GREMLIN Database
NIRC - Nitrite transporter NirC
UniProt: P0AC26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10654
Length: 268 (246)
Sequences: 2200 (1473)
Seq/√Len: 93.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_F235_L7.3751.00
154_F231_L4.7331.00
177_A181_I3.9131.00
153_L229_V3.9021.00
31_S111_G3.8991.00
91_V98_H3.6671.00
231_L235_L3.3481.00
32_A118_F3.2621.00
28_W111_G3.1641.00
109_W230_T3.1111.00
39_G119_V2.9851.00
150_A228_W2.8621.00
44_L189_A2.4811.00
121_M125_W2.3381.00
16_I90_G2.2501.00
80_F84_T2.2481.00
162_W240_F2.1931.00
66_G184_W2.1451.00
91_V101_M2.1091.00
28_W107_Q2.0901.00
101_M105_L1.9961.00
21_A100_Q1.9431.00
83_H104_I1.9261.00
32_A114_V1.8491.00
75_A245_Y1.8491.00
158_A235_L1.8391.00
70_T180_F1.7911.00
91_V96_I1.7831.00
149_P152_V1.7801.00
174_T178_A1.7691.00
24_P107_Q1.7641.00
102_W106_P1.7581.00
105_L234_T1.7351.00
80_F234_T1.7291.00
27_F107_Q1.7281.00
120_A210_F1.7211.00
36_A162_W1.6891.00
28_W114_V1.6851.00
148_A156_K1.6601.00
109_W198_S1.6351.00
28_W32_A1.6281.00
122_L155_F1.6071.00
75_A169_W1.5791.00
84_T105_L1.5681.00
121_M210_F1.5531.00
113_L202_M1.5521.00
140_S143_L1.5371.00
71_L166_L1.5111.00
45_I61_M1.5021.00
198_S230_T1.4801.00
217_Y221_G1.4751.00
151_M155_F1.4751.00
9_C250_P1.4601.00
44_L188_L1.4601.00
240_F244_G1.4160.99
90_G96_I1.4060.99
170_M182_A1.3820.99
40_L162_W1.3740.99
99_G103_A1.3740.99
14_A95_S1.3740.99
8_K173_R1.3700.99
59_L188_L1.3560.99
122_L159_L1.3560.99
106_P110_L1.3450.99
98_H102_W1.3300.99
30_S248_A1.3080.99
234_T238_A1.3040.99
205_F209_W1.2980.99
62_G192_A1.2900.99
201_N225_N1.2840.99
117_V210_F1.2520.99
152_V156_K1.2490.99
42_I204_L1.2450.99
63_A184_W1.2400.99
67_I189_A1.2340.98
49_G137_I1.2220.98
144_A147_T1.2180.98
137_I140_S1.2060.98
97_S100_Q1.2030.98
157_G228_W1.1820.98
44_L192_A1.1820.98
227_L231_L1.1770.98
33_M244_G1.1670.98
53_D56_V1.1590.98
241_M245_Y1.1560.98
148_A153_L1.1470.98
239_V243_L1.1450.98
77_S245_Y1.1430.97
16_I19_L1.1430.97
223_G227_L1.1320.97
110_L114_V1.1320.97
143_L147_T1.1300.97
68_A191_I1.1290.97
109_W226_L1.1250.97
230_T234_T1.1230.97
46_F141_V1.1200.97
92_K243_L1.1180.97
43_I193_S1.1160.97
207_L211_G1.1150.97
36_A39_G1.1040.97
40_L163_L1.1030.97
113_L117_V1.0970.97
150_A231_L1.0960.97
48_L60_V1.0940.97
93_A246_W1.0880.97
89_F242_G1.0780.96
72_V77_S1.0760.96
17_A95_S1.0710.96
52_L56_V1.0680.96
40_L119_V1.0550.96
120_A207_L1.0440.96
7_N10_A1.0370.96
160_C199_I1.0330.95
199_I202_M1.0290.95
162_W241_M1.0160.95
63_A188_L1.0150.95
49_G61_M1.0120.95
127_G152_V1.0080.95
12_N172_L1.0020.95
72_V157_G0.9990.95
30_S78_E0.9940.94
92_K246_W0.9830.94
119_V162_W0.9810.94
23_N26_G0.9730.94
