GREMLIN Database
DUSB - tRNA-dihydrouridine synthase B
UniProt: P0ABT5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11311
Length: 321 (296)
Sequences: 6679 (3871)
Seq/√Len: 225.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E261_A4.5211.00
190_K219_D4.4301.00
205_D208_K3.3091.00
204_T208_K2.9201.00
129_V164_Q2.8981.00
87_V133_D2.7331.00
211_A215_Y2.7021.00
65_G92_Q2.6171.00
159_E194_S2.5991.00
125_L163_I2.4721.00
187_R191_Q2.4311.00
184_D215_Y2.3781.00
79_M96_I2.3671.00
126_T130_N2.3311.00
210_R214_D2.2661.00
199_A212_V2.2021.00
116_Q144_W2.1741.00
305_D308_E2.1391.00
83_A132_V2.1251.00
25_F29_C2.1161.00
142_T185_S2.0191.00
210_R240_Y2.0031.00
188_A191_Q2.0011.00
203_I212_V1.9801.00
122_K161_C1.9721.00
98_M121_V1.9471.00
117_Y120_V1.9121.00
132_V136_V1.9111.00
260_C310_L1.9031.00
264_R310_L1.8991.00
175_C182_E1.8671.00
211_A214_D1.8411.00
81_D84_R1.8401.00
68_T93_I1.8391.00
159_E195_I1.8321.00
77_K81_D1.8171.00
182_E185_S1.8021.00
121_V154_I1.8011.00
208_K211_A1.7911.00
204_T226_A1.7801.00
186_I199_A1.7661.00
122_K157_L1.7641.00
84_R131_A1.7541.00
298_R302_A1.7141.00
109_L117_Y1.6841.00
36_L68_T1.6821.00
79_M128_V1.6651.00
209_A221_L1.6541.00
156_Q192_K1.6491.00
80_A131_A1.6451.00
119_D123_S1.6381.00
262_H286_Y1.6321.00
69_V86_N1.6251.00
151_C189_V1.6101.00
122_K126_T1.5971.00
75_D78_E1.5921.00
199_A203_I1.5761.00
13_I198_I1.5751.00
122_K160_D1.5711.00
153_E156_Q1.5621.00
140_I168_I1.5581.00
145_A148_H1.5571.00
152_E192_K1.5561.00
235_R254_E1.5551.00
35_G238_Q1.5511.00
193_V197_V1.5381.00
198_I222_M1.5371.00
207_L211_A1.5151.00
119_D157_L1.5121.00
198_I220_A1.5081.00
181_A202_D1.5041.00
185_S188_A1.5021.00
165_A198_I1.4981.00
76_P80_A1.4901.00
187_R212_V1.4801.00
123_S126_T1.4771.00
73_G79_M1.4701.00
295_Q298_R1.4621.00
96_I128_V1.4571.00
120_V123_S1.4501.00
230_R236_E1.4431.00
10_N35_G1.4391.00
190_K197_V1.4381.00
138_L158_A1.4311.00
187_R215_Y1.4201.00
156_Q159_E1.4121.00
126_T161_C1.3631.00
86_N94_I1.3521.00
112_S173_R1.3161.00
87_V134_V1.3141.00
45_N78_E1.3051.00
87_V132_V1.2921.00
137_T165_A1.2891.00
12_L221_L1.2881.00
251_P254_E1.2741.00
170_G186_I1.2621.00
199_A218_A1.2611.00
15_A224_G1.2461.00
155_A193_V1.2461.00
303_I308_E1.2441.00
261_A265_E1.2241.00
125_L161_C1.2201.00
264_R268_D1.2121.00
38_V167_T1.2111.00
147_E150_N1.2041.00
84_R88_E1.1971.00
223_I237_I1.1881.00
115_L140_I1.1841.00
156_Q160_D1.1821.00
209_A237_I1.1781.00
27_T31_E1.1711.00
27_T265_E1.1611.00
142_T182_E1.1581.00
155_A189_V1.1551.00
12_L237_I1.1551.00
27_T63_E1.1521.00
146_P175_C1.1471.00
256_K260_C1.1451.00
47_Q85_I1.1411.00
269_F274_K1.1351.00
115_L154_I1.1301.00
154_I158_A1.1241.00
206_P236_E1.1191.00
36_L93_I1.1191.00
153_E157_L1.1181.00
138_L163_I1.1121.00
38_V68_T1.1051.00
13_I36_L1.1051.00
76_P120_V1.1041.00
51_S54_S1.1001.00
304_E308_E1.0961.00
115_L150_N1.0911.00
30_Y64_P1.0901.00
188_A192_K1.0831.00
168_I189_V1.0801.00
152_E193_V1.0781.00
125_L158_A1.0771.00
183_Y212_V1.0631.00
79_M124_I1.0631.00
259_L283_V1.0581.00
129_V136_V1.0531.00
212_V218_A1.0521.00
152_E188_A1.0491.00
212_V216_T1.0481.00
32_M258_L1.0401.00
114_L124_I1.0361.00
14_A29_C1.0351.00
23_R27_T1.0341.00
