GREMLIN Database
SFMA - Uncharacterized fimbrial-like protein SfmA
UniProt: P0ABW5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13881
Length: 180 (163)
Sequences: 3514 (2761)
Seq/√Len: 216.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_L120_G3.1131.00
117_T165_S3.1031.00
121_I155_A2.9281.00
64_A67_N2.8201.00
122_E156_R2.7791.00
124_L156_R2.7561.00
42_S80_D2.7341.00
75_T150_V2.6571.00
122_E158_K2.6321.00
89_A177_M2.5731.00
105_L133_P2.4261.00
107_I169_A2.3901.00
77_Q150_V2.3041.00
44_N79_N2.2821.00
63_N67_N2.2381.00
157_Y169_A2.2331.00
118_G164_A2.2321.00
128_S154_S2.2231.00
121_I171_A2.0961.00
115_T168_Q2.0411.00
105_L173_A2.0361.00
125_D129_A1.9201.00
75_T152_H1.8831.00
71_L156_R1.8141.00
122_E130_I1.7281.00
73_P154_S1.7271.00
24_V27_G1.7141.00
95_G105_L1.7121.00
44_N77_Q1.6591.00
104_L158_K1.6071.00
103_N132_K1.5701.00
94_S134_D1.5331.00
68_T122_E1.5071.00
10_L13_A1.4721.00
94_S176_I1.4571.00
57_Y69_S1.4561.00
44_N47_S1.4351.00
55_G72_I1.4341.00
65_V162_T1.4071.00
68_T156_R1.3761.00
45_T50_Q1.3741.00
74_F123_I1.3581.00
55_G70_A1.3541.00
62_F159_G1.3521.00
90_A178_R1.3511.00
47_S50_Q1.3361.00
55_G169_A1.3231.00
35_E56_Q1.3101.00
54_L157_Y1.2951.00
50_Q76_I1.2831.00
64_A159_G1.2771.00
73_P152_H1.2541.00
17_A21_Y1.2531.00
47_S77_Q1.2411.00
68_T124_L1.2291.00
20_S24_V1.2151.00
98_D160_T1.2081.00
144_L149_N1.1811.00
89_A149_N1.1771.00
97_A103_N1.1761.00
104_L122_E1.1651.00
52_V74_F1.1601.00
99_A120_G1.1511.00
123_I173_A1.1501.00
99_A102_D1.1481.00
63_N159_G1.1371.00
159_G164_A1.1251.00
159_G162_T1.1171.00
54_L169_A1.0951.00
62_F164_A1.0941.00
54_L121_I1.0871.00
12_A15_F1.0861.00
13_A16_A1.0811.00
42_S79_N1.0701.00
28_G32_F1.0661.00
91_V151_L1.0661.00
11_A14_L1.0611.00
31_H172_D1.0601.00
71_L154_S1.0351.00
38_N59_T1.0291.00
68_T158_K1.0241.00
76_I175_F1.0151.00
132_K137_S1.0111.00
93_F153_F1.0051.00
62_F67_N0.9901.00
18_T22_A0.9741.00
93_F123_I0.9641.00
18_T21_Y0.9561.00
58_R61_I0.9551.00
124_L154_S0.9441.00
92_A178_R0.9381.00
126_N152_H0.9371.00
88_N143_N0.9320.99
105_L171_A0.9260.99
98_D102_D0.9240.99
61_I69_S0.9200.99
108_A172_D0.8970.99
78_L149_N0.8890.99
17_A20_S0.8760.99
62_F119_V0.8760.99
14_L17_A0.8710.99
57_Y169_A0.8640.99
88_N141_N0.8620.99
28_G175_F0.8620.99
57_Y62_F0.8580.99
114_T168_Q0.8430.99
119_V157_Y0.8410.99
16_A20_S0.8330.99
124_L130_I0.8310.99
16_A19_G0.8280.99
123_I133_P0.8220.99
15_F18_T0.8180.99
19_G22_A0.8150.99
57_Y157_Y0.8080.99
116_A119_V0.8030.98
38_N82_D0.8020.98
53_T157_Y0.7980.98
33_E51_V0.7950.98
95_G98_D0.7910.98
17_A22_A0.7910.98
97_A133_P0.7860.98
50_Q175_F0.7850.98
62_F160_T0.7840.98
10_L14_L0.7820.98
96_Q106_A0.7750.98
23_A26_D0.7730.98
98_D101_N0.7700.98
108_A170_N0.7650.98
