SDHA - ECOLI - GREMLIN Contacts

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SDHA - Succinate dehydrogenase flavoprotein subunit

UniProt:	P0AC41	Sequences: MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTHEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQAARTAAAADRTGHALLHTLYQQNLKNHTTIFSEWYALDLVKNQDGAVVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGVPVQDMEMWQFHPTGIAGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDVVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPIPVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGLHLQESIAEQGALRDASESDVEASLDRLNRWNNNRNGEDPVAIRKALQECMQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLMETAYATAVSANFRTESRGAHSRFDFPDRDDENWLCHSLYLPESESMTRRSVNMEPKLRPAFPPKIRTY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10931
Length:	588 (516)
Sequences:	5506 (2760)
Seq/√Len:	121.5

ECOLI - SDHA FRDA NADB
BACSU - SDHA NADB
HALSA - Q9HQ66 NADB
SULSO - Q97W79 NADB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
549_D	552_N	4.597	1.00
11_V	180_C	3.917	1.00
363_K	367_Q	3.800	1.00
166_A	225_M	3.413	1.00
8_F	34_A	3.321	1.00
86_E	90_K	3.311	1.00
270_E	275_R	3.182	1.00
80_G	85_I	3.149	1.00
266_N	270_E	3.023	1.00
471_F	527_A	3.001	1.00
477_G	534_T	2.953	1.00
88_M	394_V	2.935	1.00
22_A	199_V	2.850	1.00
491_R	524_Y	2.828	1.00
470_N	482_K	2.815	1.00
266_N	296_E	2.809	1.00
274_E	281_K	2.657	1.00
253_V	257_C	2.601	1.00
384_F	418_H	2.540	1.00
477_G	481_A	2.532	1.00
161_F	193_F	2.492	1.00
271_R	282_D	2.464	1.00
152_Q	155_K	2.441	1.00
484_L	527_A	2.431	1.00
476_E	543_F	2.390	1.00
13_I	180_C	2.390	1.00
184_C	187_T	2.383	1.00
227_I	525_A	2.364	1.00
32_T	159_T	2.362	1.00
91_T	414_A	2.358	1.00
462_A	486_Q	2.335	1.00
534_T	545_F	2.328	1.00
34_A	161_F	2.262	1.00
488_K	524_Y	2.249	1.00
17_G	408_L	2.249	1.00
481_A	531_N	2.242	1.00
360_I	389_I	2.231	1.00
67_W	131_A	2.181	1.00
7_E	194_K	2.175	1.00
22_A	386_V	2.170	1.00
26_I	419_L	2.115	1.00
471_F	483_G	2.109	1.00
367_Q	418_H	2.108	1.00
87_Y	414_A	2.102	1.00
36_L	182_A	2.070	1.00
223_V	233_V	2.063	1.00
168_D	228_R	2.044	1.00
385_A	389_I	2.035	1.00
476_E	479_A	2.021	1.00
17_G	46_T	2.020	1.00
232_P	379_V	2.019	1.00
9_D	196_R	2.003	1.00
200_L	360_I	1.992	1.00
88_M	411_F	1.962	1.00
144_A	147_H	1.961	1.00
265_L	316_D	1.912	1.00
265_L	346_P	1.907	1.00
320_K	324_E	1.894	1.00
26_I	416_G	1.893	1.00
293_I	311_A	1.890	1.00
245_G	352_T	1.875	1.00
