FRLB - ECOLI - GREMLIN Contacts

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FRLB - Fructoselysine 6-phosphate deglycase

UniProt:	P0AC00	Sequences: MLDIDKSTVDFLVTENMVQEVEKVLSHDVPLVHAIVEEMVKRDIDRIYFVACGSPLNAAQTAKHLADRFSDLQVYAISGWEFCDNTPYRLDDRCAVIGVSDYGKTEEVIKALELGRACGALTAAFTKRADSPITSAAEFSIDYQADCIWEIHLLLCYSVVLEMITRLAPNAEIGKIKNDLKQLPNALGHLVRTWEEKGRQLGELASQWPMIYTVAAGPLRPLGYKEGIVTLMEFTWTHGCVIESGEFRHGPLEIVEPGVPFLFLLGNDESRHTTERAINFVKQRTDNVIVIDYAEISQGLHPWLAPFLMFVPMEWLCYYLSIYKDHNPDERRYYGGLVEY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12909
Length:	340 (324)
Sequences:	5522 (3345)
Seq/√Len:	185.9

ECOLI - FRLB GLMS AGAS
BACSU - GLMS FRLB
HALSA - GLMS
SULSO - Q980D3 Q97YQ6 Q97W10 PGMI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
45_D	93_R	4.601	1.00
124_A	137_A	4.223	1.00
113_E	136_A	3.691	1.00
24_V	187_L	3.436	1.00
22_E	26_S	3.388	1.00
153_L	156_C	3.094	1.00
195_E	319_Y	2.985	1.00
49_F	59_A	2.970	1.00
188_G	192_R	2.933	1.00
116_R	138_E	2.840	1.00
25_L	188_G	2.747	1.00
99_V	164_I	2.727	1.00
24_V	162_E	2.630	1.00
244_S	274_T	2.497	1.00
46_R	75_Y	2.484	1.00
59_A	99_V	2.469	1.00
187_L	311_V	2.435	1.00
98_G	112_L	2.412	1.00
227_G	313_M	2.382	1.00
203_E	323_Y	2.376	1.00
157_Y	222_L	2.357	1.00
114_L	117_A	2.286	1.00
62_A	164_I	2.129	1.00
263_F	278_I	2.118	1.00
45_D	91_D	2.100	1.00
44_I	95_A	2.077	1.00
18_V	195_E	2.038	1.00
322_I	328_P	2.014	1.00
14_T	18_V	2.012	1.00
95_A	123_A	1.973	1.00
189_H	192_R	1.972	1.00
204_L	287_N	1.952	1.00
179_D	301_H	1.940	1.00
228_I	239_G	1.909	1.00
172_E	175_K	1.886	1.00
56_L	60_Q	1.885	1.00
23_K	159_V	1.885	1.00
96_V	120_A	1.850	1.00
100_S	133_I	1.848	1.00
225_K	241_V	1.834	1.00
193_T	197_K	1.831	1.00
112_L	133_I	1.821	1.00
206_S	323_Y	1.820	1.00
78_S	243_E	1.814	1.00
22_E	188_G	1.793	1.00
268_D	302_P	1.781	1.00
63_K	67_D	1.762	1.00
143_Y	159_V	1.735	1.00
66_A	74_V	1.716	1.00
46_R	73_Q	1.689	1.00
157_Y	310_F	1.679	1.00
114_L	118_C	1.666	1.00
182_Q	186_A	1.657	1.00
27_H	143_Y	1.657	1.00
110_K	113_E	1.650	1.00
48_Y	94_C	1.639	1.00
264_L	313_M	1.631	1.00
126_T	134_T	1.625	1.00
196_E	199_R	1.625	1.00
121_L	139_F	1.615	1.00
104_K	132_P	1.615	1.00
129_A	142_D	1.604	1.00
134_T	140_S	1.600	1.00
295_E	299_G	1.598	1.00
220_R	225_K	1.565	1.00
232_M	240_C	1.556	1.00
63_K	75_Y	1.537	1.00
186_A	308_L	1.512	1.00
90_L	120_A	1.508	1.00
47_I	95_A	1.501	1.00
96_V	115_G	1.500	1.00
319_Y	323_Y	1.499	1.00
265_L	278_I	1.497	1.00
91_D	94_C	1.485	1.00
65_L	165_T	1.482	1.00
