GREMLIN Database
FLIT - Flagellar protein FliT
UniProt: P0ABY2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11389
Length: 121 (109)
Sequences: 165 (117)
Seq/√Len: 11.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_G98_V4.1890.99
86_M104_S3.7200.99
77_K80_Q3.2600.97
33_L82_L2.9430.94
11_W15_V2.4840.87
72_L98_V2.3680.84
28_E107_G2.2630.81
82_L85_R2.2090.79
14_L41_V2.1010.76
48_A75_E2.0900.75
47_I71_I2.0860.75
85_R88_E1.9370.69
7_L11_W1.8410.65
14_L68_L1.7760.62
43_A50_L1.7520.61
14_L86_M1.7290.60
29_Q32_E1.7220.60
37_E93_V1.6420.56
7_L64_L1.6400.56
12_Q97_S1.5050.49
11_W71_I1.5030.49
12_Q95_Q1.4990.49
88_E111_G1.4360.46
57_S96_S1.4240.45
18_S74_N1.3390.41
47_I90_A1.3310.41
51_T64_L1.3290.41
74_N78_V1.3260.41
23_R27_E1.3170.40
14_L21_M1.3170.40
35_A39_A1.2600.38
65_R102_V1.2590.38
84_I87_D1.2450.37
63_Q102_V1.2280.36
24_L61_Q1.2100.36
88_E92_L1.2010.35
56_P100_K1.1810.34
65_R86_M1.1730.34
44_V80_Q1.1580.33
88_E93_V1.1570.33
54_V105_A1.1420.33
11_W47_I1.1200.32
10_A108_D1.0970.31
61_Q83_Q1.0800.30
57_S66_P1.0680.29
14_L108_D1.0620.29
96_S103_L1.0480.29
23_R69_R1.0470.29
22_L81_L1.0420.28
91_K98_V1.0350.28
18_S64_L1.0330.28
33_L37_E1.0270.28
34_I111_G1.0240.28
13_Q24_L1.0140.27
27_E94_G1.0140.27
69_R102_V1.0090.27
21_M77_K1.0080.27
15_V71_I1.0050.27
70_L78_V0.9860.26
75_E79_K0.9830.26
55_D105_A0.9790.26
12_Q103_L0.9780.26
46_E58_T0.9740.26
75_E83_Q0.9590.25
74_N99_Q0.9510.25
17_K109_Q0.9350.24
12_Q63_Q0.9340.24
13_Q86_M0.9260.24
60_M95_Q0.9200.24
50_L78_V0.9160.24
5_P63_Q0.9120.24
23_R78_V0.9040.23
19_Q108_D0.8950.23
45_Q68_L0.8730.22
79_K97_S0.8680.22
18_S22_L0.8620.22
37_E61_Q0.8600.22
35_A45_Q0.8380.21
37_E48_A0.8330.21
41_V74_N0.8260.21
4_A102_V0.8240.21
81_L86_M0.8190.20
32_E101_S0.8190.20
29_Q36_S0.8170.20
101_S111_G0.7990.20
78_V96_S0.7980.20
27_E32_E0.7890.20
72_L79_K0.7760.19
40_Y43_A0.7710.19
71_I98_V0.7610.19
16_E62_E0.7570.19
45_Q74_N0.7550.19
8_Y69_R0.7500.18
41_V44_V0.7440.18
29_Q33_L0.7350.18
33_L85_R0.7320.18
10_A17_K0.7250.18
8_Y50_L0.7230.18
12_Q74_N0.7220.18
19_Q100_K0.7200.18
24_L43_A0.7100.17
84_I94_G0.7070.17
16_E43_A0.7070.17
18_S103_L0.7010.17
35_A63_Q0.7010.17
12_Q79_K0.6980.17
34_I65_R0.6950.17
21_M79_K0.6870.17
16_E29_Q0.6870.17
74_N107_G0.6860.17
9_F86_M0.6850.17
33_L95_Q0.6830.17
45_Q92_L0.6740.16
64_L75_E0.6700.16
37_E83_Q0.6670.16
4_A9_F0.6660.16
74_N81_L0.6560.16
73_D77_K0.6440.16
18_S81_L0.6410.15
54_V63_Q0.6380.15
12_Q99_Q0.6350.15
65_R85_R0.6330.15
70_L84_I0.6330.15
23_R102_V0.6250.15
26_T31_D0.6240.15
43_A61_Q0.6180.15
98_V103_L0.6140.15
26_T36_S0.6080.15
20_L44_V0.6080.15
61_Q82_L0.5980.14
48_A74_N0.5930.14
28_E81_L0.5920.14
15_V56_P0.5920.14
49_H58_T0.5920.14
37_E74_N0.5910.14
38_M82_L0.5880.14
92_L96_S0.5830.14
29_Q93_V0.5830.14
72_L94_G0.5790.14
16_E23_R0.5730.14
91_K94_G0.5720.14
26_T49_H0.5700.14
14_L76_S0.5680.14
77_K108_D0.5610.14
27_E41_V0.5610.14
55_D98_V0.5550.13
47_I70_L0.5550.13
99_Q111_G0.5490.13
24_L55_D0.5480.13
47_I76_S0.5470.13
8_Y35_A0.5390.13
27_E36_S0.5360.13
56_P78_V0.5360.13
61_Q85_R0.5350.13
41_V82_L0.5300.13
26_T29_Q0.5300.13
8_Y92_L0.5210.13
67_M77_K0.5180.13
26_T41_V0.5120.12
24_L34_I0.5070.12
41_V68_L0.5060.12
28_E73_D0.5040.12
55_D94_G0.5020.12
51_T79_K0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7mA 2 0.9669 100 0.197 Contact Map
3nkzA 4 0.7769 100 0.214 Contact Map
3h3mA 2 0.7355 100 0.258 Contact Map
2fupA 1 0.7851 30.3 0.923 Contact Map
3opcA 2 0.8182 7.6 0.942 Contact Map
4n4pA 3 0.6033 7.4 0.942 Contact Map
2w2uA 1 0.6116 7 0.943 Contact Map
2wkjA 3 0.6198 6.5 0.943 Contact Map
4kikA 2 0.8347 5.8 0.945 Contact Map
1jocA 2 0.4959 5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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