GREMLIN Database
DHSD - Succinate dehydrogenase hydrophobic membrane anchor subunit
UniProt: P0AC44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10934
Length: 115 (111)
Sequences: 490 (290)
Seq/√Len: 27.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_L93_L4.1841.00
65_L108_G3.3891.00
80_L97_I2.5570.99
77_W81_T2.5350.99
100_A104_Y2.4290.99
97_I101_L2.3780.99
25_V64_A2.2360.98
32_Y51_F2.1530.98
17_I91_L2.1170.97
51_F57_T2.1090.97
18_L70_I1.9370.95
65_L69_L1.9030.95
45_Y49_I1.8000.93
15_D113_W1.7840.93
26_L64_A1.7050.91
21_A95_L1.7000.91
93_L103_V1.6880.91
26_L68_I1.6790.90
33_M57_T1.6420.89
69_L105_V1.6190.89
106_I114_G1.5930.88
32_Y60_F1.5900.88
33_M37_F1.5870.88
67_S104_Y1.5610.87
13_V16_F1.5370.86
66_F105_V1.5370.86
44_T47_V1.5260.86
37_F43_L1.5170.85
5_A11_N1.4900.84
34_V37_F1.4770.84
60_F102_V1.4530.83
78_Q81_T1.3950.80
16_F19_V1.3670.78
22_T70_I1.3570.78
32_Y57_T1.3000.75
36_F43_L1.2780.74
7_A11_N1.2750.73
6_S11_N1.2590.72
39_T49_I1.2340.71
4_N111_V1.1920.68
107_Y111_V1.1900.68
8_L11_N1.1800.67
36_F51_F1.1740.67
80_L94_Q1.1670.66
4_N11_N1.1560.66
26_L102_V1.1240.63
86_P92_M1.1010.62
10_R15_D1.0690.60
59_V63_L1.0690.60
88_A92_M1.0660.59
61_T112_V1.0650.59
29_Y36_F1.0590.59
18_L79_V1.0460.58
69_L101_L1.0450.58
63_L100_A1.0420.58
8_L74_I1.0270.56
16_F91_L1.0250.56
17_I97_I1.0250.56
25_V95_L1.0080.55
84_V87_L1.0030.55
17_I80_L0.9980.54
31_I35_G0.9590.51
49_I59_V0.9530.51
13_V54_S0.9520.51
33_M68_I0.9460.50
66_F76_M0.9440.50
25_V67_S0.9370.50
39_T96_V0.9350.49
49_I53_A0.9280.49
41_G111_V0.9210.48
37_F79_V0.9210.48
94_Q98_V0.9070.47
108_G114_G0.8980.47
63_L67_S0.8890.46
19_V107_Y0.8720.45
19_V78_Q0.8700.45
5_A84_V0.8590.44
8_L77_W0.8540.43
11_N77_W0.8220.41
9_G14_H0.8130.40
76_M97_I0.8110.40
46_E50_G0.8070.40
36_F109_F0.7970.39
97_I112_V0.7810.38
17_I98_V0.7640.37
10_R14_H0.7620.37
51_F112_V0.7470.36
106_I111_V0.7460.36
8_L81_T0.7360.35
10_R112_V0.7280.34
16_F107_Y0.7280.34
10_R81_T0.7240.34
37_F102_V0.7090.33
29_Y61_T0.7060.33
4_N77_W0.7040.33
22_T34_V0.6980.32
27_T34_V0.6960.32
4_N8_L0.6910.32
14_H98_V0.6890.32
95_L101_L0.6880.32
67_S100_A0.6870.32
6_S16_F0.6820.31
31_I65_L0.6760.31
37_F84_V0.6740.31
4_N78_Q0.6720.31
24_I89_L0.6680.30
58_K62_L0.6670.30
11_N81_T0.6650.30
40_S47_V0.6600.30
5_A13_V0.6600.30
67_S76_M0.6600.30
85_K114_G0.6590.30
36_F65_L0.6590.30
22_T103_V0.6510.29
60_F65_L0.6500.29
9_G81_T0.6420.29
80_L84_V0.6380.28
54_S59_V0.6380.28
93_L109_F0.6380.28
31_I61_T0.6380.28
29_Y64_A0.6330.28
19_V72_A0.6270.28
28_L45_Y0.6230.27
27_T30_I0.6220.27
107_Y112_V0.6210.27
49_I104_Y0.6190.27
18_L63_L0.6190.27
35_G54_S0.6190.27
4_N86_P0.6170.27
34_V49_I0.6170.27
107_Y110_V0.6110.27
28_L60_F0.6110.27
59_V103_V0.6100.27
38_A43_L0.6100.27
79_V112_V0.6070.27
98_V101_L0.6040.26
38_A47_V0.5980.26
17_I21_A0.5950.26
41_G104_Y0.5840.25
58_K114_G0.5840.25
50_G96_V0.5780.25
7_A107_Y0.5760.25
62_L114_G0.5760.25
56_F74_I0.5740.25
66_F70_I0.5730.25
48_W61_T0.5720.24
5_A107_Y0.5700.24
33_M65_L0.5570.24
34_V38_A0.5510.23
51_F54_S0.5480.23
30_I110_V0.5420.23
8_L33_M0.5380.23
61_T98_V0.5360.23
46_E49_I0.5330.22
72_A76_M0.5310.22
7_A80_L0.5280.22
37_F89_L0.5250.22
58_K100_A0.5190.22
6_S95_L0.5160.21
6_S70_I0.5120.21
14_H74_I0.5110.21
15_D81_T0.5060.21
62_L70_I0.5060.21
29_Y35_G0.5030.21
18_L67_S0.5000.21
91_L98_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wdqD 2 0.913 99.9 0.455 Contact Map
2h88D 1 0.7565 99.6 0.637 Contact Map
2wdqC 1 0.9217 99.4 0.67 Contact Map
4ytpC 1 0.9478 99.3 0.68 Contact Map
4ytpD 1 0.7652 99.3 0.691 Contact Map
4ysxD 1 0.8174 99.2 0.699 Contact Map
2h88C 2 0.9478 99.2 0.7 Contact Map
1zoyC 1 0.9478 99.2 0.701 Contact Map
4ysxC 1 0.9913 99.2 0.705 Contact Map
2bs2C 2 0.9652 97 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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