54_S	153_L	1.463	1.00
20_E	158_S	1.461	1.00
179_D	186_A	1.441	1.00
292_D	297_S	1.435	1.00
124_A	133_I	1.433	1.00
77_I	85_N	1.432	1.00
182_Q	185_N	1.426	1.00
122_T	137_A	1.417	1.00
27_H	163_M	1.399	1.00
209_P	258_G	1.389	1.00
50_V	96_V	1.388	1.00
68_R	86_T	1.381	1.00
190_L	308_L	1.380	1.00
98_G	122_T	1.380	1.00
178_N	182_Q	1.372	1.00
185_N	188_G	1.371	1.00
199_R	319_Y	1.370	1.00
60_Q	225_K	1.357	1.00
47_I	97_I	1.344	1.00
201_L	289_I	1.336	1.00
183_L	307_F	1.336	1.00
209_P	256_E	1.323	1.00
11_F	318_Y	1.316	1.00
178_N	181_K	1.316	1.00
199_R	203_E	1.315	1.00
162_E	307_F	1.315	1.00
169_P	172_E	1.301	1.00
49_F	74_V	1.299	1.00
46_R	94_C	1.296	1.00
71_D	88_Y	1.294	1.00
48_Y	82_F	1.281	1.00
227_G	264_L	1.281	1.00
161_L	307_F	1.274	1.00
265_L	271_R	1.261	1.00
269_E	302_P	1.247	1.00
130_D	134_T	1.243	1.00
106_E	110_K	1.233	1.00
195_E	199_R	1.230	1.00
14_T	318_Y	1.216	1.00
262_L	316_L	1.213	1.00
197_K	200_Q	1.201	1.00
46_R	91_D	1.201	1.00
266_G	309_M	1.192	1.00
205_A	316_L	1.188	1.00
115_G	120_A	1.167	1.00
50_V	82_F	1.160	1.00
248_R	280_F	1.155	1.00
124_A	140_S	1.151	1.00
271_R	275_E	1.148	1.00
26_S	29_V	1.144	1.00
69_F	303_W	1.141	1.00
177_K	181_K	1.135	1.00
125_F	164_I	1.134	1.00
222_L	310_F	1.134	1.00
279_N	282_K	1.132	1.00
315_W	319_Y	1.127	1.00
226_E	230_T	1.127	1.00
82_F	90_L	1.124	1.00
49_F	97_I	1.113	1.00
71_D	86_T	1.108	1.00
12_L	15_E	1.108	1.00
43_D	93_R	1.106	1.00
23_K	27_H	1.103	1.00
190_L	193_T	1.103	1.00
327_N	330_E	1.098	1.00
35_I	38_E	1.091	1.00
219_L	305_A	1.089	1.00
186_A	300_L	1.084	1.00
189_H	294_A	1.081	1.00
316_L	320_L	1.068	1.00
210_M	238_H	1.068	1.00
112_L	137_A	1.064	1.00
37_E	40_V	1.059	1.00
292_D	295_E	1.058	1.00
98_G	108_V	1.057	1.00
281_V	286_D	1.057	1.00
175_K	179_D	1.056	1.00
209_P	324_K	1.055	1.00
116_R	122_T	1.052	1.00
255_V	261_F	1.046	1.00
11_F	14_T	1.041	1.00
278_I	288_V	1.039	1.00
200_Q	203_E	1.037	1.00
214_V	247_F	1.034	1.00
186_A	189_H	1.031	1.00
60_Q	76_A	1.026	1.00
146_D	155_L	1.023	1.00
121_L	138_E	1.018	1.00
321_S	326_H	1.017	1.00
36_V	39_M	1.016	1.00
183_L	308_L	1.014	1.00
52_C	79_G	1.011	0.99
18_V	191_V	1.010	0.99
236_W	332_R	1.006	0.99
261_F	281_V	1.006	0.99
172_E	176_I	1.002	0.99
256_E	332_R	1.001	0.99
264_L	309_M	0.995	0.99
130_D	135_S	0.984	0.99
112_L	122_T	0.982	0.99
116_R	136_A	0.965	0.99
202_G	316_L	0.964	0.99
56_L	78_S	0.963	0.99
52_C	105_T	0.960	0.99
293_Y	299_G	0.953	0.99
261_F	286_D	0.952	0.99
152_H	234_F	0.950	0.99
189_H	193_T	0.950	0.99
219_L	309_M	0.949	0.99
