FTSX - ECOLI - GREMLIN Contacts

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FTSX - Cell division protein FtsX

UniProt:	P0AC30	Sequences: MNKRDAINHIRQFGGRLDRFRKSVGGSGDGGRNAPKRAKSSPKPVNRKTNVFNEQVRYAFHGALQDLKSKPFATFLTVMVIAISLTLPSVCYMVYKNVNQAATQYYPSPQITVYLQKTLDDDAAAGVVAQLQAEQGVEKVNYLSREDALGEFRNWSGFGGALDMLEENPLPAVAVVIPKLDFQGTESLNTLRDRITQINGIDEVRMDDSWFARLAALTGLVGRVSAMIGVLMVAAVFLVIGNSVRLSIFARRDSINVQKLIGATDGFILRPFLYGGALLGFSGALLSLILSEILVLRLSSAVAEVAQVFGTKFDINGLSFDECLLLLLVCSMIGWVAAWLATVQHLRHFTPE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10345
Length:	352 (278)
Sequences:	27006 (22729)
Seq/√Len:	1363.2

ECOLI - FTSX MACB LOLE LOLC
BACSU - FTSX YCLI YKNZ YTRF
HALSA - Q9HT02
SULSO - Q7LXM6 Q97XD5 Q97Z54

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
111_I	115_L	3.594	1.00
255_I	272_F	3.572	1.00
128_V	132_Q	3.208	1.00
251_R	275_G	3.005	1.00
124_A	127_V	2.825	1.00
187_S	190_T	2.694	1.00
68_K	71_P	2.676	1.00
259_K	265_D	2.662	1.00
192_R	196_T	2.542	1.00
82_A	286_L	2.457	1.00
194_R	198_I	2.446	1.00
339_W	343_V	2.366	1.00
264_T	267_F	2.346	1.00
105_Y	109_P	2.336	1.00
136_G	179_K	2.325	1.00
129_A	132_Q	2.234	1.00
123_A	127_V	2.200	1.00
269_L	343_V	2.192	1.00
276_G	338_A	2.104	1.00
284_A	327_L	2.101	1.00
190_T	194_R	2.023	1.00
63_A	274_Y	1.994	1.00
138_E	179_K	1.918	1.00
184_G	187_S	1.892	1.00
319_S	322_E	1.885	1.00
337_A	341_A	1.862	1.00
258_Q	271_P	1.856	1.00
189_N	192_R	1.852	1.00
78_V	82_A	1.830	1.00
89_S	291_S	1.808	1.00
320_F	324_L	1.793	1.00
86_T	290_L	1.745	1.00
188_L	192_R	1.738	1.00
321_D	325_L	1.736	1.00
287_S	291_S	1.724	1.00
125_A	129_A	1.716	1.00
126_G	130_Q	1.703	1.00
82_A	290_L	1.695	1.00
102_A	105_Y	1.695	1.00
251_R	254_S	1.689	1.00
189_N	193_D	1.674	1.00
96_K	99_N	1.671	1.00
130_Q	134_E	1.650	1.00
280_G	334_G	1.637	1.00
343_V	347_R	1.623	1.00
194_R	197_Q	1.622	1.00
100_Q	317_G	1.610	1.00
129_A	133_A	1.603	1.00
163_D	167_E	1.600	1.00
106_Y	109_P	1.597	1.00
65_Q	68_K	1.594	1.00
138_E	177_I	1.594	1.00
188_L	191_L	1.593	1.00
206_M	209_S	1.582	1.00
66_D	275_G	1.580	1.00
280_G	284_A	1.579	1.00
193_D	196_T	1.568	1.00
111_I	117_K	1.560	1.00
81_I	283_G	1.557	1.00
136_G	194_R	1.547	1.00
101_A	106_Y	1.546	1.00
293_I	297_R	1.521	1.00
134_E	194_R	1.519	1.00
283_G	287_S	1.506	1.00
128_V	174_A	1.486	1.00
110_Q	114_Y	1.479	1.00
78_V	283_G	1.477	1.00
73_A	250_A	1.476	1.00
258_Q	263_A	1.454	1.00
125_A	128_V	1.434	1.00
291_S	295_V	1.430	1.00
126_G	129_A	1.420	1.00
130_Q	133_A	1.415	1.00
293_I	296_L	1.394	1.00
174_A	178_P	1.394	1.00
263_A	267_F	1.392	1.00
223_R	227_M	1.392	1.00
112_T	116_Q	1.388	1.00
67_L	74_T	1.366	1.00
127_V	130_Q	1.362	1.00
139_K	177_I	1.361	1.00
111_I	114_Y	1.358	1.00
256_N	260_L	1.355	1.00
101_A	105_Y	1.355	1.00
