GREMLIN Database
FOLX - D-erythro-7,8-dihydroneopterin triphosphate epimerase
UniProt: P0AC19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG14263
Length: 120 (114)
Sequences: 2410 (1695)
Seq/√Len: 158.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_N59_T3.1771.00
26_I74_S2.9101.00
14_R31_D2.5051.00
101_D111_S2.4831.00
48_S53_D2.4191.00
39_H95_Y2.3421.00
36_V64_I2.3031.00
38_I60_V2.2901.00
97_E117_S2.2361.00
37_T97_E2.1511.00
99_E115_T2.1361.00
63_N90_H2.1011.00
95_Y117_S2.0241.00
44_K53_D2.0101.00
81_Q85_D2.0021.00
31_D104_H1.7931.00
73_F82_D1.7641.00
12_N35_N1.7171.00
87_A93_V1.7141.00
9_R113_S1.6971.00
68_V79_L1.6681.00
21_I51_I1.6621.00
97_E115_T1.5961.00
26_I72_R1.5691.00
16_R31_D1.5491.00
65_I69_E1.5181.00
78_K82_D1.4761.00
7_I37_T1.4711.00
36_V98_V1.4531.00
66_Q70_N1.4461.00
12_N110_D1.3951.00
34_I68_V1.3641.00
67_H86_I1.3631.00
84_L116_L1.3411.00
50_D53_D1.2841.00
63_N86_I1.2791.00
40_Y55_L1.2651.00
35_N101_D1.2461.00
7_I115_T1.2391.00
14_R33_V1.2351.00
73_F79_L1.2171.00
12_N33_V1.2051.00
24_E27_N1.1981.00
63_N91_H1.1891.00
24_E28_N1.1701.00
22_K58_R1.1661.00
46_R81_Q1.1551.00
34_I83_V1.1551.00
60_V87_A1.1111.00
55_L93_V1.1081.00
15_L68_V1.1031.00
99_E113_S1.0720.99
73_F78_K1.0690.99
10_I61_T1.0610.99
18_F29_R1.0590.99
13_L61_T1.0550.99
80_T116_L1.0540.99
64_I83_V1.0400.99
35_N99_E1.0280.99
58_R62_K1.0230.99
11_K99_E1.0160.99
11_K37_T1.0000.99
80_T114_M0.9850.99
15_L61_T0.9840.99
11_K111_S0.9770.99
25_E102_K0.9680.99
51_I56_N0.9550.99
7_I39_H0.9360.98
81_Q116_L0.9250.98
62_K66_Q0.9240.98
107_R112_V0.8910.98
44_K48_S0.8890.98
18_F28_N0.8760.98
9_R37_T0.8680.97
46_R78_K0.8610.97
67_H82_D0.8520.97
9_R115_T0.8500.97
38_I93_V0.8480.97
56_N62_K0.8460.97
34_I100_I0.8450.97
42_A46_R0.8450.97
51_I54_A0.8420.97
17_T32_I0.8360.97
85_D89_E0.8330.97
77_E102_K0.8300.97
71_N82_D0.8290.97
13_L64_I0.8260.96
11_K110_D0.8240.96
83_V98_V0.8070.96
16_R29_R0.8060.96
43_D81_Q0.8010.96
43_D47_T0.7850.95
39_H97_E0.7750.95
25_E77_E0.7690.95
81_Q118_W0.7660.95
26_I71_N0.7660.95
84_L98_V0.7520.94
101_D105_A0.7500.94
19_I32_I0.7490.94
32_I106_L0.7470.94
23_E27_N0.7330.93
15_L65_I0.7320.93
61_T109_A0.7270.93
44_K47_T0.7230.93
19_I106_L0.7220.93
25_E75_L0.7200.93
65_I108_Y0.7040.92
13_L109_A0.6920.91
28_N31_D0.6830.91
32_I76_L0.6820.91
39_H117_S0.6820.91
79_L82_D0.6800.90
49_E57_Y0.6740.90
84_L118_W0.6710.90
54_A75_L0.6640.89
64_I98_V0.6620.89
40_Y54_A0.6620.89
84_L96_A0.6590.89
67_H83_V0.6570.89
38_I96_A0.6540.89
10_I13_L0.6520.89
12_N101_D0.6460.88
46_R116_L0.6440.88
42_A116_L0.6360.87
62_K65_I0.6350.87
14_R110_D0.6310.87
20_G102_K0.6230.86
9_R99_E0.6230.86
58_R107_R0.6150.85
36_V39_H0.6080.85
43_D46_R0.6030.84
8_I54_A0.5920.83
6_A46_R0.5890.83
11_K101_D0.5880.83
18_F71_N0.5880.83
7_I97_E0.5830.82
88_R96_A0.5760.82
87_A96_A0.5730.81
67_H71_N0.5710.81
84_L88_R0.5680.81
14_R104_H0.5660.80
5_A39_H0.5660.80
42_A54_A0.5630.80
32_I79_L0.5620.80
75_L102_K0.5560.79
41_P46_R0.5500.79
6_A118_W0.5460.78
39_H94_T0.5460.78
18_F72_R0.5430.78
36_V93_V0.5360.77
105_A109_A0.5350.77
12_N111_S0.5340.77
8_I38_I0.5330.76
15_L69_E0.5330.76
38_I64_I0.5280.76
22_K62_K0.5280.76
5_A117_S0.5270.76
63_N89_E0.5260.75
22_K27_N0.5230.75
55_L92_W0.5220.75
47_T50_D0.5220.75
59_T62_K0.5180.74
51_I59_T0.5130.74
79_L83_V0.5130.74
47_T89_E0.5090.73
104_H112_V0.5070.73
33_V101_D0.5030.72
23_E26_I0.5030.72
19_I107_R0.5020.72
17_T83_V0.5010.72
5_A94_T0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b9lA 4 0.9917 100 0.118 Contact Map
4aeyA 3 0.8917 100 0.125 Contact Map
2o90A 4 0.9583 100 0.131 Contact Map
3o1kA 4 0.9833 100 0.132 Contact Map
3r2eA 4 0.975 100 0.135 Contact Map
1dhnA 4 0.975 100 0.152 Contact Map
3v9oA 3 0.95 100 0.152 Contact Map
1nbuA 4 0.9667 100 0.155 Contact Map
1sqlA 5 0.975 100 0.156 Contact Map
1z9wA 3 0.875 100 0.157 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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