GREMLIN Database
DHPS - Dihydropteroate synthase
UniProt: P0AC13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50011
Length: 282 (262)
Sequences: 4528 (3146)
Seq/√Len: 194.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_L50_A3.0041.00
263_V267_R2.8981.00
107_A134_L2.8941.00
203_R206_E2.8841.00
59_G78_V2.7751.00
71_V101_E2.7701.00
218_M242_C2.6911.00
224_I238_G2.6531.00
86_A112_H2.6291.00
205_A249_Q2.5551.00
48_I91_V2.5291.00
104_R131_E2.4891.00
107_A132_T2.4241.00
173_E179_K2.3821.00
72_E76_Q2.2711.00
237_S264_E2.2051.00
45_N88_R2.2011.00
225_G235_R2.1231.00
230_V264_E2.1161.00
168_Q171_R2.1161.00
114_I129_A2.0891.00
95_V106_S2.0241.00
124_G127_E2.0061.00
216_V246_A2.0011.00
75_L79_I1.9881.00
17_V263_V1.9721.00
43_H46_L1.9091.00
169_I212_L1.9081.00
128_A132_T1.8651.00
19_G47_M1.8631.00
222_S226_Q1.8631.00
236_L261_E1.8291.00
243_A262_T1.8271.00
100_P122_E1.8031.00
244_V269_V1.7651.00
73_E76_Q1.7601.00
240_L265_A1.7551.00
236_L258_D1.7361.00
34_H43_H1.7031.00
50_A260_K1.7011.00
245_I248_M1.6961.00
113_I137_C1.6881.00
105_E108_K1.6741.00
239_S243_A1.6731.00
120_L136_V1.6411.00
170_A174_Q1.6411.00
44_A85_I1.6381.00
60_E99_K1.6171.00
104_R108_K1.6161.00
247_A266_M1.6091.00
16_H53_T1.5871.00
21_L47_M1.5861.00
62_T117_I1.5841.00
208_H252_H1.5761.00
161_V200_L1.5751.00
103_I125_A1.5621.00
199_S203_R1.5591.00
75_L105_E1.5441.00
152_P196_H1.5321.00
14_H53_T1.5301.00
70_S73_E1.5261.00
236_L240_L1.5211.00
67_A146_K1.5091.00
33_T233_S1.5091.00
183_L253_I1.4981.00
40_A81_V1.4591.00
97_T103_I1.4531.00
75_L102_V1.4361.00
108_K132_T1.4351.00
101_E105_E1.4081.00
18_M215_L1.4051.00
156_D159_A1.3781.00
36_S39_D1.3761.00
107_A128_A1.3651.00
172_C177_I1.3621.00
239_S262_T1.3381.00
45_N49_N1.3331.00
188_F218_M1.3331.00
194_L223_M1.3221.00
121_S164_Y1.3091.00
42_K45_N1.2971.00
227_L268_V1.2881.00
127_E175_A1.2781.00
45_N89_F1.2741.00
231_G234_E1.2681.00
204_L216_V1.2671.00
162_N206_E1.2581.00
15_P270_E1.2511.00
84_A88_R1.2471.00
194_L227_L1.2371.00
179_K212_L1.2351.00
78_V95_V1.2321.00
38_I42_K1.2201.00
142_Q191_G1.2181.00
82_V106_S1.2111.00
57_V85_I1.2111.00
41_V45_N1.2071.00
170_A173_E1.1991.00
243_A254_I1.1971.00
104_R132_T1.1961.00
53_T263_V1.1911.00
193_N196_H1.1891.00
208_H214_L1.1711.00
245_I272_T1.1671.00
120_L126_L1.1611.00
119_S138_L1.1591.00
198_Y227_L1.1451.00
178_A181_K1.1351.00
244_V265_A1.1341.00
240_L262_T1.1331.00
44_A55_I1.1301.00
237_S240_L1.1271.00
161_V165_F1.1251.00
247_A254_I1.0981.00
30_D34_H1.0921.00
135_P183_L1.0901.00
127_E131_E1.0891.00
133_G181_K1.0871.00
142_Q152_P1.0821.00
184_L212_L1.0771.00
41_V44_A1.0741.00
21_L55_I1.0711.00
82_V109_V1.0591.00
41_V84_A1.0501.00
169_I184_L1.0481.00
86_A93_I1.0431.00
48_I89_F1.0421.00
121_S168_Q1.0421.00
99_K102_V1.0411.00
162_N207_F1.0371.00
162_N209_H1.0371.00
218_M243_A1.0331.00