182_A	193_F	1.867	1.00
487_L	527_A	1.853	1.00
466_C	483_G	1.842	1.00
471_F	480_M	1.837	1.00
109_L	113_R	1.835	1.00
200_L	389_I	1.821	1.00
316_D	346_P	1.819	1.00
263_Y	271_R	1.808	1.00
34_A	193_F	1.794	1.00
199_V	419_L	1.788	1.00
331_L	335_R	1.771	1.00
226_A	360_I	1.760	1.00
368_A	385_A	1.740	1.00
46_T	146_L	1.739	1.00
77_D	548_R	1.731	1.00
82_Q	86_E	1.718	1.00
27_S	156_N	1.718	1.00
462_A	493_R	1.718	1.00
202_T	222_G	1.702	1.00
95_A	98_E	1.701	1.00
467_M	471_F	1.701	1.00
484_L	524_Y	1.699	1.00
205_A	356_M	1.684	1.00
257_C	262_G	1.676	1.00
175_G	381_P	1.670	1.00
233_V	236_M	1.669	1.00
365_T	418_H	1.662	1.00
184_C	191_V	1.662	1.00
295_I	299_E	1.658	1.00
232_P	361_P	1.657	1.00
208_I	526_T	1.654	1.00
324_E	331_L	1.653	1.00
69_M	86_E	1.652	1.00
76_S	80_G	1.641	1.00
176_A	382_G	1.636	1.00
58_G	62_E	1.634	1.00
463_L	487_L	1.631	1.00
484_L	528_V	1.629	1.00
466_C	486_Q	1.625	1.00
84_A	364_V	1.625	1.00
477_G	542_R	1.621	1.00
228_R	518_N	1.620	1.00
10_A	26_I	1.581	1.00
177_V	198_T	1.570	1.00
320_K	343_V	1.534	1.00
362_T	390_A	1.530	1.00
226_A	231_V	1.528	1.00
153_N	160_I	1.522	1.00
315_L	318_L	1.519	1.00
415_A	419_L	1.512	1.00
491_R	521_E	1.510	1.00
366_G	415_A	1.506	1.00
324_E	343_V	1.499	1.00
56_A	65_W	1.498	1.00
483_G	527_A	1.492	1.00
97_L	101_H	1.480	1.00
53_I	145_L	1.480	1.00
170_V	192_Y	1.476	1.00
65_W	90_K	1.470	1.00
38_K	515_E	1.460	1.00
486_Q	489_V	1.459	1.00
43_R	48_S	1.455	1.00
484_L	531_N	1.453	1.00
84_A	88_M	1.452	1.00
470_N	483_G	1.448	1.00
254_T	257_C	1.444	1.00
8_F	11_V	1.440	1.00
25_Q	417_L	1.440	1.00
470_N	479_A	1.439	1.00
69_M	73_V	1.438	1.00
38_K	221_D	1.430	1.00
65_W	69_M	1.424	1.00
416_G	420_Q	1.424	1.00
195_A	198_T	1.421	1.00
91_T	94_E	1.410	1.00
454_E	493_R	1.409	1.00
213_T	245_G	1.396	1.00
418_H	422_S	1.387	1.00
197_A	422_S	1.384	1.00
28_Q	156_N	1.384	1.00
176_A	381_P	1.377	1.00
54_T	402_G	1.377	1.00
357_M	539_A	1.373	1.00
8_F	159_T	1.373	1.00
205_A	239_W	1.371	1.00
200_L	383_L	1.367	1.00
234_Q	361_P	1.367	1.00
46_T	408_L	1.359	1.00
109_L	112_G	1.357	1.00
38_K	219_T	1.354	1.00
169_L	177_V	1.346	1.00
209_Y	471_F	1.345	1.00
296_E	301_R	1.344	1.00
95_A	413_R	1.339	1.00
477_G	531_N	1.338	1.00
465_E	469_H	1.333	1.00
524_Y	528_V	1.332	1.00
8_F	32_T	1.331	1.00
271_R	274_E	1.330	1.00
254_T	330_I	1.328	1.00
331_L	343_V	1.322	1.00
20_M	153_N	1.319	1.00
221_D	518_N	1.315	1.00
471_F	526_T	1.314	1.00
199_V	386_V	1.313	1.00
210_Q	465_E	1.313	1.00
