ASPA - ECOLI - GREMLIN Contacts

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ASPA - Aspartate ammonia-lyase

UniProt:	P0AC38	Sequences: MSNNIRIEEDLLGTREVPADAYYGVHTLRAIENFYISNNKISDIPEFVRGMVMVKKAAAMANKELQTIPKSVANAIIAACDEVLNNGKCMDQFPVDVYQGGAGTSVNMNTNEVLANIGLELMGHQKGEYQYLNPNDHVNKCQSTNDAYPTGFRIAVYSSLIKLVDAINQLREGFERKAVEFQDILKMGRTQLQDAVPMTLGQEFRAFSILLKEEVKNIQRTAELLLEVNLGATAIGTGLNTPKEYSPLAVKKLAEVTGFPCVPAEDLIEATSDCGAYVMVHGALKRLAVKMSKICNDLRLLSSGPRAGLNEINLPELQAGSSIMPAKVNPVVPEVVNQVCFKVIGNDTTVTMAAEAGQLQLNVMEPVIGQAMFESVHILTNACYNLLEKCINGITANKEVCEGYVYNSIGIVTYLNPFIGHHNGDIVGKICAETGKSVREVVLERGLLTEAELDDIFSVQNLMHPAYKAKRYTDESEQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10095
Length:	478 (406)
Sequences:	10906 (5656)
Seq/√Len:	280.7

ECOLI - ASPA FUMC ARLY PUR8
BACSU - ASPA FUMC ARLY PUR8
HALSA - FUMC Q9HS42 ARLY
SULSO - FUMC Q980P8 ARLY

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
63_K	73_A	3.951	1.00
72_V	137_H	3.550	1.00
56_K	81_D	3.392	1.00
64_E	252_K	3.343	1.00
60_M	77_I	3.279	1.00
400_V	403_G	3.268	1.00
161_I	222_A	3.144	1.00
50_G	158_S	2.911	1.00
60_M	256_V	2.836	1.00
168_N	215_V	2.820	1.00
288_A	343_V	2.782	1.00
171_R	212_K	2.747	1.00
173_G	392_N	2.676	1.00
402_E	406_Y	2.658	1.00
160_L	280_V	2.650	1.00
449_T	452_E	2.641	1.00
117_I	121_L	2.631	1.00
46_E	377_H	2.604	1.00
164_V	219_Q	2.599	1.00
346_N	375_S	2.537	1.00
224_L	279_M	2.510	1.00
200_L	396_A	2.494	1.00
252_K	255_E	2.446	1.00
164_V	215_V	2.436	1.00
177_K	180_E	2.360	1.00
339_V	382_A	2.337	1.00
69_P	72_V	2.336	1.00
285_K	347_D	2.330	1.00
157_Y	226_L	2.273	1.00
63_K	70_K	2.236	1.00
183_D	398_K	2.233	1.00
226_L	260_P	2.226	1.00
168_N	219_Q	2.089	1.00
403_G	407_N	2.059	1.00
313_N	395_T	2.058	1.00
342_K	371_A	2.032	1.00
166_A	384_Y	2.012	1.00
171_R	215_V	2.002	1.00
176_R	392_N	1.970	1.00
173_G	387_L	1.959	1.00
70_K	74_N	1.945	1.00
400_V	404_Y	1.941	1.00
252_K	256_V	1.936	1.00
220_R	224_L	1.928	1.00
173_G	391_I	1.920	1.00
436_K	444_E	1.912	1.00
176_R	180_E	1.905	1.00
215_V	219_Q	1.882	1.00
295_C	336_V	1.868	1.00
289_V	344_I	1.860	1.00
74_N	78_A	1.821	1.00
217_N	279_M	1.819	1.00
53_M	158_S	1.806	1.00
167_I	287_L	1.795	1.00
264_A	270_A	1.776	1.00
228_V	254_A	1.761	1.00
82_E	121_L	1.757	1.00
56_K	77_I	1.754	1.00
220_R	223_E	1.750	1.00
291_M	336_V	1.738	1.00
175_E	212_K	1.738	1.00
439_R	454_D	1.725	1.00
387_L	392_N	1.725	1.00
181_F	184_I	1.721	1.00
402_E	460_Q	1.704	1.00
450_E	454_D	1.700	1.00
423_N	426_I	1.699	1.00
458_S	461_N	1.677	1.00
60_M	252_K	1.656	1.00
171_R	208_S	1.655	1.00
278_V	354_A	1.639	1.00
214_E	290_K	1.636	1.00
