GREMLIN Database
KDSC - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
UniProt: P0ABZ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12804
Length: 188 (162)
Sequences: 1962 (1400)
Seq/√Len: 110.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_S154_D3.3401.00
57_R144_D3.2201.00
45_G49_E2.8461.00
41_L53_A2.7561.00
106_F117_P2.7431.00
110_L117_P2.5111.00
133_M153_A2.4841.00
30_I73_A2.4121.00
160_A163_R2.3741.00
140_V169_V2.3341.00
31_L166_V2.2771.00
110_L120_V2.2411.00
101_N104_I2.2201.00
130_W149_L2.2121.00
74_I87_C2.1951.00
94_H113_L2.1791.00
133_M139_S2.1651.00
65_A170_C2.1611.00
27_R119_N2.1331.00
43_Y53_A2.1101.00
141_A145_A2.0721.00
71_E93_T1.9991.00
140_V157_T1.9371.00
158_R168_E1.8711.00
96_Y105_A1.7761.00
30_I106_F1.7461.00
84_E88_A1.7131.00
107_S135_K1.6661.00
85_D88_A1.6421.00
108_D112_K1.6351.00
81_K84_E1.6261.00
123_V169_V1.6091.00
22_K154_D1.5921.00
23_A138_L1.5631.00
65_A70_I1.5541.00
99_Q105_A1.5471.00
45_G51_L1.5471.00
174_L179_K1.4601.00
106_F110_L1.4021.00
103_L135_K1.4021.00
94_H112_K1.3821.00
78_R89_T1.3711.00
41_L163_R1.3441.00
106_F132_V1.3291.00
25_N118_E1.3261.00
31_L123_V1.2980.99
71_E94_H1.2850.99
116_A119_N1.2740.99
71_E113_L1.2690.99
175_L180_L1.2680.99
42_I56_V1.2660.99
123_V165_A1.2660.99
76_T97_Q1.2270.99
121_A169_V1.2230.99
59_G86_R1.2180.99
31_L72_V1.2010.99
115_I120_V1.1940.99
134_E152_R1.1880.99
130_W152_R1.1750.99
41_L55_N1.1700.99
84_E97_Q1.1670.99
148_L175_L1.1550.99
122_Y132_V1.1530.99
29_L121_A1.1500.99
63_R67_T1.1390.98
148_L180_L1.1280.98
159_I168_E1.0700.98
146_H171_D1.0700.98
23_A172_L1.0520.97
68_S174_L1.0500.97
171_D180_L1.0450.97
39_D53_A1.0410.97
110_L115_I1.0350.97
25_N119_N1.0310.97
26_I138_L1.0240.97
86_R90_L1.0050.97
28_L109_L0.9960.96
66_L72_V0.9920.96
149_L152_R0.9820.96
150_I156_V0.9800.96
44_M89_T0.9700.96
142_V165_A0.9640.96
79_K84_E0.9620.96
139_S153_A0.9620.96
62_I72_V0.9610.96
107_S111_E0.9580.96
109_L113_L0.9520.95
29_L65_A0.9510.95
157_T168_E0.9500.95
63_R66_L0.9450.95
37_L166_V0.9450.95
96_Y99_Q0.9440.95
70_I174_L0.9420.95
75_I96_Y0.9400.95
105_A108_D0.9400.95
37_L62_I0.9390.95
87_C97_Q0.9390.95
55_N163_R0.9200.95
148_L152_R0.9080.94
39_D163_R0.9060.94
144_D160_A0.9050.94
29_L70_I0.9020.94
87_C95_L0.8970.94
107_S117_P0.8950.94
155_Y172_L0.8900.93
103_L107_S0.8890.93
121_A140_V0.8840.93
85_D89_T0.8830.93
31_L37_L0.8800.93
132_V136_V0.8760.93
117_P135_K0.8750.93
40_G54_F0.8650.92
73_A109_L0.8630.92
21_A24_E0.8590.92
144_D163_R0.8580.92
29_L170_C0.8470.92
143_A160_A0.8430.92
29_L62_I0.8250.91
30_I109_L0.8250.91
123_V142_V0.8130.90
29_L169_V0.8130.90
81_K85_D0.8110.90
44_M85_D0.8110.90
46_N82_L0.8000.89
123_V157_T0.7990.89
62_I170_C0.7980.89
60_Y128_I0.7920.89
107_S110_L0.7910.89