418_H	421_E	1.313	1.00
161_F	164_W	1.308	1.00
104_L	145_L	1.306	1.00
18_A	386_V	1.302	1.00
294_M	298_R	1.291	1.00
200_L	226_A	1.289	1.00
234_Q	391_C	1.275	1.00
8_F	161_F	1.273	1.00
263_Y	282_D	1.273	1.00
10_A	199_V	1.269	1.00
206_G	353_C	1.262	1.00
164_W	182_A	1.256	0.99
84_A	394_V	1.246	0.99
416_G	419_L	1.244	0.99
481_A	485_E	1.244	0.99
170_V	181_T	1.241	0.99
291_R	541_S	1.228	0.99
13_I	200_L	1.226	0.99
164_W	184_C	1.226	0.99
35_L	160_I	1.219	0.99
91_T	95_A	1.207	0.99
470_N	486_Q	1.207	0.99
92_G	406_L	1.206	0.99
36_L	180_C	1.202	0.99
24_L	153_N	1.200	0.99
65_W	89_C	1.196	0.99
384_F	422_S	1.194	0.99
21_R	25_Q	1.193	0.99
11_V	36_L	1.193	0.99
530_A	540_H	1.192	0.99
264_L	349_V	1.191	0.99
166_A	180_C	1.187	0.99
66_E	86_E	1.183	0.99
66_E	70_Y	1.179	0.99
272_F	293_I	1.169	0.99
15_A	37_S	1.164	0.99
70_Y	74_K	1.163	0.99
166_A	182_A	1.161	0.99
68_H	403_N	1.156	0.99
260_E	326_R	1.148	0.99
205_A	526_T	1.147	0.99
164_W	191_V	1.147	0.99
228_R	521_E	1.146	0.99
134_T	402_G	1.146	0.99
223_V	522_T	1.134	0.99
154_L	162_S	1.126	0.99
168_D	225_M	1.122	0.99
69_M	89_C	1.121	0.99
323_L	331_L	1.120	0.99
360_I	385_A	1.117	0.99
237_E	533_R	1.114	0.99
25_Q	413_R	1.107	0.99
318_L	322_V	1.107	0.99
9_D	32_T	1.106	0.99
481_A	484_L	1.104	0.99
413_R	417_L	1.103	0.99
461_K	465_E	1.099	0.99
10_A	419_L	1.092	0.99
551_E	554_L	1.088	0.99
477_G	545_F	1.082	0.98
362_T	385_A	1.081	0.98
419_L	423_I	1.078	0.98
87_Y	91_T	1.077	0.98
87_Y	411_F	1.072	0.98
79_I	537_R	1.066	0.98
22_A	419_L	1.064	0.98
143_H	147_H	1.062	0.98
20_M	35_L	1.061	0.98
35_L	153_N	1.061	0.98
68_H	72_T	1.058	0.98
460_R	464_Q	1.058	0.98
87_Y	364_V	1.056	0.98
22_A	415_A	1.052	0.98
67_W	130_Q	1.051	0.98
104_L	148_T	1.051	0.98
231_V	383_L	1.049	0.98
25_Q	416_G	1.047	0.98
153_N	158_T	1.047	0.98
276_Y	296_E	1.045	0.98
57_L	135_A	1.044	0.98
341_D	344_K	1.042	0.98
466_C	470_N	1.041	0.98
104_L	144_A	1.038	0.98
197_A	384_F	1.035	0.98
223_V	356_M	1.033	0.98
460_R	519_L	1.031	0.98
98_E	413_R	1.031	0.98
332_E	336_T	1.027	0.98
85_I	89_C	1.027	0.98
412_G	416_G	1.021	0.98
333_L	336_T	1.018	0.98
340_V	345_E	1.017	0.98
276_Y	292_S	1.015	0.98
152_Q	156_N	1.014	0.98
13_I	166_A	1.013	0.98
181_T	190_V	1.009	0.98
482_K	486_Q	1.006	0.98
466_C	490_I	1.006	0.98
69_M	82_Q	1.006	0.98
534_T	553_W	1.004	0.98
41_P	150_Y	0.997	0.97
165_Y	514_L	0.994	0.97
150_Y	160_I	0.993	0.97
320_K	344_K	0.992	0.97
394_V	411_F	0.992	0.97