169_Q	387_L	1.636	1.00
73_A	77_I	1.635	1.00
398_K	402_E	1.633	1.00
251_K	255_E	1.623	1.00
451_A	454_D	1.611	1.00
213_E	269_E	1.611	1.00
452_E	455_D	1.600	1.00
230_L	249_A	1.599	1.00
227_E	262_V	1.586	1.00
436_K	441_V	1.569	1.00
443_L	450_E	1.539	1.00
349_T	367_V	1.526	1.00
166_A	380_T	1.521	1.00
446_G	449_T	1.492	1.00
61_A	252_K	1.486	1.00
177_K	181_F	1.484	1.00
232_A	270_A	1.481	1.00
75_A	122_M	1.471	1.00
178_A	208_S	1.462	1.00
221_T	283_A	1.450	1.00
285_K	351_T	1.442	1.00
117_I	120_E	1.427	1.00
348_T	352_M	1.419	1.00
223_E	260_P	1.404	1.00
213_E	275_G	1.401	1.00
110_T	114_L	1.401	1.00
159_S	380_T	1.384	1.00
430_I	445_R	1.382	1.00
333_P	390_C	1.377	1.00
397_N	400_V	1.370	1.00
274_C	365_E	1.367	1.00
56_K	84_L	1.362	1.00
94_P	119_L	1.362	1.00
430_I	434_T	1.359	1.00
49_R	53_M	1.342	1.00
216_K	224_L	1.331	1.00
437_S	440_E	1.320	1.00
46_E	159_S	1.318	1.00
282_G	286_R	1.315	1.00
300_L	358_Q	1.312	1.00
156_V	280_V	1.312	1.00
56_K	60_M	1.308	1.00
171_R	211_L	1.308	1.00
423_N	447_L	1.303	1.00
436_K	440_E	1.301	1.00
164_V	222_A	1.300	1.00
289_V	354_A	1.298	1.00
399_E	403_G	1.296	1.00
281_H	350_V	1.294	1.00
175_E	179_V	1.293	1.00
204_F	207_F	1.291	1.00
278_V	286_R	1.286	1.00
51_M	147_A	1.286	1.00
82_E	117_I	1.281	1.00
295_C	386_L	1.276	1.00
169_Q	392_N	1.275	1.00
207_F	360_Q	1.267	1.00
415_L	418_F	1.262	1.00
173_G	176_R	1.259	1.00
200_L	204_F	1.250	1.00
59_A	68_I	1.246	1.00
342_K	374_E	1.237	1.00
75_A	78_A	1.231	1.00
184_I	398_K	1.224	1.00
87_G	121_L	1.218	1.00
67_T	140_K	1.215	1.00
311_E	397_N	1.214	1.00
167_I	211_L	1.214	1.00
345_G	349_T	1.208	1.00
344_I	352_M	1.204	1.00
179_V	182_Q	1.196	1.00
81_D	86_N	1.193	1.00
49_R	84_L	1.186	1.00
311_E	395_T	1.184	1.00
141_C	241_T	1.167	1.00
254_A	260_P	1.165	1.00
166_A	387_L	1.162	1.00
218_I	287_L	1.151	1.00
336_V	382_A	1.151	1.00
350_V	372_M	1.151	1.00
205_R	266_D	1.150	1.00
181_F	398_K	1.149	1.00
175_E	208_S	1.145	1.00
52_V	110_T	1.134	1.00
52_V	83_V	1.133	1.00
200_L	401_C	1.124	1.00
418_F	452_E	1.121	1.00
141_C	242_P	1.118	1.00
94_P	97_V	1.117	1.00
182_Q	201_G	1.110	1.00
168_N	172_E	1.109	1.00
101_G	109_N	1.109	1.00
298_L	333_P	1.107	1.00
156_V	372_M	1.104	1.00
52_V	84_L	1.100	1.00
170_L	211_L	1.096	1.00
174_F	294_I	1.095	1.00
166_A	169_Q	1.090	1.00
57_A	256_V	1.090	1.00
79_A	82_E	1.083	1.00
340_C	344_I	1.083	1.00
207_F	294_I	1.078	1.00
157_Y	259_F	1.076	1.00
419_I	424_G	1.075	1.00
170_L	391_I	1.074	1.00
164_V	168_N	1.073	1.00
169_Q	384_Y	1.073	1.00
216_K	223_E	1.069	1.00
347_D	351_T	1.067	1.00
82_E	88_K	1.067	1.00
183_D	201_G	1.066	1.00
434_T	441_V	1.063	1.00
