GREMLIN Database
TTDB - L(+)-tartrate dehydratase subunit beta
UniProt: P0AC35 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11169
Length: 201 (175)
Sequences: 1595 (757)
Seq/√Len: 57.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_E158_K5.3301.00
107_P111_E4.2991.00
139_E154_V4.2871.00
39_R145_E4.1131.00
11_A97_K3.7031.00
137_E156_R3.5291.00
59_A75_V2.9271.00
15_Q117_K2.8911.00
92_E116_F2.7601.00
43_L143_W2.7571.00
4_I159_E2.5951.00
98_L121_V2.3851.00
122_I166_S2.3471.00
55_A98_L2.2221.00
10_K13_D2.1511.00
25_L163_L2.1121.00
92_E115_K2.0701.00
28_T154_V2.0651.00
110_E173_N2.0471.00
31_T155_C2.0451.00
136_E156_R1.9861.00
17_I165_V1.9831.00
75_V135_V1.9831.00
7_T25_L1.9811.00
87_E91_I1.9251.00
111_E115_K1.8741.00
49_Y141_V1.8741.00
4_I24_Y1.8430.99
58_H87_E1.8200.99
110_E167_I1.7830.99
167_I173_N1.7660.99
18_R170_H1.7590.99
72_M155_C1.7400.99
28_T156_R1.6790.99
40_L152_L1.6200.99
98_L119_L1.5040.98
68_D71_E1.5000.98
57_F75_V1.4900.98
91_I118_A1.4680.97
26_T156_R1.4590.97
172_N177_E1.4300.97
18_R172_N1.3980.97
13_D16_D1.3490.96
41_I89_E1.3480.96
29_L157_V1.3420.96
160_F163_L1.3310.95
88_R112_G1.3160.95
11_A117_K1.3020.95
36_C152_L1.2920.95
166_S174_L1.2890.95
38_R42_E1.2840.94
80_S101_G1.2750.94
180_K183_A1.2700.94
32_C36_C1.2620.94
14_L97_K1.2560.94
112_G116_F1.2450.93
49_Y152_L1.2270.93
112_G115_K1.2000.92
12_E15_Q1.1890.92
173_N176_A1.1710.91
24_Y159_E1.1580.91
40_L47_I1.1540.91
51_L90_F1.1530.91
176_A180_K1.1330.90
59_A62_I1.1320.90
23_I163_L1.0850.88
131_A134_Q1.0750.87
84_E105_M1.0680.87
89_E94_T1.0680.87
177_E181_L1.0570.86
25_L55_A1.0560.86
31_T59_A1.0550.86
65_K68_D1.0550.86
89_E92_E1.0200.84
178_N182_F1.0190.84
122_I175_I1.0080.83
91_I99_V0.9950.83
23_I121_V0.9940.83
88_R92_E0.9890.82
123_F131_A0.9800.82
64_R71_E0.9760.81
5_L13_D0.9600.80
140_E153_W0.9560.80
111_E114_Q0.9540.80
131_A160_F0.9480.80
9_I98_L0.9480.80
80_S120_H0.9420.79
14_L119_L0.9270.78
108_L111_E0.9260.78
13_D53_G0.9250.78
117_K169_T0.9180.77
55_A121_V0.8970.76
49_Y53_G0.8960.76
40_L43_L0.8940.75
138_I153_W0.8840.75
87_E99_V0.8830.74
168_D172_N0.8730.74
15_Q169_T0.8680.73
17_I119_L0.8600.72
17_I23_I0.8580.72
90_F96_V0.8580.72
26_T158_K0.8570.72
91_I116_F0.8540.72
39_R144_T0.8510.72
18_R52_N0.8410.71
14_L169_T0.8400.71
88_R109_T0.8390.71
88_R115_K0.8340.70
9_I14_L0.8300.70
7_T55_A0.8290.70
167_I170_H0.8230.69
57_F127_C0.8210.69
51_L94_T0.8200.69
30_V49_Y0.8130.68
9_I55_A0.8080.68
107_P176_A0.8060.68
46_P52_N0.7990.67
15_Q170_H0.7980.67
30_V54_K0.7950.66
37_H60_G0.7900.66
166_S175_I0.7840.65
64_R73_V0.7790.65
178_N181_L0.7750.64
14_L55_A0.7740.64
88_R116_F0.7680.64
58_H105_M0.7660.64
121_V165_V0.7620.63
144_T153_W0.7480.62
62_I74_S0.7460.62
124_P131_A0.7400.61
37_H77_P0.7190.59
43_L47_I0.7150.58
84_E109_T0.7120.58
177_E180_K0.7120.58
5_L25_L0.7070.57
104_G166_S0.7060.57
96_V99_V0.6990.57
7_T163_L0.6970.56