85_L	287_S	1.348	1.00
289_I	293_I	1.346	1.00
130_Q	198_I	1.345	1.00
124_A	128_V	1.343	1.00
324_L	328_L	1.331	1.00
255_I	268_I	1.325	1.00
288_L	323_C	1.311	1.00
86_T	291_S	1.311	1.00
317_G	320_F	1.311	1.00
267_F	270_R	1.301	1.00
266_G	270_R	1.295	1.00
226_A	230_V	1.292	1.00
100_Q	103_T	1.286	1.00
96_K	319_S	1.272	1.00
102_A	106_Y	1.272	1.00
318_L	323_C	1.257	1.00
297_R	301_A	1.255	1.00
123_A	126_G	1.210	1.00
185_T	188_L	1.210	1.00
89_S	326_L	1.195	1.00
285_L	289_I	1.194	1.00
100_Q	104_Q	1.192	1.00
112_T	118_T	1.189	1.00
74_T	279_L	1.188	1.00
105_Y	108_S	1.184	1.00
195_I	198_I	1.151	1.00
251_R	272_F	1.135	1.00
86_T	294_L	1.130	1.00
104_Q	108_S	1.124	1.00
152_F	155_W	1.121	1.00
212_A	216_A	1.115	1.00
103_T	106_Y	1.113	1.00
330_C	337_A	1.110	1.00
143_L	173_V	1.108	1.00
99_N	222_G	1.102	1.00
82_A	86_T	1.101	1.00
104_Q	107_P	1.099	1.00
96_K	100_Q	1.097	1.00
84_S	229_G	1.097	1.00
60_F	274_Y	1.095	1.00
103_T	107_P	1.090	1.00
193_D	197_Q	1.089	1.00
276_G	280_G	1.089	1.00
148_A	152_F	1.085	1.00
296_L	300_S	1.079	1.00
254_S	258_Q	1.079	1.00
244_V	276_G	1.079	1.00
297_R	300_S	1.074	1.00
321_D	324_L	1.071	1.00
199_N	202_D	1.063	1.00
219_G	223_R	1.062	1.00
70_K	250_A	1.056	1.00
64_L	68_K	1.052	1.00
101_A	109_P	1.050	1.00
93_M	295_V	1.045	1.00
86_T	287_S	1.041	1.00
112_T	117_K	1.040	1.00
248_I	255_I	1.036	1.00
280_G	330_C	1.034	1.00
75_F	79_M	1.027	1.00
187_S	194_R	1.022	1.00
343_V	346_L	1.021	1.00
72_F	75_F	1.010	1.00
78_V	282_S	1.006	1.00
342_T	346_L	1.006	1.00
289_I	292_E	1.006	1.00
101_A	108_S	1.005	1.00
96_K	322_E	1.003	1.00
93_M	97_N	1.002	1.00
284_A	330_C	0.999	1.00
325_L	328_L	0.986	1.00
270_R	274_Y	0.986	1.00
110_Q	115_L	0.984	1.00
286_L	289_I	0.982	1.00
216_A	219_G	0.974	1.00
190_T	193_D	0.973	1.00
192_R	198_I	0.959	1.00
151_E	155_W	0.955	1.00
178_P	184_G	0.954	1.00
215_A	219_G	0.950	1.00
232_M	239_V	0.948	1.00
295_V	299_S	0.945	1.00
123_A	128_V	0.939	1.00
191_L	194_R	0.939	1.00
338_A	342_T	0.937	1.00
194_R	199_N	0.933	1.00
192_R	206_M	0.932	1.00
252_R	256_N	0.924	1.00
78_V	286_L	0.922	1.00
136_G	191_L	0.919	1.00
207_D	211_F	0.916	1.00
80_V	239_V	0.914	1.00
99_N	102_A	0.911	1.00
237_F	333_I	0.907	1.00
136_G	187_S	0.905	1.00
254_S	257_V	0.901	1.00
191_L	195_I	0.900	1.00
344_Q	347_R	0.895	1.00
62_G	271_P	0.895	1.00
341_A	345_H	0.894	1.00
269_L	339_W	0.886	1.00
329_V	333_I	0.885	1.00
88_P	92_Y	0.874	1.00
66_D	254_S	0.871	1.00
185_T	189_N	0.868	1.00
179_K	185_T	0.864	1.00
342_T	345_H	0.861	1.00
237_F	337_A	0.860	1.00
150_G	154_N	0.858	1.00
179_K	187_S	0.856	1.00
178_P	191_L	0.856	1.00
62_G	66_D	0.854	1.00
263_A	268_I	0.848	1.00
340_L	343_V	0.847	1.00
82_A	85_L	0.844	1.00
328_L	332_M	0.842	1.00
127_V	131_L	0.837	1.00
259_K	268_I	0.833	1.00
