GREMLIN Database
FTSX - Cell division protein FtsX
UniProt: P0AC30 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10345
Length: 352 (278)
Sequences: 27006 (22729)
Seq/√Len: 1363.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_I115_L3.5941.00
255_I272_F3.5721.00
128_V132_Q3.2081.00
251_R275_G3.0051.00
124_A127_V2.8251.00
187_S190_T2.6941.00
68_K71_P2.6761.00
259_K265_D2.6621.00
192_R196_T2.5421.00
82_A286_L2.4571.00
194_R198_I2.4461.00
339_W343_V2.3661.00
264_T267_F2.3461.00
105_Y109_P2.3361.00
136_G179_K2.3251.00
129_A132_Q2.2341.00
123_A127_V2.2001.00
269_L343_V2.1921.00
276_G338_A2.1041.00
284_A327_L2.1011.00
190_T194_R2.0231.00
63_A274_Y1.9941.00
138_E179_K1.9181.00
184_G187_S1.8921.00
319_S322_E1.8851.00
337_A341_A1.8621.00
258_Q271_P1.8561.00
189_N192_R1.8521.00
78_V82_A1.8301.00
89_S291_S1.8081.00
320_F324_L1.7931.00
86_T290_L1.7451.00
188_L192_R1.7381.00
321_D325_L1.7361.00
287_S291_S1.7241.00
125_A129_A1.7161.00
126_G130_Q1.7031.00
82_A290_L1.6951.00
102_A105_Y1.6951.00
251_R254_S1.6891.00
189_N193_D1.6741.00
96_K99_N1.6711.00
130_Q134_E1.6501.00
280_G334_G1.6371.00
343_V347_R1.6231.00
194_R197_Q1.6221.00
100_Q317_G1.6101.00
129_A133_A1.6031.00
163_D167_E1.6001.00
106_Y109_P1.5971.00
65_Q68_K1.5941.00
138_E177_I1.5941.00
188_L191_L1.5931.00
206_M209_S1.5821.00
66_D275_G1.5801.00
280_G284_A1.5791.00
193_D196_T1.5681.00
111_I117_K1.5601.00
81_I283_G1.5571.00
136_G194_R1.5471.00
101_A106_Y1.5461.00
293_I297_R1.5211.00
134_E194_R1.5191.00
283_G287_S1.5061.00
128_V174_A1.4861.00
110_Q114_Y1.4791.00
78_V283_G1.4771.00
73_A250_A1.4761.00
258_Q263_A1.4541.00
125_A128_V1.4341.00
291_S295_V1.4301.00
126_G129_A1.4201.00
130_Q133_A1.4151.00
293_I296_L1.3941.00
174_A178_P1.3941.00
263_A267_F1.3921.00
223_R227_M1.3921.00
112_T116_Q1.3881.00
67_L74_T1.3661.00
127_V130_Q1.3621.00
139_K177_I1.3611.00
111_I114_Y1.3581.00
256_N260_L1.3551.00
101_A105_Y1.3551.00
85_L287_S1.3481.00
289_I293_I1.3461.00
130_Q198_I1.3451.00
124_A128_V1.3431.00
324_L328_L1.3311.00
255_I268_I1.3251.00
288_L323_C1.3111.00
86_T291_S1.3111.00
317_G320_F1.3111.00
267_F270_R1.3011.00
266_G270_R1.2951.00
226_A230_V1.2921.00
100_Q103_T1.2861.00
96_K319_S1.2721.00
102_A106_Y1.2721.00
318_L323_C1.2571.00
297_R301_A1.2551.00
123_A126_G1.2101.00
185_T188_L1.2101.00
89_S326_L1.1951.00
285_L289_I1.1941.00
100_Q104_Q1.1921.00
112_T118_T1.1891.00
74_T279_L1.1881.00
105_Y108_S1.1841.00
195_I198_I1.1511.00
251_R272_F1.1351.00
86_T294_L1.1301.00
104_Q108_S1.1241.00
152_F155_W1.1211.00
212_A216_A1.1151.00
103_T106_Y1.1131.00
330_C337_A1.1101.00
143_L173_V1.1081.00
99_N222_G1.1021.00
82_A86_T1.1011.00
104_Q107_P1.0991.00
96_K100_Q1.0971.00
84_S229_G1.0971.00
60_F274_Y1.0951.00
103_T107_P1.0901.00
193_D197_Q1.0891.00
276_G280_G1.0891.00
148_A152_F1.0851.00
296_L300_S1.0791.00
254_S258_Q1.0791.00
244_V276_G1.0791.00
297_R300_S1.0741.00
321_D324_L1.0711.00
199_N202_D1.0631.00
219_G223_R1.0621.00
70_K250_A1.0561.00
64_L68_K1.0521.00
101_A109_P1.0501.00
93_M295_V1.0451.00
