GREMLIN Database
FRDB - Fumarate reductase iron-sulfur subunit
UniProt: P0AC47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10331
Length: 244 (228)
Sequences: 2577 (1067)
Seq/√Len: 70.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_Y47_N4.6451.00
8_K28_E4.5381.00
10_E90_K3.9441.00
118_K122_I3.8121.00
9_I40_A3.7211.00
42_G54_Y3.7051.00
53_S104_V3.6631.00
10_E26_F3.5201.00
9_I44_I2.9801.00
68_M77_A2.8151.00
40_A82_L2.7991.00
174_I228_G2.6741.00
146_F224_A2.5771.00
15_N18_V2.4471.00
25_A49_A2.4361.00
123_G187_H2.4081.00
181_N228_G2.3561.00
30_P43_Y2.2981.00
110_F153_G2.2781.00
37_L70_V2.2631.00
6_N30_P2.2431.00
175_T219_V2.1891.00
43_Y48_L2.1471.00
170_G224_A2.1321.00
160_P208_V2.0961.00
70_V75_K2.0511.00
29_V44_I2.0491.00
74_P158_A2.0341.00
6_N28_E1.9981.00
118_K191_E1.9761.00
12_V22_P1.9751.00
137_P141_A1.9381.00
67_G154_L1.8721.00
227_Q230_V1.8681.00
73_V214_V1.8001.00
35_T43_Y1.7591.00
209_G221_P1.7501.00
10_E24_S1.7181.00
69_M157_A1.7131.00
183_D186_D1.6560.99
67_G94_L1.6440.99
112_E115_E1.6360.99
9_I89_M1.6090.99
75_K80_T1.5910.99
8_K26_F1.5380.99
24_S90_K1.5250.99
139_Q184_S1.5000.99
135_Q184_S1.4980.99
12_V92_E1.4810.99
196_L200_N1.4670.99
122_I188_G1.4610.99
124_N187_H1.4490.99
30_P47_N1.4380.99
160_P170_G1.3910.98
168_F182_E1.3720.98
12_V24_S1.3660.98
196_L199_Q1.3610.98
147_S153_G1.3570.98
15_N23_H1.3390.98
177_A231_E1.3280.98
178_H182_E1.3250.98
212_S222_A1.3250.98
231_E234_K1.3170.97
181_N231_E1.3060.97
212_S220_D1.2910.97
11_V52_L1.2900.97
113_S200_N1.2860.97
140_M144_H1.2800.97
73_V213_E1.2770.97
169_I173_A1.2760.97
20_T23_H1.2690.97
190_K194_A1.2580.97
44_I52_L1.2540.97
178_H227_Q1.2330.96
55_R65_S1.2170.96
17_E20_T1.2170.96
136_T139_Q1.2170.96
31_Y40_A1.2140.96
123_G133_N1.1950.95
31_Y82_L1.1550.95
19_D23_H1.1320.94
68_M91_V1.1210.94
98_P109_H1.1150.93
154_L214_V1.1090.93
97_F157_A1.0990.93
86_T100_E1.0900.93
27_Y53_S1.0880.93
126_R130_Q1.0870.93
139_Q142_K1.0840.92
194_A235_D1.0810.92
175_T221_P1.0730.92
69_M95_A1.0720.92
85_Y88_G1.0660.92
24_S92_E1.0590.91
29_V40_A1.0430.91
29_V43_Y1.0330.90
126_R129_D1.0170.90
190_K235_D1.0140.90
174_I177_A1.0110.89
107_M110_F1.0090.89
10_E88_G1.0010.89
59_R62_I0.9970.89
175_T224_A0.9930.89
62_I79_K0.9910.89
188_G191_E0.9770.88
11_V91_V0.9760.88
25_A48_L0.9680.87
45_K53_S0.9620.87
32_D35_T0.9550.87
14_Y18_V0.9520.86
107_M111_I0.9500.86
79_K146_F0.9460.86
38_L59_R0.9460.86
76_L186_D0.9440.86
188_G192_R0.9390.86
