GREMLIN Database
MENB - 1,4-dihydroxy-2-naphthoyl-CoA synthase
UniProt: P0ABU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11368
Length: 285 (249)
Sequences: 29461 (19223)
Seq/√Len: 1218.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_I189_Q3.1691.00
203_T213_E2.9701.00
146_A201_V2.9141.00
148_D206_P2.8751.00
124_A141_C2.8291.00
213_E216_R2.7281.00
36_K215_V2.6521.00
61_A114_Q2.4921.00
64_R119_P2.4321.00
188_R220_E2.2871.00
149_N207_L2.2641.00
29_K35_A2.1711.00
26_R40_N2.1681.00
194_Q197_D2.1581.00
45_R80_K2.1311.00
36_K75_T2.0721.00
191_D194_Q2.0451.00
184_W232_L2.0091.00
182_E188_R1.9721.00
179_K198_M1.9701.00
125_M214_T1.9591.00
38_T77_A1.9581.00
33_G70_G1.9491.00
57_I114_Q1.9371.00
268_N272_Q1.9111.00
158_K224_N1.9051.00
29_K66_D1.8881.00
40_N77_A1.8771.00
38_T75_T1.8751.00
45_R81_A1.8591.00
27_Y35_A1.8541.00
125_M211_E1.8441.00
215_V219_R1.7811.00
51_L55_E1.7541.00
62_D66_D1.7411.00
131_I153_G1.7381.00
145_I205_V1.7371.00
148_D193_K1.7301.00
181_R237_N1.7171.00
209_D212_K1.7021.00
35_A63_A1.7001.00
177_Q181_R1.6491.00
194_Q198_M1.6401.00
148_D207_L1.6371.00
265_E274_R1.6371.00
182_E202_N1.6251.00
35_A69_I1.6221.00
24_D55_E1.5721.00
72_I118_C1.5711.00
145_I217_W1.5581.00
193_K197_D1.5461.00
54_K107_N1.5441.00
146_A152_F1.5431.00
205_V213_E1.5311.00
182_E203_T1.5201.00
209_D213_E1.5031.00
63_A72_I1.4971.00
28_E31_T1.4961.00
113_R117_T1.4931.00
31_T215_V1.4911.00
24_D49_R1.4841.00
26_R77_A1.4721.00
64_R114_Q1.4501.00
37_I59_A1.4491.00
147_A207_L1.4411.00
142_D233_K1.4401.00
32_D219_R1.4291.00
113_R244_A1.4211.00
231_C256_L1.4051.00
138_H144_T1.4031.00
57_I61_A1.4011.00
126_V138_H1.4001.00
181_R185_F1.3971.00
127_A147_A1.3691.00
27_Y63_A1.3591.00
181_R236_L1.3571.00
127_A149_N1.3431.00
60_L118_C1.3391.00
144_T174_I1.3361.00
144_T178_K1.3331.00
196_L204_V1.3281.00
31_T219_R1.3151.00
179_K182_E1.3071.00
115_I122_V1.2981.00
31_T36_K1.2961.00
135_H154_Q1.2951.00
183_I190_Y1.2861.00
116_R170_Y1.2821.00
36_K211_E1.2721.00
71_V218_C1.2681.00
242_G245_G1.2461.00
75_T127_A1.2441.00
188_R194_Q1.2421.00
57_I110_D1.2401.00
81_A129_Y1.2401.00
64_R118_C1.2351.00
129_Y151_I1.2351.00
126_V130_S1.2301.00
75_T211_E1.2271.00
50_P90_V1.2161.00
28_E38_T1.2131.00
234_A238_A1.1851.00
179_K194_Q1.1811.00
238_A249_L1.1791.00
178_K202_N1.1791.00
211_E215_V1.1791.00
29_K68_N1.1711.00
80_K127_A1.1641.00
49_R52_T1.1601.00
147_A210_L1.1591.00
153_G189_Q1.1591.00
136_V167_G1.1551.00
39_I52_T1.1521.00
55_E59_A1.1511.00
224_N229_L1.1371.00
24_D51_L1.1161.00
192_A204_V1.1151.00
263_G267_R1.1121.00
41_R44_V1.1071.00
44_V89_K1.0951.00
29_K62_D1.0931.00
117_T244_A1.0921.00
242_G249_L1.0781.00
28_E36_K1.0771.00
210_L214_T1.0761.00
50_P54_K1.0751.00