86_T287_S1.0411.00
112_T117_K1.0401.00
248_I255_I1.0361.00
280_G330_C1.0341.00
75_F79_M1.0271.00
187_S194_R1.0221.00
343_V346_L1.0211.00
72_F75_F1.0101.00
78_V282_S1.0061.00
342_T346_L1.0061.00
289_I292_E1.0061.00
101_A108_S1.0051.00
96_K322_E1.0031.00
93_M97_N1.0021.00
284_A330_C0.9991.00
325_L328_L0.9861.00
270_R274_Y0.9861.00
110_Q115_L0.9841.00
286_L289_I0.9821.00
216_A219_G0.9741.00
190_T193_D0.9731.00
192_R198_I0.9591.00
151_E155_W0.9551.00
178_P184_G0.9541.00
215_A219_G0.9501.00
232_M239_V0.9481.00
295_V299_S0.9451.00
123_A128_V0.9391.00
191_L194_R0.9391.00
338_A342_T0.9371.00
194_R199_N0.9331.00
192_R206_M0.9321.00
252_R256_N0.9241.00
78_V286_L0.9221.00
136_G191_L0.9191.00
207_D211_F0.9161.00
80_V239_V0.9141.00
99_N102_A0.9111.00
237_F333_I0.9071.00
136_G187_S0.9051.00
254_S257_V0.9011.00
191_L195_I0.9001.00
344_Q347_R0.8951.00
62_G271_P0.8951.00
341_A345_H0.8941.00
269_L339_W0.8861.00
329_V333_I0.8851.00
88_P92_Y0.8741.00
66_D254_S0.8711.00
185_T189_N0.8681.00
179_K185_T0.8641.00
342_T345_H0.8611.00
237_F337_A0.8601.00
150_G154_N0.8581.00
179_K187_S0.8561.00
178_P191_L0.8561.00
62_G66_D0.8541.00
263_A268_I0.8481.00
340_L343_V0.8471.00
82_A85_L0.8441.00
328_L332_M0.8421.00
127_V131_L0.8371.00
259_K268_I0.8331.00
128_V142_Y0.8281.00
151_E154_N0.8231.00
143_L146_E0.8231.00
132_Q140_V0.8151.00
112_T115_L0.8141.00
110_Q117_K0.8111.00
70_K73_A0.8101.00
147_D150_G0.8081.00
202_D206_M0.8061.00
196_T199_N0.8051.00
281_F331_S0.8051.00
71_P75_F0.8001.00
131_L134_E0.7991.00
191_L198_I0.7941.00
274_Y278_L0.7921.00
152_F158_F0.7811.00
99_N103_T0.7811.00
284_A334_G0.7801.00
137_V176_V0.7771.00
277_A335_W0.7761.00
102_A109_P0.7731.00
282_S285_L0.7731.00
171_P174_A0.7731.00
115_L119_L0.7731.00
201_I204_V0.7721.00
340_L344_Q0.7701.00
274_Y277_A0.7701.00
152_F156_S0.7671.00
59_A270_R0.7661.00
187_S199_N0.7601.00
323_C327_L0.7591.00
276_G334_G0.7561.00
62_G258_Q0.7561.00
205_R210_W0.7551.00
265_D269_L0.7541.00
220_L224_V0.7531.00
329_V332_M0.7521.00
218_T222_G0.7521.00
332_M336_V0.7471.00
207_D210_W0.7461.00
96_K321_D0.7451.00
186_E191_L0.7441.00
80_V84_S0.7441.00
322_E326_L0.7431.00
292_E296_L0.7391.00
242_N246_L0.7391.00
257_V260_L0.7381.00
300_S303_A0.7381.00
290_L293_I0.7351.00
95_Y225_S0.7331.00
111_I116_Q0.7311.00
186_E190_T0.7311.00
178_P188_L0.7261.00
213_R216_A0.7231.00
288_L327_L0.7221.00
131_L195_I0.7211.00
84_S239_V0.7211.00
151_E158_F0.7181.00
143_L175_V0.7141.00
132_Q135_Q0.7141.00
322_E325_L0.7131.00
205_R209_S0.7131.00
241_G245_R0.7131.00
115_L118_T0.7111.00
110_Q113_V0.7101.00
203_E206_M0.7101.00
277_A334_G0.7091.00
80_V232_M0.7071.00
273_L335_W0.7011.00
168_N171_P0.6981.00
95_Y222_G0.6961.00
159_G162_L0.6951.00
144_S147_D0.6931.00
296_L299_S0.6931.00
137_V140_V0.6891.00
77_T276_G0.6891.00
111_I118_T0.6871.00
90_V291_S0.6851.00
241_G337_A0.6821.00
196_T204_V0.6821.00
82_A283_G0.6811.00
61_H65_Q0.6801.00
171_P175_V0.6751.00
253_D257_V0.6741.00
292_E318_L0.6711.00
236_V239_V0.6711.00
206_M211_F0.6691.00
285_L327_L0.6681.00
134_E191_L0.6641.00