124_N188_G0.9350.85
113_S196_L0.9350.85
94_L170_G0.9320.85
212_S221_P0.9310.85
210_Y214_V0.9310.85
145_Q148_G0.9260.85
27_Y49_A0.9250.85
142_K223_A0.9240.85
100_E104_V0.9210.85
75_K85_Y0.9110.84
69_M74_P0.9110.84
37_L40_A0.9100.84
107_M153_G0.9060.84
148_G219_V0.9060.84
97_F107_M0.9030.83
174_I196_L0.8970.83
37_L82_L0.8970.83
36_S59_R0.8960.83
177_A184_S0.8960.83
65_S68_M0.8840.82
109_H113_S0.8820.82
213_E222_A0.8810.82
196_L228_G0.8560.80
59_R66_C0.8510.80
225_I228_G0.8470.79
7_L88_G0.8410.79
95_A157_A0.8330.78
7_L234_K0.8250.77
110_F172_A0.8200.77
69_M208_V0.8190.77
140_M148_G0.8140.77
68_M89_M0.8130.76
158_A214_V0.8130.76
173_A228_G0.8130.76
37_L80_T0.8110.76
65_S76_L0.8060.76
118_K195_Q0.8040.76
89_M190_K0.8040.76
9_I37_L0.8040.76
7_L89_M0.7980.75
74_P210_Y0.7970.75
209_G213_E0.7970.75
8_K87_D0.7930.75
85_Y89_M0.7920.75
29_V52_L0.7900.74
29_V47_N0.7880.74
52_L103_L0.7860.74
140_M143_Y0.7810.74
205_C211_C0.7790.73
209_G212_S0.7740.73
21_A25_A0.7670.72
25_A71_N0.7630.72
143_Y147_S0.7630.72
66_C96_N0.7590.71
110_F147_S0.7580.71
42_G46_D0.7570.71
127_T130_Q0.7550.71
19_D22_P0.7540.71
49_A183_D0.7530.71
186_D192_R0.7500.70
71_N85_Y0.7450.70
161_Q208_V0.7410.70
176_L180_Y0.7410.70
54_Y59_R0.7400.69
75_K111_I0.7360.69
80_T85_Y0.7360.69
53_S101_R0.7350.69
207_F226_Q0.7340.69
15_N19_D0.7340.69
26_F84_D0.7290.68
160_P210_Y0.7280.68
166_P228_G0.7280.68
74_P154_L0.7280.68
197_N232_S0.7230.68
18_V21_A0.7200.67
142_K178_H0.7200.67
110_F156_Y0.7190.67
18_V25_A0.7120.66
7_L31_Y0.7110.66
138_A188_G0.7110.66
106_D109_H0.7100.66
32_D43_Y0.7060.66
57_S172_A0.7020.65
220_D223_A0.6990.65
194_A197_N0.6990.65
24_S168_F0.6980.65
41_L68_M0.6970.65
128_A133_N0.6960.65
12_V99_I0.6960.65
27_Y48_L0.6960.65
167_E199_Q0.6920.64
37_L91_V0.6910.64
97_F153_G0.6870.64
7_L40_A0.6840.63
144_H148_G0.6830.63
143_Y175_T0.6830.63
122_I191_E0.6810.63
36_S60_M0.6810.63
43_Y46_D0.6800.63
7_L32_D0.6760.62
146_F182_E0.6750.62
126_R187_H0.6670.61
219_V222_A0.6650.61
226_Q230_V0.6620.61
65_S186_D0.6590.60
159_C211_C0.6580.60
41_L54_Y0.6560.60
113_S162_F0.6560.60
121_I180_Y0.6480.59
117_I173_A0.6460.59
95_A217_K0.6450.59
21_A101_R0.6440.59
135_Q139_Q0.6420.58
121_I184_S0.6420.58
82_L168_F0.6410.58
193_M232_S0.6390.58
15_N20_T0.6380.58
56_W154_L0.6330.57
76_L179_R0.6310.57
11_V44_I0.6280.57
123_G126_R0.6260.57
36_S81_F0.6220.56
21_A98_P0.6210.56
63_C78_C0.6210.56
109_H162_F0.6200.56
119_P135_Q0.6200.56
35_T46_D0.6180.56
