GREMLIN Database
SURA - Chaperone SurA
UniProt: P0ABZ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10985
Length: 428 (391)
Sequences: 942 (827)
Seq/√Len: 41.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_A71_M4.9271.00
250_A256_V4.5691.00
93_D133_R4.0391.00
203_V207_R4.0251.00
95_Q140_E3.6521.00
289_H293_K3.6441.00
290_I293_K3.5371.00
173_E274_R3.3371.00
33_N82_Q3.2011.00
289_H292_L3.1671.00
196_E200_R3.1441.00
251_K254_D3.0541.00
237_Q244_A3.0141.00
241_G245_Q2.9641.00
290_I294_P2.9411.00
160_L164_V2.7861.00
205_Q210_A2.7211.00
162_Q165_G2.7091.00
114_M129_R2.5901.00
289_H294_P2.5611.00
216_A229_G2.5191.00
290_I295_S2.3741.00
117_R121_D2.3581.00
371_S374_G2.2731.00
192_V260_R2.2271.00
220_S229_G2.2271.00
156_E405_K2.1961.00
289_H295_S2.1580.99
91_I137_I2.1570.99
92_S95_Q2.1540.99
320_T323_A2.0960.99
110_T113_Q2.0870.99
49_V70_I2.0830.99
261_S264_G2.0760.99
233_W272_D2.0290.99
158_E282_V2.0250.99
14_I18_S2.0250.99
12_A16_N1.9810.99
202_I215_L1.9700.99
212_F232_G1.9700.99
181_I195_A1.9540.99
212_F220_S1.9470.99
233_W274_R1.9340.99
10_G14_I1.9300.99
157_V282_V1.9100.99
177_S271_N1.9080.99
83_M86_K1.9060.99
360_L366_S1.8930.99
291_L295_S1.8930.99
113_Q116_S1.8870.99
203_V257_G1.8580.98
30_A75_I1.8510.98
9_L13_M1.8460.98
236_I248_S1.8260.98
220_S228_G1.8190.98
212_F216_A1.8190.98
288_R293_K1.8180.98
164_V167_Q1.7860.98
250_A270_V1.7850.98
356_A359_R1.7850.98
212_F222_D1.7810.98
311_A315_K1.7570.98
247_L268_L1.7450.98
361_N364_Q1.7450.98
261_S266_H1.7270.97
175_N271_N1.7160.97
289_H296_P1.7110.97
97_D129_R1.7100.97
33_N79_I1.7060.97
154_P158_E1.6980.97
212_F228_G1.6960.97
396_R399_R1.6910.97
301_E305_V1.6840.97
45_L77_D1.6800.97
281_S285_V1.6680.97
260_R265_F1.6590.97
196_E260_R1.6460.97
234_G239_L1.6180.96
281_S284_E1.5930.96
141_V413_W1.5820.96
206_A267_I1.5550.95
103_I107_N1.5530.95
189_S193_N1.5460.95
240_P263_V1.5460.95
71_M75_I1.5210.95
140_E143_N1.5190.95
288_R291_L1.5120.94
195_A199_A1.4950.94
203_V258_P1.4920.94
8_L18_S1.4790.94
232_G284_E1.4620.93
174_L248_S1.4530.93
282_V285_V1.4500.93
216_A220_S1.4390.93
77_D80_I1.4310.93
178_H266_H1.4280.93
225_A229_G1.4160.92
158_E394_K1.4070.92
252_K272_D1.4050.92
11_I18_S1.3960.92
175_N272_D1.3950.92
35_G82_Q1.3710.91
382_D405_K1.3680.91
288_R292_L1.3680.91
45_L49_V1.3680.91
179_I267_I1.3630.91
298_M301_E1.3560.91
180_L264_G1.3530.90
294_P298_M1.3360.90
15_A18_S1.3290.90
99_A102_N1.3290.90
255_I269_K1.3260.89
197_S200_R1.3250.89