102_M	152_Q	0.989	0.97
274_E	282_D	0.987	0.97
171_K	177_V	0.987	0.97
463_L	516_L	0.985	0.97
181_T	192_Y	0.983	0.97
494_L	520_M	0.979	0.97
25_Q	28_Q	0.975	0.97
27_S	157_H	0.968	0.97
93_P	97_L	0.965	0.97
367_Q	422_S	0.963	0.97
334_S	342_P	0.962	0.97
107_S	136_A	0.962	0.97
340_V	347_I	0.960	0.97
362_T	392_V	0.960	0.97
140_R	329_G	0.958	0.97
486_Q	490_I	0.958	0.97
488_K	528_V	0.954	0.97
475_R	530_A	0.953	0.97
24_L	156_N	0.952	0.97
169_L	198_T	0.949	0.97
386_V	415_A	0.947	0.96
231_V	379_V	0.946	0.96
197_A	423_I	0.945	0.96
11_V	195_A	0.943	0.96
319_G	322_V	0.939	0.96
47_V	143_H	0.939	0.96
443_R	517_D	0.937	0.96
24_L	102_M	0.937	0.96
72_T	403_N	0.934	0.96
105_P	144_A	0.930	0.96
298_R	469_H	0.929	0.96
529_S	557_S	0.928	0.96
23_A	158_T	0.924	0.96
165_Y	515_E	0.919	0.96
169_L	180_C	0.918	0.96
53_I	96_I	0.918	0.96
323_L	343_V	0.917	0.96
125_N	132_A	0.913	0.96
463_L	490_I	0.911	0.96
132_A	260_E	0.910	0.96
231_V	380_V	0.910	0.96
362_T	411_F	0.908	0.96
324_E	335_R	0.908	0.96
151_Q	155_K	0.906	0.95
210_Q	468_Q	0.897	0.95
21_R	95_A	0.896	0.95
55_V	96_I	0.896	0.95
284_A	289_V	0.893	0.95
296_E	299_E	0.892	0.95
273_M	281_K	0.890	0.95
537_R	546_P	0.889	0.95
321_E	325_S	0.887	0.95
265_L	314_K	0.885	0.95
420_Q	423_I	0.883	0.95
262_G	315_L	0.874	0.95
25_Q	98_E	0.873	0.94
312_K	346_P	0.871	0.94
236_M	526_T	0.869	0.94
88_M	406_L	0.869	0.94
275_R	299_E	0.868	0.94
219_T	515_E	0.867	0.94
474_F	543_F	0.867	0.94
224_G	228_R	0.865	0.94
315_L	323_L	0.865	0.94
11_V	198_T	0.863	0.94
263_Y	317_H	0.862	0.94
108_R	114_I	0.860	0.94
224_G	522_T	0.859	0.94
98_E	102_M	0.858	0.94
491_R	520_M	0.858	0.94
83_D	364_V	0.854	0.94
94_E	97_L	0.852	0.94
201_A	386_V	0.851	0.94
84_A	87_Y	0.850	0.94
537_R	545_F	0.848	0.94
460_R	516_L	0.848	0.94
284_A	288_V	0.844	0.93
271_R	281_K	0.844	0.93
171_K	175_G	0.842	0.93
73_V	85_I	0.842	0.93
236_M	529_S	0.841	0.93
10_A	31_Q	0.839	0.93
73_V	80_G	0.838	0.93
232_P	558_L	0.838	0.93
39_V	43_R	0.837	0.93
11_V	34_A	0.836	0.93
196_R	423_I	0.835	0.93
484_L	488_K	0.833	0.93
53_I	409_V	0.829	0.93
69_M	85_I	0.828	0.93
10_A	30_G	0.822	0.93
463_L	520_M	0.818	0.92
236_M	522_T	0.818	0.92
99_L	145_L	0.818	0.92
220_G	522_T	0.818	0.92
528_V	532_F	0.816	0.92
26_I	31_Q	0.815	0.92
276_Y	295_I	0.813	0.92
175_G	380_V	0.811	0.92
272_F	282_D	0.811	0.92
232_P	560_L	0.811	0.92
467_M	523_A	0.811	0.92
39_V	217_I	0.809	0.92
275_R	296_E	0.808	0.92
334_S	340_V	0.806	0.92