26_R38_T1.0731.00
212_K216_R1.0731.00
190_Y198_M1.0681.00
72_I120_K1.0531.00
59_A62_D1.0371.00
157_P187_C1.0281.00
39_I83_C1.0181.00
55_E58_Q1.0121.00
75_T125_M1.0051.00
211_E214_T1.0041.00
122_V141_C1.0011.00
218_C222_L1.0001.00
58_Q62_D0.9971.00
176_G179_K0.9871.00
206_P209_D0.9851.00
119_P230_R0.9851.00
193_K196_L0.9821.00
175_V179_K0.9811.00
72_I122_V0.9781.00
264_Q268_N0.9781.00
174_I178_K0.9651.00
83_C134_G0.9641.00
143_L217_W0.9641.00
108_V165_G0.9641.00
73_I214_T0.9601.00
177_Q240_C0.9541.00
227_M262_E0.9531.00
234_A253_A0.9511.00
231_C234_A0.9511.00
34_I71_V0.9401.00
125_M210_L0.9311.00
226_P230_R0.9221.00
69_I120_K0.9221.00
135_H152_F0.9111.00
231_C253_A0.9081.00
151_I191_D0.9011.00
196_L201_V0.9011.00
157_P232_L0.9011.00
245_G248_E0.8891.00
169_S246_L0.8801.00
249_L252_N0.8771.00
127_A210_L0.8741.00
41_R87_D0.8741.00
78_G127_A0.8711.00
126_V152_F0.8691.00
148_D204_V0.8681.00
36_K73_I0.8581.00
57_I107_N0.8531.00
53_V111_F0.8491.00
184_W236_L0.8461.00
162_F257_F0.8431.00
61_A65_Y0.8421.00
147_A208_A0.8411.00
37_I72_I0.8331.00
216_R220_E0.8311.00
131_I189_Q0.8301.00
183_I198_M0.8231.00
60_L115_I0.8211.00
196_L203_T0.8191.00
168_A250_A0.8141.00
50_P107_N0.8111.00
89_K271_N0.8051.00
175_V183_I0.8031.00
213_E217_W0.8021.00
212_K215_V0.8011.00
215_V218_C0.7921.00
143_L202_N0.7891.00
214_T218_C0.7871.00
231_C257_F0.7871.00
158_K189_Q0.7841.00
238_A242_G0.7841.00
171_M175_V0.7791.00
182_E186_L0.7771.00
223_Q275_Q0.7761.00
220_E224_N0.7761.00
45_R84_S0.7741.00
249_L253_A0.7721.00
64_R120_K0.7691.00
253_A256_L0.7671.00
25_I59_A0.7651.00
29_K69_I0.7641.00
203_T217_W0.7621.00
54_K58_Q0.7621.00
126_V144_T0.7601.00
67_D120_K0.7521.00
57_I111_F0.7521.00
235_A253_A0.7501.00
61_A110_D0.7501.00
261_E264_Q0.7471.00
221_M229_L0.7451.00
95_G98_K0.7411.00
119_P234_A0.7371.00
106_L251_G0.7361.00
63_A69_I0.7271.00
192_A201_V0.7261.00
145_I203_T0.7251.00
139_M200_L0.7231.00
29_K32_D0.7231.00
27_Y59_A0.7221.00
41_R49_R0.7211.00
112_Q140_M0.7121.00
48_F52_T0.7101.00
24_D52_T0.7081.00
216_R219_R0.7041.00
126_V150_A0.7041.00
81_A127_A0.7041.00
106_L110_D0.7041.00
118_C122_V0.7021.00
169_S172_A0.6991.00
127_A207_L0.6991.00
92_G268_N0.6981.00
217_W220_E0.6941.00
195_A200_L0.6921.00
219_R223_Q0.6921.00
102_G106_L0.6871.00
176_G180_A0.6831.00
186_L217_W0.6831.00
179_K196_L0.6821.00
34_I73_I0.6811.00
248_E252_N0.6781.00
177_Q237_N0.6771.00
45_R129_Y0.6771.00
33_G68_N0.6761.00
267_R271_N0.6761.00
225_S262_E0.6691.00
59_A63_A0.6671.00
70_G226_P0.6661.00
136_V156_G0.6641.00
154_Q167_G0.6631.00
251_G255_M0.6621.00
201_V204_V0.6611.00
74_L141_C0.6601.00
61_A64_R0.6591.00
51_L54_K0.6571.00
74_L122_V0.6561.00
44_V87_D0.6541.00
131_I155_T0.6491.00