159_S	162_K	1.061	1.00
194_D	305_P	1.059	1.00
74_N	77_I	1.058	1.00
197_P	405_V	1.056	1.00
445_R	449_T	1.051	1.00
54_V	147_A	1.048	1.00
64_E	256_V	1.044	1.00
277_Y	372_M	1.043	1.00
162_K	380_T	1.040	1.00
45_P	90_M	1.039	1.00
186_K	401_C	1.039	1.00
75_A	79_A	1.035	1.00
440_E	444_E	1.035	1.00
50_G	154_I	1.033	1.00
152_F	369_G	1.033	1.00
417_P	452_E	1.030	1.00
77_I	81_D	1.030	1.00
184_I	401_C	1.027	1.00
292_S	337_N	1.024	1.00
160_L	222_A	1.019	1.00
177_K	204_F	1.019	1.00
39_N	374_E	1.019	1.00
49_R	158_S	1.019	1.00
177_K	391_I	1.018	1.00
418_F	456_I	1.006	1.00
283_A	287_L	1.005	1.00
428_G	432_A	1.004	1.00
429_K	433_E	0.997	1.00
182_Q	199_T	0.997	1.00
191_Q	334_E	0.996	1.00
209_I	265_E	0.995	1.00
53_M	256_V	0.994	1.00
313_N	397_N	0.993	1.00
198_M	235_I	0.992	1.00
150_T	228_V	0.992	1.00
291_M	383_C	0.978	1.00
317_L	389_K	0.976	1.00
152_F	277_Y	0.974	1.00
75_A	134_P	0.973	1.00
280_V	372_M	0.972	1.00
45_P	49_R	0.972	1.00
220_R	279_M	0.971	1.00
157_Y	222_A	0.970	1.00
70_K	73_A	0.970	1.00
157_Y	161_I	0.968	1.00
300_L	359_L	0.968	1.00
199_T	463_M	0.967	1.00
312_I	394_I	0.964	1.00
209_I	213_E	0.956	1.00
167_I	215_V	0.955	1.00
160_L	218_I	0.953	1.00
298_L	394_I	0.951	1.00
49_R	89_C	0.950	1.00
228_V	253_L	0.948	1.00
65_L	242_P	0.945	1.00
222_A	226_L	0.945	1.00
226_L	259_F	0.940	1.00
54_V	150_T	0.935	1.00
78_A	121_L	0.927	1.00
188_G	198_M	0.926	1.00
81_D	84_L	0.925	1.00
63_K	74_N	0.923	1.00
189_R	194_D	0.921	1.00
89_C	117_I	0.913	1.00
53_M	253_L	0.909	1.00
216_K	220_R	0.909	1.00
69_P	137_H	0.907	1.00
194_D	304_G	0.906	1.00
250_V	254_A	0.905	1.00
425_D	429_K	0.901	1.00
430_I	441_V	0.898	1.00
71_S	74_N	0.896	1.00
46_E	158_S	0.894	1.00
119_L	135_N	0.893	1.00
281_H	372_M	0.890	1.00
281_H	347_D	0.888	1.00
282_G	347_D	0.887	1.00
198_M	268_I	0.883	1.00
405_V	459_V	0.880	1.00
51_M	54_V	0.878	1.00
416_N	419_I	0.876	1.00
171_R	175_E	0.875	1.00
93_F	97_V	0.874	1.00
78_A	82_E	0.874	1.00
61_A	249_A	0.874	1.00
61_A	65_L	0.872	1.00
50_G	155_A	0.872	1.00
97_V	101_G	0.868	1.00
185_L	463_M	0.864	1.00
172_E	176_R	0.862	1.00
174_F	204_F	0.862	1.00
192_L	300_L	0.860	1.00
180_E	395_T	0.858	1.00
184_I	396_A	0.857	1.00
178_A	205_R	0.856	1.00
342_K	370_Q	0.854	1.00
133_N	136_D	0.853	1.00
439_R	443_L	0.851	1.00
203_E	360_Q	0.849	1.00
287_L	383_C	0.849	1.00
308_G	400_V	0.848	1.00
223_E	226_L	0.846	1.00
430_I	444_E	0.845	1.00
174_F	208_S	0.845	1.00
208_S	212_K	0.842	1.00
64_E	70_K	0.840	1.00
439_R	450_E	0.838	1.00
93_F	99_Q	0.836	1.00
115_A	118_G	0.835	1.00
86_N	90_M	0.829	1.00
312_I	393_G	0.828	1.00
173_G	177_K	0.826	1.00