81_D	391_C	0.805	0.92
255_E	258_R	0.804	0.92
91_T	413_R	0.803	0.92
26_I	30_G	0.800	0.91
32_T	157_H	0.799	0.91
225_M	228_R	0.799	0.91
341_D	345_E	0.799	0.91
196_R	427_G	0.798	0.91
137_A	144_A	0.797	0.91
435_S	438_E	0.795	0.91
70_Y	82_Q	0.795	0.91
239_W	526_T	0.795	0.91
12_V	33_C	0.793	0.91
331_L	342_P	0.793	0.91
89_C	92_G	0.790	0.91
480_M	527_A	0.789	0.91
65_W	93_P	0.789	0.91
100_E	114_I	0.788	0.91
535_E	546_P	0.787	0.91
265_L	312_K	0.784	0.91
417_L	421_E	0.783	0.91
459_I	516_L	0.783	0.91
487_L	524_Y	0.782	0.91
126_F	134_T	0.780	0.90
98_E	101_H	0.778	0.90
207_R	464_Q	0.778	0.90
416_G	423_I	0.778	0.90
126_F	402_G	0.776	0.90
422_S	426_Q	0.771	0.90
128_G	357_M	0.768	0.90
277_A	285_G	0.768	0.90
298_R	543_F	0.764	0.89
56_A	89_C	0.762	0.89
365_T	414_A	0.760	0.89
458_A	462_A	0.759	0.89
29_S	421_E	0.759	0.89
197_A	419_L	0.758	0.89
7_E	32_T	0.758	0.89
45_H	218_N	0.758	0.89
235_D	556_H	0.754	0.89
478_D	482_K	0.752	0.89
54_T	129_E	0.751	0.89
27_S	158_T	0.747	0.88
41_P	160_I	0.746	0.88
22_A	26_I	0.744	0.88
126_F	129_E	0.744	0.88
73_V	82_Q	0.742	0.88
105_P	108_R	0.742	0.88
257_C	315_L	0.740	0.88
41_P	162_S	0.738	0.88
213_T	352_T	0.738	0.88
205_A	223_V	0.737	0.88
108_R	112_G	0.736	0.88
475_R	540_H	0.736	0.88
199_V	415_A	0.735	0.88
21_R	98_E	0.734	0.88
209_Y	526_T	0.733	0.87
266_N	271_R	0.733	0.87
233_V	525_A	0.732	0.87
105_P	148_T	0.731	0.87
30_G	33_C	0.730	0.87
207_R	519_L	0.726	0.87
29_S	420_Q	0.725	0.87
11_V	193_F	0.724	0.87
454_E	458_A	0.724	0.87
54_T	134_T	0.723	0.87
27_S	33_C	0.721	0.87
529_S	559_Y	0.720	0.87
294_M	474_F	0.719	0.86
94_E	413_R	0.719	0.86
182_A	191_V	0.717	0.86
462_A	465_E	0.717	0.86
297_I	310_H	0.715	0.86
295_I	474_F	0.715	0.86
470_N	527_A	0.714	0.86
146_L	150_Y	0.714	0.86
333_L	337_F	0.712	0.86
171_K	174_D	0.712	0.86
222_G	389_I	0.711	0.86
258_R	261_G	0.710	0.86
117_R	260_E	0.710	0.86
173_Q	178_V	0.709	0.86
525_A	559_Y	0.708	0.86
272_F	276_Y	0.706	0.85
164_W	193_F	0.706	0.85
456_P	513_C	0.704	0.85
322_V	325_S	0.703	0.85
100_E	108_R	0.703	0.85
421_E	425_E	0.702	0.85
35_L	41_P	0.702	0.85
171_K	178_V	0.702	0.85
147_H	151_Q	0.701	0.85
481_A	528_V	0.700	0.85
238_M	533_R	0.699	0.85
150_Y	154_L	0.696	0.85
206_G	212_T	0.696	0.85
272_F	275_R	0.695	0.85
242_H	255_E	0.691	0.84
211_S	468_Q	0.690	0.84
335_R	343_V	0.690	0.84
334_S	347_I	0.690	0.84
367_Q	384_F	0.690	0.84
196_R	429_L	0.688	0.84
489_V	492_E	0.688	0.84
253_V	347_I	0.685	0.84
