DPS - ECOLI - GREMLIN Contacts

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DPS - DNA protection during starvation protein

UniProt:	P0ABT2	Sequences: MSTAKLVKSKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGANFIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYPLDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKFLWFIESNIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11415
Length:	167 (146)
Sequences:	2922 (1664)
Seq/√Len:	137.7

ECOLI - DPS
BACSU - MRGA G20U
HALSA - DPS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
113_N	116_D	3.296	1.00
30_V	89_G	2.921	1.00
146_D	150_A	2.730	1.00
46_I	124_R	2.559	1.00
50_A	120_E	2.528	1.00
96_Q	100_S	2.441	1.00
39_Q	103_P	2.395	1.00
60_I	64_E	2.388	1.00
146_D	149_T	2.382	1.00
47_T	73_L	2.222	1.00
50_A	107_Y	2.135	1.00
136_I	149_T	2.101	1.00
92_L	101_K	1.981	1.00
137_G	145_A	1.927	1.00
67_D	71_T	1.880	1.00
145_A	149_T	1.875	1.00
143_D	152_S	1.787	1.00
62_V	66_L	1.759	1.00
126_A	163_E	1.753	1.00
41_I	98_I	1.751	1.00
45_L	95_T	1.720	1.00
72_A	158_F	1.637	1.00
142_D	145_A	1.624	1.00
83_R	141_D	1.610	1.00
50_A	117_H	1.576	1.00
65_M	68_G	1.575	1.00
122_A	159_L	1.574	1.00
32_L	135_A	1.573	1.00
126_A	130_N	1.548	1.00
34_N	92_L	1.521	1.00
22_S	25_E	1.516	1.00
65_M	69_F	1.497	1.00
119_K	123_D	1.481	1.00
40_F	80_M	1.456	1.00
28_A	31_E	1.428	1.00
107_Y	120_E	1.417	1.00
67_D	70_R	1.408	1.00
137_G	142_D	1.405	1.00
83_R	144_T	1.404	1.00
129_A	159_L	1.401	1.00
72_A	76_H	1.359	1.00
159_L	163_E	1.348	1.00
49_Q	93_G	1.330	1.00
72_A	154_D	1.325	1.00
129_A	156_D	1.320	1.00
42_D	99_N	1.317	1.00
79_T	147_I	1.298	1.00
40_F	73_L	1.291	1.00
96_Q	106_S	1.290	1.00
76_H	151_A	1.285	1.00
69_F	125_Y	1.275	1.00
39_Q	131_D	1.264	1.00
141_D	144_T	1.256	1.00
116_D	119_K	1.252	1.00
115_Q	119_K	1.234	1.00
27_K	31_E	1.228	1.00
38_I	101_K	1.220	1.00
76_H	154_D	1.217	1.00
130_N	134_K	1.197	1.00
47_T	69_F	1.179	1.00
126_A	159_L	1.173	0.99
88_G	163_E	1.130	0.99
42_D	102_T	1.121	0.99
133_R	156_D	1.118	0.99
83_R	156_D	1.106	0.99
41_I	77_L	1.105	0.99
118_L	162_I	1.102	0.99
129_A	152_S	1.099	0.99
136_I	145_A	1.093	0.99
107_Y	117_H	1.073	0.99
154_D	157_K	1.069	0.99
60_I	68_G	1.061	0.99
133_R	152_S	1.055	0.99
34_N	84_A	1.049	0.99
44_S	74_I	1.049	0.99
60_I	65_M	1.047	0.99
48_K	77_L	1.036	0.99
135_A	148_L	1.032	0.99
66_L	117_H	1.023	0.99
137_G	140_K	1.019	0.99
87_L	144_T	1.018	0.99
23_D	26_K	1.017	0.99
35_R	131_D	0.996	0.98
103_P	131_D	0.993	0.98
143_D	153_R	0.992	0.98
103_P	127_I	0.987	0.98
125_Y	158_F	0.980	0.98
42_D	106_S	0.971	0.98
142_D	149_T	0.968	0.98
46_I	106_S	0.964	0.98
74_I	77_L	0.959	0.98
123_D	126_A	0.953	0.98
36_Q	135_A	0.951	0.98
122_A	163_E	0.945	0.98
21_V	26_K	0.935	0.97
136_I	152_S	0.925	0.97
30_V	84_A	0.918	0.97
36_Q	132_V	0.912	0.97
35_R	103_P	0.912	0.97
42_D	95_T	0.889	0.97
23_D	27_K	0.883	0.96
63_H	82_E	0.859	0.96
125_Y	155_L	0.858	0.96
39_Q	102_T	0.855	0.96
58_N	114_V	0.845	0.95
59_F	82_E	0.843	0.95
122_A	126_A	0.840	0.95
60_I	165_N	0.838	0.95
