GREMLIN Database
FOCA - Probable formate transporter 1
UniProt: P0AC23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11258
Length: 285 (247)
Sequences: 2168 (1443)
Seq/√Len: 91.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
165_V264_I6.9251.00
165_V260_I4.6661.00
38_A120_G3.8381.00
164_A258_V3.8241.00
189_M193_F3.7941.00
100_K107_W3.5361.00
23_G26_K3.2161.00
39_I127_L3.0681.00
35_F120_G3.0231.00
118_Y259_T2.9101.00
260_I264_I2.9021.00
46_S128_F2.8201.00
161_F257_P2.7871.00
23_G99_A2.5441.00
51_F201_M2.4231.00
217_I250_F2.4191.00
90_F94_V2.2201.00
35_F116_N2.1841.00
130_L134_L2.1791.00
100_K110_L2.1621.00
173_L269_L2.1241.00
76_S196_V2.0101.00
160_T163_E1.8581.00
85_C274_Y1.8531.00
28_T109_Q1.8431.00
110_L114_W1.8321.00
187_S190_D1.8211.00
93_T113_N1.8051.00
185_G190_D1.7521.00
114_W263_I1.7251.00
31_P116_N1.7171.00
39_I123_V1.7111.00
100_K105_I1.7101.00
111_A115_L1.6981.00
80_I192_A1.6941.00
129_V222_V1.6641.00
43_V173_L1.6541.00
118_Y210_S1.6471.00
90_F263_I1.6201.00
169_I264_I1.5961.00
34_T116_N1.5951.00
221_I250_F1.5801.00
122_L214_M1.5251.00
221_I247_V1.5251.00
94_V114_W1.5201.00
131_L166_C1.5121.00
151_Q154_D1.4981.00
52_Y71_G1.4901.00
159_H167_L1.4871.00
81_L177_L1.4771.00
11_L14_A1.4581.00
130_L222_V1.4531.00
47_I173_L1.4531.00
246_T249_N1.4440.99
99_A105_I1.4350.99
35_F39_I1.4340.99
85_C180_W1.4270.99
210_S259_T1.4180.99
16_A279_L1.4090.99
51_F200_A1.3910.99
251_I256_I1.3860.99
69_L200_A1.3840.99
162_I166_C1.3620.99
35_F123_V1.3550.99
184_S188_L1.3520.99
37_L277_I1.3440.99
21_E104_R1.3130.99
24_V104_R1.3120.99
269_L273_T1.3100.99
263_I267_G1.3050.99
107_W111_A1.3020.99
15_M184_S1.2870.99
115_L119_F1.2800.99
181_M194_I1.2770.99
72_G204_A1.2660.99
108_G112_K1.2460.98
126_L222_V1.2250.98
185_G188_L1.2230.98
73_I196_V1.2200.98
159_H164_A1.2120.98
119_F123_V1.2090.98
163_E167_L1.1950.98
131_L170_L1.1910.98
168_G257_P1.1880.98
122_L126_L1.1850.98
77_L201_M1.1810.98
98_V271_G1.1800.98
161_F260_I1.1770.98
51_F204_A1.1730.98
154_D158_H1.1660.98
106_T109_Q1.1610.98
56_T148_N1.1510.97
40_T273_T1.1490.97
60_G63_P1.1490.97
256_I260_I1.1470.97
53_I152_T1.1260.97
171_A211_I1.1190.97
78_G203_V1.1170.97
84_V188_L1.1150.97
63_P66_M1.1150.97
87_A274_Y1.1150.97
118_Y255_L1.1110.97
224_R244_H1.1000.97
217_I221_I1.0940.96
259_T263_I1.0900.96
49_F216_M1.0880.96
211_I214_M1.0870.96
50_V205_S1.0840.96
225_D244_H1.0820.96
270_V274_Y1.0800.96
148_N151_Q1.0790.96
55_A70_V1.0730.96
213_N254_N1.0700.96
30_H33_K1.0690.96
129_V219_M1.0640.96
219_M223_I1.0630.96
173_L270_V1.0590.96
56_T71_G1.0500.96
143_G147_L1.0300.95
47_I174_M1.0280.95
19_A183_Y1.0260.95
34_T112_K1.0200.95
37_L88_D1.0150.95