152_F	372_M	0.825	1.00
53_M	84_L	0.825	1.00
292_S	355_E	0.823	1.00
49_R	90_M	0.819	0.99
282_G	351_T	0.818	0.99
174_F	391_I	0.815	0.99
430_I	433_E	0.814	0.99
194_D	408_S	0.812	0.99
452_E	456_I	0.812	0.99
192_L	303_S	0.806	0.99
202_Q	267_L	0.804	0.99
370_Q	374_E	0.802	0.99
336_V	386_L	0.801	0.99
289_V	351_T	0.800	0.99
185_L	405_V	0.798	0.99
346_N	374_E	0.796	0.99
273_D	290_K	0.794	0.99
227_E	276_A	0.794	0.99
58_A	142_Q	0.791	0.99
294_I	386_L	0.791	0.99
87_G	117_I	0.787	0.99
189_R	305_P	0.786	0.99
161_I	259_F	0.783	0.99
59_A	73_A	0.781	0.99
63_K	68_I	0.781	0.99
203_E	301_L	0.777	0.99
181_F	396_A	0.775	0.99
341_F	349_T	0.775	0.99
82_E	89_C	0.773	0.99
72_V	134_P	0.772	0.99
51_M	110_T	0.772	0.99
233_T	323_I	0.771	0.99
213_E	227_E	0.764	0.99
111_N	115_A	0.761	0.99
227_E	264_A	0.756	0.99
263_P	267_L	0.755	0.99
429_K	432_A	0.753	0.99
268_I	360_Q	0.753	0.99
167_I	383_C	0.752	0.99
180_E	398_K	0.752	0.99
229_N	270_A	0.751	0.99
279_M	282_G	0.751	0.99
186_K	203_E	0.749	0.99
353_A	367_V	0.748	0.99
39_N	42_S	0.747	0.99
426_I	430_I	0.747	0.99
315_P	393_G	0.744	0.99
344_I	348_T	0.744	0.99
76_I	134_P	0.744	0.99
211_L	383_C	0.742	0.99
80_C	83_V	0.742	0.99
342_K	346_N	0.739	0.99
183_D	460_Q	0.737	0.99
349_T	371_A	0.737	0.99
445_R	448_L	0.737	0.99
451_A	455_D	0.736	0.99
60_M	64_E	0.734	0.99
406_Y	439_R	0.734	0.99
160_L	221_T	0.732	0.99
390_C	394_I	0.730	0.99
301_L	359_L	0.730	0.99
280_V	284_L	0.728	0.99
313_N	316_E	0.727	0.99
275_G	290_K	0.725	0.99
346_N	376_V	0.723	0.99
184_I	199_T	0.722	0.99
453_L	457_F	0.719	0.99
87_G	92_Q	0.716	0.99
211_L	214_E	0.716	0.99
68_I	140_K	0.714	0.99
250_V	263_P	0.713	0.99
72_V	76_I	0.712	0.99
47_F	148_Y	0.712	0.99
206_A	293_K	0.712	0.99
272_S	360_Q	0.712	0.99
313_N	393_G	0.711	0.99
172_E	175_E	0.710	0.99
56_K	256_V	0.709	0.99
295_C	333_P	0.708	0.99
83_V	114_L	0.705	0.98
56_K	73_A	0.705	0.98
226_L	254_A	0.703	0.98
120_E	123_G	0.702	0.98
163_L	376_V	0.701	0.98
64_E	242_P	0.700	0.98
97_V	100_G	0.700	0.98
43_D	370_Q	0.698	0.98
210_L	290_K	0.697	0.98
99_Q	113_V	0.697	0.98
187_M	307_A	0.696	0.98
308_G	397_N	0.696	0.98
269_E	275_G	0.693	0.98
262_V	265_E	0.691	0.98
448_L	456_I	0.690	0.98
83_V	93_F	0.689	0.98
253_L	256_V	0.689	0.98
174_F	211_L	0.687	0.98
217_N	275_G	0.687	0.98
93_F	100_G	0.685	0.98
162_K	166_A	0.683	0.98
372_M	376_V	0.682	0.98
436_K	442_V	0.682	0.98
396_A	401_C	0.681	0.98
230_L	253_L	0.680	0.98
342_K	378_I	0.679	0.98
341_F	353_A	0.679	0.98
67_T	242_P	0.679	0.98
419_I	423_N	0.678	0.98
71_S	75_A	0.676	0.98
383_C	387_L	0.675	0.98
280_V	377_H	0.674	0.98
68_I	72_V	0.674	0.98
