GREMLIN Database
FRLB - Fructoselysine 6-phosphate deglycase
UniProt: P0AC00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12909
Length: 340 (324)
Sequences: 5522 (3345)
Seq/√Len: 185.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D93_R4.6011.00
124_A137_A4.2231.00
113_E136_A3.6911.00
24_V187_L3.4361.00
22_E26_S3.3881.00
153_L156_C3.0941.00
195_E319_Y2.9851.00
49_F59_A2.9701.00
188_G192_R2.9331.00
116_R138_E2.8401.00
25_L188_G2.7471.00
99_V164_I2.7271.00
24_V162_E2.6301.00
244_S274_T2.4971.00
46_R75_Y2.4841.00
59_A99_V2.4691.00
187_L311_V2.4351.00
98_G112_L2.4121.00
227_G313_M2.3821.00
203_E323_Y2.3761.00
157_Y222_L2.3571.00
114_L117_A2.2861.00
62_A164_I2.1291.00
263_F278_I2.1181.00
45_D91_D2.1001.00
44_I95_A2.0771.00
18_V195_E2.0381.00
322_I328_P2.0141.00
14_T18_V2.0121.00
95_A123_A1.9731.00
189_H192_R1.9721.00
204_L287_N1.9521.00
179_D301_H1.9401.00
228_I239_G1.9091.00
172_E175_K1.8861.00
56_L60_Q1.8851.00
23_K159_V1.8851.00
96_V120_A1.8501.00
100_S133_I1.8481.00
225_K241_V1.8341.00
193_T197_K1.8311.00
112_L133_I1.8211.00
206_S323_Y1.8201.00
78_S243_E1.8141.00
22_E188_G1.7931.00
268_D302_P1.7811.00
63_K67_D1.7621.00
143_Y159_V1.7351.00
66_A74_V1.7161.00
46_R73_Q1.6891.00
157_Y310_F1.6791.00
114_L118_C1.6661.00
182_Q186_A1.6571.00
27_H143_Y1.6571.00
110_K113_E1.6501.00
48_Y94_C1.6391.00
264_L313_M1.6311.00
126_T134_T1.6251.00
196_E199_R1.6251.00
121_L139_F1.6151.00
104_K132_P1.6151.00
129_A142_D1.6041.00
134_T140_S1.6001.00
295_E299_G1.5981.00
220_R225_K1.5651.00
232_M240_C1.5561.00
63_K75_Y1.5371.00
186_A308_L1.5121.00
90_L120_A1.5081.00
47_I95_A1.5011.00
96_V115_G1.5001.00
319_Y323_Y1.4991.00
265_L278_I1.4971.00
91_D94_C1.4851.00
65_L165_T1.4821.00
54_S153_L1.4631.00
20_E158_S1.4611.00
179_D186_A1.4411.00
292_D297_S1.4351.00
124_A133_I1.4331.00
77_I85_N1.4321.00
182_Q185_N1.4261.00
122_T137_A1.4171.00
27_H163_M1.3991.00
209_P258_G1.3891.00
50_V96_V1.3881.00
68_R86_T1.3811.00
190_L308_L1.3801.00
98_G122_T1.3801.00
178_N182_Q1.3721.00
185_N188_G1.3711.00
199_R319_Y1.3701.00
60_Q225_K1.3571.00
47_I97_I1.3441.00
201_L289_I1.3361.00
183_L307_F1.3361.00
209_P256_E1.3231.00
11_F318_Y1.3161.00
178_N181_K1.3161.00
199_R203_E1.3151.00
162_E307_F1.3151.00
169_P172_E1.3011.00
49_F74_V1.2991.00
46_R94_C1.2961.00
71_D88_Y1.2941.00
48_Y82_F1.2811.00
227_G264_L1.2811.00
161_L307_F1.2741.00
265_L271_R1.2611.00
269_E302_P1.2471.00
130_D134_T1.2431.00
106_E110_K1.2331.00
195_E199_R1.2301.00
14_T318_Y1.2161.00
262_L316_L1.2131.00
197_K200_Q1.2011.00
46_R91_D1.2011.00
266_G309_M1.1921.00
205_A316_L1.1881.00
