GREMLIN Database
ELBB - Enhancing lycopene biosynthesis protein 2
UniProt: P0ABU5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11383
Length: 217 (213)
Sequences: 524 (323)
Seq/√Len: 22.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D77_P4.2641.00
103_N107_L4.0571.00
163_L168_A3.2691.00
46_V106_S3.2411.00
82_D85_E2.9220.99
43_K114_D2.8600.99
151_L163_L2.8500.99
5_G86_L2.6690.99
90_I209_V2.6070.99
195_A201_A2.5520.98
7_I91_V2.5170.98
81_A120_L2.4300.98
187_V212_V2.4060.98
81_A124_M2.3450.97
39_F86_L2.2950.97
132_G208_L2.2520.96
189_T204_G2.1760.95
111_C166_M2.1730.95
142_P168_A2.1720.95
4_I29_I2.1270.95
30_S199_A2.1060.95
25_T90_I2.0560.94
119_A123_A2.0160.93
43_K63_V2.0120.93
149_L186_I2.0070.93
196_Q200_E1.9960.93
131_L145_F1.9930.93
132_G212_V1.9750.92
5_G37_V1.9700.92
50_N53_T1.9650.92
97_A140_M1.9320.92
31_R206_D1.9160.91
29_I36_A1.8900.91
76_R80_Q1.8460.90
150_R179_V1.8430.89
48_V59_E1.8380.89
211_R214_V1.8320.89
37_V86_L1.8010.88
34_A213_L1.7440.87
153_I159_T1.7180.86
90_I212_V1.7170.86
47_D99_K1.6710.84
133_F141_L1.6540.84
20_H70_I1.6510.83
22_A71_T1.6170.82
5_G36_A1.5930.81
95_F98_A1.5920.81
44_Q60_T1.5890.81
125_H145_F1.5700.80
208_L212_V1.5670.80
124_M129_K1.5450.79
111_C143_K1.5420.79
90_I132_G1.5370.79
118_K122_Q1.5170.78
121_A131_L1.5010.77
180_V187_V1.4830.76
36_A86_L1.4820.76
26_L38_C1.4460.74
178_I207_K1.4390.74
28_A206_D1.4280.73
6_V26_L1.4130.72
141_L188_T1.4040.72
50_N55_E1.3920.71
150_R169_E1.3840.71
103_N112_T1.3670.70
39_F81_A1.3580.69
9_S97_A1.3550.69
153_I163_L1.3510.69
24_L27_L1.3460.69
29_I34_A1.3450.69
121_A145_F1.3040.66
17_S22_A1.2900.65
5_G81_A1.2810.65
175_V195_A1.2510.63
83_A123_A1.2140.60
91_V117_L1.2120.60
132_G187_V1.2100.60
121_A144_I1.2030.60
133_F145_F1.1990.60
202_A206_D1.1940.59
40_A63_V1.1710.58
107_L112_T1.1630.57
175_V191_A1.1630.57
28_A202_A1.1590.57
107_L110_E1.1420.56
155_T172_P1.1420.56
18_E135_C1.1350.55
113_V139_A1.1250.55
27_L31_R1.1210.54
145_F151_L1.1020.53
191_A205_I1.0700.51
5_G120_L1.0680.51
189_T205_I1.0650.50
125_H184_N1.0540.50
5_G39_F1.0510.50
49_I57_M1.0430.49
89_L121_A1.0280.48
47_D54_G1.0210.47
32_S210_S1.0180.47
116_E119_A1.0120.47
50_N65_I1.0030.46
5_G124_M1.0010.46
102_S215_L0.9980.46
173_C205_I0.9920.46
164_E169_E0.9570.43
132_G209_V0.9570.43
139_A159_T0.9550.43
178_I187_V0.9500.43
3_K35_Q0.9480.43
28_A31_R0.9460.42
142_P208_L0.9420.42
102_S140_M0.9330.42
175_V205_I0.9240.41
150_R171_V0.9190.41
23_V192_Y0.9090.40
113_V119_A0.9060.40
28_A133_F0.9040.40
151_L168_A0.8920.39
191_A195_A0.8850.38
20_H198_I0.8840.38
102_S159_T0.8790.38
7_I120_L0.8790.38
54_G63_V0.8780.38
131_L142_P0.8740.38
149_L184_N0.8730.38
30_S133_F0.8680.37
34_A87_D0.8670.37
121_A133_F0.8650.37
133_F144_I0.8560.37
197_N200_E0.8550.37
138_P193_M0.8540.36
90_I201_A0.8440.36
125_H131_L0.8420.36
47_D56_A0.8410.36
2_K29_I0.8380.35
57_M65_I0.8370.35
11_C19_I0.8360.35
134_M208_L0.8340.35
13_V20_H0.8320.35
120_L124_M0.8270.35
195_A200_E0.8130.34
91_V144_I0.8120.34
4_I88_A0.8090.34
102_S113_V0.8090.34
30_S197_N0.8010.33
160_A170_H0.8000.33
91_V121_A0.7980.33
134_M191_A0.7940.33
139_A163_L0.7930.33
46_V56_A0.7880.32
122_Q140_M0.7860.32
45_Q48_V0.7830.32
22_A70_I0.7760.32
68_A71_T0.7750.32
4_I213_L0.7710.31
133_F186_I0.7660.31
45_Q59_E0.7620.31
133_F142_P0.7610.31
27_L194_L0.7600.31
161_E165_E0.7570.31
90_I180_V0.7560.31
82_D123_A0.7560.31
39_F76_R0.7480.30
153_I170_H0.7470.30
150_R183_D0.7380.29
187_V209_V0.7360.29
140_M143_K0.7350.29