23_G97_V1.0110.95
27_A105_I1.0070.94
43_V46_S1.0060.94
102_S275_W1.0030.94
155_H158_H0.9880.94
101_A272_L0.9750.93
222_V247_V0.9710.93
147_L151_Q0.9660.93
268_L272_L0.9540.93
82_C168_G0.9530.93
168_G259_T0.9490.92
161_F165_V0.9490.92
47_I128_F0.9450.92
80_I197_L0.9450.92
31_P35_F0.9430.92
44_F87_A0.9380.92
22_A26_K0.9380.92
83_V195_M0.9360.92
66_M70_V0.9340.92
53_I149_V0.9260.92
82_C87_A0.9220.91
128_F173_L0.9150.91
59_T66_M0.9100.91
161_F253_D0.9060.91
40_T44_F0.9050.91
253_D257_P0.9030.90
172_N202_F0.8950.90
101_A275_W0.8920.90
175_V202_F0.8910.90
210_S255_L0.8910.90
73_I200_A0.8900.90
24_V28_T0.8870.90
137_E167_L0.8820.89
157_V249_N0.8670.89
156_K212_A0.8640.88
156_K172_N0.8600.88
249_N253_D0.8490.88
180_W274_Y0.8490.88
14_A17_K0.8410.87
113_N117_V0.8390.87
21_E25_Y0.8380.87
58_G72_G0.8310.86
149_V219_M0.8270.86
20_E23_G0.8210.86
32_L276_V0.8200.86
153_A220_G0.8190.86
44_F274_Y0.8180.86
96_I99_A0.8130.85
38_A117_V0.8110.85
85_C181_M0.8100.85
126_L129_V0.8100.85
55_A74_C0.8070.85
167_L208_E0.8070.85
21_E24_V0.8060.85
90_F211_I0.8030.85
57_T148_N0.8020.84
136_G163_E0.8020.84
100_K111_A0.8010.84
31_P115_L0.7990.84
117_V180_W0.7970.84
156_K202_F0.7900.84
156_K213_N0.7860.83
126_L218_P0.7860.83
88_D93_T0.7850.83
85_C177_L0.7840.83
257_P260_I0.7830.83
107_W110_L0.7830.83
143_G146_G0.7830.83
83_V179_V0.7820.83
154_D244_H0.7790.83
118_Y122_L0.7740.82
181_M198_P0.7660.82
266_G271_G0.7660.82
268_L273_T0.7630.81
53_I215_F0.7620.81
133_W222_V0.7560.81
153_A217_I0.7550.81
37_L180_W0.7540.81
18_V183_Y0.7490.80
88_D117_V0.7470.80
109_Q112_K0.7460.80
174_M195_M0.7410.79
81_L174_M0.7390.79
46_S215_F0.7380.79
90_F259_T0.7380.79
164_A168_G0.7330.79
36_Y273_T0.7300.78
76_S80_I0.7260.78
44_F81_L0.7230.78
73_I80_I0.7220.78
20_E102_S0.7210.78
84_V184_S0.7200.77
218_P222_V0.7180.77
173_L177_L0.7180.77
202_F213_N0.7140.77
171_A258_V0.7140.77
127_L130_L0.7140.77
34_T117_V0.7120.77
17_K21_E0.7060.76
154_D245_L0.7060.76
129_V218_P0.7030.76
94_V266_G0.6970.75
165_V168_G0.6960.75
18_V22_A0.6950.75
178_A202_F0.6930.75
221_I245_L0.6890.74
267_G271_G0.6860.74
147_L150_L0.6840.74
180_W278_Y0.6840.74
161_F164_A0.6770.73
95_L192_A0.6730.73
118_Y211_I0.6640.72
90_F118_Y0.6630.71
16_A180_W0.6620.71
150_L220_G0.6590.71
91_T171_A0.6580.71
154_D157_V0.6570.71
202_F212_A0.6570.71
172_N213_N0.6520.70
103_G107_W0.6520.70
16_A98_V0.6490.70
53_I216_M0.6470.70
132_M170_L0.6430.69
210_S258_V0.6420.69
100_K103_G0.6410.69
180_W270_V0.6380.69
149_V220_G0.6370.68
12_P15_M0.6360.68
172_N199_V0.6350.68
41_A92_S0.6320.68
48_A78_G0.6300.68
157_V221_I0.6250.67
248_M253_D0.6220.67
192_A197_L0.6220.67
157_V220_G0.6220.67
52_Y56_T0.6190.66
