GREMLIN Database
5FCL - 5-formyltetrahydrofolate cyclo-ligase
UniProt: P0AC28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11158
Length: 182 (170)
Sequences: 4715 (3843)
Seq/√Len: 294.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_Q163_V2.9121.00
62_R80_N2.8011.00
154_D177_S2.6701.00
36_T64_Y2.6601.00
41_L65_L2.5151.00
121_D125_Q2.3931.00
36_T62_R2.2331.00
148_P171_P2.2201.00
42_S49_T2.1281.00
76_L137_T2.0791.00
21_A47_L2.0341.00
39_V53_I2.0211.00
26_M55_Q2.0031.00
25_M114_I1.9511.00
88_V98_K1.9511.00
55_Q59_A1.9481.00
38_A78_F1.9321.00
150_G170_L1.9321.00
56_L63_V1.9271.00
122_E178_K1.9221.00
10_T13_Q1.9211.00
38_A113_L1.8891.00
24_R178_K1.8771.00
69_H77_L1.8401.00
18_G153_H1.8381.00
147_Q172_A1.8091.00
117_L120_F1.7791.00
31_V56_L1.7571.00
154_D178_K1.7571.00
34_A61_K1.7431.00
90_N96_E1.7061.00
122_E157_L1.7021.00
49_T151_Y1.6791.00
89_M95_H1.6721.00
14_Q45_G1.6551.00
65_L81_Y1.5891.00
64_Y110_L1.5891.00
31_V59_A1.5771.00
14_Q18_G1.5191.00
13_Q17_M1.5091.00
67_V79_L1.4381.00
122_E159_E1.4361.00
154_D176_P1.4301.00
138_L148_P1.3791.00
90_N94_I1.3771.00
125_Q169_P1.3691.00
152_A156_Q1.3591.00
112_V149_V1.3551.00
74_G131_G1.3381.00
115_T148_P1.3371.00
174_V179_V1.3101.00
17_M176_P1.3021.00
121_D161_L1.2791.00
42_S50_Q1.2741.00
14_Q153_H1.2471.00
149_V172_A1.2381.00
53_I63_V1.2311.00
38_A137_T1.2251.00
31_V61_K1.2231.00
7_R45_G1.2061.00
120_F150_G1.1951.00
36_T110_L1.1921.00
28_Y172_A1.1731.00
22_A52_L1.1721.00
55_Q58_R1.1651.00
30_P172_A1.1511.00
172_A179_V1.1501.00
78_F137_T1.1451.00
42_S48_D1.1381.00
22_A26_M1.1371.00
117_L157_L1.1211.00
68_L133_F1.1181.00
21_A151_Y1.1181.00
30_P147_Q1.1161.00
28_Y149_V1.1071.00
50_Q95_H1.1001.00
31_V112_V1.0891.00
118_V129_M1.0831.00
74_G136_R1.0821.00
154_D157_L1.0781.00
39_V114_I1.0781.00
113_L138_L1.0761.00
115_T138_L1.0701.00
89_M93_K1.0681.00
119_A127_L1.0491.00
17_M153_H1.0431.00
18_G48_D1.0351.00
107_L140_N1.0301.00
82_H85_S1.0251.00
43_F129_M1.0231.00
45_G129_M1.0141.00
117_L170_L1.0111.00
41_L50_Q1.0061.00
4_Q8_A1.0041.00
64_Y105_L0.9931.00
35_H111_D0.9871.00
25_M174_V0.9831.00
6_R129_M0.9791.00
20_Q24_R0.9611.00
158_V161_L0.9551.00
155_C176_P0.9551.00
31_V34_A0.9451.00
70_P74_G0.9341.00
123_Y160_K0.9311.00
28_Y174_V0.9291.00
43_F94_I0.9251.00
25_M52_L0.9241.00
117_L152_A0.9121.00
81_Y87_L0.8991.00
29_P33_M0.8961.00
67_V96_E0.8931.00
120_F152_A0.8781.00
148_P168_I0.8771.00
127_L162_P0.8761.00
28_Y179_V0.8621.00
48_D51_P0.8581.00
148_P170_L0.8561.00
119_A158_V0.8561.00
41_L87_L0.8531.00
35_H61_K0.8451.00
31_V55_Q0.8431.00
64_Y78_F0.8351.00
34_A37_V0.8351.00
75_N140_N0.8281.00
78_F110_L0.8251.00
78_F113_L0.8251.00
113_L137_T0.8231.00
18_G22_A0.8141.00
52_L151_Y0.8081.00
143_H146_T0.8051.00
36_T111_D0.8041.00
29_P32_V0.8031.00
83_P86_E0.8001.00