401_L404_R1.3230.89
112_D115_R1.3150.89
11_I14_I1.3140.89
114_M240_P1.3090.89
13_M17_T1.3080.89
118_L121_D1.2920.88
191_Q194_E1.2900.88
222_D266_H1.2880.88
254_D269_K1.2690.87
159_S163_Q1.2660.87
103_I109_M1.2600.87
289_H300_D1.2470.86
154_P282_V1.2380.86
13_M18_S1.2330.86
197_S219_H1.2290.86
10_G16_N1.2260.85
129_R133_R1.2230.85
197_S201_A1.2190.85
408_E412_S1.2170.85
404_R407_S1.2150.85
158_E162_Q1.2120.85
28_V36_V1.2070.84
204_D207_R1.2030.84
294_P300_D1.1880.84
294_P297_I1.1760.83
46_M50_K1.1750.83
13_M16_N1.1750.83
224_Q228_G1.1740.83
212_F229_G1.1730.83
243_F285_V1.1710.83
214_K218_A1.1670.82
29_A32_V1.1650.82
35_G85_Q1.1600.82
216_A228_G1.1550.82
291_L294_P1.1530.82
380_L383_T1.1500.81
84_G141_V1.1490.81
408_E411_A1.1470.81
111_L115_R1.1420.81
353_F366_S1.1370.81
202_I206_A1.1330.81
42_V71_M1.1320.80
180_L266_H1.1310.80
231_M234_G1.1270.80
288_R295_S1.1190.80
231_M259_I1.1170.80
288_R294_P1.1120.79
173_E235_R1.1090.79
307_L311_A1.1010.79
26_D38_L1.1000.78
141_V173_E1.0980.78
84_G137_I1.0900.78
37_V198_Q1.0860.78
263_V266_H1.0830.77
222_D228_G1.0830.77
342_G347_D1.0820.77
397_A404_R1.0790.77
243_F268_L1.0780.77
178_H243_F1.0760.77
203_V256_V1.0720.77
87_M141_V1.0640.76
35_G78_Q1.0640.76
293_K296_P1.0530.75
178_H263_V1.0510.75
366_S378_I1.0450.75
284_E288_R1.0420.75
321_F325_A1.0400.74
125_Y129_R1.0380.74
259_I266_H1.0340.74
292_L296_P1.0280.74
360_L380_L1.0260.73
243_F266_H1.0250.73
282_V286_H1.0170.73
216_A222_D1.0060.72
60_L63_D1.0020.72
45_L48_S1.0010.72
73_R77_D0.9980.71
344_A347_D0.9960.71
240_P243_F0.9930.71
105_K139_S0.9930.71
161_A282_V0.9930.71
283_T286_H0.9930.71
201_A205_Q0.9920.71
132_I179_I0.9830.70
206_A215_L0.9780.70
209_G232_G0.9750.70
83_M87_M0.9730.69
239_L243_F0.9720.69
42_V46_M0.9700.69
31_V36_V0.9690.69
103_I106_Q0.9680.69
153_L156_E0.9640.69
51_L139_S0.9600.68
179_I216_A0.9600.68
193_N197_S0.9540.68
404_R408_E0.9530.68
91_I96_L0.9530.68
12_A18_S0.9520.68
403_N407_S0.9490.67
178_H239_L0.9480.67
37_V96_L0.9460.67
309_Q313_D0.9460.67
182_P221_A0.9450.67
76_M80_I0.9440.67
156_E298_M0.9330.66
194_E198_Q0.9230.65
189_S192_V0.9190.65
212_F231_M0.9180.65
305_V309_Q0.9180.65
349_F353_F0.9110.64
394_K401_L0.9110.64
313_D318_K0.9100.64
138_I317_G0.9090.64
91_I136_M0.9090.64
259_I268_L0.9070.64
105_K109_M0.9040.64
246_A259_I0.9030.64
108_N241_G0.8970.63
9_L14_I0.8950.63
255_I258_P0.8930.63
201_A253_G0.8930.63
230_Q233_W0.8900.62
26_D40_S0.8870.62
225_A228_G0.8840.62