43_Y51_L0.7860.88
59_G90_L0.7770.88
96_Y108_D0.7770.88
42_I78_R0.7750.88
142_V157_T0.7740.88
123_V166_V0.7720.88
141_A153_A0.7710.87
87_C92_I0.7670.87
63_R91_G0.7670.87
61_G170_C0.7580.87
80_A83_V0.7520.86
76_T83_V0.7520.86
52_K125_D0.7510.86
20_I24_E0.7320.85
33_V37_L0.7290.84
144_D161_G0.7250.84
70_I170_C0.7240.84
147_P150_I0.7230.84
46_N81_K0.7230.84
136_V139_S0.7210.84
123_V140_V0.7200.84
147_P151_P0.7190.84
84_E95_L0.7190.84
29_L166_V0.7110.83
82_L97_Q0.7100.83
103_L132_V0.7040.82
121_A138_L0.7020.82
139_S142_V0.7020.82
28_L115_I0.7010.82
66_L93_T0.6990.82
61_G70_I0.6920.81
126_D167_R0.6890.81
57_R146_H0.6880.81
120_V137_G0.6850.80
28_L71_E0.6850.80
50_E82_L0.6790.80
63_R100_S0.6730.79
75_I106_F0.6720.79
122_Y136_V0.6570.78
66_L91_G0.6570.78
104_I107_S0.6550.77
149_L153_A0.6530.77
74_I95_L0.6520.77
36_V143_A0.6480.77
141_A144_D0.6450.76
60_Y64_C0.6420.76
68_S177_Q0.6390.76
79_K97_Q0.6390.76
57_R159_I0.6290.75
44_M54_F0.6270.74
108_D111_E0.6250.74
26_I121_A0.6200.74
70_I179_K0.6180.73
122_Y133_M0.6180.73
110_L116_A0.6170.73
141_A156_V0.6130.73
150_I159_I0.6100.72
21_A25_N0.6090.72
68_S179_K0.6090.72
70_I173_L0.6080.72
155_Y169_V0.6040.72
63_R128_I0.6010.71
62_I166_V0.6000.71
28_L73_A0.5950.70
76_T82_L0.5930.70
127_L180_L0.5900.70
28_L113_L0.5880.70
52_K78_R0.5830.69
52_K77_G0.5820.69
133_M141_A0.5820.69
82_L89_T0.5750.68
96_Y109_L0.5740.68
33_V54_F0.5740.68
37_L87_C0.5710.67
77_G125_D0.5700.67
30_I132_V0.5660.67
33_V83_V0.5650.67
28_L120_V0.5620.66
143_A158_R0.5610.66
41_L51_L0.5580.66
88_A93_T0.5550.65
52_K80_A0.5550.65
155_Y158_R0.5550.65
62_I66_L0.5540.65
140_V155_Y0.5520.65
143_A150_I0.5500.64
103_L131_P0.5480.64
45_G50_E0.5430.63
61_G167_R0.5420.63
166_V170_C0.5400.63
132_V135_K0.5390.63
36_V141_A0.5370.63
22_K137_G0.5260.61
61_G142_V0.5240.61
110_L132_V0.5230.61
32_D125_D0.5230.61
78_R97_Q0.5220.60
36_V142_V0.5220.60
50_E78_R0.5220.60
94_H109_L0.5210.60
131_P134_E0.5210.60
30_I122_Y0.5210.60
28_L70_I0.5190.60
60_Y78_R0.5150.59
79_K98_G0.5140.59
53_A163_R0.5140.59
127_L148_L0.5130.59
94_H115_I0.5130.59
150_I158_R0.5120.59
56_V59_G0.5080.58
145_A149_L0.5060.58
169_V172_L0.5040.58
56_V89_T0.5040.58
64_C174_L0.5030.58
83_V97_Q0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r8eA 5 0.9628 100 0.555 Contact Map
3n07A 3 0.9521 100 0.558 Contact Map
3ij5A 4 0.9894 100 0.561 Contact Map
3n1uA 3 0.9574 100 0.566 Contact Map
4navD 3 0.9628 100 0.573 Contact Map
4um7A 3 0.9309 100 0.582 Contact Map
3ewiA 3 0.8351 100 0.584 Contact Map
1k1eA 5 0.8989 100 0.584 Contact Map
4hgnA 3 0.8777 100 0.585 Contact Map
3mn1A 4 0.9574 100 0.589 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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