GREMLIN Database
ZUR - Zinc uptake regulation protein
UniProt: P0AC51 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11929
Length: 171 (136)
Sequences: 5802 (3747)
Seq/√Len: 321.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_D133_R4.0421.00
105_R142_L3.9541.00
108_A145_A3.4771.00
131_A147_V3.0811.00
35_M76_V2.8771.00
132_L139_A2.4711.00
14_E29_L2.2531.00
129_G144_A2.1261.00
34_L50_L2.1141.00
104_D142_L2.0781.00
44_A67_L2.0351.00
104_D140_H2.0311.00
71_L78_K1.9811.00
106_C143_C1.8741.00
71_L76_V1.8711.00
48_L60_P1.8671.00
24_L29_L1.8561.00
22_V73_Q1.7891.00
15_K19_Q1.7751.00
68_D78_K1.7511.00
133_R142_L1.6941.00
38_Q50_L1.6671.00
49_D52_R1.6501.00
101_F110_K1.6051.00
43_S46_D1.5701.00
106_C146_C1.5691.00
31_V66_A1.5591.00
34_L47_L1.5361.00
78_K86_V1.5311.00
101_F130_F1.5281.00
99_A135_N1.5201.00
123_T127_K1.4951.00
130_F144_A1.4841.00
38_Q42_I1.4811.00
33_R37_L1.4621.00
41_A100_M1.4601.00
48_L52_R1.4591.00
30_E54_A1.4411.00
41_A89_H1.3671.00
27_Q62_T1.3561.00
16_I20_R1.3521.00
103_C106_C1.3461.00
110_K130_F1.3251.00
29_L33_R1.3101.00
143_C146_C1.3091.00
41_A98_S1.2851.00
30_E33_R1.2731.00
97_T135_N1.2371.00
70_L75_F1.2291.00
103_C143_C1.2251.00
122_H126_A1.2111.00
34_L42_I1.1971.00
34_L51_L1.1831.00
41_A111_E1.1761.00
50_L53_E1.1291.00
32_L70_L1.1181.00
110_K128_M1.1121.00
48_L63_V1.1001.00
66_A69_F1.0581.00
75_F90_L1.0481.00
11_A14_E1.0451.00
144_A148_E1.0411.00
119_D123_T1.0261.00
22_V69_F1.0151.00
16_I19_Q1.0081.00
35_M42_I0.9941.00
42_I87_L0.9851.00
131_A142_L0.9691.00
91_F96_H0.9651.00
102_I140_H0.9621.00
142_L147_V0.9181.00
114_A117_V0.9121.00
129_G147_V0.9101.00
99_A121_M0.9061.00
40_G50_L0.9051.00
107_G110_K0.9001.00
130_F141_G0.8951.00
14_E18_A0.8911.00
26_P30_E0.8851.00
101_F128_M0.8801.00
69_F73_Q0.8781.00
34_L38_Q0.8761.00
99_A115_E0.8731.00
42_I47_L0.8721.00
99_A112_E0.8711.00
102_I107_G0.8691.00
135_N139_A0.8651.00
51_L58_A0.8611.00
103_C146_C0.8531.00
105_R149_V0.8381.00
25_T62_T0.8301.00
134_H140_H0.8191.00
145_A149_V0.8131.00
42_I50_L0.8091.00
62_T66_A0.8081.00
98_S111_E0.8061.00
18_A24_L0.8041.00
45_Y60_P0.8041.00
68_D71_L0.8021.00
44_A63_V0.8001.00
12_Q16_I0.7971.00
45_Y48_L0.7891.00
114_A120_I0.7891.00
52_R60_P0.7841.00
101_F141_G0.7801.00
27_Q58_A0.7771.00
51_L55_E0.7771.00
26_P29_L0.7751.00
41_A59_K0.7691.00
51_L56_P0.7590.99
116_G119_D0.7560.99
44_A60_P0.7470.99
45_Y49_D0.7460.99
40_G46_D0.7370.99
13_A32_L0.7370.99
79_V111_E0.7330.99
85_Y88_C0.7330.99
14_E24_L0.7330.99
125_A132_L0.7320.99
49_D53_E0.7290.99
34_L54_A0.7270.99
37_L50_L0.7250.99
117_V121_M0.7190.99
11_A15_K0.7180.99
33_R54_A0.7150.99
145_A148_E0.7080.99
24_L32_L0.7050.99
41_A109_V0.7010.99
30_E55_E0.6990.99
67_L76_V0.6920.99
17_C32_L0.6910.99
35_M43_S0.6890.99
77_H91_F0.6840.99
102_I138_E0.6650.99
102_I109_V0.6650.99
31_V34_L0.6610.99
144_A147_V0.6610.99
35_M47_L0.6590.99
135_N140_H0.6580.98
104_D134_H0.6560.98
68_D72_E0.6520.98
27_Q66_A0.6510.98
97_T115_E0.6500.98
48_L58_A0.6480.98
100_M111_E0.6460.98
99_A137_I0.6460.98
31_V47_L0.6440.98
41_A45_Y0.6430.98
119_D122_H0.6420.98
28_R66_A0.6410.98
28_R69_F0.6400.98
121_M135_N0.6350.98
115_E139_A0.6320.98
110_K145_A0.6320.98
80_E84_S0.6270.98
81_S136_V0.6240.98
46_D49_D0.6240.98
17_C69_F0.6230.98
97_T118_E0.6210.98
44_A85_Y0.6190.98
16_I36_S0.6180.98
17_C22_V0.6170.98
114_A119_D0.6130.98
115_E135_N0.6130.98
36_S90_L0.6090.98
50_L54_A0.6030.97
13_A75_F0.5990.97
35_M87_L0.5970.97
123_T126_A0.5910.97
114_A123_T0.5880.97
117_V120_I0.5850.97
32_L75_F0.5850.97
12_Q15_K0.5820.97
62_T65_R0.5800.97
89_H98_S0.5760.97
136_V140_H0.5700.96
126_A147_V0.5690.96
87_L90_L0.5640.96
30_E51_L0.5630.96
78_K88_C0.5630.96
67_L71_L0.5610.96
79_V138_E0.5610.96
15_K18_A0.5570.96
39_D91_F0.5540.96
20_R73_Q0.5530.96
32_L90_L0.5500.95
83_N87_L0.5500.95
141_G146_C0.5470.95
30_E58_A0.5440.95
118_E135_N0.5380.95
45_Y111_E0.5370.95
17_C24_L0.5340.95
27_Q59_K0.5310.95
37_L54_A0.5290.94
47_L76_V0.5290.94
116_G120_I0.5210.94
45_Y85_Y0.5180.94
70_L76_V0.5170.94
81_S140_H0.5160.94
30_E34_L0.5100.93
48_L61_P0.5070.93
44_A71_L0.5060.93
43_S85_Y0.5010.93
45_Y78_K0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mtdA 2 0.883 100 0.166 Contact Map
2fe3A 2 0.8363 100 0.215 Contact Map
2xigA 4 0.8713 100 0.216 Contact Map
4etsA 2 0.8772 100 0.227 Contact Map
3eyyA 2 0.7778 100 0.239 Contact Map
3mwmA 2 0.7427 100 0.243 Contact Map
2w57A 2 0.7602 100 0.254 Contact Map
4lmyA 2 0.8947 100 0.265 Contact Map
2o03A 2 0.7544 100 0.272 Contact Map
1mzbA 4 0.7719 100 0.291 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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