GREMLIN Database
TOLQ - Protein TolQ
UniProt: P0ABU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11010
Length: 230 (199)
Sequences: 4451 (2853)
Seq/√Len: 202.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_I191_A4.4961.00
151_H173_E4.2141.00
81_Q119_E4.1641.00
64_R67_Q4.0001.00
36_I40_R3.6691.00
132_T190_M3.5721.00
31_S188_A3.5261.00
129_F133_V3.4781.00
134_G189_V3.3671.00
38_R41_I3.2021.00
120_L203_E2.9701.00
182_L186_I2.7811.00
20_I143_F2.6511.00
86_G112_M2.3561.00
21_M180_I2.3551.00
132_T193_N2.2521.00
17_V21_M2.2251.00
14_S18_K2.0861.00
31_S35_I1.9511.00
143_F183_F1.8821.00
34_I129_F1.8601.00
119_E122_N1.8021.00
127_I199_V1.7951.00
194_R198_R1.7531.00
118_R208_N1.7221.00
22_L26_G1.7111.00
67_Q71_G1.6981.00
85_S115_S1.6801.00
154_I172_A1.6691.00
152_A170_G1.6471.00
116_M120_L1.6321.00
24_L184_A1.6161.00
14_S22_L1.5711.00
44_A48_E1.5071.00
43_N47_R1.4961.00
46_A198_R1.4851.00
39_T195_L1.4791.00
68_E72_K1.4681.00
51_A55_K1.4221.00
28_S33_A1.4031.00
37_Q41_I1.4011.00
146_V178_T1.3991.00
25_I29_I1.3811.00
39_T43_N1.3671.00
13_A18_K1.3601.00
128_P197_Q1.3461.00
31_S130_L1.3461.00
34_I130_L1.3451.00
28_S32_W1.3431.00
42_L199_V1.3381.00
150_M179_A1.3311.00
23_I140_I1.3261.00
52_F56_F1.3171.00
27_F140_I1.3041.00
136_I140_I1.2951.00
139_Y149_I1.2911.00
123_L199_V1.2891.00
115_S119_E1.2741.00
147_W173_E1.2581.00
153_F170_G1.2461.00
120_L199_V1.2401.00
24_L180_I1.2341.00
84_Y88_K1.2161.00
50_E205_N1.2031.00
139_Y185_A1.1881.00
133_V188_A1.1771.00
56_F209_F1.1651.00
136_I189_V1.1611.00
60_I64_R1.1491.00
20_I23_I1.1461.00
105_V109_S1.1441.00
174_A178_T1.1441.00
35_I195_L1.1441.00
191_A195_L1.1411.00
116_M210_M1.1251.00
78_G206_Y1.1241.00
81_Q84_Y1.1211.00
136_I190_M1.1151.00
143_F179_A1.1141.00
121_E204_L1.1091.00
15_L22_L1.1001.00
152_A167_V1.0861.00
61_E64_R1.0831.00
192_Y196_N1.0831.00
86_G111_A1.0801.00
116_M203_E1.0641.00
83_F209_F1.0511.00
114_I208_N1.0451.00
21_M25_I1.0241.00
203_E207_D1.0001.00
24_L28_S0.9971.00
155_A166_M0.9971.00
13_A17_V0.9891.00
156_L162_A0.9761.00
10_F18_K0.9741.00
188_A192_Y0.9721.00
14_S19_L0.9721.00
65_L69_S0.9701.00
64_R68_E0.9650.99
16_L143_F0.9600.99
47_R51_A0.9550.99
81_Q115_S0.9350.99
24_L140_I0.9330.99
14_S21_M0.9330.99
45_A202_L0.9290.99
153_F172_A0.9240.99
143_F186_I0.9160.99
209_F213_F0.9080.99
199_V204_L0.9070.99
156_L161_Q0.9000.99
169_P173_E0.8880.99
82_I115_S0.8850.99
79_S209_F0.8830.99
40_R44_A0.8770.99
19_L23_I0.8760.99
134_G187_P0.8760.99
51_A54_D0.8740.99
67_Q70_Q0.8660.99
134_G167_V0.8600.99
162_A172_A0.8580.99
104_V107_G0.8540.99
120_L124_E0.8530.99
29_I33_A0.8510.99
31_S191_A0.8510.99
42_L202_L0.8460.99
78_G119_E0.8450.99
30_A129_F0.8320.98
142_L178_T0.8300.98
82_I206_Y0.8290.98
111_A115_S0.8280.98
157_G172_A0.8230.98
72_K80_E0.8210.98
39_T191_A0.8200.98
52_F80_E0.8140.98
18_K22_L0.8100.98
121_E201_K0.8090.98
131_G168_A0.8030.98
45_A78_G0.7980.98
198_R202_L0.7870.98
23_I27_F0.7860.98
44_A51_A0.7850.98
108_A112_M0.7840.98
143_F147_W0.7830.98
20_I147_W0.7830.98
104_V108_A0.7780.98
151_H154_I0.7760.98
14_S25_I0.7740.98
49_A79_S0.7720.98
17_V173_E0.7710.97
110_R113_R0.7710.97
130_L188_A0.7710.97
66_Y69_S0.7710.97
27_F133_V0.7690.97
80_E84_Y0.7680.97
42_L198_R0.7650.97
200_N203_E0.7620.97