115_G120_A1.1671.00
50_V82_F1.1601.00
248_R280_F1.1551.00
124_A140_S1.1511.00
271_R275_E1.1481.00
26_S29_V1.1441.00
69_F303_W1.1411.00
177_K181_K1.1351.00
125_F164_I1.1341.00
222_L310_F1.1341.00
279_N282_K1.1321.00
315_W319_Y1.1271.00
226_E230_T1.1271.00
82_F90_L1.1241.00
49_F97_I1.1131.00
71_D86_T1.1081.00
12_L15_E1.1081.00
43_D93_R1.1061.00
23_K27_H1.1031.00
190_L193_T1.1031.00
327_N330_E1.0981.00
35_I38_E1.0911.00
219_L305_A1.0891.00
186_A300_L1.0841.00
189_H294_A1.0811.00
316_L320_L1.0681.00
210_M238_H1.0681.00
112_L137_A1.0641.00
37_E40_V1.0591.00
292_D295_E1.0581.00
98_G108_V1.0571.00
281_V286_D1.0571.00
175_K179_D1.0561.00
209_P324_K1.0551.00
116_R122_T1.0521.00
255_V261_F1.0461.00
11_F14_T1.0411.00
278_I288_V1.0391.00
200_Q203_E1.0371.00
214_V247_F1.0341.00
186_A189_H1.0311.00
60_Q76_A1.0261.00
146_D155_L1.0231.00
121_L138_E1.0181.00
321_S326_H1.0171.00
36_V39_M1.0161.00
183_L308_L1.0141.00
52_C79_G1.0110.99
18_V191_V1.0100.99
236_W332_R1.0060.99
261_F281_V1.0060.99
172_E176_I1.0020.99
256_E332_R1.0010.99
264_L309_M0.9950.99
130_D135_S0.9840.99
112_L122_T0.9820.99
116_R136_A0.9650.99
202_G316_L0.9640.99
56_L78_S0.9630.99
52_C105_T0.9600.99
293_Y299_G0.9530.99
261_F286_D0.9520.99
152_H234_F0.9500.99
189_H193_T0.9500.99
219_L309_M0.9490.99
113_E117_A0.9490.99
170_N173_I0.9490.99
98_G115_G0.9470.99
255_V286_D0.9470.99
45_D94_C0.9440.99
25_L29_V0.9420.99
168_A173_I0.9410.99
97_I123_A0.9400.99
25_L181_K0.9370.99
94_C120_A0.9360.99
208_W287_N0.9300.99
173_I177_K0.9290.99
19_Q155_L0.9280.99
175_K301_H0.9220.99
211_I231_L0.9190.99
109_I113_E0.9180.99
213_T231_L0.9070.99
223_G264_L0.9040.99
25_L185_N0.9000.99
52_C246_E0.8950.99
36_V40_V0.8950.99
211_I237_T0.8920.99
14_T195_E0.8910.99
280_F284_R0.8880.99
83_C110_K0.8830.99
170_N174_G0.8830.99
143_Y160_V0.8810.99
44_I121_L0.8810.99
186_A190_L0.8810.99
67_D85_N0.8790.99
212_Y259_V0.8740.99
213_T262_L0.8710.98
214_V281_V0.8640.98
278_I290_V0.8610.98
227_G310_F0.8610.98
318_Y322_I0.8580.98
51_A55_P0.8570.98
267_N271_R0.8530.98
125_F163_M0.8500.98
179_D182_Q0.8490.98
44_I94_C0.8470.98
300_L308_L0.8450.98
294_A297_S0.8440.98
320_L324_K0.8400.98
158_S307_F0.8400.98
217_G270_S0.8350.98
237_T320_L0.8350.98
169_P173_I0.8350.98
11_F322_I0.8320.98
214_V263_F0.8310.98
23_K26_S0.8300.98
129_A140_S0.8290.98
13_V234_F0.8270.98
294_A299_G0.8150.98
291_I312_P0.8140.98
141_I163_M0.8060.98
14_T315_W0.8050.97
174_G178_N0.8040.97
86_T118_C0.8010.97
219_L264_L0.8010.97
165_T176_I0.7990.97
172_E301_H0.7940.97
20_E314_E0.7940.97
247_F252_L0.7910.97
129_A144_Q0.7900.97
109_I132_P0.7880.97