150_G159_G0.6631.00
175_V178_P0.6631.00
318_L322_E0.6621.00
284_A331_S0.6621.00
81_I85_L0.6611.00
222_G226_A0.6591.00
142_Y145_R0.6581.00
148_A151_E0.6581.00
184_G199_N0.6571.00
101_A104_Q0.6561.00
317_G321_D0.6551.00
92_Y96_K0.6551.00
212_A215_A0.6541.00
223_R226_A0.6541.00
60_F64_L0.6541.00
153_R157_G0.6541.00
156_S159_G0.6531.00
149_L156_S0.6521.00
77_T243_S0.6511.00
72_F76_L0.6501.00
239_V242_N0.6501.00
63_A271_P0.6491.00
298_L302_V0.6451.00
325_L329_V0.6411.00
330_C334_G0.6381.00
134_E195_I0.6341.00
151_E156_S0.6341.00
80_V246_L0.6281.00
173_V176_V0.6211.00
140_V143_L0.6211.00
239_V258_Q0.6171.00
59_A63_A0.6161.00
247_S275_G0.6161.00
114_Y118_T0.6151.00
154_N157_G0.6141.00
187_S191_L0.6141.00
327_L331_S0.6141.00
292_E323_C0.6131.00
320_F323_C0.6111.00
232_M236_V0.6091.00
81_I240_I0.6071.00
155_W159_G0.6071.00
149_L152_F0.6061.00
247_S251_R0.6051.00
128_V140_V0.6051.00
174_A177_I0.6031.00
84_S233_V0.6031.00
248_I345_H0.6021.00
211_F215_A0.6011.00
176_V179_K0.5981.00
58_Y62_G0.5931.00
184_G188_L0.5921.00
153_R156_S0.5911.00
151_E157_G0.5911.00
93_M291_S0.5911.00
138_E178_P0.5881.00
248_I272_F0.5871.00
272_F342_T0.5871.00
209_S212_A0.5861.00
249_F252_R0.5821.00
86_T90_V0.5821.00
314_D317_G0.5821.00
128_V134_E0.5811.00
66_D251_R0.5811.00
266_G269_L0.5791.00
201_I205_R0.5781.00
80_V242_N0.5751.00
94_V298_L0.5751.00
90_V294_L0.5731.00
240_I280_G0.5721.00
179_K184_G0.5681.00
150_G153_R0.5661.00
195_I199_N0.5661.00
229_G233_V0.5651.00
154_N158_F0.5651.00
140_V176_V0.5631.00
116_Q203_E0.5631.00
89_S287_S0.5631.00
85_L89_S0.5621.00
231_L235_A0.5611.00
158_F161_A0.5601.00
230_V234_A0.5591.00
244_V247_S0.5591.00
265_D346_L0.5591.00
240_I244_V0.5541.00
192_R209_S0.5521.00
265_D343_V0.5511.00
269_L273_L0.5511.00
74_T78_V0.5511.00
208_D212_A0.5481.00
60_F278_L0.5481.00
138_E141_N0.5481.00
120_D123_A0.5471.00
186_E189_N0.5471.00
254_S275_G0.5421.00
85_L330_C0.5401.00
132_Q139_K0.5391.00
80_V260_L0.5381.00
146_E149_L0.5371.00
59_A267_F0.5341.00
89_S93_M0.5331.00
326_L330_C0.5321.00
59_A271_P0.5301.00
249_F344_Q0.5301.00
208_D211_F0.5291.00
152_F157_G0.5291.00
295_V315_I0.5271.00
86_T89_S0.5261.00
66_D73_A0.5241.00
148_A161_A0.5241.00
114_Y205_R0.5221.00
156_S160_G0.5221.00
188_L194_R0.5221.00
142_Y171_P0.5211.00
140_V174_A0.5181.00
73_A247_S0.5181.00
146_E152_F0.5171.00
338_A341_A0.5161.00
139_K142_Y0.5151.00
276_G337_A0.5121.00
155_W158_F0.5111.00
130_Q135_Q0.5101.00
77_T242_N0.5091.00
196_T200_G0.5031.00
77_T241_G0.5011.00
84_S87_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n8nA 1 0.2727 96.9 0.869 Contact Map
2onkA 2 0.1705 95.1 0.889 Contact Map
4p32A 1 0.1278 93.2 0.898 Contact Map
4hziA 2 0.179 93 0.899 Contact Map
2qi9C 2 0.179 93 0.899 Contact Map
2ihyA 2 0.1761 91.7 0.903 Contact Map
4huqA 1 0.2443 91.6 0.903 Contact Map
2yz2A 6 0.2131 91.6 0.903 Contact Map
3zdqA 2 0.1051 90.6 0.905 Contact Map
2nq2C 2 0.1989 90.4 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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