113_E	117_A	0.949	0.99
170_N	173_I	0.949	0.99
98_G	115_G	0.947	0.99
255_V	286_D	0.947	0.99
45_D	94_C	0.944	0.99
25_L	29_V	0.942	0.99
168_A	173_I	0.941	0.99
97_I	123_A	0.940	0.99
25_L	181_K	0.937	0.99
94_C	120_A	0.936	0.99
208_W	287_N	0.930	0.99
173_I	177_K	0.929	0.99
19_Q	155_L	0.928	0.99
175_K	301_H	0.922	0.99
211_I	231_L	0.919	0.99
109_I	113_E	0.918	0.99
213_T	231_L	0.907	0.99
223_G	264_L	0.904	0.99
25_L	185_N	0.900	0.99
52_C	246_E	0.895	0.99
36_V	40_V	0.895	0.99
211_I	237_T	0.892	0.99
14_T	195_E	0.891	0.99
280_F	284_R	0.888	0.99
83_C	110_K	0.883	0.99
170_N	174_G	0.883	0.99
143_Y	160_V	0.881	0.99
44_I	121_L	0.881	0.99
186_A	190_L	0.881	0.99
67_D	85_N	0.879	0.99
212_Y	259_V	0.874	0.99
213_T	262_L	0.871	0.98
214_V	281_V	0.864	0.98
278_I	290_V	0.861	0.98
227_G	310_F	0.861	0.98
318_Y	322_I	0.858	0.98
51_A	55_P	0.857	0.98
267_N	271_R	0.853	0.98
125_F	163_M	0.850	0.98
179_D	182_Q	0.849	0.98
44_I	94_C	0.847	0.98
300_L	308_L	0.845	0.98
294_A	297_S	0.844	0.98
320_L	324_K	0.840	0.98
158_S	307_F	0.840	0.98
217_G	270_S	0.835	0.98
237_T	320_L	0.835	0.98
169_P	173_I	0.835	0.98
11_F	322_I	0.832	0.98
214_V	263_F	0.831	0.98
23_K	26_S	0.830	0.98
129_A	140_S	0.829	0.98
13_V	234_F	0.827	0.98
294_A	299_G	0.815	0.98
291_I	312_P	0.814	0.98
141_I	163_M	0.806	0.98
14_T	315_W	0.805	0.97
174_G	178_N	0.804	0.97
86_T	118_C	0.801	0.97
219_L	264_L	0.801	0.97
165_T	176_I	0.799	0.97
172_E	301_H	0.794	0.97
20_E	314_E	0.794	0.97
247_F	252_L	0.791	0.97
129_A	144_Q	0.790	0.97
109_I	132_P	0.788	0.97
157_Y	221_P	0.779	0.97
50_V	111_A	0.777	0.97
47_I	72_L	0.776	0.97
247_F	281_V	0.773	0.97
166_R	173_I	0.773	0.97
63_K	76_A	0.769	0.97
49_F	76_A	0.765	0.97
185_N	189_H	0.762	0.97
51_A	76_A	0.762	0.97
35_I	39_M	0.761	0.96
54_S	226_E	0.761	0.96
176_I	304_L	0.760	0.96
267_N	293_Y	0.758	0.96
198_G	316_L	0.754	0.96
210_M	259_V	0.752	0.96
242_I	251_P	0.752	0.96
263_F	274_T	0.750	0.96
302_P	305_A	0.746	0.96
257_P	285_T	0.744	0.96
58_A	164_I	0.740	0.96
101_D	127_K	0.738	0.96
166_R	169_P	0.737	0.96
101_D	153_L	0.734	0.96
13_V	150_E	0.732	0.96
281_V	288_V	0.732	0.96
29_V	181_K	0.730	0.96
57_N	225_K	0.729	0.96
12_L	149_W	0.724	0.95
265_L	275_E	0.723	0.95
57_N	60_Q	0.717	0.95
300_L	304_L	0.714	0.95
27_H	159_V	0.712	0.95
148_I	155_L	0.710	0.95
38_E	139_F	0.709	0.95
49_F	66_A	0.708	0.95
132_P	136_A	0.707	0.95
122_T	138_E	0.707	0.95
24_V	143_Y	0.705	0.95
301_H	304_L	0.702	0.94
198_G	315_W	0.701	0.94
230_T	253_E	0.701	0.94
110_K	114_L	0.696	0.94