145_K200_A0.9730.94
27_F103_A0.9730.94
70_T185_W0.9680.94
73_I183_I0.9590.93
20_S96_I0.9510.93
33_M37_Y0.9430.93
154_F157_G0.9410.93
46_F138_V0.9380.92
37_Y245_Y0.9360.92
209_W219_L0.9330.92
138_V207_L0.9310.92
113_L223_G0.9300.92
224_H228_W0.9220.92
37_Y77_S0.9170.92
125_W155_F0.9160.92
146_T221_G0.9150.92
78_E83_H0.9090.91
24_P28_W0.9080.91
136_S140_S0.9070.91
56_V60_V0.9060.91
16_I87_L0.9050.91
142_A208_S0.9040.91
17_A21_A0.8990.91
87_L90_G0.8950.91
157_G230_T0.8940.91
80_F199_I0.8930.91
145_K161_N0.8880.90
198_S226_L0.8870.90
164_V190_F0.8860.90
46_F203_T0.8810.90
104_I108_T0.8800.90
14_A18_R0.8680.89
25_L247_Y0.8580.89
110_L223_G0.8560.89
73_I168_I0.8550.89
163_L183_I0.8550.89
150_A154_F0.8540.88
205_F222_I0.8540.88
29_V244_G0.8500.88
169_W245_Y0.8490.88
156_K196_E0.8480.88
14_A17_A0.8450.88
50_N137_I0.8440.88
145_K190_F0.8440.88
117_V206_A0.8350.87
75_A170_M0.8190.86
51_L62_G0.8150.86
132_P136_S0.8130.86
161_N190_F0.8130.86
48_L64_T0.8080.86
216_A221_G0.8070.85
109_W113_L0.8070.85
206_A210_F0.8060.85
39_G203_T0.8050.85
27_F108_T0.8020.85
117_V120_A0.8020.85
160_C229_V0.7980.85
209_W217_Y0.7970.85
237_G242_G0.7960.85
162_W166_L0.7920.84
142_A205_F0.7910.84
108_T169_W0.7910.84
136_S139_H0.7880.84
75_A166_L0.7880.84
145_K201_N0.7870.84
216_A220_A0.7860.84
80_F109_W0.7850.84
74_I173_R0.7810.84
5_T8_K0.7780.83
190_F201_N0.7760.83
221_G224_H0.7740.83
80_F230_T0.7720.83
63_A70_T0.7710.83
91_V102_W0.7680.83
153_L157_G0.7670.82
66_G70_T0.7640.82
120_A206_A0.7630.82
98_H101_M0.7630.82
167_A190_F0.7600.82
24_P106_P0.7590.82
37_Y71_L0.7590.82
150_A224_H0.7580.82
100_Q103_A0.7570.82
170_M186_C0.7570.82
78_E108_T0.7520.81
239_V244_G0.7460.81
11_A172_L0.7450.81
86_F90_G0.7390.80
190_F200_A0.7380.80
118_F121_M0.7380.80
30_S169_W0.7350.80
71_L163_L0.7340.80
228_W231_L0.7290.79
70_T183_I0.7260.79
161_N201_N0.7130.78
109_W199_I0.7120.78
52_L55_S0.7110.77
81_T160_C0.7090.77
45_I49_G0.7080.77
85_M180_F0.7070.77
84_T237_G0.7060.77
10_A14_A0.6940.76
10_A95_S0.6920.76
31_S108_T0.6890.75
226_L230_T0.6880.75
198_S229_V0.6870.75
137_I141_V0.6860.75
141_V204_L0.6860.75
124_S211_G0.6840.75
150_A153_L0.6800.74
196_E201_N0.6720.73
13_A93_A0.6710.73
169_W249_T0.6690.73
164_V187_L0.6670.73
139_H208_S0.6640.72
133_V136_S0.6630.72
46_F204_L0.6600.72
163_L186_C0.6590.72
11_A15_R0.6580.72
5_T249_T0.6570.72
220_A224_H0.6540.71
82_G144_A0.6500.71
146_T208_S0.6500.71
146_T209_W0.6490.71
169_W241_M0.6480.71
52_L60_V0.6480.71
225_N229_V0.6410.70
127_G156_K0.6390.70
9_C249_T0.6340.69
210_F219_L0.6300.69
40_L86_F0.6290.68
180_F185_W0.6270.68
130_L152_V0.6260.68
29_V248_A0.6250.68
147_T216_A0.6220.68