128_V	142_Y	0.828	1.00
151_E	154_N	0.823	1.00
143_L	146_E	0.823	1.00
132_Q	140_V	0.815	1.00
112_T	115_L	0.814	1.00
110_Q	117_K	0.811	1.00
70_K	73_A	0.810	1.00
147_D	150_G	0.808	1.00
202_D	206_M	0.806	1.00
196_T	199_N	0.805	1.00
281_F	331_S	0.805	1.00
71_P	75_F	0.800	1.00
131_L	134_E	0.799	1.00
191_L	198_I	0.794	1.00
274_Y	278_L	0.792	1.00
152_F	158_F	0.781	1.00
99_N	103_T	0.781	1.00
284_A	334_G	0.780	1.00
137_V	176_V	0.777	1.00
277_A	335_W	0.776	1.00
102_A	109_P	0.773	1.00
282_S	285_L	0.773	1.00
171_P	174_A	0.773	1.00
115_L	119_L	0.773	1.00
201_I	204_V	0.772	1.00
340_L	344_Q	0.770	1.00
274_Y	277_A	0.770	1.00
152_F	156_S	0.767	1.00
59_A	270_R	0.766	1.00
187_S	199_N	0.760	1.00
323_C	327_L	0.759	1.00
276_G	334_G	0.756	1.00
62_G	258_Q	0.756	1.00
205_R	210_W	0.755	1.00
265_D	269_L	0.754	1.00
220_L	224_V	0.753	1.00
329_V	332_M	0.752	1.00
218_T	222_G	0.752	1.00
332_M	336_V	0.747	1.00
207_D	210_W	0.746	1.00
96_K	321_D	0.745	1.00
186_E	191_L	0.744	1.00
80_V	84_S	0.744	1.00
322_E	326_L	0.743	1.00
292_E	296_L	0.739	1.00
242_N	246_L	0.739	1.00
257_V	260_L	0.738	1.00
300_S	303_A	0.738	1.00
290_L	293_I	0.735	1.00
95_Y	225_S	0.733	1.00
111_I	116_Q	0.731	1.00
186_E	190_T	0.731	1.00
178_P	188_L	0.726	1.00
213_R	216_A	0.723	1.00
288_L	327_L	0.722	1.00
131_L	195_I	0.721	1.00
84_S	239_V	0.721	1.00
151_E	158_F	0.718	1.00
143_L	175_V	0.714	1.00
132_Q	135_Q	0.714	1.00
322_E	325_L	0.713	1.00
205_R	209_S	0.713	1.00
241_G	245_R	0.713	1.00
115_L	118_T	0.711	1.00
110_Q	113_V	0.710	1.00
203_E	206_M	0.710	1.00
277_A	334_G	0.709	1.00
80_V	232_M	0.707	1.00
273_L	335_W	0.701	1.00
168_N	171_P	0.698	1.00
95_Y	222_G	0.696	1.00
159_G	162_L	0.695	1.00
144_S	147_D	0.693	1.00
296_L	299_S	0.693	1.00
137_V	140_V	0.689	1.00
77_T	276_G	0.689	1.00
111_I	118_T	0.687	1.00
90_V	291_S	0.685	1.00
241_G	337_A	0.682	1.00
196_T	204_V	0.682	1.00
82_A	283_G	0.681	1.00
61_H	65_Q	0.680	1.00
171_P	175_V	0.675	1.00
253_D	257_V	0.674	1.00
292_E	318_L	0.671	1.00
236_V	239_V	0.671	1.00
206_M	211_F	0.669	1.00
285_L	327_L	0.668	1.00
134_E	191_L	0.664	1.00
150_G	159_G	0.663	1.00
175_V	178_P	0.663	1.00
318_L	322_E	0.662	1.00
284_A	331_S	0.662	1.00
81_I	85_L	0.661	1.00
222_G	226_A	0.659	1.00
142_Y	145_R	0.658	1.00
148_A	151_E	0.658	1.00
184_G	199_N	0.657	1.00
101_A	104_Q	0.656	1.00
317_G	321_D	0.655	1.00
92_Y	96_K	0.655	1.00
212_A	215_A	0.654	1.00
223_R	226_A	0.654	1.00
60_F	64_L	0.654	1.00
153_R	157_G	0.654	1.00
156_S	159_G	0.653	1.00
149_L	156_S	0.652	1.00
77_T	243_S	0.651	1.00
72_F	76_L	0.650	1.00
239_V	242_N	0.650	1.00
63_A	271_P	0.649	1.00
298_L	302_V	0.645	1.00
325_L	329_V	0.641	1.00
330_C	334_G	0.638	1.00
134_E	195_I	0.634	1.00
151_E	156_S	0.634	1.00
80_V	246_L	0.628	1.00
173_V	176_V	0.621	1.00
140_V	143_L	0.621	1.00
