GREMLIN Database
YIJE - Uncharacterized inner membrane transporter yiJE
UniProt: P0ABT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11902
Length: 301 (276)
Sequences: 38916 (28567)
Seq/√Len: 1719.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A157_A3.4291.00
14_G237_F2.8571.00
98_K154_A2.7831.00
262_S268_E2.6781.00
237_F241_N2.6611.00
89_W156_L2.4511.00
43_A199_S2.4501.00
50_A192_L2.4281.00
129_A284_A2.4181.00
86_L159_L2.3681.00
28_F222_Y2.3071.00
237_F240_K2.2201.00
109_W161_G2.1841.00
120_E172_K2.1501.00
30_K268_E2.1211.00
86_L156_L2.0861.00
214_P218_W2.0811.00
113_F169_I2.0761.00
15_L238_V1.9711.00
100_A258_G1.9661.00
23_S257_C1.9541.00
115_A122_L1.9531.00
48_F224_A1.9391.00
82_G163_S1.9271.00
47_I195_A1.8971.00
94_G154_A1.8761.00
29_M88_Q1.8711.00
111_V130_I1.8671.00
114_A120_E1.8061.00
155_M159_L1.8041.00
105_T109_W1.7801.00
54_F188_S1.7691.00
110_V248_S1.7591.00
224_A229_A1.7251.00
123_R126_Q1.7191.00
23_S261_F1.6731.00
94_G153_S1.6561.00
200_V203_L1.6531.00
93_S152_K1.6521.00
55_I58_L1.6211.00
50_A195_A1.6211.00
133_A252_L1.6031.00
286_A290_R1.6021.00
24_Y222_Y1.5951.00
243_P246_I1.5931.00
196_L200_V1.5821.00
86_L163_S1.5761.00
151_M154_A1.5731.00
182_D185_S1.5671.00
109_W165_G1.5211.00
20_L257_C1.5131.00
68_P180_R1.5091.00
43_A195_A1.4951.00
271_G274_E1.4911.00
209_E212_W1.4901.00
129_A288_V1.4751.00
36_I216_V1.4611.00
99_V157_A1.4501.00
18_L238_V1.4171.00
113_F117_F1.4111.00
54_F58_L1.4061.00
56_V60_R1.3921.00
272_A276_S1.3911.00
89_W93_S1.3901.00
261_F265_L1.3771.00
94_G98_K1.3761.00
109_W162_V1.3731.00
35_Y216_V1.3681.00
213_Q216_V1.3571.00
70_K74_A1.3491.00
96_A262_S1.3421.00
114_A118_L1.3361.00
21_I226_L1.3311.00
41_F223_S1.3271.00
171_A236_L1.3251.00
32_V41_F1.3231.00
139_L280_L1.3161.00
55_I59_L1.3101.00
275_G279_V1.3091.00
214_P217_F1.2921.00
22_W231_A1.2901.00
52_V229_A1.2881.00
151_M155_M1.2851.00
133_A284_A1.2841.00
257_C261_F1.2821.00
124_R128_F1.2721.00
14_G234_L1.2711.00
65_R68_P1.2711.00
27_I261_F1.2711.00
31_Q219_A1.2681.00
136_G277_G1.2601.00
89_W92_V1.2591.00
95_G98_K1.2591.00
215_T218_W1.2541.00
93_S156_L1.2481.00
127_Y131_L1.2421.00
49_G191_M1.2421.00
210_I213_Q1.2411.00
51_L55_I1.2391.00
279_V283_L1.2321.00
71_Y170_V1.2281.00
139_L273_V1.2261.00
129_A287_L1.2241.00
113_F166_A1.2241.00
253_A257_C1.2191.00
97_G259_V1.2171.00
67_T71_Y1.2011.00
218_W222_Y1.1911.00
37_G40_D1.1871.00
172_K243_P1.1741.00
270_P275_G1.1731.00
12_I250_S1.1701.00
197_V200_V1.1691.00
131_L135_F1.1681.00
125_G287_L1.1671.00
74_A170_V1.1661.00
101_I278_I1.1651.00
165_G169_I1.1641.00
73_L193_Y1.1581.00
67_T70_K1.1581.00
13_S17_V1.1431.00
215_T219_A1.1371.00
43_A202_A1.1311.00
152_K156_L1.1251.00
81_C197_V1.1181.00
45_R228_T1.1181.00
140_V277_G1.1171.00
116_L119_G1.1131.00
110_V244_A1.1051.00
91_L99_V1.1051.00
30_K34_S1.0991.00
58_L62_R1.0991.00
81_C198_M1.0851.00
136_G281_I1.0841.00
43_A47_I1.0841.00
172_K176_A1.0821.00
122_L127_Y1.0761.00
28_F219_A1.0731.00
