GREMLIN Database
TOLR - Protein TolR
UniProt: P0ABV6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11011
Length: 142 (127)
Sequences: 4416 (3081)
Seq/√Len: 273.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_S73_Q4.5801.00
113_K118_D3.3081.00
73_Q85_R2.9281.00
87_P90_Q2.8481.00
19_V22_L2.6551.00
117_Y137_L2.5721.00
118_D122_K2.5241.00
70_G114_D2.4941.00
92_V129_S2.4291.00
84_E94_E2.2561.00
95_V127_L2.2421.00
68_V123_A2.2241.00
69_S75_T2.0651.00
74_Y123_A1.9931.00
18_I22_L1.9181.00
92_V96_S1.9021.00
119_E122_K1.8651.00
117_Y120_I1.8641.00
116_P119_E1.8561.00
88_P122_K1.7031.00
99_F132_V1.6971.00
29_L32_F1.6581.00
45_V67_E1.6121.00
94_E97_S1.6041.00
75_T85_R1.5281.00
88_P119_E1.5131.00
90_Q94_E1.5031.00
111_G120_I1.4581.00
98_R101_A1.4551.00
102_N105_T1.4471.00
92_V126_L1.3911.00
94_E98_R1.3801.00
64_V76_V1.3401.00
96_S100_K1.3391.00
88_P126_L1.3001.00
93_A96_S1.2931.00
76_V94_E1.2911.00
19_V27_V1.2791.00
30_L33_M1.2411.00
65_I110_G1.2411.00
108_L138_M1.2301.00
126_L129_S1.2221.00
124_L135_V1.2161.00
17_N27_V1.2121.00
111_G117_Y1.2081.00
66_V123_A1.1851.00
68_V115_V1.1801.00
67_E75_T1.1781.00
121_I125_N1.1631.00
121_I137_L1.1431.00
107_F132_V1.1401.00
27_V31_I1.1221.00
93_A97_S1.1031.00
72_G115_V1.0991.00
95_V132_V1.0901.00
83_L86_L1.0881.00
86_L90_Q1.0691.00
68_V111_G1.0551.00
25_L28_L1.0541.00
115_V119_E1.0451.00
107_F127_L1.0361.00
84_E90_Q1.0321.00
50_A139_T1.0281.00
72_G119_E1.0211.00
17_N31_I1.0171.00
90_Q93_A1.0051.00
66_V76_V1.0011.00
16_I27_V0.9871.00
67_E110_G0.9861.00
52_E125_N0.9861.00
88_P92_V0.9661.00
125_N129_S0.9661.00
70_G112_A0.9521.00
92_V130_A0.9381.00
7_R10_R0.9211.00
29_L33_M0.9191.00
68_V119_E0.9141.00
66_V107_F0.9141.00
26_L31_I0.9061.00
27_V34_A0.8761.00
74_Y88_P0.8741.00
18_I31_I0.8731.00
106_V136_G0.8621.00
97_S101_A0.8551.00
22_L26_L0.8551.00
27_V33_M0.8511.00
46_D114_D0.8451.00
127_L132_V0.8451.00
121_I139_T0.8270.99
77_V83_L0.8270.99
21_L31_I0.8250.99
128_H133_K0.8200.99
53_S56_V0.8080.99
47_L117_Y0.7980.99
19_V30_L0.7920.99
74_Y91_V0.7850.99
21_L27_V0.7810.99
21_L26_L0.7690.99
36_A39_I0.7680.99
19_V25_L0.7630.99
16_I21_L0.7520.99
45_V112_A0.7490.99
110_G138_M0.7470.99
89_E126_L0.7270.99
86_L94_E0.7260.99
16_I19_V0.7260.99
35_T39_I0.7240.99
51_T129_S0.7220.99
19_V37_P0.7200.99
99_F105_T0.7170.99
15_E27_V0.7100.98
25_L30_L0.7080.98
18_I30_L0.7070.98
27_V37_P0.7060.98
46_D113_K0.7050.98
125_N128_H0.7050.98
43_V75_T0.7030.98
50_A125_N0.7010.98
104_K134_S0.6980.98
41_Q132_V0.6930.98
14_S32_F0.6920.98
74_Y119_E0.6860.98
24_V117_Y0.6820.98
14_S31_I0.6740.98
20_P26_L0.6650.98
53_S139_T0.6620.98
99_F134_S0.6490.97
31_I37_P0.6450.97
75_T86_L0.6400.97
50_A121_I0.6400.97
76_V86_L0.6380.97
19_V28_L0.6340.97
18_I21_L0.6240.96
26_L32_F0.6240.96
117_Y124_L0.6220.96
111_G115_V0.6200.96
22_L27_V0.6140.96
64_V77_V0.6080.96
19_V26_L0.6080.96
30_L34_A0.6070.96
121_I124_L0.6070.96
27_V30_L0.6060.96
65_I108_L0.6060.96
19_V24_V0.6050.96
43_V121_I0.6030.96
25_L34_A0.5900.95
119_E137_L0.5880.95
91_V95_V0.5850.95
68_V74_Y0.5830.95
40_T45_V0.5820.95
85_R90_Q0.5810.95
46_D106_V0.5780.95
64_V99_F0.5730.94
88_P93_A0.5730.94
105_T132_V0.5700.94
95_V130_A0.5610.94
62_P102_N0.5600.94
24_V27_V0.5590.94
15_E34_A0.5580.94
95_V107_F0.5560.93
18_I26_L0.5540.93
61_N102_N0.5520.93
22_L25_L0.5490.93
26_L37_P0.5440.93
56_V60_D0.5410.92
51_T83_L0.5400.92
35_T40_T0.5400.92
72_G111_G0.5380.92
68_V120_I0.5360.92
115_V137_L0.5340.92
18_I29_L0.5330.92
16_I31_I0.5320.92
72_G116_P0.5300.92
75_T83_L0.5300.92
42_S124_L0.5300.92
124_L137_L0.5260.91
77_V98_R0.5210.91
26_L35_T0.5210.91
25_L32_F0.5210.91
47_L50_A0.5210.91
8_G11_D0.5200.91
33_M110_G0.5200.91
14_S18_I0.5200.91
52_E129_S0.5200.91
91_V123_A0.5130.90
75_T110_G0.5090.90
76_V98_R0.5020.89
36_A111_G0.5020.89
97_S100_K0.5010.89
114_D118_D0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pfuA 1 0.669 99.8 0.504 Contact Map
2jwkA 2 0.5211 99.4 0.63 Contact Map
2w3zA 1 0.5 71.9 0.893 Contact Map
3l8cA 1 0.3944 23.4 0.922 Contact Map
3ghfA 2 0.5282 19.5 0.925 Contact Map
4pzpA 1 0.3803 18.5 0.926 Contact Map
1uuqA 1 0.4577 18.2 0.926 Contact Map
1hf2A 2 0.5282 17.9 0.926 Contact Map
3w5fA 1 0.4155 17.6 0.926 Contact Map
2re3A 1 0.7324 13.3 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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