8_L12_A0.8790.61
91_I259_I0.8770.61
296_P300_D0.8750.61
92_S110_T0.8730.61
152_I157_V0.8720.61
6_T18_S0.8690.61
63_D215_L0.8650.60
356_A360_L0.8630.60
31_V34_N0.8620.60
9_L19_F0.8610.60
175_N230_Q0.8610.60
295_S303_A0.8600.60
196_E258_P0.8600.60
204_D208_N0.8540.59
290_I300_D0.8520.59
203_V255_I0.8520.59
20_A23_Q0.8450.58
6_T11_I0.8410.58
15_A81_L0.8370.58
213_G269_K0.8340.57
96_L160_L0.8340.57
58_Q64_A0.8330.57
179_I229_G0.8290.57
154_P286_H0.8290.57
338_G341_L0.8270.57
118_L128_Y0.8230.56
7_L17_T0.8210.56
386_V398_Y0.8200.56
11_I153_L0.8190.56
9_L16_N0.8130.55
212_F383_T0.8120.55
401_L406_F0.8110.55
66_L258_P0.8100.55
211_D214_K0.8080.55
350_D353_F0.8080.55
224_Q229_G0.8040.55
307_L314_I0.8020.54
304_R308_E0.7970.54
397_A401_L0.7970.54
37_V102_N0.7950.54
175_N233_W0.7930.54
344_A378_I0.7920.53
243_F247_L0.7900.53
212_F267_I0.7880.53
343_W380_L0.7850.53
250_A257_G0.7840.53
203_V267_I0.7820.53
132_I266_H0.7820.53
32_V75_I0.7820.53
101_A328_F0.7820.53
7_L16_N0.7790.52
81_L138_I0.7780.52
91_I260_R0.7780.52
316_S365_M0.7760.52
311_A316_S0.7760.52
404_R412_S0.7750.52
6_T13_M0.7720.52
82_Q259_I0.7710.52
100_I115_R0.7710.52
181_I202_I0.7700.51
216_A223_Q0.7690.51
188_T191_Q0.7690.51
126_N129_R0.7680.51
297_I300_D0.7680.51
100_I317_G0.7670.51
247_L261_S0.7610.51
403_N408_E0.7590.50
267_I368_P0.7590.50
321_F324_A0.7570.50
128_Y399_R0.7560.50
6_T311_A0.7560.50
128_Y297_I0.7540.50
235_R238_E0.7520.50
179_I220_S0.7440.49
307_L310_I0.7430.49
217_I309_Q0.7430.49
100_I109_M0.7400.49
94_E98_Q0.7400.49
302_Q306_K0.7380.48
271_N322_A0.7370.48
107_N307_L0.7360.48
222_D243_F0.7350.48
43_D67_R0.7330.48
45_L74_L0.7310.48
136_M139_S0.7270.47
8_L19_F0.7270.47
8_L322_A0.7270.47
12_A15_A0.7260.47
409_E414_M0.7190.47
33_N75_I0.7190.47
44_G146_V0.7170.46
400_M407_S0.7160.46
108_N114_M0.7160.46
398_Y412_S0.7160.46
84_G134_K0.7140.46
326_K401_L0.7140.46
41_D45_L0.7130.46
193_N201_A0.7130.46
304_R307_L0.7110.46
289_H297_I0.7080.46
131_Q134_K0.7070.46
191_Q195_A0.7070.46
303_A306_K0.7070.46
6_T276_E0.7040.45
210_A215_L0.7030.45
135_E217_I0.7030.45
399_R402_M0.7020.45
6_T17_T0.7020.45
97_D101_A0.6990.45
109_M114_M0.6980.45
212_F215_L0.6970.45
104_A108_N0.6960.45
32_V37_V0.6950.44
396_R414_M0.6950.44
163_Q237_Q0.6940.44
82_Q86_K0.6940.44
151_T155_Q0.6930.44
192_V196_E0.6930.44
26_D88_G0.6920.44
103_I118_L0.6920.44
377_L397_A0.6920.44
274_R374_G0.6920.44
301_E306_K0.6910.44
61_P64_A0.6880.44
245_Q326_K0.6880.44
114_M118_L0.6880.44
