106_C	143_C	1.874	1.00
71_L	76_V	1.871	1.00
48_L	60_P	1.867	1.00
24_L	29_L	1.856	1.00
22_V	73_Q	1.789	1.00
15_K	19_Q	1.775	1.00
68_D	78_K	1.751	1.00
133_R	142_L	1.694	1.00
38_Q	50_L	1.667	1.00
49_D	52_R	1.650	1.00
101_F	110_K	1.605	1.00
43_S	46_D	1.570	1.00
106_C	146_C	1.569	1.00
31_V	66_A	1.559	1.00
34_L	47_L	1.536	1.00
78_K	86_V	1.531	1.00
101_F	130_F	1.528	1.00
99_A	135_N	1.520	1.00
123_T	127_K	1.495	1.00
130_F	144_A	1.484	1.00
38_Q	42_I	1.481	1.00
33_R	37_L	1.462	1.00
41_A	100_M	1.460	1.00
48_L	52_R	1.459	1.00
30_E	54_A	1.441	1.00
41_A	89_H	1.367	1.00
27_Q	62_T	1.356	1.00
16_I	20_R	1.352	1.00
103_C	106_C	1.346	1.00
110_K	130_F	1.325	1.00
29_L	33_R	1.310	1.00
143_C	146_C	1.309	1.00
41_A	98_S	1.285	1.00
30_E	33_R	1.273	1.00
97_T	135_N	1.237	1.00
70_L	75_F	1.229	1.00
103_C	143_C	1.225	1.00
122_H	126_A	1.211	1.00
34_L	42_I	1.197	1.00
34_L	51_L	1.183	1.00
41_A	111_E	1.176	1.00
50_L	53_E	1.129	1.00
32_L	70_L	1.118	1.00
110_K	128_M	1.112	1.00
48_L	63_V	1.100	1.00
66_A	69_F	1.058	1.00
75_F	90_L	1.048	1.00
11_A	14_E	1.045	1.00
144_A	148_E	1.041	1.00
119_D	123_T	1.026	1.00
22_V	69_F	1.015	1.00
16_I	19_Q	1.008	1.00
35_M	42_I	0.994	1.00
42_I	87_L	0.985	1.00
131_A	142_L	0.969	1.00
91_F	96_H	0.965	1.00
102_I	140_H	0.962	1.00
142_L	147_V	0.918	1.00
114_A	117_V	0.912	1.00
129_G	147_V	0.910	1.00
99_A	121_M	0.906	1.00
40_G	50_L	0.905	1.00
107_G	110_K	0.900	1.00
130_F	141_G	0.895	1.00
14_E	18_A	0.891	1.00
26_P	30_E	0.885	1.00
101_F	128_M	0.880	1.00
69_F	73_Q	0.878	1.00
34_L	38_Q	0.876	1.00
99_A	115_E	0.873	1.00
42_I	47_L	0.872	1.00
99_A	112_E	0.871	1.00
102_I	107_G	0.869	1.00
135_N	139_A	0.865	1.00
51_L	58_A	0.861	1.00
103_C	146_C	0.853	1.00
105_R	149_V	0.838	1.00
25_T	62_T	0.830	1.00
134_H	140_H	0.819	1.00
145_A	149_V	0.813	1.00
42_I	50_L	0.809	1.00
62_T	66_A	0.808	1.00
98_S	111_E	0.806	1.00
18_A	24_L	0.804	1.00
45_Y	60_P	0.804	1.00
68_D	71_L	0.802	1.00
44_A	63_V	0.800	1.00
12_Q	16_I	0.797	1.00
45_Y	48_L	0.789	1.00
114_A	120_I	0.789	1.00
52_R	60_P	0.784	1.00
101_F	141_G	0.780	1.00
27_Q	58_A	0.777	1.00
51_L	55_E	0.777	1.00
26_P	29_L	0.775	1.00
41_A	59_K	0.769	1.00
51_L	56_P	0.759	0.99
116_G	119_D	0.756	0.99
44_A	60_P	0.747	0.99
45_Y	49_D	0.746	0.99
40_G	46_D	0.737	0.99
13_A	32_L	0.737	0.99
79_V	111_E	0.733	0.99
85_Y	88_C	0.733	0.99
14_E	24_L	0.733	0.99
125_A	132_L	0.732	0.99
49_D	53_E	0.729	0.99
