GREMLIN Database
FLHC - Flagellar transcriptional regulator FlhC
UniProt: P0ABY7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10319
Length: 192 (171)
Sequences: 242 (126)
Seq/√Len: 9.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_A151_P3.0560.93
42_K95_V2.5290.83
77_C162_P2.5280.83
6_I28_M2.4050.80
122_T125_R2.2680.76
19_L37_R2.1710.72
15_L93_D2.1310.71
100_R162_P2.0860.69
15_L26_L2.0830.69
92_V146_T2.0720.69
7_V47_L2.0400.67
69_Q116_A1.9640.64
139_C149_H1.9270.63
83_L93_D1.9160.62
28_M171_K1.8990.61
61_T131_L1.8910.61
6_I86_T1.8480.59
79_A87_G1.8390.59
9_E124_V1.8170.58
15_L129_S1.8070.57
21_T47_L1.7880.57
95_V159_L1.7660.56
133_Q148_A1.7650.56
148_A170_R1.6630.51
117_L161_Q1.6570.51
68_E169_R1.5860.48
82_F150_Q1.5830.47
133_Q151_P1.5810.47
63_W72_H1.5580.46
63_W119_R1.5560.46
20_I43_L1.5430.46
44_Y118_T1.5160.44
134_L151_P1.5130.44
26_L96_I1.4920.43
28_M117_L1.4830.43
72_H119_R1.4820.43
13_I26_L1.4700.42
58_P74_S1.4640.42
59_F148_A1.4600.42
116_A150_Q1.4590.42
17_M21_T1.4500.41
92_V129_S1.4460.41
77_C89_C1.4210.40
71_V96_I1.4130.40
69_Q158_S1.4030.39
3_E116_A1.3790.38
63_W70_N1.3530.37
53_P122_T1.3340.37
91_G116_A1.3170.36
3_E38_G1.2900.35
73_A89_C1.2840.34
89_C94_A1.2840.34
33_T40_L1.2830.34
136_S143_N1.2770.34
67_W163_P1.2710.34
8_Q73_A1.2660.34
45_K115_L1.2630.34
75_M158_S1.2560.33
75_M96_I1.2380.33
72_H126_F1.2310.32
37_R56_M1.2260.32
6_I21_T1.2170.32
26_L129_S1.2090.31
25_R57_L1.2060.31
100_R130_G1.2030.31
13_I95_V1.2020.31
25_R58_P1.1970.31
70_N119_R1.1750.30
108_Q173_S1.1730.30
21_T95_V1.1710.30
38_G68_E1.1610.30
34_Q41_I1.1600.30
68_E159_L1.1570.29
8_Q151_P1.1570.29
30_E122_T1.1570.29
64_F92_V1.1560.29
7_V117_L1.1400.29
79_A83_L1.1390.29
7_V14_Q1.1310.29
32_E71_V1.1290.28
7_V45_K1.1290.28
62_D70_N1.1290.28
14_Q171_K1.1250.28
135_S146_T1.1070.28
12_D34_Q1.1010.27
21_T158_S1.1000.27
60_S126_F1.0980.27
10_A87_G1.0870.27
151_P172_L1.0820.27
66_T149_H1.0760.27
99_Y103_L1.0740.26
78_N135_S1.0690.26
68_E117_L1.0670.26
7_V42_K1.0610.26
6_I117_L1.0560.26
12_D28_M1.0460.25
92_V95_V1.0450.25
24_A51_P1.0390.25
8_Q91_G1.0180.25
73_A153_G1.0140.24
25_R55_G0.9980.24
137_C157_C0.9960.24
140_C157_C0.9960.24
140_C160_C0.9960.24
137_C140_C0.9960.24
157_C160_C0.9960.24
137_C160_C0.9960.24
82_F116_A0.9960.24
31_S117_L0.9960.24
56_M114_L0.9950.24
53_P59_F0.9860.23
6_I83_L0.9830.23
17_M128_E0.9750.23
6_I151_P0.9690.23
29_L40_L0.9660.23
50_S151_P0.9660.23
66_T98_A0.9610.23
146_T151_P0.9580.23
38_G117_L0.9540.22
24_A44_Y0.9530.22
73_A164_S0.9470.22
3_E151_P0.9460.22
19_L90_N0.9120.21
169_R173_S0.9110.21
58_P63_W0.9090.21
100_R131_L0.9070.21
146_T150_Q0.8970.21
58_P119_R0.8860.20
28_M51_P0.8800.20
12_D41_I0.8760.20
9_E73_A0.8570.20
97_K117_L0.8570.20
103_L107_P0.8560.20
139_C146_T0.8510.19
167_V172_L0.8500.19