66_D69_I0.6491.00
152_F201_V0.6481.00
73_I125_M0.6471.00
162_F235_A0.6461.00
269_A276_P0.6441.00
244_A248_E0.6411.00
102_G255_M0.6411.00
49_R90_V0.6411.00
66_D120_K0.6391.00
73_I215_V0.6381.00
102_G252_N0.6331.00
235_A249_L0.6331.00
205_V210_L0.6311.00
193_K204_V0.6301.00
163_D232_L0.6291.00
153_G187_C0.6211.00
266_G276_P0.6191.00
41_R47_A0.6181.00
71_V222_L0.6171.00
110_D113_R0.6171.00
227_M260_T0.6171.00
185_F229_L0.6161.00
265_E276_P0.6131.00
58_Q61_A0.6111.00
110_D114_Q0.6101.00
177_Q236_L0.6081.00
145_I210_L0.6041.00
70_G222_L0.6041.00
52_T55_E0.6041.00
252_N256_L0.6021.00
34_I215_V0.6011.00
29_K33_G0.6011.00
71_V123_V0.5991.00
86_G91_R0.5961.00
129_Y189_Q0.5941.00
118_C121_P0.5931.00
123_V218_C0.5921.00
27_Y62_D0.5911.00
154_Q184_W0.5871.00
161_S263_G0.5861.00
268_N271_N0.5861.00
190_Y195_A0.5861.00
146_A150_A0.5841.00
168_A246_L0.5821.00
261_E265_E0.5821.00
138_H141_C0.5811.00
156_G164_G0.5801.00
37_I74_L0.5781.00
227_M257_F0.5771.00
175_V198_M0.5751.00
169_S173_R0.5751.00
92_G271_N0.5731.00
145_I214_T0.5721.00
175_V180_A0.5701.00
56_M111_F0.5701.00
135_H200_L0.5701.00
132_G155_T0.5691.00
124_A144_T0.5651.00
182_E194_Q0.5651.00
34_I218_C0.5641.00
186_L221_M0.5621.00
149_N192_A0.5621.00
179_K197_D0.5611.00
24_D41_R0.5591.00
232_L235_A0.5591.00
186_L220_E0.5571.00
145_I213_E0.5571.00
63_A120_K0.5551.00
192_A196_L0.5541.00
143_L221_M0.5511.00
60_L122_V0.5501.00
78_G81_A0.5491.00
60_L114_Q0.5491.00
265_E269_A0.5451.00
265_E268_N0.5441.00
144_T201_V0.5431.00
248_E251_G0.5381.00
182_E217_W0.5361.00
174_I202_N0.5341.00
44_V47_A0.5311.00
51_L90_V0.5301.00
209_D216_R0.5291.00
181_R233_K0.5291.00
124_A138_H0.5281.00
157_P229_L0.5271.00
173_R243_Q0.5251.00
127_A211_E0.5251.00
37_I60_L0.5241.00
69_I72_I0.5211.00
220_E223_Q0.5201.00
172_A239_D0.5191.00
157_P224_N0.5161.00
242_G246_L0.5161.00
103_V107_N0.5151.00
38_T211_E0.5141.00
27_Y37_I0.5141.00
63_A118_C0.5121.00
191_D197_D0.5121.00
92_G267_R0.5111.00
140_M170_Y0.5101.00
135_H139_M0.5101.00
53_V57_I0.5101.00
34_I222_L0.5091.00
178_K181_R0.5081.00
37_I63_A0.5071.00
136_V154_Q0.5031.00
160_G225_S0.5011.00
88_Q159_V0.5011.00
158_K220_E0.5001.00
127_A150_A0.5001.00
188_R203_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i42A 7 0.9965 100 0.123 Contact Map
2fbmA 3 0.8667 100 0.154 Contact Map
4lk5A 3 0.8772 100 0.157 Contact Map
1nzyA 4 0.9228 100 0.159 Contact Map
3kqfA 3 0.9018 100 0.16 Contact Map
4k3wA 3 0.9018 100 0.161 Contact Map
2uzfA 5 0.9123 100 0.162 Contact Map
2ppyA 6 0.9193 100 0.162 Contact Map
4mouA 3 0.9088 100 0.163 Contact Map
4i4zA 6 0.9474 100 0.163 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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