34_N73_R0.6830.43
32_V79_I0.6800.43
44_G48_S0.6800.43
325_A363_G0.6780.43
33_N83_M0.6780.43
133_R140_E0.6770.43
27_K380_L0.6770.43
161_A165_G0.6760.43
199_A202_I0.6740.42
49_V73_R0.6720.42
240_P244_A0.6710.42
202_I241_G0.6710.42
373_F380_L0.6700.42
387_D413_W0.6690.42
96_L136_M0.6690.42
293_K375_W0.6680.42
12_A17_T0.6630.41
107_N117_R0.6580.41
362_K374_G0.6570.41
130_N134_K0.6570.41
72_E211_D0.6560.41
411_A414_M0.6510.40
29_A341_L0.6490.40
50_K140_E0.6490.40
387_D394_K0.6490.40
92_S358_T0.6480.40
400_M404_R0.6470.40
216_A233_W0.6450.40
396_R408_E0.6450.40
11_I148_R0.6440.40
105_K110_T0.6440.40
54_A58_Q0.6440.40
250_A254_D0.6420.40
24_V133_R0.6420.40
7_L20_A0.6420.40
128_Y290_I0.6420.40
220_S233_W0.6390.39
230_Q237_Q0.6390.39
134_K137_I0.6380.39
93_D97_D0.6370.39
38_L243_F0.6340.39
385_N402_M0.6330.39
157_V227_N0.6320.39
103_I113_Q0.6310.39
150_I257_G0.6300.39
395_D398_Y0.6300.39
399_R407_S0.6280.38
10_G13_M0.6280.38
46_M70_I0.6280.38
367_A370_H0.6270.38
130_N133_R0.6240.38
5_K197_S0.6220.38
65_T72_E0.6220.38
243_F256_V0.6210.38
310_I314_I0.6200.38
305_V308_E0.6200.38
96_L295_S0.6170.37
88_G141_V0.6170.37
292_L295_S0.6160.37
83_M256_V0.6160.37
18_S285_V0.6150.37
139_S372_S0.6140.37
30_A82_Q0.6140.37
41_D131_Q0.6120.37
176_L239_L0.6100.37
256_V268_L0.6100.37
105_K143_N0.6100.37
112_D242_I0.6080.37
310_I324_A0.6070.36
176_L270_V0.6070.36
146_V275_G0.6060.36
286_H291_L0.6030.36
137_I141_V0.6010.36
10_G17_T0.6010.36
14_I197_S0.5980.36
231_M263_V0.5960.36
151_T398_Y0.5950.35
28_V106_Q0.5940.35
94_E346_P0.5940.35
104_A107_N0.5930.35
237_Q284_E0.5930.35
116_S120_Y0.5930.35
104_A109_M0.5930.35
355_D380_L0.5920.35
190_D193_N0.5920.35
70_I300_D0.5910.35
138_I381_L0.5910.35
249_T284_E0.5900.35
208_N251_K0.5880.35
11_I166_N0.5880.35
360_L364_Q0.5860.35
114_M128_Y0.5850.35
303_A314_I0.5840.35
400_M403_N0.5840.35
196_E199_A0.5830.34
96_L107_N0.5830.34
172_T273_L0.5790.34
104_A114_M0.5790.34
89_V144_N0.5780.34
209_G215_L0.5780.34
153_L281_S0.5780.34
5_K9_L0.5770.34
249_T345_T0.5760.34
10_G29_A0.5760.34
100_I129_R0.5750.34
38_L48_S0.5740.34
250_A269_K0.5740.34
285_V288_R0.5740.34
399_R403_N0.5740.34
70_I265_F0.5730.34
57_R61_P0.5730.34
252_K397_A0.5710.33
293_K310_I0.5700.33
373_F402_M0.5700.33
7_L11_I0.5700.33
38_L87_M0.5700.33
321_F329_S0.5690.33
41_D74_L0.5690.33
258_P305_V0.5680.33
378_I383_T0.5660.33
140_E156_E0.5650.33
9_L108_N0.5650.33
206_A255_I0.5650.33
42_V67_R0.5650.33
38_L88_G0.5650.33
