GREMLIN Database
EXBB - Biopolymer transport protein ExbB
UniProt: P0ABU7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10271
Length: 244 (202)
Sequences: 4343 (2770)
Seq/√Len: 194.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_F194_I4.3511.00
154_N176_E4.0281.00
86_H122_V3.9601.00
135_T193_V3.8401.00
42_F46_V3.8061.00
70_Q73_D3.5451.00
132_Y136_I3.5071.00
137_G192_V3.4241.00
37_T191_A3.2971.00
44_K47_E3.1381.00
123_G206_K2.7971.00
185_L189_I2.7971.00
26_V146_F2.6111.00
135_T196_N2.3941.00
91_A115_L2.3381.00
27_M183_I2.2851.00
23_V27_M2.1341.00
20_D24_K2.0101.00
40_I132_Y2.0071.00
37_T41_F1.9911.00
146_F186_V1.9301.00
121_A211_D1.8431.00
30_L187_A1.8291.00
197_V201_Q1.8191.00
122_V125_Q1.8031.00
119_V123_G1.7841.00
130_N202_I1.7561.00
157_I175_A1.7521.00
28_I32_L1.7241.00
155_S173_G1.6731.00
58_E62_L1.6131.00
52_K201_Q1.5611.00
90_E118_R1.5461.00
20_D28_I1.5441.00
49_F53_R1.5301.00
131_G200_R1.4731.00
153_M182_A1.4691.00
50_N54_R1.4541.00
43_S47_E1.4461.00
45_S198_F1.4301.00
57_R61_L1.4261.00
149_V181_T1.4251.00
118_R122_V1.4211.00
142_F152_I1.4181.00
73_D77_D1.4051.00
34_S39_A1.3861.00
150_W176_E1.3631.00
29_G143_V1.3461.00
139_I192_V1.3281.00
34_S38_W1.3271.00
73_D76_A1.3221.00
45_S49_F1.3041.00
40_I133_L1.2891.00
37_T133_L1.2641.00
156_F173_G1.2521.00
48_F202_I1.2521.00
19_A24_K1.2361.00
139_I143_V1.2351.00
20_D25_C1.2271.00
30_L183_I1.2101.00
31_I35_V1.2041.00
56_K208_M1.1901.00
177_A181_T1.1821.00
91_A114_R1.1811.00
126_M202_I1.1671.00
33_A143_V1.1651.00
62_L212_V1.1531.00
142_F188_A1.1481.00
146_F182_A1.1411.00
70_Q74_I1.1381.00
139_I193_V1.1291.00
124_R207_A1.1261.00
88_L212_V1.1191.00
89_N93_N1.1131.00
155_S170_V1.1101.00
61_L74_I1.1091.00
119_V213_A1.1071.00
191_A195_Y1.0991.00
123_G202_I1.0951.00
195_Y199_A1.0931.00
108_K112_S1.0891.00
27_M31_I1.0841.00
41_F198_F1.0801.00
117_R211_D1.0701.00
23_V176_E1.0611.00
69_N74_I1.0501.00
26_V29_G1.0491.00
16_Y24_K1.0421.00
19_A23_V1.0391.00
194_I198_F1.0291.00
83_L209_L1.0281.00
51_Q205_F1.0251.00
66_R70_Q1.0171.00
158_G169_V1.0091.00
45_S194_I1.0031.00
46_V50_N0.9961.00
159_I164_T0.9921.00
119_V206_K0.9911.00
212_V216_V0.9901.00
67_S70_Q0.9901.00
15_M24_K0.9810.99
86_H118_R0.9790.99
74_I77_D0.9790.99
156_F175_A0.9670.99
20_D27_M0.9640.99
202_I207_A0.9580.99
74_I78_F0.9420.99
87_L118_R0.9420.99
83_L122_V0.9390.99
36_V132_Y0.9370.99
21_I28_I0.9300.99
123_G127_G0.9270.99
48_F205_F0.9150.99
86_H89_N0.9130.99
85_L89_N0.9040.99
59_Q208_M0.9030.99
146_F189_I0.9020.99
165_T175_A0.9010.99
159_I165_T0.8990.99
30_L143_V0.8920.99
137_G190_P0.8890.99
145_L181_T0.8780.99
32_L36_V0.8760.99
33_A136_I0.8680.99
37_T194_I0.8670.99
172_P176_E0.8650.99
66_R74_I0.8650.99
82_S85_L0.8550.99
146_F150_W0.8530.99
137_G170_V0.8420.98
20_D154_N0.8380.98
75_A89_N0.8290.98
113_F116_E0.8280.98
124_R204_G0.8270.98
76_A79_G0.8220.98
139_I189_I0.8220.98
206_K210_G0.8190.98
157_I160_A0.8170.98
24_K29_G0.8160.98
22_V146_F0.8060.98
87_L122_V0.7980.98
85_L88_L0.7970.98
65_A68_L0.7940.98
157_I161_Q0.7920.98
30_L34_S0.7910.98
50_N57_R0.7900.98
145_L188_A0.7850.97
179_L183_I0.7810.97
71_A75_A0.7800.97
43_S128_R0.7780.97
61_L65_A0.7780.97
107_I111_T0.7760.97
136_I191_A0.7710.97
69_N96_E0.7680.97
201_Q205_F0.7640.97
134_A171_A0.7600.97
29_G33_A0.7600.97
128_R204_G0.7590.97
35_V39_A0.7580.97