71_T	75_D	0.835	0.95
37_V	80_M	0.830	0.95
61_A	165_N	0.829	0.95
97_V	109_L	0.818	0.94
75_D	79_T	0.814	0.94
116_D	120_E	0.811	0.94
97_V	100_S	0.791	0.93
53_N	91_A	0.790	0.93
64_E	68_G	0.789	0.93
45_L	93_G	0.789	0.93
129_A	155_L	0.786	0.93
48_K	67_D	0.772	0.93
99_N	106_S	0.757	0.92
51_H	82_E	0.755	0.92
48_K	70_R	0.754	0.92
136_I	142_D	0.751	0.92
36_Q	131_D	0.748	0.91
21_V	133_R	0.745	0.91
28_A	138_E	0.745	0.91
154_D	158_F	0.735	0.91
32_L	35_R	0.730	0.90
21_V	25_E	0.729	0.90
97_V	101_K	0.728	0.90
24_S	27_K	0.727	0.90
150_A	153_R	0.725	0.90
65_M	161_F	0.722	0.90
44_S	80_M	0.720	0.90
118_L	165_N	0.703	0.89
90_V	111_I	0.690	0.88
121_L	125_Y	0.690	0.88
51_H	63_H	0.687	0.87
39_Q	127_I	0.686	0.87
68_G	71_T	0.686	0.87
132_V	151_A	0.685	0.87
40_F	76_H	0.683	0.87
34_N	38_I	0.683	0.87
157_K	160_W	0.681	0.87
83_R	87_L	0.679	0.87
19_N	23_D	0.677	0.87
79_T	150_A	0.677	0.87
66_L	118_L	0.677	0.87
61_A	64_E	0.675	0.87
45_L	98_I	0.674	0.86
37_V	40_F	0.672	0.86
86_Q	157_K	0.667	0.86
132_V	155_L	0.666	0.86
58_N	115_Q	0.666	0.86
54_M	117_H	0.662	0.85
53_N	93_G	0.660	0.85
67_D	74_I	0.647	0.84
57_A	115_Q	0.646	0.84
132_V	148_L	0.642	0.84
69_F	162_I	0.636	0.83
34_N	91_A	0.633	0.83
84_A	89_G	0.633	0.83
48_K	161_F	0.632	0.83
105_K	123_D	0.627	0.82
104_L	124_R	0.622	0.82
58_N	165_N	0.621	0.82
43_L	47_T	0.619	0.81
32_L	134_K	0.618	0.81
46_I	104_L	0.617	0.81
95_T	99_N	0.616	0.81
141_D	156_D	0.612	0.81
29_T	139_A	0.612	0.81
143_D	156_D	0.609	0.80
31_E	35_R	0.605	0.80
59_F	63_H	0.602	0.80
55_R	164_S	0.601	0.80
37_V	77_L	0.601	0.80
92_L	97_V	0.598	0.79
44_S	77_L	0.595	0.79
107_Y	110_D	0.587	0.78
146_D	153_R	0.586	0.78
36_Q	148_L	0.577	0.77
54_M	66_L	0.576	0.77
26_K	29_T	0.574	0.76
115_Q	118_L	0.574	0.76
122_A	162_I	0.574	0.76
66_L	114_V	0.569	0.76
94_T	97_V	0.562	0.75
70_R	161_F	0.555	0.74
51_H	59_F	0.549	0.73
55_R	85_V	0.547	0.73
28_A	139_A	0.547	0.73
132_V	135_A	0.544	0.73
129_A	143_D	0.543	0.72
152_S	156_D	0.540	0.72
80_M	151_A	0.539	0.72
149_T	152_S	0.539	0.72
33_L	52_W	0.537	0.72
120_E	124_R	0.537	0.72
35_R	101_K	0.531	0.71
24_S	28_A	0.527	0.70
125_Y	162_I	0.526	0.70
62_V	118_L	0.523	0.70
32_L	131_D	0.520	0.69
121_L	124_R	0.515	0.68
70_R	81_A	0.512	0.68
79_T	153_R	0.512	0.68
69_F	121_L	0.510	0.68
80_M	147_I	0.509	0.68
107_Y	112_H	0.509	0.68
129_A	133_R	0.506	0.67
34_N	89_G	0.503	0.67
36_Q	39_Q	0.503	0.67
123_D	127_I	0.502	0.66
114_V	117_H	0.502	0.66
71_T	74_I	0.501	0.66
144_T	156_D	0.501	0.66
40_F	155_L	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ak8A	6	0.9281	100	0.25	Contact Map
1zs3A	6	0.9581	100	0.301	Contact Map
1zujA	6	0.9401	100	0.313	Contact Map
1tjoA	6	0.994	100	0.333	Contact Map
2c2jA	6	0.8683	100	0.341	Contact Map
2c2uA	6	1	100	0.347	Contact Map
4cybA	6	0.9701	100	0.349	Contact Map
4a25A	8	0.9701	100	0.362	Contact Map
2yw6A	6	0.8683	100	0.362	Contact Map
2xgwA	6	0.9341	100	0.363	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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