201_N229_V0.6190.67
10_A13_A0.6170.67
203_T206_A0.6160.67
106_P227_L0.6130.66
161_N225_N0.6120.66
126_G155_F0.6080.66
50_N133_V0.6070.66
138_V208_S0.6070.66
91_V94_G0.6040.65
7_N175_E0.5990.65
17_A96_I0.5990.65
238_A242_G0.5990.65
30_S77_S0.5990.65
128_G156_K0.5990.65
68_A108_T0.5990.65
161_N165_C0.5970.64
34_A82_G0.5970.64
64_T188_L0.5960.64
51_L55_S0.5950.64
188_L192_A0.5930.64
160_C190_F0.5930.64
52_L57_R0.5920.64
45_I191_I0.5900.63
22_N27_F0.5870.63
43_I129_S0.5870.63
28_W157_G0.5850.63
94_G97_S0.5830.63
19_L31_S0.5820.62
143_L146_T0.5800.62
161_N164_V0.5790.62
190_F196_E0.5760.62
85_M241_M0.5760.62
63_A181_I0.5730.61
166_L241_M0.5690.61
245_Y249_T0.5690.61
32_A36_A0.5660.60
173_R249_T0.5640.60
94_G98_H0.5630.60
91_V100_Q0.5620.60
27_F104_I0.5600.59
85_M165_C0.5600.59
135_T208_S0.5590.59
102_W235_L0.5590.59
124_S207_L0.5580.59
42_I203_T0.5580.59
65_F190_F0.5570.59
165_C242_G0.5560.59
19_L203_T0.5550.59
191_I200_A0.5550.59
67_I71_L0.5530.59
71_L189_A0.5510.58
113_L222_I0.5510.58
191_I204_L0.5490.58
75_A173_R0.5480.58
85_M249_T0.5460.58
119_V199_I0.5460.58
78_E104_I0.5460.58
199_I244_G0.5420.57
161_N187_L0.5410.57
44_L156_K0.5400.57
124_S155_F0.5360.56
31_S34_A0.5360.56
165_C196_E0.5360.56
13_A250_P0.5360.56
150_A227_L0.5350.56
64_T75_A0.5350.56
40_L199_I0.5350.56
25_L94_G0.5340.56
209_W212_N0.5340.56
153_L228_W0.5340.56
96_I100_Q0.5330.56
143_L213_H0.5320.56
19_L104_I0.5320.56
48_L107_Q0.5300.55
153_L224_H0.5300.55
233_N237_G0.5290.55
41_G64_T0.5270.55
171_A182_A0.5260.55
109_W202_M0.5250.55
74_I174_T0.5240.55
38_V42_I0.5230.54
86_F96_I0.5230.54
219_L223_G0.5220.54
74_I170_M0.5210.54
123_Y159_L0.5200.54
148_A151_M0.5180.54
80_F237_G0.5170.54
69_L183_I0.5170.54
173_R182_A0.5150.53
224_H227_L0.5150.53
24_P103_A0.5130.53
236_S241_M0.5130.53
73_I97_S0.5130.53
140_S144_A0.5120.53
124_S210_F0.5110.53
128_G131_L0.5100.53
96_I161_N0.5090.52
151_M166_L0.5090.52
80_F198_S0.5080.52
80_F88_T0.5070.52
29_V33_M0.5070.52
88_T92_K0.5070.52
206_A209_W0.5060.52
6_I14_A0.5050.52
48_L192_A0.5050.52
9_C13_A0.5030.52
124_S135_T0.5020.51
20_S104_I0.5020.51
205_F221_G0.5010.51
32_A175_E0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kcuA 3 0.8545 100 0.121 Contact Map
3tdsE 3 0.9627 100 0.129 Contact Map
3klyA 3 0.8731 100 0.131 Contact Map
4fc4A 3 0.9216 100 0.133 Contact Map
3zojA 3 0.8843 87.7 0.935 Contact Map
3c02A 3 0.8246 84.2 0.938 Contact Map
3llqA 3 0.8209 77 0.942 Contact Map
3cn5A 3 0.7948 76.9 0.943 Contact Map
3iyzA 3 0.75 73.9 0.944 Contact Map
2zz9A 3 0.7649 72.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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