GREMLIN Database
FOLB - Dihydroneopterin aldolase
UniProt: P0AC16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11673
Length: 122 (115)
Sequences: 2554 (1819)
Seq/√Len: 169.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_S55_D3.0871.00
22_Q70_A2.8121.00
97_S107_N2.4181.00
10_S27_K2.4081.00
44_S49_D2.3241.00
34_M56_I2.3131.00
32_I60_V2.2891.00
93_R113_E2.1941.00
33_E93_R2.1821.00
35_A91_W2.1741.00
95_K111_I2.0321.00
40_K49_D1.9841.00
91_W113_E1.9751.00
59_T86_R1.9701.00
77_E81_E1.8631.00
69_F78_E1.8061.00
27_K100_G1.7141.00
8_Q31_D1.7051.00
17_V47_V1.7041.00
91_W115_G1.6971.00
64_V75_V1.6761.00
22_Q68_R1.6171.00
5_F109_G1.5931.00
93_R111_I1.5731.00
83_L89_S1.5621.00
8_Q106_A1.5421.00
61_V65_E1.5281.00
3_I33_E1.4681.00
12_I27_K1.4581.00
62_S66_G1.4341.00
32_I94_I1.4071.00
74_R78_E1.3991.00
80_A112_I1.3901.00
63_H82_L1.3881.00
30_F64_V1.3771.00
10_S29_V1.3281.00
20_W23_T1.3161.00
20_W24_I1.3121.00
59_T82_L1.2581.00
42_A77_E1.2561.00
3_I111_I1.2451.00
8_Q29_V1.2331.00
46_D49_D1.2321.00
31_D97_S1.2251.00
36_W51_L1.2191.00
18_Y54_A1.1951.00
59_T87_F1.1721.00
69_F75_V1.1341.00
56_I83_L1.0961.00
95_K109_G1.0931.00
30_F79_V1.0781.00
57_A105_A1.0701.00
11_V64_V1.0631.00
14_T25_E1.0200.99
6_I57_A1.0180.99
9_L57_A1.0140.99
84_L116_N1.0050.99
47_V52_S1.0020.99
31_D95_K1.0000.99
103_A108_V0.9710.99
54_A58_E0.9670.99
11_V57_A0.9620.99
60_V79_V0.9600.99
69_F74_R0.9580.99
7_E107_N0.9470.99
7_E95_K0.9410.99
21_E98_K0.9270.99
77_E112_I0.9220.99
80_A94_I0.9140.99
13_T28_L0.9090.98
7_E33_E0.9050.98
76_A112_I0.9030.98
67_A78_E0.8980.98
5_F33_E0.8870.98
34_M89_S0.8780.98
3_I35_A0.8770.98
51_L89_S0.8760.98
76_A110_V0.8660.98
47_V50_C0.8620.98
38_N42_A0.8620.98
58_E105_A0.8610.98
40_K44_S0.8590.98
5_F111_I0.8590.98
58_E62_S0.8510.98
63_H78_E0.8420.97
22_Q67_A0.8390.97
14_T24_I0.8320.97
52_S58_E0.8190.97
9_L60_V0.8180.97
30_F96_L0.8090.97
19_D23_T0.8030.97
12_I25_E0.8020.97
42_A74_R0.7890.96
61_V105_A0.7880.96
15_I28_L0.7880.96
81_E85_A0.7850.96
73_E98_K0.7780.96
7_E106_A0.7760.96
97_S101_A0.7750.96
39_R43_K0.7740.96
39_R77_E0.7680.96
2_D42_A0.7560.95
38_N112_I0.7510.95
61_V104_R0.7440.95
79_V94_I0.7410.95
58_E104_R0.7250.94
77_E114_R0.7200.94
9_L105_A0.7150.94
15_I102_V0.7110.93
2_D114_R0.6950.93
35_A93_R0.6940.93
21_E73_E0.6860.92
63_H79_V0.6840.92
6_I9_L0.6780.92
24_I27_K0.6760.92
39_R42_A0.6690.91
80_A92_V0.6620.91
2_D26_Q0.6610.91
28_L102_V0.6600.91
34_M92_V0.6590.91
60_V94_I0.6550.90
11_V61_V0.6510.90
45_D53_Y0.6500.90
36_W50_C0.6500.90
4_V50_C0.6450.90
58_E61_V0.6380.89
21_E71_L0.6320.89
35_A90_P0.6300.89
8_Q97_S0.6250.88
38_N50_C0.6240.88
35_A113_E0.6220.88
5_F95_K0.6190.88
16_G98_K0.6180.88
54_A103_A0.6130.87
80_A114_R0.6130.87
37_D42_A0.6060.87
10_S106_A0.5990.86
32_I35_A0.5950.86
50_C71_L0.5950.86
28_L72_V0.5940.85
38_N41_A0.5940.85
27_K104_R0.5880.85
88_N116_N0.5880.85
84_L92_V0.5870.85
29_V97_S0.5780.84
40_K43_K0.5690.83
43_K81_E0.5660.83
63_H67_A0.5610.82
24_I100_G0.5600.82
11_V65_E0.5570.82
42_A112_I0.5540.81
14_T68_R0.5520.81
76_A96_L0.5500.81
83_L92_V0.5460.80
84_L115_G0.5370.79
28_L75_V0.5370.79
3_I93_R0.5360.79
82_L86_R0.5350.79
6_I108_V0.5340.79
7_E97_S0.5330.79
90_P116_N0.5300.78
15_I103_A0.5290.78
84_L96_L0.5280.78
80_A84_L0.5250.78
11_V105_A0.5250.78
43_K46_D0.5240.78
71_L98_K0.5220.77
36_W89_S0.5170.77
75_V78_E0.5130.76
4_V34_M0.5090.76
55_D58_E0.5080.75
8_Q107_N0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o90A 4 0.9426 100 0.091 Contact Map
3r2eA 4 0.9508 100 0.125 Contact Map
1sqlA 5 0.9754 100 0.13 Contact Map
3o1kA 4 0.9508 100 0.133 Contact Map
4aeyA 3 0.8607 100 0.143 Contact Map
1b9lA 4 0.9508 100 0.147 Contact Map
1dhnA 4 0.959 100 0.147 Contact Map
1nbuA 4 0.9508 100 0.151 Contact Map
1z9wA 3 0.8689 100 0.153 Contact Map
3v9oA 3 0.9098 100 0.154 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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