199_V	423_I	0.685	0.84
267_K	300_G	0.683	0.84
490_I	520_M	0.683	0.84
270_E	296_E	0.682	0.83
277_A	284_A	0.682	0.83
386_V	412_G	0.681	0.83
53_I	406_L	0.681	0.83
125_N	128_G	0.681	0.83
105_P	147_H	0.681	0.83
315_L	319_G	0.681	0.83
208_I	522_T	0.680	0.83
180_C	195_A	0.680	0.83
272_F	296_E	0.679	0.83
323_L	342_P	0.679	0.83
197_A	382_G	0.679	0.83
297_I	300_G	0.679	0.83
202_T	389_I	0.678	0.83
252_L	255_E	0.677	0.83
17_G	149_L	0.677	0.83
44_S	146_L	0.673	0.83
482_K	485_E	0.672	0.83
224_G	518_N	0.672	0.83
55_V	135_A	0.672	0.83
244_T	258_R	0.671	0.82
388_E	399_R	0.669	0.82
45_H	215_A	0.669	0.82
49_A	52_G	0.668	0.82
368_A	380_V	0.667	0.82
184_C	189_E	0.667	0.82
492_E	495_K	0.666	0.82
196_R	428_A	0.666	0.82
64_N	67_W	0.665	0.82
100_E	135_A	0.665	0.82
239_W	356_M	0.665	0.82
27_S	420_Q	0.664	0.82
9_D	31_Q	0.664	0.82
8_F	193_F	0.662	0.82
488_K	492_E	0.661	0.82
285_G	288_V	0.660	0.81
459_I	462_A	0.659	0.81
178_V	194_K	0.659	0.81
24_L	152_Q	0.658	0.81
367_Q	381_P	0.658	0.81
134_T	401_G	0.657	0.81
65_W	86_E	0.657	0.81
450_N	453_G	0.654	0.81
15_A	35_L	0.654	0.81
294_M	297_I	0.654	0.81
257_C	323_L	0.652	0.81
231_V	368_A	0.650	0.80
362_T	366_G	0.650	0.80
536_S	541_S	0.647	0.80
474_F	541_S	0.647	0.80
267_K	301_R	0.645	0.80
536_S	546_P	0.645	0.80
31_Q	420_Q	0.644	0.80
553_W	556_H	0.644	0.80
34_A	159_T	0.644	0.80
293_I	349_V	0.643	0.80
242_H	258_R	0.643	0.80
48_S	215_A	0.642	0.80
67_W	70_Y	0.642	0.80
56_A	68_H	0.641	0.80
469_H	479_A	0.640	0.79
12_V	199_V	0.640	0.79
36_L	193_F	0.639	0.79
292_S	295_I	0.637	0.79
384_F	419_L	0.636	0.79
479_A	483_G	0.636	0.79
485_E	488_K	0.636	0.79
79_I	238_M	0.635	0.79
478_D	481_A	0.635	0.79
253_V	330_I	0.635	0.79
163_E	186_E	0.634	0.79
461_K	464_Q	0.634	0.79
227_I	521_E	0.634	0.79
272_F	292_S	0.633	0.79
206_G	239_W	0.633	0.79
95_A	409_V	0.632	0.79
192_Y	437_V	0.632	0.79
167_L	190_V	0.632	0.79
521_E	524_Y	0.632	0.79
36_L	161_F	0.631	0.78
54_T	89_C	0.629	0.78
79_I	237_E	0.626	0.78
17_G	409_V	0.626	0.78
177_V	380_V	0.626	0.78
206_G	214_N	0.625	0.78
466_C	487_L	0.625	0.78
176_A	422_S	0.624	0.78
129_E	402_G	0.624	0.78
352_T	355_Y	0.621	0.77
47_V	147_H	0.621	0.77
167_L	183_L	0.621	0.77
12_V	419_L	0.620	0.77
264_L	273_M	0.620	0.77
62_E	131_A	0.620	0.77
168_D	229_A	0.619	0.77
445_N	449_N	0.619	0.77
31_Q	423_I	0.619	0.77
364_V	411_F	0.619	0.77
419_L	422_S	0.618	0.77
487_L	520_M	0.616	0.77
469_H	482_K	0.615	0.77
45_H	48_S	0.614	0.77