107_P110_E0.6960.56
140_E144_T0.6930.56
34_D150_E0.6920.56
167_I172_N0.6870.55
104_G131_A0.6840.55
30_V154_V0.6810.55
166_S173_N0.6810.55
106_G111_E0.6800.54
138_I155_C0.6690.53
62_I148_M0.6680.53
29_L55_A0.6670.53
33_R61_P0.6600.52
130_L162_P0.6540.52
33_R150_E0.6530.52
83_M150_E0.6510.51
141_V144_T0.6500.51
76_G83_M0.6500.51
18_R21_D0.6500.51
60_G77_P0.6490.51
63_V73_V0.6480.51
170_H173_N0.6450.51
19_V177_E0.6440.51
87_E109_T0.6420.50
7_T10_K0.6410.50
75_V128_A0.6410.50
11_A15_Q0.6400.50
91_I113_C0.6380.50
34_D76_G0.6380.50
83_M146_L0.6380.50
119_L165_V0.6380.50
41_I94_T0.6350.50
54_K119_L0.6340.49
135_V160_F0.6340.49
43_L46_P0.6300.49
113_C167_I0.6300.49
128_A148_M0.6300.49
87_E175_I0.6290.49
110_E114_Q0.6250.48
14_L117_K0.6250.48
6_T53_G0.6240.48
72_M138_I0.6230.48
28_T139_E0.6230.48
38_R128_A0.6220.48
25_L160_F0.6220.48
32_C56_I0.6210.48
45_R158_K0.6200.48
122_I164_I0.6160.47
35_V127_C0.6160.47
20_G127_C0.6150.47
91_I115_K0.6130.47
122_I174_L0.6100.47
32_C96_V0.6100.47
23_I119_L0.6080.47
53_G97_K0.6060.46
135_V157_V0.6040.46
44_K48_P0.6030.46
40_L182_F0.6010.46
22_V173_N0.5990.46
30_V141_V0.5980.46
34_D83_M0.5980.46
38_R86_F0.5950.45
4_I50_D0.5890.45
59_A128_A0.5880.44
124_P130_L0.5870.44
32_C124_P0.5860.44
22_V124_P0.5850.44
139_E156_R0.5840.44
26_T159_E0.5840.44
40_L51_L0.5830.44
58_H73_V0.5820.44
76_G150_E0.5820.44
35_V38_R0.5810.44
110_E176_A0.5800.44
99_V113_C0.5780.43
40_L90_F0.5780.43
6_T13_D0.5750.43
5_L8_P0.5730.43
34_D79_T0.5730.43
59_A123_F0.5690.42
99_V105_M0.5670.42
52_N136_E0.5670.42
57_F74_S0.5650.42
97_K117_K0.5620.42
80_S163_L0.5620.42
7_T13_D0.5610.42
57_F122_I0.5540.41
63_V72_M0.5500.40
148_M153_W0.5490.40
84_E106_G0.5470.40
72_M75_V0.5460.40
11_A52_N0.5450.40
87_E90_F0.5430.40
10_K16_D0.5420.40
100_V163_L0.5390.39
90_F94_T0.5390.39
109_T129_V0.5370.39
141_V151_S0.5370.39
105_M140_E0.5370.39
113_C173_N0.5360.39
15_Q29_L0.5350.39
61_P83_M0.5340.39
81_M85_S0.5340.39
73_V105_M0.5300.38
82_R126_G0.5290.38
85_S122_I0.5240.38
71_E80_S0.5230.38
55_A119_L0.5210.37
92_E112_G0.5180.37
24_Y130_L0.5170.37
179_K182_F0.5140.37
40_L143_W0.5130.37
81_M153_W0.5120.36
75_V132_A0.5120.36
77_P147_G0.5110.36
18_R22_V0.5090.36
14_L113_C0.5090.36
25_L164_I0.5070.36
59_A81_M0.5070.36
74_S128_A0.5050.36
151_S157_V0.5040.36
105_M109_T0.5010.35
113_C118_A0.5010.35
60_G127_C0.5000.35
40_L81_M0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2isbA 1 0.8706 100 0.136 Contact Map
3r6oA 2 0.7562 34.8 0.959 Contact Map
2owbA 2 0.5124 32.3 0.96 Contact Map
3lzkA 2 0.8557 28.2 0.961 Contact Map
3myuA 1 0.5572 21.5 0.963 Contact Map
2ozbB 1 0.2637 19.5 0.964 Contact Map
3m2wA 1 0.5572 18.8 0.964 Contact Map
2clyA 1 0.1642 18.5 0.964 Contact Map
1lwuA 2 0.1642 18 0.964 Contact Map
3cr8A 4 0.8458 17.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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