28_D	184_P	0.695	0.94
271_R	292_D	0.694	0.94
129_A	134_T	0.693	0.94
86_T	114_L	0.690	0.94
134_T	142_D	0.690	0.94
61_T	222_L	0.690	0.94
25_L	184_P	0.689	0.94
166_R	170_N	0.688	0.94
54_S	251_P	0.687	0.94
68_R	303_W	0.687	0.94
308_L	311_V	0.685	0.94
201_L	205_A	0.685	0.94
55_P	126_T	0.683	0.94
21_V	191_V	0.681	0.94
101_D	148_I	0.679	0.93
248_R	252_L	0.675	0.93
265_L	274_T	0.674	0.93
50_V	98_G	0.672	0.93
277_A	280_F	0.667	0.93
113_E	135_S	0.667	0.93
148_I	154_L	0.666	0.93
198_G	312_P	0.663	0.93
22_E	25_L	0.663	0.93
125_F	143_Y	0.662	0.93
174_G	182_Q	0.662	0.93
107_E	245_G	0.661	0.93
48_Y	75_Y	0.660	0.92
43_D	121_L	0.660	0.92
17_M	20_E	0.658	0.92
130_D	140_S	0.658	0.92
54_S	229_V	0.657	0.92
291_I	313_M	0.657	0.92
21_V	188_G	0.655	0.92
54_S	230_T	0.652	0.92
153_L	253_E	0.651	0.92
204_L	289_I	0.649	0.92
275_E	279_N	0.649	0.92
208_W	260_P	0.649	0.92
63_K	74_V	0.649	0.92
48_Y	96_V	0.648	0.92
98_G	133_I	0.648	0.92
131_S	134_T	0.648	0.92
159_V	163_M	0.647	0.92
156_C	337_L	0.646	0.92
211_I	262_L	0.645	0.92
158_S	314_E	0.644	0.92
230_T	329_D	0.644	0.92
123_A	141_I	0.643	0.92
179_D	304_L	0.643	0.92
20_E	311_V	0.643	0.92
158_S	311_V	0.641	0.91
71_D	74_V	0.638	0.91
280_F	283_Q	0.637	0.91
331_R	334_Y	0.636	0.91
200_Q	204_L	0.634	0.91
282_K	288_V	0.632	0.91
213_T	227_G	0.626	0.90
176_I	179_D	0.625	0.90
291_I	309_M	0.625	0.90
175_K	178_N	0.624	0.90
226_E	329_D	0.624	0.90
42_R	121_L	0.624	0.90
32_V	181_K	0.620	0.90
62_A	66_A	0.620	0.90
50_V	115_G	0.619	0.90
205_A	211_I	0.618	0.90
127_K	153_L	0.618	0.90
78_S	245_G	0.614	0.90
237_T	324_K	0.611	0.89
65_L	218_P	0.610	0.89
49_F	164_I	0.608	0.89
219_L	266_G	0.608	0.89
26_S	144_Q	0.607	0.89
107_E	248_R	0.606	0.89
65_L	303_W	0.606	0.89
56_L	76_A	0.605	0.89
149_W	330_E	0.605	0.89
49_F	62_A	0.603	0.89
101_D	155_L	0.602	0.89
167_L	173_I	0.601	0.89
173_I	176_I	0.601	0.89
144_Q	147_C	0.601	0.89
202_G	323_Y	0.599	0.88
235_T	326_H	0.597	0.88
226_E	314_E	0.597	0.88
279_N	283_Q	0.597	0.88
80_W	245_G	0.596	0.88
127_K	155_L	0.595	0.88
80_W	216_A	0.594	0.88
199_R	323_Y	0.594	0.88
187_L	307_F	0.594	0.88
26_S	30_P	0.593	0.88
300_L	305_A	0.592	0.88
293_Y	305_A	0.589	0.88
191_V	311_V	0.586	0.87
197_K	201_L	0.586	0.87
16_N	102_Y	0.585	0.87
19_Q	23_K	0.584	0.87
320_L	323_Y	0.582	0.87
207_Q	287_N	0.581	0.87
126_T	162_E	0.581	0.87
160_V	164_I	0.580	0.87
275_E	282_K	0.577	0.86
154_L	314_E	0.576	0.86
58_A	161_L	0.576	0.86
17_M	314_E	0.576	0.86
265_L	290_V	0.576	0.86
36_V	42_R	0.575	0.86