127_G	279_N	0.613	0.76
297_I	302_G	0.613	0.76
354_H	357_M	0.612	0.76
224_G	521_E	0.612	0.76
319_G	343_V	0.611	0.76
294_M	473_V	0.611	0.76
104_L	409_V	0.611	0.76
126_F	401_G	0.611	0.76
318_L	323_L	0.611	0.76
457_V	512_E	0.608	0.76
84_A	392_V	0.608	0.76
292_S	296_E	0.607	0.76
297_I	350_I	0.607	0.76
139_D	258_R	0.607	0.76
267_K	302_G	0.606	0.76
206_G	356_M	0.606	0.76
12_V	22_A	0.605	0.76
321_E	324_E	0.605	0.76
73_V	78_Y	0.605	0.76
255_E	259_G	0.603	0.75
382_G	422_S	0.603	0.75
9_D	34_A	0.600	0.75
489_V	493_R	0.600	0.75
251_V	333_L	0.599	0.75
180_C	198_T	0.598	0.75
234_Q	392_V	0.598	0.75
169_L	200_L	0.597	0.75
219_T	518_N	0.596	0.74
275_R	282_D	0.593	0.74
268_H	301_R	0.592	0.74
114_I	117_R	0.591	0.74
205_A	208_I	0.589	0.74
480_M	530_A	0.589	0.74
354_H	400_L	0.588	0.73
115_Y	136_A	0.587	0.73
467_M	470_N	0.585	0.73
424_A	434_E	0.584	0.73
227_I	233_V	0.584	0.73
25_Q	412_G	0.583	0.73
21_R	102_M	0.582	0.73
170_V	194_K	0.582	0.73
412_G	419_L	0.581	0.73
140_R	144_A	0.580	0.72
411_F	414_A	0.580	0.72
287_D	291_R	0.579	0.72
459_I	497_A	0.578	0.72
553_W	557_S	0.578	0.72
22_A	412_G	0.577	0.72
293_I	297_I	0.574	0.72
40_F	162_S	0.574	0.72
351_P	354_H	0.573	0.72
251_V	330_I	0.572	0.71
206_G	209_Y	0.572	0.71
29_S	417_L	0.572	0.71
208_I	523_A	0.572	0.71
52_G	242_H	0.572	0.71
454_E	462_A	0.571	0.71
386_V	408_L	0.571	0.71
488_K	491_R	0.571	0.71
253_V	333_L	0.571	0.71
97_L	100_E	0.571	0.71
266_N	275_R	0.570	0.71
483_G	486_Q	0.570	0.71
497_A	513_C	0.569	0.71
492_E	496_N	0.567	0.71
244_T	255_E	0.567	0.71
272_F	355_Y	0.567	0.71
273_M	277_A	0.567	0.71
178_V	198_T	0.566	0.71
402_G	407_D	0.564	0.70
144_A	148_T	0.563	0.70
171_K	381_P	0.563	0.70
72_T	85_I	0.562	0.70
323_L	327_L	0.561	0.70
25_Q	29_S	0.561	0.70
177_V	382_G	0.561	0.70
222_G	229_A	0.560	0.70
56_A	69_M	0.560	0.70
428_A	431_D	0.559	0.70
28_Q	98_E	0.559	0.70
266_N	282_D	0.559	0.70
421_E	426_Q	0.558	0.70
167_L	181_T	0.556	0.69
459_I	520_M	0.556	0.69
221_D	515_E	0.555	0.69
453_G	498_R	0.555	0.69
211_S	350_I	0.554	0.69
276_Y	300_G	0.554	0.69
286_R	290_A	0.554	0.69
459_I	493_R	0.553	0.69
460_R	515_E	0.551	0.69
27_S	30_G	0.550	0.68
288_V	291_R	0.550	0.68
279_N	282_D	0.550	0.68
252_L	258_R	0.549	0.68
28_Q	152_Q	0.549	0.68
515_E	519_L	0.549	0.68
355_Y	358_G	0.549	0.68
316_D	319_G	0.549	0.68
21_R	412_G	0.547	0.68
12_V	30_G	0.547	0.68
86_E	89_C	0.546	0.68
246_I	368_A	0.546	0.68
279_N	288_V	0.544	0.68
89_C	411_F	0.544	0.68