160_A175_A0.7570.97
65_A73_D0.7570.97
91_A95_L0.7560.97
214_A218_L0.7500.97
87_L115_L0.7480.97
138_A178_L0.7460.97
55_L83_L0.7420.96
68_L71_A0.7410.96
25_C29_G0.7380.96
138_A192_V0.7360.96
53_R57_R0.7330.96
66_R78_F0.7280.96
22_V179_L0.7270.96
51_Q83_L0.7260.96
17_Q21_I0.7260.96
22_V176_E0.7240.96
107_I110_R0.7240.96
91_A216_V0.7220.96
23_V180_A0.7210.96
111_T115_L0.7190.96
58_E85_L0.7180.96
79_G89_N0.7160.96
171_A190_P0.7110.95
48_F201_Q0.7090.95
87_L209_L0.7080.95
112_S116_E0.7080.95
133_L191_A0.7060.95
90_E94_E0.7060.95
36_V40_I0.7050.95
20_D23_V0.7030.95
135_T171_A0.7010.95
65_A70_Q0.7000.95
25_C28_I0.7000.95
55_L84_S0.6990.95
20_D150_W0.6980.95
65_A69_N0.6980.95
27_M179_L0.6960.95
57_R60_Q0.6920.95
159_I172_P0.6910.95
163_Q166_N0.6910.95
149_V171_A0.6870.95
154_N157_I0.6860.95
61_L64_E0.6850.94
151_G173_G0.6830.94
20_D31_I0.6820.94
175_A180_A0.6810.94
77_D80_S0.6760.94
18_H21_I0.6740.94
137_G140_S0.6730.94
66_R69_N0.6730.94
165_T178_L0.6730.94
81_K129_G0.6640.94
213_A217_L0.6560.93
172_P175_A0.6520.93
174_I180_A0.6500.93
162_T169_V0.6490.93
160_A172_P0.6490.93
114_R118_R0.6440.92
127_G210_G0.6400.92
158_G173_G0.6400.92
64_E68_L0.6390.92
134_A195_Y0.6380.92
203_G206_K0.6350.92
153_M167_L0.6340.92
18_H22_V0.6320.92
106_G221_S0.6280.92
174_I177_A0.6270.91
152_I178_L0.6250.91
24_K27_M0.6240.91
112_S217_L0.6220.91
205_F208_M0.6180.91
145_L175_A0.6170.91
149_V190_P0.6150.91
19_A22_V0.6130.91
21_I24_K0.6070.90
154_N158_G0.6060.90
152_I172_P0.6060.90
180_A183_I0.6030.90
114_R117_R0.6030.90
201_Q204_G0.6010.90
158_G162_T0.6000.90
27_M176_E0.5960.89
153_M175_A0.5930.89
84_S212_V0.5920.89
63_A215_Q0.5920.89
117_R215_Q0.5880.89
202_I206_K0.5870.89
59_Q63_A0.5860.89
38_W191_A0.5840.88
51_Q55_L0.5830.88
116_E214_A0.5820.88
198_F202_I0.5820.88
66_R71_A0.5820.88
150_W182_A0.5810.88
149_V185_L0.5790.88
139_I194_I0.5790.88
171_A174_I0.5780.88
37_T187_A0.5780.88
155_S190_P0.5780.88
26_V150_W0.5760.88
170_V180_A0.5750.88
42_F45_S0.5620.86
23_V153_M0.5600.86
110_R221_S0.5580.86
61_L77_D0.5570.86
30_L140_S0.5550.86
131_G134_A0.5550.86
139_I171_A0.5540.86
159_I162_T0.5530.85
113_F218_L0.5520.85
21_I25_C0.5510.85
26_V180_A0.5460.85
152_I182_A0.5450.85
219_L223_D0.5450.85
182_A186_V0.5440.85
153_M180_A0.5420.84
52_K56_K0.5420.84
136_I140_S0.5420.84
76_A96_E0.5380.84
116_E123_G0.5370.84
54_R57_R0.5360.84
134_A137_G0.5330.83
83_L86_H0.5300.83
202_I205_F0.5290.83
108_K221_S0.5260.83
119_V210_G0.5240.82
51_Q126_M0.5230.82
43_S129_G0.5230.82
49_F52_K0.5220.82
87_L213_A0.5180.82
111_T217_L0.5160.81
87_L91_A0.5160.81
142_F159_I0.5140.81
124_R129_G0.5130.81
138_A180_A0.5130.81
60_Q64_E0.5130.81
42_F49_F0.5120.81
24_K28_I0.5120.81
19_A182_A0.5080.80
155_S168_A0.5060.80
159_I166_N0.5020.80
34_S191_A0.5010.79
157_I179_L0.5000.79
154_N173_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tllB 2 0.1967 20 0.952 Contact Map
4i5sA 2 0.8033 17.2 0.954 Contact Map
3b60A 2 0.8156 10.4 0.958 Contact Map
1pi7A 1 0.0779 8.3 0.96 Contact Map
3eb7A 2 0.8361 7.2 0.961 Contact Map
4u6uB 1 0.4836 6.9 0.961 Contact Map
2mi2A 1 0.3852 6.2 0.962 Contact Map
3b5xA 2 0.8197 5.9 0.962 Contact Map
4w8jA 2 0.8115 5.6 0.963 Contact Map
4f4sA 3 0.2664 5.5 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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