5_R8_A0.7960.99
15_Q19_Q0.7920.99
64_Y80_N0.7900.99
19_Q51_P0.7880.99
120_F156_Q0.7880.99
47_L156_Q0.7850.99
86_E98_K0.7820.99
49_T53_I0.7790.99
123_Y163_V0.7740.99
17_M20_Q0.7710.99
121_D160_K0.7670.99
57_W81_Y0.7650.99
70_P73_A0.7590.99
139_Q168_I0.7440.99
19_Q23_T0.7430.99
115_T170_L0.7430.99
16_E20_Q0.7420.99
117_L150_G0.7370.99
138_L168_I0.7370.99
26_M52_L0.7340.99
7_R44_D0.7320.99
57_W63_V0.7310.99
57_W84_Q0.7250.99
39_V49_T0.7240.99
77_L104_V0.7200.99
25_M151_Y0.7190.99
50_Q54_E0.7160.99
153_H156_Q0.7140.99
13_Q16_E0.7140.99
54_E57_W0.7130.99
51_P54_E0.7100.99
127_L161_L0.7100.99
114_I151_Y0.7090.99
22_A55_Q0.7080.99
125_Q161_L0.7070.99
12_E16_E0.7060.99
112_V147_Q0.7060.99
24_R179_V0.7040.99
39_V52_L0.7040.99
56_L59_A0.7020.99
69_H75_N0.7010.99
147_Q171_P0.6950.99
113_L146_T0.6910.99
38_A64_Y0.6820.98
53_I65_L0.6790.98
21_A114_I0.6770.98
54_E58_R0.6750.98
98_K101_V0.6730.98
117_L156_Q0.6730.98
24_R27_T0.6720.98
29_P61_K0.6690.98
40_F47_L0.6620.98
6_R10_T0.6590.98
39_V65_L0.6570.98
81_Y84_Q0.6570.98
141_W146_T0.6570.98
44_D129_M0.6560.98
118_V127_L0.6550.98
37_V56_L0.6530.98
26_M59_A0.6460.98
68_L90_N0.6440.98
24_R174_V0.6410.98
29_P34_A0.6340.97
52_L56_L0.6340.97
79_L99_L0.6290.97
37_V61_K0.6270.97
121_D158_V0.6270.97
37_V112_V0.6260.97
18_G47_L0.6240.97
69_H73_A0.6240.97
40_F49_T0.6230.97
110_L113_L0.6210.97
15_Q48_D0.6210.97
70_P133_F0.6190.97
70_P75_N0.6180.97
16_E19_Q0.6180.97
39_V63_V0.6130.97
81_Y86_E0.6090.97
87_L95_H0.6080.97
41_L95_H0.6050.97
152_A173_V0.6040.97
20_Q23_T0.6030.97
124_G170_L0.5990.96
17_M155_C0.5900.96
38_A110_L0.5840.96
57_W83_P0.5820.96
56_L61_K0.5800.96
9_L13_Q0.5770.96
117_L173_V0.5760.96
67_V97_P0.5740.95
82_H86_E0.5690.95
9_L155_C0.5690.95
9_L14_Q0.5690.95
152_A155_C0.5680.95
35_H62_R0.5610.95
49_T52_L0.5590.95
12_E15_Q0.5580.95
120_F173_V0.5530.94
75_N137_T0.5500.94
163_V169_P0.5490.94
152_A170_L0.5480.94
22_A49_T0.5480.94
149_V174_V0.5460.94
11_P15_Q0.5380.94
91_R94_I0.5370.94
68_L94_I0.5350.93
32_V35_H0.5350.93
117_L121_D0.5350.93
17_M21_A0.5320.93
157_L173_V0.5300.93
43_F68_L0.5230.93
53_I81_Y0.5190.92
4_Q7_R0.5180.92
79_L101_V0.5170.92
79_L104_V0.5160.92
76_L133_F0.5120.92
78_F156_Q0.5100.92
91_R96_E0.5040.91
131_G164_E0.5030.91
28_Y31_V0.5030.91
68_L129_M0.5020.91
123_Y169_P0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jcbA 1 0.978 100 0.094 Contact Map
1ydmA 3 0.978 100 0.1 Contact Map
1souA 1 0.9505 100 0.115 Contact Map
3hy3A 2 0.9505 100 0.132 Contact Map
1wkcA 1 0.8626 100 0.171 Contact Map
1sbqA 1 0.8462 100 0.23 Contact Map
3ecsA 4 0.9121 30.3 0.94 Contact Map
1z7mA 4 0.7473 12.4 0.95 Contact Map
3rrlA 2 0.8681 9.6 0.952 Contact Map
2mpvA 1 0.5055 9.5 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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