14_L18_T0.7650.98
20_S23_A0.7620.98
90_A141_N0.7620.98
36_L164_A0.7610.98
13_A17_A0.7610.98
107_I114_T0.7460.98
65_V118_G0.7430.97
11_A15_F0.7410.97
22_A26_D0.7370.97
54_L72_I0.7360.97
120_G160_T0.7340.97
131_L153_F0.7320.97
12_A16_A0.7320.97
29_T49_D0.7280.97
133_P171_A0.7270.97
54_L155_A0.7270.97
65_V159_G0.7230.97
15_F19_G0.7160.97
119_V164_A0.7130.97
67_N159_G0.7130.97
59_T164_A0.7120.97
121_I169_A0.7100.97
53_T72_I0.7040.96
98_D120_G0.7020.96
19_G24_V0.7020.96
98_D106_A0.6970.96
92_A138_F0.6960.96
13_A18_T0.6880.96
65_V161_G0.6870.96
33_E53_T0.6860.96
139_S142_Q0.6790.96
77_Q148_T0.6760.96
75_T97_A0.6700.95
71_L124_L0.6680.95
23_A27_G0.6670.95
10_L17_A0.6660.95
11_A16_A0.6640.95
45_T48_A0.6630.95
91_V177_M0.6630.95
61_I70_A0.6580.95
21_Y25_V0.6530.95
21_Y24_V0.6510.95
68_T71_L0.6480.94
82_D124_L0.6470.94
36_L57_Y0.6460.94
107_I170_N0.6390.94
40_A157_Y0.6390.94
98_D161_G0.6380.94
101_N104_L0.6320.94
107_I119_V0.6290.94
10_L19_G0.6290.94
118_G161_G0.6270.93
37_V82_D0.6260.93
59_T166_A0.6260.93
139_S144_L0.6230.93
118_G163_S0.6180.93
26_D29_T0.6110.93
82_D85_V0.6080.92
95_G172_D0.6080.92
19_G23_A0.6060.92
13_A19_G0.6050.92
90_A138_F0.6030.92
130_I133_P0.6000.92
38_N87_A0.6000.92
54_L74_F0.5990.92
15_F21_Y0.5950.92
10_L18_T0.5890.91
21_Y26_D0.5880.91
143_N148_T0.5870.91
140_T143_N0.5840.91
133_P153_F0.5820.91
141_N144_L0.5800.90
55_G170_N0.5800.90
14_L22_A0.5770.90
79_N148_T0.5740.90
92_A134_D0.5710.90
69_S157_Y0.5710.90
31_H51_V0.5700.90
93_F175_F0.5700.90
13_A20_S0.5690.90
28_G34_G0.5650.89
83_P87_A0.5630.89
158_K162_T0.5570.89
124_L158_K0.5560.89
108_A115_T0.5530.88
100_I103_N0.5530.88
62_F66_G0.5520.88
36_L107_I0.5480.88
30_I93_F0.5430.87
107_I116_A0.5420.87
94_S174_T0.5400.87
45_T79_N0.5400.87
65_V164_A0.5360.87
15_F20_S0.5350.87
30_I173_A0.5340.87
40_A82_D0.5340.87
11_A23_A0.5310.86
52_V155_A0.5300.86
88_N146_P0.5300.86
124_L128_S0.5270.86
63_N164_A0.5240.85
118_G160_T0.5210.85
39_A60_D0.5200.85
107_I171_A0.5200.85
12_A18_T0.5170.85
83_P146_P0.5160.85
18_T23_A0.5150.85
49_D175_F0.5090.84
12_A21_Y0.5090.84
16_A21_Y0.5080.84
36_L155_A0.5050.83
140_T144_L0.5040.83
144_L147_G0.5030.83
54_L156_R0.5030.83
69_S156_R0.5020.83
53_T56_Q0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jtyA 1 0.8778 100 0.23 Contact Map
2jmrA 1 0.85 100 0.233 Contact Map
2xg5B 1 0.7778 100 0.244 Contact Map
2uy6B 2 0.8056 100 0.264 Contact Map
1pdkB 1 0.7833 100 0.274 Contact Map
3bwuF 1 0.7 100 0.328 Contact Map
4dwhB 1 0.7611 100 0.342 Contact Map
2w07B 1 0.65 99.9 0.359 Contact Map
3bfqG 1 0.7222 99.9 0.362 Contact Map
5afoA 1 0.95 99.9 0.37 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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