34_L	54_A	0.727	0.99
37_L	50_L	0.725	0.99
117_V	121_M	0.719	0.99
11_A	15_K	0.718	0.99
33_R	54_A	0.715	0.99
145_A	148_E	0.708	0.99
24_L	32_L	0.705	0.99
41_A	109_V	0.701	0.99
30_E	55_E	0.699	0.99
67_L	76_V	0.692	0.99
17_C	32_L	0.691	0.99
35_M	43_S	0.689	0.99
77_H	91_F	0.684	0.99
102_I	138_E	0.665	0.99
102_I	109_V	0.665	0.99
31_V	34_L	0.661	0.99
144_A	147_V	0.661	0.99
35_M	47_L	0.659	0.99
135_N	140_H	0.658	0.98
104_D	134_H	0.656	0.98
68_D	72_E	0.652	0.98
27_Q	66_A	0.651	0.98
97_T	115_E	0.650	0.98
48_L	58_A	0.648	0.98
100_M	111_E	0.646	0.98
99_A	137_I	0.646	0.98
31_V	47_L	0.644	0.98
41_A	45_Y	0.643	0.98
119_D	122_H	0.642	0.98
28_R	66_A	0.641	0.98
28_R	69_F	0.640	0.98
121_M	135_N	0.635	0.98
115_E	139_A	0.632	0.98
110_K	145_A	0.632	0.98
80_E	84_S	0.627	0.98
81_S	136_V	0.624	0.98
46_D	49_D	0.624	0.98
17_C	69_F	0.623	0.98
97_T	118_E	0.621	0.98
44_A	85_Y	0.619	0.98
16_I	36_S	0.618	0.98
17_C	22_V	0.617	0.98
114_A	119_D	0.613	0.98
115_E	135_N	0.613	0.98
36_S	90_L	0.609	0.98
50_L	54_A	0.603	0.97
13_A	75_F	0.599	0.97
35_M	87_L	0.597	0.97
123_T	126_A	0.591	0.97
114_A	123_T	0.588	0.97
117_V	120_I	0.585	0.97
32_L	75_F	0.585	0.97
12_Q	15_K	0.582	0.97
62_T	65_R	0.580	0.97
89_H	98_S	0.576	0.97
136_V	140_H	0.570	0.96
126_A	147_V	0.569	0.96
87_L	90_L	0.564	0.96
30_E	51_L	0.563	0.96
78_K	88_C	0.563	0.96
67_L	71_L	0.561	0.96
79_V	138_E	0.561	0.96
15_K	18_A	0.557	0.96
39_D	91_F	0.554	0.96
20_R	73_Q	0.553	0.96
32_L	90_L	0.550	0.95
83_N	87_L	0.550	0.95
141_G	146_C	0.547	0.95
30_E	58_A	0.544	0.95
118_E	135_N	0.538	0.95
45_Y	111_E	0.537	0.95
17_C	24_L	0.534	0.95
27_Q	59_K	0.531	0.95
37_L	54_A	0.529	0.94
47_L	76_V	0.529	0.94
116_G	120_I	0.521	0.94
45_Y	85_Y	0.518	0.94
70_L	76_V	0.517	0.94
81_S	140_H	0.516	0.94
30_E	34_L	0.510	0.93
48_L	61_P	0.507	0.93
44_A	71_L	0.506	0.93
43_S	85_Y	0.501	0.93
45_Y	78_K	0.500	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mtdA	2	0.883	100	0.166	Contact Map
2fe3A	2	0.8363	100	0.215	Contact Map
2xigA	4	0.8713	100	0.216	Contact Map
4etsA	2	0.8772	100	0.227	Contact Map
3eyyA	2	0.7778	100	0.239	Contact Map
3mwmA	2	0.7427	100	0.243	Contact Map
2w57A	2	0.7602	100	0.254	Contact Map
4lmyA	2	0.8947	100	0.265	Contact Map
2o03A	2	0.7544	100	0.272	Contact Map
1mzbA	4	0.7719	100	0.291	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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