239_V	258_Q	0.617	1.00
59_A	63_A	0.616	1.00
247_S	275_G	0.616	1.00
114_Y	118_T	0.615	1.00
154_N	157_G	0.614	1.00
187_S	191_L	0.614	1.00
327_L	331_S	0.614	1.00
292_E	323_C	0.613	1.00
320_F	323_C	0.611	1.00
232_M	236_V	0.609	1.00
81_I	240_I	0.607	1.00
155_W	159_G	0.607	1.00
149_L	152_F	0.606	1.00
247_S	251_R	0.605	1.00
128_V	140_V	0.605	1.00
174_A	177_I	0.603	1.00
84_S	233_V	0.603	1.00
248_I	345_H	0.602	1.00
211_F	215_A	0.601	1.00
176_V	179_K	0.598	1.00
58_Y	62_G	0.593	1.00
184_G	188_L	0.592	1.00
153_R	156_S	0.591	1.00
151_E	157_G	0.591	1.00
93_M	291_S	0.591	1.00
138_E	178_P	0.588	1.00
248_I	272_F	0.587	1.00
272_F	342_T	0.587	1.00
209_S	212_A	0.586	1.00
249_F	252_R	0.582	1.00
86_T	90_V	0.582	1.00
314_D	317_G	0.582	1.00
128_V	134_E	0.581	1.00
66_D	251_R	0.581	1.00
266_G	269_L	0.579	1.00
201_I	205_R	0.578	1.00
80_V	242_N	0.575	1.00
94_V	298_L	0.575	1.00
90_V	294_L	0.573	1.00
240_I	280_G	0.572	1.00
179_K	184_G	0.568	1.00
150_G	153_R	0.566	1.00
195_I	199_N	0.566	1.00
229_G	233_V	0.565	1.00
154_N	158_F	0.565	1.00
140_V	176_V	0.563	1.00
116_Q	203_E	0.563	1.00
89_S	287_S	0.563	1.00
85_L	89_S	0.562	1.00
231_L	235_A	0.561	1.00
158_F	161_A	0.560	1.00
230_V	234_A	0.559	1.00
244_V	247_S	0.559	1.00
265_D	346_L	0.559	1.00
240_I	244_V	0.554	1.00
192_R	209_S	0.552	1.00
265_D	343_V	0.551	1.00
269_L	273_L	0.551	1.00
74_T	78_V	0.551	1.00
208_D	212_A	0.548	1.00
60_F	278_L	0.548	1.00
138_E	141_N	0.548	1.00
120_D	123_A	0.547	1.00
186_E	189_N	0.547	1.00
254_S	275_G	0.542	1.00
85_L	330_C	0.540	1.00
132_Q	139_K	0.539	1.00
80_V	260_L	0.538	1.00
146_E	149_L	0.537	1.00
59_A	267_F	0.534	1.00
89_S	93_M	0.533	1.00
326_L	330_C	0.532	1.00
59_A	271_P	0.530	1.00
249_F	344_Q	0.530	1.00
208_D	211_F	0.529	1.00
152_F	157_G	0.529	1.00
295_V	315_I	0.527	1.00
86_T	89_S	0.526	1.00
66_D	73_A	0.524	1.00
148_A	161_A	0.524	1.00
114_Y	205_R	0.522	1.00
156_S	160_G	0.522	1.00
188_L	194_R	0.522	1.00
142_Y	171_P	0.521	1.00
140_V	174_A	0.518	1.00
73_A	247_S	0.518	1.00
146_E	152_F	0.517	1.00
338_A	341_A	0.516	1.00
139_K	142_Y	0.515	1.00
276_G	337_A	0.512	1.00
155_W	158_F	0.511	1.00
130_Q	135_Q	0.510	1.00
77_T	242_N	0.509	1.00
196_T	200_G	0.503	1.00
77_T	241_G	0.501	1.00
84_S	87_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n8nA	1	0.2727	96.9	0.869	Contact Map
2onkA	2	0.1705	95.1	0.889	Contact Map
4p32A	1	0.1278	93.2	0.898	Contact Map
4hziA	2	0.179	93	0.899	Contact Map
2qi9C	2	0.179	93	0.899	Contact Map
2ihyA	2	0.1761	91.7	0.903	Contact Map
4huqA	1	0.2443	91.6	0.903	Contact Map
2yz2A	6	0.2131	91.6	0.903	Contact Map
3zdqA	2	0.1051	90.6	0.905	Contact Map
2nq2C	2	0.1989	90.4	0.905	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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