71_V75_L1.0291.00
39_D42_K1.0231.00
26_D63_R1.0151.00
71_V99_K1.0081.00
60_E98_S1.0061.00
135_P181_K1.0041.00
216_V251_A1.0021.00
54_I113_I0.9931.00
100_P128_A0.9921.00
248_M269_V0.9870.99
83_E109_V0.9850.99
169_I182_L0.9850.99
230_V234_E0.9810.99
14_H270_E0.9780.99
126_L171_R0.9770.99
217_G253_I0.9730.99
15_P254_I0.9660.99
104_R128_A0.9600.99
122_E125_A0.9580.99
162_N210_F0.9570.99
98_S118_R0.9480.99
83_E108_K0.9430.99
162_N166_I0.9420.99
245_I249_Q0.9400.99
206_E209_H0.9360.99
83_E87_Q0.9320.99
143_G148_M0.9320.99
54_I253_I0.9280.99
118_R122_E0.9280.99
152_P191_G0.9260.99
198_Y271_A0.9240.99
43_H47_M0.9220.99
244_V248_M0.9200.99
92_W112_H0.9190.99
17_V266_M0.9130.99
159_A163_R0.9130.99
57_V93_I0.9090.99
194_L226_Q0.9010.99
41_V81_V0.8970.99
188_F216_V0.8850.99
84_A87_Q0.8820.99
157_V161_V0.8810.99
246_A251_A0.8790.99
31_G34_H0.8750.99
240_L244_V0.8750.99
182_L212_L0.8740.99
44_A89_F0.8730.99
237_S241_A0.8730.99
142_Q164_Y0.8620.99
188_F223_M0.8580.99
133_G178_A0.8510.98
262_T265_A0.8510.98
93_I111_A0.8380.98
188_F204_L0.8350.98
69_V99_K0.8320.98
50_A261_E0.8310.98
169_I173_E0.8310.98
244_V266_M0.8280.98
184_L214_L0.8270.98
101_E104_R0.8270.98
95_V111_A0.8250.98
158_F203_R0.8250.98
29_S236_L0.8240.98
248_M273_L0.8230.98
199_S202_A0.8220.98
220_R258_D0.8190.98
121_S141_M0.8160.98
184_L210_F0.8160.98
158_F161_V0.8140.98
79_I105_E0.8120.98
52_A259_V0.8070.98
21_L43_H0.8030.98
46_L49_N0.8030.98
258_D261_E0.8030.98
265_A269_V0.8010.98
241_A244_V0.8000.98
169_I210_F0.7900.98
138_L172_C0.7800.97
198_Y223_M0.7780.97
165_F184_L0.7740.97
158_F200_L0.7730.97
166_I210_F0.7710.97
104_R124_G0.7690.97
154_Y160_E0.7650.97
23_V59_G0.7630.97
15_P247_A0.7600.97
204_L246_A0.7580.97
196_H199_S0.7530.97
37_L84_A0.7530.97
79_I109_V0.7510.97
129_A136_V0.7510.97
145_P148_M0.7470.97
172_C175_A0.7460.97
140_H192_K0.7440.96
202_A273_L0.7420.96
60_E68_E0.7360.96
85_I89_F0.7360.96
119_S168_Q0.7360.96
247_A269_V0.7350.96
19_G259_V0.7320.96
173_E212_L0.7280.96
159_A206_E0.7270.96
42_K46_L0.7260.96
85_I93_I0.7240.96
142_Q196_H0.7230.96
130_A175_A0.7230.96
47_M52_A0.7230.96
121_S167_E0.7180.96
18_M253_I0.7180.96
53_T92_W0.7170.96
155_D160_E0.7170.96
201_L223_M0.7160.96
30_D33_T0.7150.96
188_F201_L0.7130.96
101_E124_G0.7130.96
100_P124_G0.7100.95
130_A177_I0.7090.95
237_S261_E0.7080.95
177_I181_K0.7020.95
198_Y268_V0.7020.95
23_V81_V0.7010.95
126_L172_C0.7000.95
225_G228_L0.6990.95
45_N48_I0.6990.95
105_E109_V0.6980.95
117_I141_M0.6970.95
149_Q222_S0.6960.95
201_L218_M0.6930.95
136_V182_L0.6870.95
171_R175_A0.6830.94
152_P193_N0.6810.94
242_C268_V0.6790.94
194_L197_N0.6790.94
165_F169_I0.6790.94
144_N147_T0.6780.94
79_I83_E0.6760.94
269_V273_L0.6760.94
75_L106_S0.6760.94
70_S76_Q0.6730.94
204_L251_A0.6690.94
222_S236_L0.6630.93
243_A266_M0.6620.93
260_K264_E0.6610.93