236_W	253_E	0.573	0.86
226_E	229_V	0.573	0.86
205_A	262_L	0.571	0.86
159_V	162_E	0.571	0.86
98_G	137_A	0.571	0.86
35_I	141_I	0.569	0.86
61_T	221_P	0.567	0.86
34_A	181_K	0.565	0.85
231_L	237_T	0.563	0.85
101_D	146_D	0.563	0.85
56_L	79_G	0.562	0.85
246_E	333_Y	0.562	0.85
222_L	264_L	0.562	0.85
28_D	32_V	0.562	0.85
247_F	255_V	0.557	0.85
41_K	44_I	0.555	0.84
314_E	317_C	0.550	0.84
162_E	183_L	0.550	0.84
150_E	156_C	0.549	0.84
166_R	172_E	0.549	0.84
60_Q	221_P	0.548	0.84
69_F	172_E	0.548	0.84
17_M	191_V	0.547	0.83
71_D	87_P	0.547	0.83
134_T	137_A	0.544	0.83
44_I	93_R	0.544	0.83
71_D	167_L	0.543	0.83
184_P	188_G	0.543	0.83
54_S	157_Y	0.543	0.83
174_G	177_K	0.542	0.83
67_D	74_V	0.542	0.83
20_E	187_L	0.542	0.83
230_T	314_E	0.541	0.83
166_R	171_A	0.540	0.83
47_I	74_V	0.540	0.83
55_P	251_P	0.540	0.83
196_E	200_Q	0.540	0.83
56_L	225_K	0.535	0.82
229_V	250_G	0.534	0.82
329_D	334_Y	0.533	0.82
150_E	153_L	0.532	0.82
248_R	335_G	0.532	0.82
273_T	276_R	0.531	0.82
30_P	33_H	0.528	0.81
67_D	73_Q	0.528	0.81
228_I	241_V	0.528	0.81
28_D	162_E	0.527	0.81
305_A	309_M	0.526	0.81
213_T	313_M	0.526	0.81
215_A	261_F	0.525	0.81
33_H	37_E	0.525	0.81
193_T	198_G	0.524	0.81
154_L	226_E	0.524	0.81
55_P	229_V	0.524	0.81
203_E	206_S	0.524	0.81
133_I	140_S	0.524	0.81
206_S	320_L	0.523	0.81
221_P	251_P	0.523	0.81
156_C	160_V	0.523	0.81
262_L	289_I	0.522	0.81
35_I	139_F	0.522	0.81
86_T	269_E	0.520	0.80
133_I	142_D	0.518	0.80
230_T	331_R	0.517	0.80
238_H	254_I	0.517	0.80
133_I	137_A	0.514	0.80
52_C	81_E	0.513	0.79
196_E	325_D	0.513	0.79
252_L	280_F	0.513	0.79
15_E	149_W	0.511	0.79
213_T	244_S	0.511	0.79
157_Y	160_V	0.511	0.79
130_D	142_D	0.511	0.79
60_Q	63_K	0.510	0.79
175_K	197_K	0.510	0.79
205_A	320_L	0.509	0.79
226_E	334_Y	0.508	0.79
107_E	153_L	0.506	0.78
154_L	230_T	0.506	0.78
79_G	105_T	0.504	0.78
140_S	143_Y	0.502	0.78
145_A	159_V	0.502	0.78
21_V	25_L	0.502	0.78
151_I	329_D	0.500	0.78
54_S	115_G	0.500	0.78
51_A	59_A	0.500	0.78

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zj3A	2	0.9765	100	0.176	Contact Map
1moqA	2	0.9824	100	0.177	Contact Map
3tbfA	2	0.9559	100	0.184	Contact Map
4s1wA	2	0.9471	100	0.184	Contact Map
2pocA	4	0.9412	100	0.185	Contact Map
4amvA	2	0.9912	100	0.199	Contact Map
3fj1A	2	0.9441	100	0.232	Contact Map
3knzA	2	0.8853	100	0.234	Contact Map
2amlA	2	0.9853	100	0.241	Contact Map
1j5xA	2	0.9206	100	0.244	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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