173_R176_A1.0651.00
111_V122_L1.0621.00
102_L161_G1.0571.00
93_S153_S1.0531.00
239_L247_A1.0481.00
29_M91_L1.0461.00
50_A188_S1.0401.00
76_A193_Y1.0391.00
17_V234_L1.0391.00
11_A238_V1.0381.00
152_K155_M1.0361.00
39_F201_V1.0351.00
24_Y261_F1.0341.00
94_G157_A1.0331.00
63_G66_P1.0311.00
120_E126_Q1.0301.00
208_R211_D1.0291.00
77_L197_V1.0231.00
87_A91_L1.0221.00
118_L169_I1.0211.00
22_W235_W1.0201.00
125_G291_K1.0191.00
172_K244_A1.0161.00
18_L22_W1.0131.00
32_V216_V1.0121.00
18_L234_L1.0101.00
105_T137_L1.0081.00
79_Q167_S1.0071.00
42_T88_Q1.0061.00
70_K73_L1.0061.00
110_V168_A1.0041.00
21_I234_L1.0031.00
113_F165_G0.9991.00
221_A224_A0.9911.00
124_R127_Y0.9881.00
96_A266_L0.9871.00
161_G165_G0.9831.00
218_W221_A0.9801.00
71_Y174_L0.9751.00
115_A121_R0.9731.00
68_P181_V0.9721.00
113_F162_V0.9701.00
38_A42_T0.9601.00
32_V219_A0.9481.00
153_S157_A0.9471.00
239_L243_P0.9431.00
272_A275_G0.9391.00
69_F193_Y0.9391.00
78_L166_A0.9381.00
125_G290_R0.9311.00
96_A268_E0.9311.00
132_I284_A0.9301.00
39_F85_G0.9241.00
93_S150_S0.9211.00
113_F116_L0.9201.00
200_V204_L0.9171.00
102_L154_A0.9141.00
243_P247_A0.9121.00
11_A241_N0.9081.00
78_L163_S0.9031.00
62_R182_D0.9001.00
201_V205_V0.8981.00
58_L61_G0.8961.00
142_Q271_G0.8931.00
27_I265_L0.8921.00
102_L157_A0.8881.00
52_V225_I0.8781.00
123_R127_Y0.8761.00
110_V165_G0.8731.00
40_D202_A0.8721.00
46_C194_A0.8661.00
138_F142_Q0.8591.00
217_F221_A0.8591.00
121_R125_G0.8571.00
201_V204_L0.8561.00
242_L246_I0.8531.00
19_T23_S0.8501.00
135_F139_L0.8491.00
47_I199_S0.8491.00
101_I138_F0.8461.00
242_L247_A0.8391.00
68_P71_Y0.8351.00
75_I79_Q0.8321.00
35_Y213_Q0.8251.00
256_V278_I0.8251.00
192_L196_L0.8191.00
19_T257_C0.8181.00
54_F192_L0.8141.00
238_V247_A0.8121.00
71_Y173_R0.8101.00
27_I262_S0.8071.00
263_W270_P0.8071.00
253_A256_V0.8031.00
115_A119_G0.8021.00
273_V276_S0.7901.00
85_G89_W0.7901.00
74_A77_L0.7901.00
135_F280_L0.7871.00
57_L61_G0.7871.00
164_W168_A0.7861.00
259_V270_P0.7791.00
71_Y75_I0.7771.00
137_L141_L0.7771.00
16_V257_C0.7741.00
166_A170_V0.7711.00
29_M33_T0.7681.00
108_F133_A0.7661.00
76_A81_C0.7661.00
278_I282_V0.7661.00
121_R124_R0.7651.00
193_Y196_L0.7641.00
128_F132_I0.7611.00
139_L276_S0.7581.00
276_S280_L0.7571.00
221_A225_I0.7561.00
188_S192_L0.7541.00
42_T198_M0.7541.00
81_C85_G0.7541.00
284_A288_V0.7471.00
157_A161_G0.7431.00
90_A99_V0.7401.00
66_P69_F0.7361.00
220_L224_A0.7351.00
259_V278_I0.7351.00
15_L250_S0.7311.00
112_I116_L0.7311.00
150_S154_A0.7301.00
82_G86_L0.7301.00
102_L158_I0.7241.00
59_L62_R0.7241.00
50_A54_F0.7171.00
189_W193_Y0.7171.00
109_W158_I0.7141.00
219_A222_Y0.7131.00
71_Y74_A0.7121.00
72_T181_V0.7121.00
66_P70_K0.7091.00
53_L229_A0.7061.00
83_M163_S0.7041.00
230_L234_L0.7041.00
52_V55_I0.7041.00
36_I41_F0.7041.00
283_L287_L0.7031.00
122_L126_Q0.7011.00
193_Y197_V0.6981.00
192_L195_A0.6971.00
226_L230_L0.6961.00
60_R182_D0.6951.00
111_V126_Q0.6931.00
194_A198_M0.6931.00
47_I51_L0.6931.00