80_I195_M0.6180.66
139_M163_E0.6180.66
115_L256_I0.6170.66
161_F256_I0.6110.65
274_Y278_Y0.6110.65
52_Y203_V0.6100.65
77_L81_L0.6080.65
135_S170_L0.6080.65
60_G67_A0.6060.65
59_T64_F0.6010.64
48_A72_G0.6010.64
17_K20_E0.6000.64
17_K104_R0.5990.64
12_P278_Y0.5980.64
146_G220_G0.5980.64
78_G117_V0.5970.63
50_V138_Y0.5940.63
174_M198_P0.5930.63
208_E213_N0.5920.63
12_P211_I0.5910.63
95_L278_Y0.5900.63
95_L270_V0.5880.62
22_A25_Y0.5880.62
215_F218_P0.5860.62
15_M180_W0.5820.62
148_N152_T0.5790.61
16_A278_Y0.5790.61
19_A23_G0.5770.61
176_C208_E0.5770.61
73_I193_F0.5760.61
105_I109_Q0.5750.61
175_V199_V0.5740.60
134_L166_C0.5720.60
247_V251_I0.5700.60
59_T65_G0.5690.60
96_I117_V0.5690.60
119_F251_I0.5630.59
90_F266_G0.5610.59
58_G65_G0.5610.59
157_V225_D0.5600.59
47_I96_I0.5590.58
77_L275_W0.5590.58
16_A20_E0.5590.58
47_I211_I0.5580.58
27_A97_V0.5580.58
152_T216_M0.5570.58
164_A257_P0.5540.58
176_C214_M0.5540.58
27_A113_N0.5540.58
111_A264_I0.5530.58
11_L15_M0.5510.57
103_G106_T0.5510.57
195_M199_V0.5510.57
122_L125_A0.5500.57
136_G167_L0.5500.57
255_L259_T0.5500.57
92_S155_H0.5490.57
122_L247_V0.5490.57
35_F168_G0.5480.57
224_R246_T0.5450.57
14_A186_R0.5450.57
36_Y277_I0.5450.57
245_L249_N0.5440.56
37_L87_A0.5430.56
202_F254_N0.5430.56
90_F210_S0.5430.56
100_K109_Q0.5400.56
265_G270_V0.5400.56
122_L218_P0.5380.56
253_D256_I0.5350.55
203_V212_A0.5350.55
74_C85_C0.5340.55
144_Q147_L0.5330.55
41_A90_F0.5320.55
83_V182_S0.5320.55
22_A183_Y0.5280.54
20_E119_F0.5280.54
247_V250_F0.5270.54
164_A253_D0.5270.54
34_T113_N0.5250.54
154_D225_D0.5250.54
132_M135_S0.5240.54
80_I278_Y0.5230.54
157_V217_I0.5230.54
221_I224_R0.5220.53
59_T63_P0.5210.53
29_K34_T0.5200.53
85_C184_S0.5200.53
83_V106_T0.5190.53
135_S166_C0.5190.53
172_N212_A0.5180.53
177_L270_V0.5170.53
51_F69_L0.5170.53
146_G150_L0.5170.53
125_A214_M0.5150.52
13_A21_E0.5150.52
49_F215_F0.5140.52
202_F208_E0.5130.52
45_I49_F0.5130.52
63_P76_S0.5110.52
38_A116_N0.5110.52
72_G210_S0.5100.52
127_L280_R0.5090.52
28_T245_L0.5060.51
39_I269_L0.5060.51
31_P112_K0.5050.51
17_K24_V0.5040.51
75_F202_F0.5030.51
155_H160_T0.5020.51
74_C200_A0.5000.50
150_L225_D0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kcuA 3 0.8842 100 0.06 Contact Map
3klyA 3 0.9018 100 0.086 Contact Map
3tdsE 3 0.9018 100 0.152 Contact Map
4fc4A 3 0.8632 100 0.177 Contact Map
3zojA 3 0.8561 92.7 0.932 Contact Map
3llqA 3 0.807 89.3 0.937 Contact Map
3cn5A 3 0.8035 83.5 0.942 Contact Map
2o9gA 3 0.807 79 0.945 Contact Map
3iyzA 3 0.7474 75.1 0.947 Contact Map
1j4nA 4 0.8035 64.4 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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