195_Q201_G0.6170.56
124_N141_A0.6160.55
148_G221_P0.6110.55
181_N193_M0.6090.55
145_Q221_P0.6080.54
44_I47_N0.6060.54
18_V26_F0.6050.54
189_K231_E0.6050.54
44_I226_Q0.6030.54
39_D55_R0.6020.54
24_S99_I0.5990.53
154_L163_G0.5980.53
144_H151_N0.5980.53
159_C205_C0.5970.53
13_R41_L0.5950.53
11_V29_V0.5950.53
182_E231_E0.5920.52
138_A234_K0.5910.52
145_Q224_A0.5870.52
32_D99_I0.5860.52
123_G129_D0.5820.51
45_K62_I0.5800.51
9_I86_T0.5800.51
223_A226_Q0.5780.51
61_A79_K0.5770.51
92_E214_V0.5740.50
70_V77_A0.5720.50
7_L82_L0.5710.50
8_K202_V0.5710.50
163_G210_Y0.5700.50
156_Y172_A0.5680.50
197_N201_G0.5660.49
135_Q177_A0.5640.49
160_P214_V0.5630.49
198_S208_V0.5620.49
6_N44_I0.5620.49
73_V116_A0.5610.49
123_G128_A0.5600.49
165_N225_I0.5590.48
112_E128_A0.5560.48
65_S192_R0.5560.48
161_Q164_L0.5550.48
21_A90_K0.5540.48
139_Q192_R0.5540.48
81_F84_D0.5530.48
122_I126_R0.5520.48
71_N89_M0.5500.47
194_A199_Q0.5500.47
160_P224_A0.5480.47
36_S153_G0.5470.47
96_N145_Q0.5440.47
66_C180_Y0.5430.47
69_M160_P0.5420.46
13_R25_A0.5370.46
62_I66_C0.5370.46
88_G130_Q0.5360.46
171_P174_I0.5350.46
66_C206_T0.5350.46
26_F86_T0.5320.45
10_E25_A0.5300.45
11_V68_M0.5250.44
23_H26_F0.5230.44
41_L160_P0.5220.44
60_M151_N0.5210.44
129_D132_T0.5210.44
8_K90_K0.5200.44
179_R183_D0.5190.44
58_C78_C0.5180.43
66_C222_A0.5180.43
55_R192_R0.5170.43
19_D112_E0.5170.43
166_P173_A0.5150.43
55_R221_P0.5150.43
204_S229_K0.5140.43
58_C63_C0.5140.43
170_G214_V0.5130.43
174_I224_A0.5130.43
183_D231_E0.5130.43
55_R76_L0.5110.43
116_A169_I0.5100.43
60_M161_Q0.5080.42
112_E116_A0.5080.42
114_L206_T0.5080.42
136_T184_S0.5070.42
168_F207_F0.5070.42
84_D89_M0.5060.42
84_D87_D0.5050.42
70_V89_M0.5050.42
61_A150_I0.5050.42
15_N26_F0.5040.42
70_V111_I0.5040.42
152_C155_C0.5040.42
45_K56_W0.5040.42
110_F169_I0.5030.42
67_G116_A0.5030.42
168_F173_A0.5030.42
65_S77_A0.5020.42
211_C215_C0.5010.41
224_A227_Q0.5010.41
117_I192_R0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.832 100 0.384 Contact Map
1kf6B 1 0.9959 100 0.429 Contact Map
2h88B 1 0.959 100 0.444 Contact Map
4ysxB 1 0.9959 100 0.445 Contact Map
2wdqB 1 0.9508 100 0.451 Contact Map
2bs2B 1 0.959 100 0.464 Contact Map
3c8yA 1 0.8566 99.9 0.754 Contact Map
1ffvA 1 0.627 99.9 0.763 Contact Map
3i9v3 1 0.8279 99.8 0.766 Contact Map
1t3qA 1 0.6475 99.8 0.777 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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