100_P118_R0.6610.93
227_L271_A0.6600.93
224_I268_V0.6590.93
149_Q152_P0.6570.93
239_S256_V0.6570.93
75_L101_E0.6560.93
162_N184_L0.6500.93
79_I106_S0.6490.93
120_L172_C0.6470.93
82_V86_A0.6470.93
194_L198_Y0.6460.93
52_A55_I0.6430.92
78_V82_V0.6420.92
264_E268_V0.6420.92
41_V89_F0.6390.92
266_M270_E0.6390.92
142_Q160_E0.6380.92
154_Y196_H0.6370.92
72_E101_E0.6360.92
230_V260_K0.6360.92
29_S32_G0.6360.92
79_I82_V0.6310.92
240_L243_A0.6290.92
245_I269_V0.6280.91
156_D160_E0.6270.91
135_P213_P0.6260.91
113_I135_P0.6250.91
56_D94_S0.6250.91
151_A191_G0.6200.91
157_V200_L0.6190.91
120_L129_A0.6180.91
17_V259_V0.6160.91
198_Y272_T0.6150.91
142_Q151_A0.6130.90
126_L130_A0.6120.90
166_I209_H0.6120.90
201_L216_V0.6120.90
130_A172_C0.6090.90
98_S117_I0.6070.90
80_P83_E0.6060.90
47_M55_I0.6050.90
21_L34_H0.6000.90
228_L264_E0.5960.89
113_I183_L0.5960.89
41_V88_R0.5950.89
35_N39_D0.5930.89
47_M259_V0.5910.89
225_G232_P0.5910.89
59_G82_V0.5890.89
141_M145_P0.5890.89
160_E163_R0.5880.89
167_E171_R0.5860.88
68_E146_K0.5860.88
140_H154_Y0.5830.88
201_L242_C0.5820.88
238_G264_E0.5820.88
125_A136_V0.5780.88
243_A256_V0.5770.88
29_S220_R0.5770.88
120_L125_A0.5770.88
156_D203_R0.5740.87
167_E170_A0.5700.87
37_L41_V0.5690.87
141_M148_M0.5670.87
267_R270_E0.5650.87
172_C182_L0.5600.86
166_I169_I0.5590.86
141_M147_T0.5580.86
29_S34_H0.5550.86
148_M154_Y0.5550.86
18_M54_I0.5550.86
57_V82_V0.5550.86
126_L136_V0.5540.86
34_H40_A0.5520.85
205_A208_H0.5510.85
129_A177_I0.5510.85
163_R166_I0.5500.85
48_I92_W0.5470.85
107_A114_I0.5470.85
37_L81_V0.5460.85
139_M187_G0.5450.85
262_T266_M0.5450.85
66_A69_V0.5430.84
163_R167_E0.5420.84
244_V273_L0.5420.84
145_P149_Q0.5410.84
145_P152_P0.5410.84
233_S236_L0.5410.84
158_F199_S0.5400.84
25_P77_R0.5400.84
82_V93_I0.5370.84
224_I242_C0.5360.84
151_A196_H0.5350.84
120_L138_L0.5350.84
230_V237_S0.5340.83
37_L40_A0.5340.83
86_A89_F0.5330.83
126_L175_A0.5330.83
166_I170_A0.5290.83
159_A162_N0.5250.82
112_H135_P0.5190.82
40_A84_A0.5190.82
32_G43_H0.5190.82
254_I266_M0.5170.81
41_V85_I0.5160.81
125_A128_A0.5160.81
138_L182_L0.5150.81
147_T151_A0.5110.81
23_V78_V0.5110.81
81_V84_A0.5100.81
74_E99_K0.5060.80
63_R66_A0.5040.80
204_L208_H0.5030.80
44_A48_I0.5030.80
25_P73_E0.5020.80
223_M242_C0.5020.80
99_K122_E0.5010.79
238_G241_A0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bmbA 1 0.9787 100 0.15 Contact Map
2vp8A 2 0.8191 100 0.162 Contact Map
2vefA 1 0.8901 100 0.178 Contact Map
2dqwA 2 0.8936 100 0.189 Contact Map
1aj0A 1 1 100 0.196 Contact Map
3tr9A 3 0.9645 100 0.196 Contact Map
2y5sA 2 0.9504 100 0.202 Contact Map
1eyeA 2 0.8794 100 0.212 Contact Map
4nirA 3 0.9539 100 0.215 Contact Map
4pzvA 1 0.8794 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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