241_F	472_S	0.544	0.68
12_V	23_A	0.543	0.67
511_V	515_E	0.542	0.67
53_I	106_F	0.542	0.67
365_T	417_L	0.542	0.67
273_M	284_A	0.541	0.67
52_G	244_T	0.539	0.67
410_V	414_A	0.539	0.67
170_V	178_V	0.538	0.67
528_V	531_N	0.537	0.67
469_H	486_Q	0.536	0.66
145_L	409_V	0.536	0.66
267_K	310_H	0.536	0.66
26_I	420_Q	0.535	0.66
532_F	557_S	0.534	0.66
549_D	553_W	0.533	0.66
424_A	428_A	0.533	0.66
148_T	152_Q	0.532	0.66
129_E	134_T	0.532	0.66
177_V	383_L	0.531	0.66
422_S	425_E	0.531	0.66
455_D	458_A	0.531	0.66
446_R	450_N	0.531	0.66
430_R	481_A	0.531	0.66
534_T	542_R	0.530	0.66
183_L	188_G	0.530	0.66
462_A	489_V	0.530	0.66
257_C	330_I	0.529	0.65
287_D	290_A	0.529	0.65
460_R	512_E	0.528	0.65
169_L	236_M	0.528	0.65
548_R	554_L	0.527	0.65
107_S	214_N	0.527	0.65
263_Y	281_K	0.527	0.65
432_A	435_S	0.527	0.65
156_N	380_V	0.526	0.65
323_L	346_P	0.526	0.65
24_L	158_T	0.525	0.65
185_I	511_V	0.525	0.65
165_Y	518_N	0.524	0.65
310_H	348_P	0.523	0.65
535_E	545_F	0.522	0.64
22_A	33_C	0.521	0.64
81_D	556_H	0.520	0.64
266_N	272_F	0.519	0.64
171_K	380_V	0.518	0.64
350_I	468_Q	0.517	0.64
256_G	259_G	0.517	0.64
109_L	115_Y	0.517	0.64
178_V	381_P	0.517	0.64
70_Y	73_V	0.516	0.64
91_T	410_V	0.516	0.64
545_F	549_D	0.516	0.64
139_D	259_G	0.515	0.63
246_I	251_V	0.515	0.63
344_K	430_R	0.515	0.63
194_K	429_L	0.514	0.63
351_P	355_Y	0.513	0.63
58_G	61_H	0.513	0.63
277_A	288_V	0.513	0.63
69_M	90_K	0.512	0.63
243_P	287_D	0.512	0.63
150_Y	153_N	0.512	0.63
479_A	482_K	0.511	0.63
534_T	552_N	0.511	0.63
50_Q	327_L	0.510	0.63
425_E	428_A	0.510	0.63
117_R	136_A	0.510	0.63
220_G	224_G	0.509	0.63
524_Y	527_A	0.509	0.63
75_G	401_G	0.507	0.62
427_G	431_D	0.506	0.62
165_Y	511_V	0.506	0.62
390_A	411_F	0.505	0.62
240_Q	399_R	0.505	0.62
107_S	138_A	0.505	0.62
302_G	311_A	0.504	0.62
494_L	497_A	0.503	0.62
354_H	388_E	0.503	0.62
527_A	531_N	0.500	0.61
37_S	160_I	0.500	0.61
47_V	146_L	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2bs2A	2	0.966	100	0.265	Contact Map
2h88A	2	0.9796	100	0.266	Contact Map
1kf6A	1	0.9524	100	0.276	Contact Map
2wdqA	1	0.9796	100	0.281	Contact Map
1chuA	2	0.7908	100	0.38	Contact Map
3gyxA	2	0.9235	100	0.381	Contact Map
1jnrA	2	0.9048	100	0.408	Contact Map
2e5vA	1	0.7993	100	0.41	Contact Map
4c3xA	4	0.6599	100	0.617	Contact Map
4at0A	2	0.6616	100	0.665	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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