120_L140_M0.7350.29
23_V27_L0.7300.29
86_L124_M0.7270.29
20_H71_T0.7250.29
134_M189_T0.7230.29
156_D160_A0.7210.29
10_G21_E0.7180.28
12_G21_E0.7180.28
128_G161_E0.7160.28
156_D170_H0.7140.28
76_R86_L0.7130.28
71_T75_I0.7100.28
7_I117_L0.7080.28
14_Y54_G0.7070.28
15_D21_E0.7050.28
59_E65_I0.7000.27
176_D203_S0.6960.27
80_Q180_V0.6930.27
27_L30_S0.6930.27
196_Q201_A0.6930.27
63_V67_A0.6880.27
137_A163_L0.6870.27
122_Q182_E0.6850.27
13_V95_F0.6830.26
31_R128_G0.6780.26
97_A137_A0.6770.26
187_V208_L0.6670.26
131_L151_L0.6660.26
141_L145_F0.6650.26
52_L65_I0.6620.25
32_S123_A0.6610.25
174_P178_I0.6600.25
136_I191_A0.6590.25
7_I186_I0.6580.25
114_D118_K0.6530.25
89_L163_L0.6530.25
18_E136_I0.6490.25
189_T208_L0.6460.25
90_I213_L0.6460.25
18_E98_A0.6440.24
201_A205_I0.6420.24
20_H97_A0.6410.24
126_Q137_A0.6380.24
18_E95_F0.6370.24
191_A200_E0.6340.24
133_F140_M0.6340.24
12_G15_D0.6330.24
10_G15_D0.6330.24
124_M144_I0.6320.24
103_N114_D0.6310.24
24_L198_I0.6300.24
113_V123_A0.6280.24
153_I194_L0.6260.24
136_I156_D0.6230.23
37_V76_R0.6230.23
80_Q110_E0.6220.23
36_A120_L0.6220.23
90_I187_V0.6200.23
142_P201_A0.6190.23
30_S67_A0.6190.23
14_Y47_D0.6190.23
16_G21_E0.6150.23
47_D63_V0.6120.23
25_T29_I0.6070.23
180_V188_T0.6050.23
47_D106_S0.6040.22
119_A183_D0.6030.22
81_A133_F0.5990.22
156_D189_T0.5980.22
7_I101_L0.5980.22
49_I56_A0.5980.22
31_R203_S0.5950.22
67_A74_E0.5950.22
140_M144_I0.5930.22
113_V126_Q0.5930.22
81_A134_M0.5920.22
109_S166_M0.5910.22
112_T137_A0.5880.22
99_K105_A0.5880.22
139_A156_D0.5870.22
98_A105_A0.5840.22
44_Q114_D0.5840.22
125_H132_G0.5840.22
9_S23_V0.5820.21
181_D184_N0.5790.21
4_I162_V0.5790.21
124_M148_P0.5760.21
83_A119_A0.5750.21
55_E116_E0.5740.21
156_D159_T0.5720.21
98_A135_C0.5700.21
119_A145_F0.5670.21
14_Y49_I0.5660.21
83_A215_L0.5660.21
151_L188_T0.5640.21
172_P197_N0.5630.21
29_I97_A0.5620.21
48_V60_T0.5610.20
82_D119_A0.5570.20
135_C193_M0.5550.20
58_T102_S0.5550.20
102_S106_S0.5540.20
18_E138_P0.5480.20
187_V215_L0.5460.20
189_T212_V0.5460.20
178_I208_L0.5460.20
159_T170_H0.5460.20
171_V180_V0.5450.20
191_A207_K0.5450.20
12_G16_G0.5440.20
10_G16_G0.5440.20
150_R182_E0.5440.20
7_I89_L0.5430.20
5_G148_P0.5420.20
42_D78_L0.5420.20
168_A211_R0.5390.20
211_R215_L0.5390.20
157_I161_E0.5380.19
97_A101_L0.5370.19
3_K165_E0.5360.19
185_K215_L0.5350.19
123_A128_G0.5350.19
173_C190_P0.5340.19
25_T212_V0.5330.19
29_I120_L0.5290.19
42_D203_S0.5290.19
182_E206_D0.5270.19
67_A210_S0.5240.19
117_L125_H0.5230.19
149_L206_D0.5230.19
77_P117_L0.5210.19
191_A196_Q0.5210.19
4_I34_A0.5200.19
168_A190_P0.5200.19
8_L17_S0.5190.19
5_G149_L0.5180.19
31_R199_A0.5160.19
196_Q203_S0.5150.19
159_T163_L0.5140.18
143_K166_M0.5140.18
7_I121_A0.5140.18
111_C139_A0.5130.18
209_V212_V0.5120.18
17_S137_A0.5110.18
118_K188_T0.5110.18
20_H159_T0.5100.18
191_A201_A0.5090.18
148_P184_N0.5070.18
145_F186_I0.5070.18
134_M212_V0.5050.18
18_E193_M0.5040.18
151_L210_S0.5010.18
113_V214_V0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l3bA 2 0.9816 100 0.629 Contact Map
1vhqA 2 0.9954 100 0.638 Contact Map
4i4nA 2 0.9171 99.8 0.783 Contact Map
1n57A 2 0.9124 99.8 0.793 Contact Map
4p5pA 1 0.8894 99.8 0.798 Contact Map
3kklA 2 0.8249 99.8 0.802 Contact Map
4lruA 1 0.894 99.8 0.804 Contact Map
4qyxA 2 0.8848 99.7 0.807 Contact Map
1u9cA 1 0.8571 99.7 0.807 Contact Map
3n7tA 2 0.8894 99.7 0.809 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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