157_Y221_P0.7790.97
50_V111_A0.7770.97
47_I72_L0.7760.97
247_F281_V0.7730.97
166_R173_I0.7730.97
63_K76_A0.7690.97
49_F76_A0.7650.97
185_N189_H0.7620.97
51_A76_A0.7620.97
35_I39_M0.7610.96
54_S226_E0.7610.96
176_I304_L0.7600.96
267_N293_Y0.7580.96
198_G316_L0.7540.96
210_M259_V0.7520.96
242_I251_P0.7520.96
263_F274_T0.7500.96
302_P305_A0.7460.96
257_P285_T0.7440.96
58_A164_I0.7400.96
101_D127_K0.7380.96
166_R169_P0.7370.96
101_D153_L0.7340.96
13_V150_E0.7320.96
281_V288_V0.7320.96
29_V181_K0.7300.96
57_N225_K0.7290.96
12_L149_W0.7240.95
265_L275_E0.7230.95
57_N60_Q0.7170.95
300_L304_L0.7140.95
27_H159_V0.7120.95
148_I155_L0.7100.95
38_E139_F0.7090.95
49_F66_A0.7080.95
132_P136_A0.7070.95
122_T138_E0.7070.95
24_V143_Y0.7050.95
301_H304_L0.7020.94
198_G315_W0.7010.94
230_T253_E0.7010.94
110_K114_L0.6960.94
28_D184_P0.6950.94
271_R292_D0.6940.94
129_A134_T0.6930.94
86_T114_L0.6900.94
134_T142_D0.6900.94
61_T222_L0.6900.94
25_L184_P0.6890.94
166_R170_N0.6880.94
54_S251_P0.6870.94
68_R303_W0.6870.94
308_L311_V0.6850.94
201_L205_A0.6850.94
55_P126_T0.6830.94
21_V191_V0.6810.94
101_D148_I0.6790.93
248_R252_L0.6750.93
265_L274_T0.6740.93
50_V98_G0.6720.93
277_A280_F0.6670.93
113_E135_S0.6670.93
148_I154_L0.6660.93
198_G312_P0.6630.93
22_E25_L0.6630.93
125_F143_Y0.6620.93
174_G182_Q0.6620.93
107_E245_G0.6610.93
48_Y75_Y0.6600.92
43_D121_L0.6600.92
17_M20_E0.6580.92
130_D140_S0.6580.92
54_S229_V0.6570.92
291_I313_M0.6570.92
21_V188_G0.6550.92
54_S230_T0.6520.92
153_L253_E0.6510.92
204_L289_I0.6490.92
275_E279_N0.6490.92
208_W260_P0.6490.92
63_K74_V0.6490.92
48_Y96_V0.6480.92
98_G133_I0.6480.92
131_S134_T0.6480.92
159_V163_M0.6470.92
156_C337_L0.6460.92
211_I262_L0.6450.92
158_S314_E0.6440.92
230_T329_D0.6440.92
123_A141_I0.6430.92
179_D304_L0.6430.92
20_E311_V0.6430.92
158_S311_V0.6410.91
71_D74_V0.6380.91
280_F283_Q0.6370.91
331_R334_Y0.6360.91
200_Q204_L0.6340.91
282_K288_V0.6320.91
213_T227_G0.6260.90
176_I179_D0.6250.90
291_I309_M0.6250.90
175_K178_N0.6240.90
226_E329_D0.6240.90
42_R121_L0.6240.90
32_V181_K0.6200.90
62_A66_A0.6200.90
50_V115_G0.6190.90
205_A211_I0.6180.90
127_K153_L0.6180.90
78_S245_G0.6140.90
237_T324_K0.6110.89
65_L218_P0.6100.89
49_F164_I0.6080.89
219_L266_G0.6080.89
26_S144_Q0.6070.89
107_E248_R0.6060.89
65_L303_W0.6060.89
56_L76_A0.6050.89
149_W330_E0.6050.89
49_F62_A0.6030.89
101_D155_L0.6020.89
167_L173_I0.6010.89
173_I176_I0.6010.89
144_Q147_C0.6010.89
202_G323_Y0.5990.88
235_T326_H0.5970.88
226_E314_E0.5970.88
279_N283_Q0.5970.88
80_W245_G0.5960.88
127_K155_L0.5950.88
80_W216_A0.5940.88
