GREMLIN Database
HCAC - 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit
UniProt: P0ABW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13458
Length: 106 (98)
Sequences: 2519 (1723)
Seq/√Len: 174.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_Y96_D4.4531.00
9_V35_F2.6811.00
38_I85_L2.5691.00
3_R91_H2.3511.00
5_Y98_F2.1951.00
58_A70_C2.0021.00
40_D50_S1.9791.00
67_A81_A1.9511.00
58_A72_K1.9081.00
47_A63_P1.8201.00
8_P96_D1.8171.00
91_H98_F1.8161.00
14_E30_N1.8111.00
34_E72_K1.7241.00
75_K84_P1.6701.00
29_F38_I1.6001.00
39_N86_T1.5981.00
93_E98_F1.5821.00
89_P100_D1.5471.00
5_Y8_P1.5411.00
8_P11_D1.5371.00
54_L71_L1.5231.00
70_C73_T1.5231.00
17_A29_F1.5141.00
17_A27_A1.4711.00
25_V40_D1.4111.00
24_P39_N1.3881.00
26_I37_A1.3831.00
47_A64_L1.3621.00
30_N33_G1.3471.00
59_T77_L1.3471.00
76_A84_P1.2961.00
40_D48_S1.2731.00
67_A76_A1.2641.00
11_D18_L1.2431.00
59_T68_S1.2241.00
39_N88_Y1.2151.00
14_E33_G1.1921.00
41_R46_N1.1571.00
9_V92_V1.1391.00
17_A54_L1.1271.00
9_V95_G1.0991.00
36_Y72_K1.0881.00
31_V34_E1.0881.00
31_V58_A1.0811.00
35_F90_V1.0741.00
30_N35_F1.0651.00
8_P95_G1.0330.99
10_A95_G1.0120.99
67_A84_P1.0100.99
49_M85_L1.0050.99
17_A60_V1.0030.99
76_A81_A1.0010.99
7_C12_V0.9970.99
21_D25_V0.9950.99
43_S67_A0.9860.99
45_G67_A0.9850.99
43_S85_L0.9850.99
19_R25_V0.9670.99
7_C28_L0.9580.99
13_P16_E0.9520.99
19_R40_D0.9240.99
35_F92_V0.9200.99
3_R100_D0.9140.99
43_S69_F0.9030.99
76_A79_L0.9020.99
15_G30_N0.8950.98
27_A38_I0.8920.98
19_R50_S0.8900.98
19_R48_S0.8860.98
14_E32_G0.8820.98
6_A99_I0.8750.98
68_S78_C0.8600.98
92_V97_I0.8570.98
29_F71_L0.8550.98
29_F60_V0.8470.98
28_L35_F0.8430.98
38_I87_T0.8400.98
81_A84_P0.8310.97
13_P30_N0.8250.97
70_C77_L0.8120.97
24_P88_Y0.8110.97
27_A50_S0.7980.97
46_N64_L0.7930.97
34_E58_A0.7790.96
36_Y87_T0.7700.96
41_R48_S0.7580.96
7_C97_I0.7550.96
45_G64_L0.7520.95
31_V36_Y0.7520.95
53_Y61_E0.7440.95
32_G58_A0.7420.95
43_S81_A0.7190.94
13_P17_A0.7090.94
38_I71_L0.6990.93
43_S84_P0.6970.93
55_E61_E0.6780.92
12_V16_E0.6610.91
40_D85_L0.6600.91
64_L82_T0.6590.91
25_V39_N0.6570.91
31_V56_D0.6560.91
35_F97_I0.6480.90
23_S100_D0.6450.90
31_V71_L0.6430.90
61_E68_S0.6370.90
67_A82_T0.6350.90
7_C18_L0.6340.89
64_L79_L0.6220.89
3_R98_F0.6200.88
68_S77_L0.6180.88
3_R93_E0.6140.88
26_I99_I0.5930.86
37_A99_I0.5910.86
88_Y100_D0.5870.86
12_V35_F0.5850.85
20_I28_L0.5810.85
25_V41_R0.5780.85
12_V97_I0.5730.84
6_A37_A0.5640.83
67_A79_L0.5640.83
45_G81_A0.5630.83
4_I22_T0.5600.83
79_L82_T0.5570.82
93_E96_D0.5560.82
54_L61_E0.5500.82
12_V18_L0.5490.82
27_A40_D0.5470.81
39_N85_L0.5470.81
59_T78_C0.5470.81
70_C75_K0.5450.81
7_C22_T0.5440.81
89_P101_L0.5410.81
67_A78_C0.5330.80
55_E68_S0.5320.80
56_D59_T0.5260.79
73_T87_T0.5250.79
53_Y66_A0.5150.77
48_S64_L0.5150.77
27_A85_L0.5140.77
45_G68_S0.5130.77
78_C82_T0.5120.77
46_N66_A0.5100.77
67_A83_D0.5100.77
6_A20_I0.5080.76
29_F47_A0.5060.76
12_V61_E0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i7fA 1 0.934 100 0.269 Contact Map
1fqtA 2 0.9906 100 0.269 Contact Map
3gceA 1 0.9434 100 0.278 Contact Map
2qpzA 1 0.9528 100 0.281 Contact Map
3dqyA 1 0.9811 100 0.285 Contact Map
2de6D 1 0.9528 100 0.286 Contact Map
1vm9A 1 0.9717 100 0.288 Contact Map
2jzaA 1 0.9811 100 0.297 Contact Map
2jo6A 1 0.9528 100 0.303 Contact Map
3c0dA 1 0.9623 100 0.308 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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