37_Q125_T0.7610.97
146_V187_P0.7550.97
60_I68_E0.7540.97
62_L65_L0.7520.97
77_T80_E0.7480.97
135_S189_V0.7460.97
211_E215_A0.7460.97
26_G30_A0.7440.97
55_K58_S0.7350.97
18_K23_I0.7340.97
80_E83_F0.7320.97
142_L189_V0.7310.97
62_L66_Y0.7290.96
171_I177_A0.7280.96
43_N46_A0.7260.96
109_S113_R0.7220.96
12_K16_L0.7220.96
59_G62_L0.7210.96
53_E205_N0.7190.96
63_S68_E0.7190.96
55_K59_G0.7120.96
168_A187_P0.7070.96
142_L185_A0.7060.96
16_L173_E0.7030.96
149_I175_L0.7010.96
82_I112_M0.6990.96
14_S151_H0.6990.96
76_L81_Q0.6990.96
148_G170_G0.6960.95
154_I158_A0.6840.95
210_M214_T0.6840.95
176_I180_I0.6790.95
134_G137_S0.6780.95
198_R201_K0.6780.95
154_I157_G0.6760.95
55_K68_E0.6760.95
49_A77_T0.6720.94
136_I186_I0.6720.94
157_G169_P0.6690.94
113_R211_E0.6670.94
132_T168_A0.6650.94
159_V166_M0.6610.94
133_V137_S0.6590.94
172_A177_A0.6580.94
59_G64_R0.6580.94
125_T201_K0.6570.94
155_A159_V0.6560.94
155_A170_G0.6550.94
85_S89_E0.6510.94
82_I119_E0.6510.94
30_A34_I0.6500.93
68_E71_G0.6490.93
20_I177_A0.6480.93
146_V182_L0.6460.93
131_G192_Y0.6460.93
66_Y87_F0.6450.93
179_A183_F0.6450.93
135_S175_L0.6440.93
16_L176_I0.6430.93
86_G90_F0.6430.93
169_P172_A0.6400.93
124_E207_D0.6390.93
146_V168_A0.6370.93
11_L15_L0.6260.92
51_A71_G0.6250.92
82_I86_G0.6230.92
59_G67_Q0.6200.92
37_Q126_H0.6180.92
62_L67_Q0.6110.91
53_E57_W0.6110.91
199_V203_E0.6100.91
55_K71_G0.6090.91
32_W188_A0.6080.91
24_L137_S0.6070.91
162_A175_L0.6030.91
76_L103_A0.6020.91
52_F65_L0.6010.91
57_W212_E0.5950.90
147_W179_A0.5950.90
86_G213_F0.5940.90
20_I179_A0.5930.90
171_I174_A0.5900.90
160_K163_T0.5860.89
109_S214_T0.5850.89
13_A16_L0.5820.89
82_I210_M0.5790.89
15_L19_L0.5790.89
151_H155_A0.5790.89
177_A180_I0.5750.89
17_V176_I0.5700.88
16_L180_I0.5690.88
64_R70_Q0.5690.88
31_S184_A0.5680.88
15_L58_S0.5680.88
107_G218_H0.5680.88
12_K15_L0.5680.88
114_I212_E0.5660.88
21_M176_I0.5650.88
156_L169_P0.5650.88
24_L32_W0.5600.87
149_I169_P0.5600.87
17_V150_M0.5590.87
150_M171_I0.5580.87
136_I168_A0.5580.87
52_F83_F0.5570.87
168_A171_I0.5560.87
17_V177_A0.5510.86
152_A187_P0.5480.86
149_I179_A0.5460.86
167_V177_A0.5450.86
109_S117_N0.5440.86
58_S62_L0.5420.85
151_H170_G0.5420.85
110_R215_A0.5380.85
156_L192_Y0.5370.85
46_A50_E0.5350.85
60_I72_K0.5330.84
116_M206_Y0.5300.84
71_G88_K0.5280.84
128_P131_G0.5260.84
111_A114_I0.5240.83
13_A21_M0.5230.83
173_E176_I0.5190.83
202_L205_N0.5190.83
142_L172_A0.5190.83
156_L163_T0.5140.82
20_I180_I0.5130.82
49_A205_N0.5120.82
60_I63_S0.5120.82
14_S147_W0.5120.82
48_E205_N0.5110.82
41_I123_L0.5110.82
27_F194_R0.5100.82
149_I171_I0.5100.82
199_V202_L0.5100.82
134_G192_Y0.5090.82
167_V172_A0.5080.82
18_K21_M0.5070.81
150_M172_A0.5060.81
188_A195_L0.5040.81
184_A188_A0.5020.81
36_I39_T0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8043 38.7 0.943 Contact Map
3b5mA 2 0.2696 14.1 0.953 Contact Map
4cq4A 4 0.3957 10.4 0.956 Contact Map
1pi7A 1 0.0826 9.4 0.957 Contact Map
2kluA 1 0.2957 6.7 0.96 Contact Map
2nr4A 2 0.2913 6 0.961 Contact Map
2f95B 2 0.1435 5.6 0.961 Contact Map
1ciyA 1 0.4043 5.3 0.962 Contact Map
4uqqA 3 0.0913 5.3 0.962 Contact Map
4u6uB 1 0.5174 5.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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