44_S82_A1.0341.00
121_V158_A1.0331.00
142_T170_G1.0291.00
125_L138_L1.0261.00
45_N49_W1.0251.00
151_C185_S1.0241.00
271_G275_G1.0211.00
273_A277_R1.0101.00
118_P153_E1.0101.00
157_L161_C1.0061.00
156_Q193_V0.9971.00
252_L255_V0.9941.00
140_I154_I0.9921.00
80_A84_R0.9871.00
203_I209_A0.9871.00
255_V290_H0.9851.00
287_L293_N0.9831.00
238_Q242_D0.9821.00
262_H266_L0.9811.00
295_Q299_T0.9731.00
303_I309_Q0.9721.00
27_T61_I0.9541.00
206_P240_Y0.9531.00
14_A227_A0.9531.00
265_E268_D0.9471.00
227_A234_F0.9471.00
32_M235_R0.9461.00
148_H188_A0.9451.00
159_E193_V0.9451.00
30_Y66_I0.9381.00
142_T149_R0.9351.00
154_I157_L0.9291.00
254_E257_R0.9211.00
109_L113_A0.9150.99
262_H283_V0.9130.99
227_A233_I0.9110.99
287_L296_F0.9100.99
77_K127_E0.9090.99
306_A310_L0.9090.99
148_H192_K0.9070.99
85_I88_E0.9040.99
163_I166_L0.9020.99
83_A128_V0.8890.99
299_T303_I0.8880.99
24_P269_F0.8880.99
187_R217_G0.8850.99
239_H248_P0.8810.99
158_A163_I0.8800.99
68_T137_T0.8770.99
127_E130_N0.8750.99
126_T160_D0.8730.99
119_D122_K0.8720.99
175_C179_G0.8710.99
207_L240_Y0.8690.99
152_E189_V0.8690.99
253_A257_R0.8680.99
48_V81_D0.8630.99
270_Y278_I0.8630.99
167_T222_M0.8630.99
102_A105_V0.8610.99
146_P174_A0.8600.99
85_I89_S0.8540.99
277_R280_R0.8520.99
203_I221_L0.8510.99
13_I38_V0.8480.99
81_D85_I0.8370.99
226_A230_R0.8360.99
140_I151_C0.8330.99
23_R59_V0.8330.99
78_E81_D0.8290.99
260_C264_R0.8280.99
202_D225_R0.8280.99
237_I241_L0.8280.99
106_N113_A0.8250.99
76_P123_S0.8240.99
59_V89_S0.8220.99
121_V125_L0.8200.99
80_A127_E0.8170.99
267_H271_G0.8130.99
263_V267_H0.8130.99
168_I197_V0.8110.99
206_P210_R0.8100.99
24_P265_E0.8090.99
165_A196_P0.8070.99
255_V259_L0.8070.99
12_L234_F0.8050.99
294_D298_R0.8040.99
20_I285_W0.7970.99
99_G200_N0.7950.99
257_R261_A0.7930.99
232_W255_V0.7890.98
56_L59_V0.7880.98
155_A166_L0.7880.98
281_K285_W0.7870.98
262_H279_A0.7870.98
307_S310_L0.7820.98
213_L221_L0.7800.98
228_Q285_W0.7740.98
98_M138_L0.7720.98
129_V163_I0.7720.98
264_R267_H0.7720.98
207_L210_R0.7710.98
11_R35_G0.7700.98
95_D167_T0.7680.98
250_L254_E0.7660.98
140_I155_A0.7630.98
29_C34_A0.7630.98
76_P124_I0.7620.98
184_D188_A0.7620.98
52_D56_L0.7580.98
15_A222_M0.7580.98
14_A21_T0.7550.98
29_C227_A0.7510.98
48_V78_E0.7510.98
148_H185_S0.7490.98
93_I137_T0.7480.98
60_H67_R0.7480.98
39_S67_R0.7390.98
127_E131_A0.7340.98
208_K212_V0.7300.97
213_L218_A0.7300.97
152_E156_Q0.7250.97
128_V136_V0.7200.97
71_I79_M0.7190.97
11_R220_A0.7170.97
166_L195_I0.7170.97
264_R306_A0.7100.97
103_K107_R0.7100.97
31_E63_E0.7100.97
145_A172_T0.7060.97
80_A132_V0.7030.97
18_A41_M0.7030.97
274_K278_I0.7020.97
113_A116_Q0.6990.97
28_L265_E0.6990.97
186_I197_V0.6970.97
140_I166_L0.6960.97
159_E166_L0.6960.97
135_P164_Q0.6940.97
74_S109_L0.6930.97
255_V258_L0.6910.97
86_N91_A0.6880.96
187_R218_A0.6860.96
44_S79_M0.6860.96
30_Y37_T0.6850.96
297_R301_N0.6840.96
29_C32_M0.6830.96
206_P209_A0.6830.96
223_I233_I0.6820.96
267_H310_L0.6810.96
90_G134_V0.6770.96
43_S72_A0.6710.96
267_H306_A0.6690.96
259_L262_H0.6670.96
24_P27_T0.6650.96
36_L165_A0.6620.96
232_W250_L0.6600.95
74_S110_A0.6580.95
269_F272_P0.6540.95
248_P251_P0.6540.95
29_C234_F0.6530.95