69_F73_L0.6911.00
83_M167_S0.6911.00
185_S189_W0.6871.00
107_P252_L0.6861.00
19_T253_A0.6861.00
27_I96_A0.6841.00
195_A199_S0.6841.00
40_D44_L0.6841.00
120_E245_S0.6801.00
164_W235_W0.6791.00
78_L170_V0.6781.00
57_L188_S0.6781.00
31_Q266_L0.6771.00
25_S227_A0.6771.00
136_G284_A0.6771.00
110_V169_I0.6761.00
222_Y226_L0.6741.00
94_G99_V0.6731.00
15_L242_L0.6721.00
105_T108_F0.6681.00
263_W269_N0.6671.00
44_L48_F0.6631.00
56_V184_L0.6611.00
132_I287_L0.6581.00
76_A79_Q0.6571.00
196_L199_S0.6571.00
181_V186_L0.6571.00
26_W87_A0.6551.00
69_F189_W0.6551.00
187_T190_Q0.6501.00
37_G206_P0.6501.00
270_P274_E0.6491.00
216_V219_A0.6481.00
262_S266_L0.6471.00
12_I246_I0.6331.00
183_L187_T0.6311.00
21_I231_A0.6301.00
87_A160_S0.6261.00
73_L77_L0.6231.00
260_L264_W0.6201.00
48_F52_V0.6201.00
233_S237_F0.6191.00
87_A99_V0.6171.00
52_V224_A0.6171.00
104_Y137_L0.6151.00
249_L288_V0.6141.00
259_V263_W0.6101.00
26_W100_A0.6101.00
56_V59_L0.6021.00
17_V21_I0.6001.00
90_A153_S0.5961.00
208_R212_W0.5961.00
156_L159_L0.5961.00
147_D150_S0.5951.00
111_V115_A0.5951.00
101_I141_L0.5941.00
86_L160_S0.5921.00
69_F72_T0.5911.00
118_L173_R0.5891.00
187_T236_L0.5881.00
72_T76_A0.5881.00
11_A242_L0.5881.00
105_T161_G0.5841.00
274_E278_I0.5841.00
104_Y107_P0.5831.00
81_C201_V0.5811.00
168_A235_W0.5811.00
126_Q243_P0.5791.00
49_G229_A0.5791.00
189_W192_L0.5691.00
269_N273_V0.5681.00
104_Y161_G0.5681.00
203_L206_P0.5641.00
73_L76_A0.5641.00
148_F151_M0.5631.00
24_Y227_A0.5621.00
19_T254_V0.5611.00
176_A180_R0.5601.00
33_T91_L0.5551.00
271_G275_G0.5541.00
282_V286_A0.5511.00
210_I214_P0.5481.00
260_L263_W0.5481.00
21_I227_A0.5481.00
36_I40_D0.5441.00
117_F166_A0.5431.00
112_I130_I0.5421.00
167_S236_L0.5421.00
60_R184_L0.5411.00
57_L185_S0.5401.00
211_D214_P0.5381.00
72_T186_L0.5361.00
88_Q92_V0.5351.00
114_A245_S0.5341.00
26_W30_K0.5341.00
118_L172_K0.5291.00
101_I140_V0.5291.00
263_W275_G0.5271.00
11_A14_G0.5261.00
141_L154_A0.5261.00
168_A248_S0.5261.00
27_I258_G0.5241.00
83_M87_A0.5241.00
251_T254_V0.5241.00
285_L288_V0.5241.00
252_L285_L0.5231.00
213_Q217_F0.5231.00
261_F264_W0.5171.00
154_A158_I0.5171.00
39_F205_V0.5131.00
105_T133_A0.5111.00
171_A239_L0.5091.00
238_V242_L0.5091.00
263_W267_G0.5081.00
12_I16_V0.5081.00
44_L220_L0.5071.00
162_V166_A0.5071.00
212_W217_F0.5061.00
57_L60_R0.5041.00
23_S258_G0.5031.00
143_P273_V0.5031.00
209_E213_Q0.5011.00
128_F135_F0.5011.00
42_T85_G0.5001.00
100_A104_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2558 98.8 0.754 Contact Map
3b5dA 2 0.3355 98.3 0.792 Contact Map
1pw4A 1 0.9635 27.8 0.931 Contact Map
4j05A 3 0.9502 27.7 0.931 Contact Map
4he8J 1 0.5083 26.5 0.931 Contact Map
1u7gA 3 0.7907 22.3 0.934 Contact Map
3wdoA 1 0.6512 17.9 0.936 Contact Map
4pgrA 1 0.6478 17 0.937 Contact Map
4ldsA 2 0.6777 16.9 0.937 Contact Map
3mktA 1 0.8704 15.9 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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