153_R	276_A	0.674	0.98
107_N	315_P	0.672	0.98
157_Y	260_P	0.670	0.98
176_R	179_V	0.670	0.98
278_V	350_V	0.670	0.98
294_I	391_I	0.669	0.98
168_N	212_K	0.668	0.98
79_A	122_M	0.667	0.98
68_I	73_A	0.665	0.98
304_G	308_G	0.664	0.98
163_L	380_T	0.663	0.98
94_P	99_Q	0.663	0.98
441_V	444_E	0.662	0.98
57_A	60_M	0.662	0.98
460_Q	464_H	0.661	0.98
399_E	402_E	0.660	0.98
277_Y	350_V	0.660	0.98
42_S	159_S	0.659	0.98
437_S	441_V	0.658	0.98
210_L	273_D	0.654	0.98
184_I	402_E	0.654	0.98
186_K	198_M	0.654	0.98
296_N	337_N	0.651	0.97
214_E	286_R	0.651	0.97
420_G	423_N	0.649	0.97
69_P	73_A	0.647	0.97
134_P	137_H	0.647	0.97
65_L	252_K	0.646	0.97
181_F	200_L	0.646	0.97
168_N	171_R	0.644	0.97
169_Q	173_G	0.644	0.97
344_I	351_T	0.642	0.97
187_M	405_V	0.642	0.97
291_M	387_L	0.641	0.97
179_V	183_D	0.641	0.97
59_A	76_I	0.640	0.97
440_E	450_E	0.639	0.97
426_I	433_E	0.639	0.97
39_N	370_Q	0.639	0.97
63_K	77_I	0.638	0.97
292_S	352_M	0.638	0.97
170_L	387_L	0.637	0.97
341_F	352_M	0.637	0.97
349_T	353_A	0.636	0.97
96_D	99_Q	0.636	0.97
441_V	445_R	0.636	0.97
204_F	401_C	0.635	0.97
119_L	123_G	0.635	0.97
269_E	290_K	0.635	0.97
89_C	92_Q	0.635	0.97
278_V	351_T	0.634	0.97
133_N	422_H	0.634	0.97
41_I	46_E	0.634	0.97
221_T	225_L	0.633	0.97
216_K	219_Q	0.630	0.97
400_V	407_N	0.629	0.97
278_V	282_G	0.628	0.97
178_A	182_Q	0.627	0.97
155_A	376_V	0.626	0.97
163_L	284_L	0.623	0.97
38_N	363_V	0.621	0.97
108_M	111_N	0.618	0.97
221_T	280_V	0.618	0.97
67_T	141_C	0.618	0.97
93_F	101_G	0.617	0.97
317_L	393_G	0.615	0.96
86_N	89_C	0.614	0.96
60_M	73_A	0.613	0.96
443_L	454_D	0.613	0.96
280_V	376_V	0.613	0.96
160_L	225_L	0.612	0.96
177_K	394_I	0.610	0.96
217_N	224_L	0.608	0.96
68_I	76_I	0.608	0.96
287_L	379_L	0.605	0.96
161_I	219_Q	0.605	0.96
52_V	90_M	0.605	0.96
332_V	386_L	0.604	0.96
116_N	120_E	0.603	0.96
336_V	390_C	0.602	0.96
159_S	376_V	0.602	0.96
404_Y	407_N	0.601	0.96
59_A	138_V	0.601	0.96
217_N	220_R	0.601	0.96
214_E	217_N	0.600	0.96
82_E	87_G	0.600	0.96
170_L	383_C	0.599	0.96
428_G	431_C	0.599	0.96
406_Y	437_S	0.599	0.96
210_L	272_S	0.597	0.96
160_L	164_V	0.597	0.96
310_N	397_N	0.597	0.96
440_E	443_L	0.594	0.96
284_L	379_L	0.594	0.96
72_V	75_A	0.592	0.96
349_T	368_I	0.591	0.96
348_T	351_T	0.591	0.96
430_I	436_K	0.586	0.95
249_A	253_L	0.585	0.95
405_V	410_G	0.585	0.95
163_L	379_L	0.583	0.95
137_H	140_K	0.582	0.95
218_I	283_A	0.580	0.95
411_I	414_Y	0.580	0.95
288_A	379_L	0.578	0.95
426_I	445_R	0.578	0.95
279_M	286_R	0.578	0.95
371_A	374_E	0.578	0.95
398_K	401_C	0.577	0.95
228_V	263_P	0.576	0.95
216_K	227_E	0.574	0.95