115_L121_V0.6510.95
165_A220_A0.6500.95
20_I228_Q0.6490.95
94_I132_V0.6490.95
60_H64_P0.6490.95
206_P237_I0.6480.95
60_H65_G0.6480.95
152_E155_A0.6440.95
274_K279_A0.6440.95
44_S78_E0.6440.95
103_K106_N0.6410.95
83_A94_I0.6410.95
263_V306_A0.6400.95
155_A168_I0.6390.95
270_Y274_K0.6300.94
115_L143_G0.6290.94
103_K176_L0.6280.94
167_T198_I0.6270.94
47_Q52_D0.6270.94
204_T224_G0.6260.94
187_R203_I0.6260.94
13_I167_T0.6240.94
149_R152_E0.6230.94
118_P157_L0.6230.94
50_E55_R0.6220.94
157_L160_D0.6210.94
23_R60_H0.6190.94
43_S46_P0.6170.94
261_A264_R0.6170.94
284_S301_N0.6150.93
256_K259_L0.6150.93
183_Y199_A0.6150.93
13_I165_A0.6130.93
197_V218_A0.6110.93
236_E249_P0.6110.93
177_F202_D0.6100.93
109_L120_V0.6090.93
163_I195_I0.6080.93
39_S69_V0.6080.93
287_L297_R0.6050.93
54_S57_R0.6040.93
106_N144_W0.6020.93
152_E185_S0.6010.93
273_A304_E0.6000.93
283_V309_Q0.5970.92
98_M158_A0.5970.92
129_V161_C0.5970.92
116_Q150_N0.5950.92
96_I125_L0.5930.92
12_L209_A0.5920.92
53_K89_S0.5880.92
210_R213_L0.5810.91
296_F299_T0.5800.91
48_V82_A0.5780.91
268_D272_P0.5740.91
150_N153_E0.5740.91
83_A136_V0.5730.91
259_L263_V0.5730.91
69_V91_A0.5710.91
12_L238_Q0.5680.90
252_L256_K0.5680.90
52_D57_R0.5670.90
23_R269_F0.5660.90
159_E196_P0.5660.90
117_Y123_S0.5650.90
61_I64_P0.5650.90
38_V137_T0.5640.90
80_A130_N0.5630.90
236_E240_Y0.5630.90
230_R233_I0.5610.90
223_I227_A0.5600.90
237_I240_Y0.5600.90
34_A37_T0.5590.90
79_M83_A0.5580.90
87_V94_I0.5570.90
151_C168_I0.5560.90
293_N297_R0.5550.89
12_L35_G0.5550.89
209_A213_L0.5530.89
102_A176_L0.5500.89
223_I234_F0.5500.89
80_A128_V0.5480.89
39_S86_N0.5470.89
84_R132_V0.5450.89
166_L193_V0.5450.89
21_T29_C0.5440.88
116_Q145_A0.5440.88
57_R60_H0.5430.88
99_G222_M0.5430.88
287_L290_H0.5420.88
53_K59_V0.5410.88
10_N238_Q0.5400.88
280_R304_E0.5370.88
49_W54_S0.5340.88
235_R239_H0.5320.87
183_Y215_Y0.5310.87
71_I128_V0.5300.87
17_M20_I0.5290.87
150_N154_I0.5290.87
50_E54_S0.5280.87
300_F303_I0.5270.87
148_H182_E0.5260.87
122_K158_A0.5260.87
18_A21_T0.5240.87
112_S115_L0.5230.87
128_V132_V0.5220.86
124_I127_E0.5180.86
186_I212_V0.5180.86
119_D153_E0.5180.86
28_L32_M0.5160.86
106_N112_S0.5160.86
31_E265_E0.5160.86
45_N75_D0.5140.86
235_R250_L0.5140.86
203_I223_I0.5140.86
261_A268_D0.5130.85
23_R61_I0.5120.85
158_A166_L0.5110.85
142_T151_C0.5090.85
186_I218_A0.5090.85
185_S192_K0.5090.85
43_S47_Q0.5080.85
106_N173_R0.5080.85
158_A161_C0.5080.85
235_R240_Y0.5070.85
41_M72_A0.5070.85
236_E239_H0.5060.85
183_Y211_A0.5060.85
121_V140_I0.5060.85
18_A42_M0.5050.85
206_P233_I0.5040.84
68_T165_A0.5040.84
38_V93_I0.5040.84
213_L241_L0.5020.84
35_G223_I0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhnA 1 0.9502 100 0.345 Contact Map
3b0pA 1 0.9315 100 0.362 Contact Map
4bfaA 1 0.9564 100 0.366 Contact Map
4xp7A 1 0.8972 100 0.401 Contact Map
1gteA 4 0.9751 100 0.579 Contact Map
3tjlA 2 0.8816 100 0.604 Contact Map
4gbuA 2 0.8567 100 0.612 Contact Map
3l5aA 1 0.8505 100 0.615 Contact Map
1o94A 2 0.9844 100 0.616 Contact Map
4tmbA 2 0.8411 100 0.618 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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