11_R19_L0.8400.19
98_A153_G0.8380.19
32_E104_E0.8330.19
29_L48_R0.8270.19
70_N126_F0.8100.18
6_I96_I0.8040.18
122_T159_L0.7900.18
4_K48_R0.7890.18
95_V124_V0.7850.18
46_E49_G0.7840.18
75_M167_V0.7820.18
126_F163_P0.7810.18
87_G171_K0.7810.18
21_T75_M0.7790.17
12_D106_C0.7770.17
38_G77_C0.7750.17
40_L60_S0.7750.17
24_A55_G0.7730.17
116_A158_S0.7720.17
118_T126_F0.7690.17
3_E6_I0.7660.17
69_Q169_R0.7620.17
79_A85_K0.7610.17
7_V12_D0.7590.17
100_R145_I0.7580.17
3_E7_V0.7580.17
77_C127_V0.7520.17
97_K171_K0.7300.16
106_C171_K0.7300.16
119_R126_F0.7170.16
6_I10_A0.7160.16
14_Q37_R0.7150.16
95_V143_N0.7090.16
28_M130_G0.7090.16
57_L115_L0.7060.16
63_W126_F0.6970.15
7_V169_R0.6950.15
29_L166_A0.6890.15
20_I25_R0.6820.15
73_A79_A0.6820.15
130_G173_S0.6800.15
38_G89_C0.6740.15
84_L94_A0.6730.15
60_S67_W0.6720.15
165_R168_K0.6700.15
81_Q117_L0.6590.15
38_G105_Q0.6590.15
152_V170_R0.6570.15
118_T163_P0.6550.14
44_Y120_A0.6520.14
138_N143_N0.6500.14
67_W70_N0.6470.14
56_M169_R0.6460.14
7_V95_V0.6460.14
17_M141_G0.6450.14
3_E172_L0.6430.14
67_W126_F0.6430.14
36_S114_L0.6420.14
69_Q167_V0.6410.14
20_I49_G0.6390.14
75_M111_E0.6380.14
103_L110_E0.6340.14
133_Q147_H0.6320.14
67_W166_A0.6310.14
151_P154_S0.6280.14
3_E65_M0.6260.14
88_L155_F0.6240.14
104_E173_S0.6230.14
36_S142_G0.6220.14
135_S148_A0.6200.14
108_Q152_V0.6200.14
10_A95_V0.6160.14
81_Q85_K0.6120.14
116_A161_Q0.6120.14
34_Q117_L0.6120.14
87_G116_A0.6110.14
41_I80_W0.6060.13
72_H99_Y0.6030.13
29_L168_K0.6010.13
3_E173_S0.5970.13
3_E143_N0.5970.13
145_I150_Q0.5780.13
15_L170_R0.5760.13
55_G58_P0.5740.13
82_F98_A0.5650.13
46_E74_S0.5630.13
3_E10_A0.5620.13
134_L159_L0.5620.13
84_L125_R0.5620.13
133_Q146_T0.5610.12
98_A171_K0.5610.12
13_I171_K0.5600.12
7_V127_V0.5600.12
164_S171_K0.5580.12
15_L96_I0.5530.12
6_I91_G0.5500.12
30_E67_W0.5450.12
79_A148_A0.5430.12
37_R164_S0.5410.12
106_C158_S0.5370.12
58_P115_L0.5340.12
95_V134_L0.5330.12
15_L31_S0.5320.12
17_M47_L0.5310.12
7_V61_T0.5280.12
24_A119_R0.5260.12
123_L146_T0.5260.12
77_C116_A0.5260.12
58_P70_N0.5230.12
28_M48_R0.5200.12
33_T114_L0.5200.12
57_L119_R0.5150.12
50_S138_N0.5140.12
51_P107_P0.5120.12
52_P57_L0.5120.12
94_A146_T0.5100.12
3_E77_C0.5090.12
85_K150_Q0.5080.11
132_L139_C0.5060.11
3_E162_P0.5050.11
45_K95_V0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2avuE 2 0.8125 100 0.115 Contact Map
2l6lA 1 0.5573 62.8 0.944 Contact Map
1gh9A 1 0.3021 49.3 0.948 Contact Map
6rxnA 1 0.2031 38.3 0.952 Contact Map
1k3xA 1 0.5052 33.5 0.953 Contact Map
1vd4A 1 0.2917 31.8 0.954 Contact Map
2aklA 1 0.3125 31.2 0.954 Contact Map
2lv9A 1 0.3854 29.2 0.955 Contact Map
3mruA 1 0.5625 28.5 0.955 Contact Map
1u8bA 1 0.3229 28 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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