165_D	169_Q	0.574	0.95
337_N	364_M	0.573	0.95
332_V	390_C	0.572	0.95
175_E	178_A	0.572	0.95
285_K	289_V	0.572	0.95
54_V	151_G	0.571	0.95
443_L	455_D	0.571	0.95
345_G	348_T	0.569	0.95
461_N	464_H	0.569	0.95
194_D	410_G	0.566	0.94
421_H	425_D	0.565	0.94
207_F	210_L	0.564	0.94
111_N	114_L	0.561	0.94
212_K	216_K	0.559	0.94
170_L	173_G	0.558	0.94
53_M	257_T	0.557	0.94
284_L	287_L	0.556	0.94
184_I	201_G	0.554	0.94
203_E	297_D	0.554	0.94
88_K	91_D	0.554	0.94
318_Q	331_V	0.553	0.94
286_R	354_A	0.551	0.94
298_L	386_L	0.551	0.94
455_D	461_N	0.549	0.93
59_A	77_I	0.549	0.93
100_G	109_N	0.546	0.93
211_L	291_M	0.545	0.93
186_K	301_L	0.544	0.93
369_G	373_F	0.542	0.93
87_G	90_M	0.542	0.93
82_E	86_N	0.541	0.93
50_G	53_M	0.541	0.93
204_F	394_I	0.540	0.93
167_I	218_I	0.538	0.93
223_E	227_E	0.537	0.93
211_L	287_L	0.536	0.93
282_G	285_K	0.536	0.93
199_T	464_H	0.536	0.93
219_Q	223_E	0.535	0.93
336_V	340_C	0.535	0.93
339_V	378_I	0.534	0.93
164_V	283_A	0.533	0.92
227_E	265_E	0.533	0.92
455_D	458_S	0.533	0.92
53_M	57_A	0.532	0.92
192_L	358_Q	0.532	0.92
221_T	279_M	0.532	0.92
156_V	225_L	0.531	0.92
428_G	433_E	0.530	0.92
217_N	286_R	0.529	0.92
54_V	230_L	0.529	0.92
166_A	385_N	0.528	0.92
209_I	212_K	0.527	0.92
191_Q	363_V	0.526	0.92
249_A	252_K	0.525	0.92
111_N	118_G	0.524	0.92
144_T	229_N	0.524	0.92
58_A	253_L	0.523	0.92
295_C	337_N	0.523	0.92
298_L	391_I	0.523	0.92
52_V	80_C	0.523	0.92
292_S	356_A	0.522	0.92
99_Q	116_N	0.522	0.92
115_A	119_L	0.519	0.91
415_L	453_L	0.518	0.91
38_N	332_V	0.518	0.91
422_H	426_I	0.516	0.91
198_M	202_Q	0.516	0.91
48_V	88_K	0.515	0.91
343_V	380_T	0.514	0.91
229_N	271_T	0.513	0.91
284_L	343_V	0.513	0.91
181_F	201_G	0.512	0.91
157_Y	225_L	0.512	0.91
387_L	391_I	0.512	0.91
185_L	459_V	0.511	0.91
46_E	162_K	0.511	0.91
158_S	161_I	0.510	0.91
116_N	123_G	0.510	0.91
300_L	303_S	0.510	0.91
83_V	90_M	0.509	0.91
281_H	375_S	0.507	0.90
275_G	279_M	0.506	0.90
95_V	99_Q	0.506	0.90
84_L	89_C	0.504	0.90
403_G	406_Y	0.504	0.90
427_V	442_V	0.502	0.90
234_A	323_I	0.502	0.90
52_V	87_G	0.500	0.90
244_E	255_E	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1yfmA	4	0.9393	100	0.145	Contact Map
1furA	4	0.9582	100	0.147	Contact Map
1vdkA	4	0.9603	100	0.155	Contact Map
1jswA	4	0.9623	100	0.158	Contact Map
3e04A	4	0.9644	100	0.16	Contact Map
3r6qA	4	0.9686	100	0.16	Contact Map
3gtdA	4	0.9498	100	0.161	Contact Map
4hgvA	4	0.9623	100	0.166	Contact Map
3ocfA	4	0.9393	100	0.175	Contact Map
4admA	4	0.9477	100	0.181	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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