362_K366_S0.5630.33
224_Q227_N0.5620.33
154_P306_K0.5620.33
297_I301_E0.5620.33
19_F22_P0.5600.33
155_Q259_I0.5590.32
364_Q379_E0.5580.32
146_V149_R0.5580.32
95_Q144_N0.5580.32
155_Q159_S0.5580.32
118_L122_G0.5570.32
93_D158_E0.5570.32
126_N352_A0.5560.32
96_L258_P0.5550.32
118_L365_M0.5540.32
92_S136_M0.5540.32
282_V294_P0.5540.32
134_K270_V0.5540.32
382_D385_N0.5530.32
48_S52_N0.5530.32
97_D110_T0.5520.32
206_A209_G0.5520.32
87_M161_A0.5520.32
295_S299_T0.5500.32
107_N114_M0.5500.32
306_K310_I0.5500.32
29_A149_R0.5490.32
237_Q247_L0.5490.32
305_V314_I0.5490.32
179_I233_W0.5490.32
81_L366_S0.5450.31
160_L183_L0.5450.31
208_N214_K0.5440.31
152_I351_P0.5430.31
398_Y401_L0.5430.31
372_S379_E0.5410.31
176_L208_N0.5400.31
181_I198_Q0.5390.31
35_G92_S0.5390.31
354_R358_T0.5390.31
399_R405_K0.5380.31
173_E247_L0.5370.31
75_I354_R0.5370.31
156_E328_F0.5360.31
33_N314_I0.5360.31
14_I166_N0.5360.31
42_V70_I0.5360.31
164_V168_N0.5350.30
250_A343_W0.5340.30
129_R311_A0.5310.30
91_I95_Q0.5310.30
50_K137_I0.5300.30
107_N110_T0.5300.30
359_R397_A0.5290.30
259_I265_F0.5290.30
202_I267_I0.5280.30
52_N227_N0.5270.30
167_Q254_D0.5260.30
348_I353_F0.5230.30
81_L134_K0.5230.30
88_G143_N0.5230.30
36_V81_L0.5220.29
58_Q63_D0.5220.29
74_L154_P0.5210.29
398_Y402_M0.5200.29
154_P327_E0.5190.29
75_I298_M0.5190.29
345_T348_I0.5190.29
98_Q265_F0.5180.29
190_D312_A0.5180.29
232_G272_D0.5170.29
21_A267_I0.5160.29
25_V355_D0.5150.29
132_I136_M0.5150.29
81_L115_R0.5140.29
166_N170_A0.5130.29
295_S310_I0.5120.29
209_G274_R0.5110.29
138_I178_H0.5110.29
57_R89_V0.5100.29
133_R316_S0.5090.28
8_L16_N0.5090.28
252_K270_V0.5080.28
242_I268_L0.5080.28
230_Q272_D0.5070.28
244_A377_L0.5060.28
343_W346_P0.5060.28
71_M344_A0.5060.28
131_Q219_H0.5060.28
94_E344_A0.5060.28
91_I249_T0.5050.28
396_R405_K0.5050.28
155_Q284_E0.5040.28
303_A307_L0.5030.28
209_G221_A0.5020.28
66_L70_I0.5020.28
116_S312_A0.5010.28
240_P268_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m5yA 1 0.9042 100 0.247 Contact Map
3nrkA 3 0.7009 100 0.46 Contact Map
3rgcA 2 0.5864 100 0.508 Contact Map
4wo7A 2 0.5888 100 0.537 Contact Map
3rfwA 2 0.5701 100 0.544 Contact Map
1yw5A 1 0.3645 99.9 0.688 Contact Map
3tc5A 1 0.3131 99.9 0.725 Contact Map
3i6cA 1 0.2407 99.9 0.733 Contact Map
2pv1A 1 0.2407 99.9 0.736 Contact Map
2mntA 1 0.2383 99.9 0.738 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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