GREMLIN Database
FLAW - Flavodoxin-2
UniProt: P0ABY4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12697
Length: 173 (135)
Sequences: 3079 (2040)
Seq/√Len: 175.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_G101_L3.9591.00
81_I114_K3.6531.00
105_H115_F3.4121.00
102_G121_T3.1591.00
109_S115_F3.1111.00
52_G85_Y2.7961.00
107_K111_K2.6981.00
107_K110_T2.4361.00
48_V81_I2.3551.00
99_D103_M2.3381.00
10_S63_E2.2721.00
5_L22_R2.0361.00
82_V105_H2.0301.00
84_L101_L1.9751.00
5_L30_V1.8701.00
35_L68_V1.8621.00
82_V115_F1.8511.00
73_D107_K1.8381.00
22_R32_L1.8211.00
39_S42_L1.8071.00
3_M25_I1.7981.00
38_D46_Y1.7901.00
6_F35_L1.7651.00
14_T52_G1.7471.00
34_N37_D1.7301.00
31_T46_Y1.6691.00
99_D102_G1.6351.00
53_I100_A1.6211.00
130_K133_I1.6121.00
15_E19_E1.5591.00
82_V113_V1.5371.00
82_V109_S1.5281.00
105_H109_S1.4731.00
85_Y122_E1.4701.00
8_G65_W1.4561.00
69_W104_L1.4501.00
57_D60_E1.4181.00
8_G53_I1.4151.00
17_A87_L1.4011.00
105_H119_W1.3671.00
102_G119_W1.3541.00
19_E32_L1.3331.00
50_I83_A1.3171.00
58_F96_W1.2871.00
6_F38_D1.2831.00
42_L45_Q1.2801.00
108_L115_F1.2751.00
108_L113_V1.2681.00
22_R26_G1.2461.00
49_L80_K1.2411.00
51_L108_L1.2341.00
16_M20_K1.2221.00
69_W100_A1.2111.00
53_I104_L1.1841.00
106_D110_T1.1771.00
61_I100_A1.1751.00
98_L101_L1.1451.00
4_G46_Y1.1431.00
8_G64_D1.1291.00
51_L104_L1.1211.00
36_K64_D1.1141.00
60_E103_M1.0931.00
79_G114_K1.0651.00
9_S14_T1.0621.00
61_I103_M1.0421.00
126_F132_V1.0390.99
25_I30_V1.0220.99
8_G62_Q0.9890.99
22_R30_V0.9820.99
4_G33_H0.9810.99
33_H38_D0.9710.99
24_I28_E0.9580.99
88_G98_L0.9400.99
68_V104_L0.9340.99
48_V116_V0.9280.99
21_I52_G0.9130.99
63_E66_E0.9030.99
16_M19_E0.8900.98
40_P71_Q0.8880.98
106_D109_S0.8810.98
69_W103_M0.8780.98
6_F33_H0.8690.98
132_V136_G0.8560.98
6_F51_L0.8500.98
35_L65_W0.8400.98
21_I50_I0.8380.98
46_Y49_L0.8330.98
126_F130_K0.8230.97
38_D68_V0.8210.97
86_G98_L0.8150.97
43_M49_L0.8110.97
26_G29_L0.7950.97
105_H118_Y0.7820.96
88_G97_F0.7790.96
40_P68_V0.7710.96
83_A117_G0.7620.96
77_L113_V0.7620.96
122_E126_F0.7600.96
53_I57_D0.7600.96
101_L119_W0.7460.95
3_M50_I0.7450.95
5_L21_I0.7400.95
13_Y17_A0.7360.95
17_A52_G0.7350.95
6_F46_Y0.7340.95
75_L111_K0.7260.95
54_P62_Q0.7180.94
117_G137_Q0.7140.94
129_P132_V0.7120.94
84_L115_F0.7090.94
47_D79_G0.6970.93
77_L111_K0.6870.93
4_G31_T0.6840.93
24_I27_P0.6830.93
33_H37_D0.6700.92
7_Y32_L0.6690.92
12_C15_E0.6690.92
84_L105_H0.6680.92
83_A116_V0.6680.92
23_D28_E0.6670.92
18_A32_L0.6600.91
39_S71_Q0.6570.91
10_S62_Q0.6570.91
105_H133_I0.6550.91
8_G100_A0.6540.91
53_I64_D0.6530.91
55_T101_L0.6520.91
53_I101_L0.6480.91
21_I86_G0.6430.90
31_T42_L0.6420.90
28_E117_G0.6290.89
66_E70_D0.6250.89
15_E63_E0.6250.89
13_Y16_M0.6250.89
20_K23_D0.6200.89
136_G141_G0.6200.89
90_Q97_F0.6160.88
4_G49_L0.6120.88
4_G38_D0.6110.88
118_Y137_Q0.6100.88
47_D80_K0.6050.87
13_Y89_D0.6040.87
87_L93_Y0.6030.87
26_G31_T0.6030.87
5_L47_D0.5970.87
127_T131_P0.5950.87
106_D133_I0.5950.87
96_W99_D0.5860.86
9_S12_C0.5840.86
14_T87_L0.5830.85
54_P100_A0.5810.85
12_C68_V0.5800.85
57_D96_W0.5790.85
9_S62_Q0.5770.85
43_M98_L0.5720.84
23_D26_G0.5710.84
120_P129_P0.5710.84
82_V108_L0.5700.84
126_F129_P0.5690.84
13_Y20_K0.5690.84
51_L62_Q0.5660.84
73_D111_K0.5640.84
11_T95_E0.5620.83
116_V139_F0.5610.83
86_G122_E0.5610.83
16_M34_N0.5600.83
35_L104_L0.5590.83
15_E56_W0.5590.83
131_P136_G0.5550.83
95_E127_T0.5520.82
54_P123_G0.5510.82
28_E56_W0.5500.82
24_I131_P0.5490.82
87_L123_G0.5490.82
127_T133_I0.5480.82
34_N64_D0.5450.81
3_M48_V0.5450.81
85_Y120_P0.5440.81
86_G120_P0.5430.81
56_W100_A0.5430.81
89_D126_F0.5370.80
33_H42_L0.5360.80
115_F118_Y0.5360.80
10_S58_F0.5320.80
58_F95_E0.5320.80
57_D99_D0.5320.80
69_W107_K0.5310.80
72_L108_L0.5300.80
57_D87_L0.5220.79
8_G87_L0.5210.78
56_W64_D0.5170.78
90_Q124_Y0.5150.78
59_G62_Q0.5150.78
98_L121_T0.5100.77
44_E75_L0.5090.77
118_Y140_V0.5090.77
109_S137_Q0.5060.76
53_I65_W0.5050.76
6_F49_L0.5040.76
18_A85_Y0.5030.76
79_G112_G0.5000.76
68_V71_Q0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1tllA 2 0.948 100 0.363 Contact Map
2bpoA 1 0.9769 100 0.379 Contact Map
1ag9A 2 0.9942 100 0.379 Contact Map
1yobA 1 0.9827 100 0.384 Contact Map
2wc1A 1 0.9884 100 0.387 Contact Map
3qe2A 1 0.9653 100 0.388 Contact Map
2bmvA 1 0.9422 100 0.403 Contact Map
2fcrA 1 0.9653 100 0.424 Contact Map
3hr4A 2 0.9075 100 0.425 Contact Map
1oboA 1 0.9711 100 0.428 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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