199_R323_Y0.5940.88
187_L307_F0.5940.88
26_S30_P0.5930.88
300_L305_A0.5920.88
293_Y305_A0.5890.88
191_V311_V0.5860.87
197_K201_L0.5860.87
16_N102_Y0.5850.87
19_Q23_K0.5840.87
320_L323_Y0.5820.87
207_Q287_N0.5810.87
126_T162_E0.5810.87
160_V164_I0.5800.87
275_E282_K0.5770.86
154_L314_E0.5760.86
58_A161_L0.5760.86
17_M314_E0.5760.86
265_L290_V0.5760.86
36_V42_R0.5750.86
236_W253_E0.5730.86
226_E229_V0.5730.86
205_A262_L0.5710.86
159_V162_E0.5710.86
98_G137_A0.5710.86
35_I141_I0.5690.86
61_T221_P0.5670.86
34_A181_K0.5650.85
231_L237_T0.5630.85
101_D146_D0.5630.85
56_L79_G0.5620.85
246_E333_Y0.5620.85
222_L264_L0.5620.85
28_D32_V0.5620.85
247_F255_V0.5570.85
41_K44_I0.5550.84
314_E317_C0.5500.84
162_E183_L0.5500.84
150_E156_C0.5490.84
166_R172_E0.5490.84
60_Q221_P0.5480.84
69_F172_E0.5480.84
17_M191_V0.5470.83
71_D87_P0.5470.83
134_T137_A0.5440.83
44_I93_R0.5440.83
71_D167_L0.5430.83
184_P188_G0.5430.83
54_S157_Y0.5430.83
174_G177_K0.5420.83
67_D74_V0.5420.83
20_E187_L0.5420.83
230_T314_E0.5410.83
166_R171_A0.5400.83
47_I74_V0.5400.83
55_P251_P0.5400.83
196_E200_Q0.5400.83
56_L225_K0.5350.82
229_V250_G0.5340.82
329_D334_Y0.5330.82
150_E153_L0.5320.82
248_R335_G0.5320.82
273_T276_R0.5310.82
30_P33_H0.5280.81
67_D73_Q0.5280.81
228_I241_V0.5280.81
28_D162_E0.5270.81
305_A309_M0.5260.81
213_T313_M0.5260.81
215_A261_F0.5250.81
33_H37_E0.5250.81
193_T198_G0.5240.81
154_L226_E0.5240.81
55_P229_V0.5240.81
203_E206_S0.5240.81
133_I140_S0.5240.81
206_S320_L0.5230.81
221_P251_P0.5230.81
156_C160_V0.5230.81
262_L289_I0.5220.81
35_I139_F0.5220.81
86_T269_E0.5200.80
133_I142_D0.5180.80
230_T331_R0.5170.80
238_H254_I0.5170.80
133_I137_A0.5140.80
52_C81_E0.5130.79
196_E325_D0.5130.79
252_L280_F0.5130.79
15_E149_W0.5110.79
213_T244_S0.5110.79
157_Y160_V0.5110.79
130_D142_D0.5110.79
60_Q63_K0.5100.79
175_K197_K0.5100.79
205_A320_L0.5090.79
226_E334_Y0.5080.79
107_E153_L0.5060.78
154_L230_T0.5060.78
79_G105_T0.5040.78
140_S143_Y0.5020.78
145_A159_V0.5020.78
21_V25_L0.5020.78
151_I329_D0.5000.78
54_S115_G0.5000.78
51_A59_A0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zj3A 2 0.9765 100 0.176 Contact Map
1moqA 2 0.9824 100 0.177 Contact Map
3tbfA 2 0.9559 100 0.184 Contact Map
4s1wA 2 0.9471 100 0.184 Contact Map
2pocA 4 0.9412 100 0.185 Contact Map
4amvA 2 0.9912 100 0.199 Contact Map
3fj1A 2 0.9441 100 0.232 Contact Map
3knzA 2 0.8853 100 0.234 Contact Map
2amlA 2 0.9853 100 0.241 Contact Map
1j5xA 2 0.9206 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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