GREMLIN Database
MHPB - 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
UniProt: P0ABR9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20274
Length: 314 (305)
Sequences: 240 (154)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_V158_I8.2601.00
47_V162_T4.5570.99
162_T171_F4.5390.99
67_L98_V4.3960.99
242_M306_G4.0760.98
102_G149_Q3.9810.98
26_E294_Y3.2980.94
249_R252_E3.1450.92
134_L161_F3.0800.91
265_A272_I3.0790.91
279_F308_L3.0400.91
67_L94_C2.9510.89
141_V268_S2.8400.87
21_Q25_D2.8020.87
162_T297_P2.7310.85
60_D203_D2.7250.85
67_L105_L2.7010.84
49_F277_A2.6100.82
44_E168_R2.5750.81
101_S160_R2.4760.79
15_G18_D2.4450.78
220_A223_F2.4060.76
8_L14_V2.3390.74
49_F281_A2.3270.74
66_C111_M2.3160.74
241_F245_L2.2870.73
95_A107_V2.2670.72
54_Y268_S2.2550.71
67_L239_N2.2380.71
156_E160_R2.0100.62
68_G106_A2.0060.62
147_G306_G1.8970.58
87_P134_L1.8670.56
60_D202_K1.8420.55
240_Q244_L1.8230.54
40_A149_Q1.8190.54
38_I170_L1.8190.54
33_S136_V1.8020.53
262_S267_K1.7810.53
7_C173_G1.7250.50
73_A118_A1.7220.50
44_E167_K1.7210.50
93_A134_L1.7040.49
48_L117_F1.6580.47
99_M103_I1.6480.47
34_A124_L1.6450.47
152_R254_D1.6390.46
101_S247_Q1.6270.46
56_G184_P1.6180.46
68_G111_M1.6060.45
110_C195_D1.5990.45
27_V202_K1.5800.44
48_L273_K1.5580.43
156_E283_S1.5550.43
36_E40_A1.5470.43
70_G88_V1.5360.42
74_I204_L1.5220.41
138_I205_P1.4770.40
89_E96_H1.4630.39
60_D201_G1.4540.39
50_A242_M1.4470.38
71_A278_A1.4390.38
127_G130_K1.4380.38
145_L258_N1.4350.38
98_V103_I1.4030.37
4_Y37_R1.3820.36
128_L173_G1.3810.36
74_I264_I1.3770.36
194_R198_L1.3700.35
260_E264_I1.3700.35
223_F268_S1.3520.35
171_F243_T1.3490.34
119_Q170_L1.3440.34
93_A96_H1.3400.34
106_A196_R1.3260.34
83_E100_K1.3220.33
149_Q163_S1.3050.33
7_C131_V1.2960.32
78_G213_Q1.2800.32
26_E296_R1.2770.32
7_C276_V1.2750.32
109_Y267_K1.2630.31
57_F111_M1.2530.31
244_L284_A1.2280.30
47_V297_P1.2250.30
125_L191_A1.2230.30
94_C161_F1.2140.29
35_R183_V1.2080.29
12_P52_D1.2080.29
80_A128_L1.2040.29
36_E85_P1.1880.29
223_F230_L1.1850.28
120_P177_L1.1820.28
57_F66_C1.1810.28
268_S305_F1.1810.28
173_G197_L1.1760.28
136_V177_L1.1670.28
143_T262_S1.1660.28
77_F268_S1.1650.28
87_P161_F1.1640.28
83_E162_T1.1490.27
22_E39_A1.1480.27
103_I288_W1.1430.27
94_C248_G1.1390.27
187_A296_R1.1330.27
105_L136_V1.1310.27
245_L280_A1.1310.27
17_V74_I1.1280.26
125_L131_V1.1240.26
73_A143_T1.1170.26
138_I154_L1.1070.26
111_M137_F1.0920.25
54_Y141_V1.0830.25
28_N263_A1.0790.25
60_D185_E1.0750.25
225_E252_E1.0720.25
83_E136_V1.0660.24
6_H131_V1.0650.24
12_P237_W1.0650.24
67_L227_Q1.0580.24
198_L204_L1.0530.24
147_G256_V1.0490.24
181_P237_W1.0490.24
250_I256_V1.0370.24
264_I269_T1.0370.24
136_V282_I1.0350.23
173_G278_A1.0310.23
259_E263_A1.0280.23
134_L239_N1.0270.23
149_Q217_I1.0230.23
183_V268_S1.0130.23
84_L121_L1.0090.23
78_G263_A1.0090.23
167_K241_F1.0090.23
154_L158_I1.0060.23
33_S100_K1.0010.22
17_V220_A0.9980.22
55_N181_P0.9960.22
260_E265_A0.9950.22
73_A77_F0.9940.22
29_G40_A0.9930.22
177_L272_I0.9920.22
59_Y99_M0.9910.22
166_N253_L0.9850.22
126_G254_D0.9790.22
186_L299_P0.9780.22
140_G242_M0.9740.22
151_T307_S0.9720.22
112_Q203_D0.9710.22
148_F276_V0.9680.21
23_V26_E0.9680.21
45_L172_L0.9640.21
36_E244_L0.9570.21
125_L309_S0.9540.21
27_V225_E0.9530.21
130_K138_I0.9470.21
167_K253_L0.9370.21
214_Q218_S0.9350.21
69_V109_Y0.9310.20
67_L291_E0.9300.20
47_V83_E0.9280.20
245_L293_R0.9270.20
136_V235_P0.9260.20
40_A129_D0.9230.20
196_R258_N0.9210.20
22_E251_Q0.9150.20
7_C161_F0.9100.20
11_S130_K0.9060.20
230_L268_S0.9040.20
48_L284_A0.8980.19
79_S211_L0.8970.19
29_G61_V0.8960.19
105_L164_T0.8950.19
31_I208_E0.8950.19
273_K307_S0.8930.19
52_D237_W0.8870.19
24_L27_V0.8870.19
111_M174_S0.8840.19
60_D249_R0.8820.19
7_C109_Y0.8810.19
90_L276_V0.8800.19
84_L160_R0.8750.19
110_C200_S0.8740.19
39_A249_R0.8730.19
51_P76_D0.8670.19
5_L300_E0.8660.19
37_R309_S0.8650.19
16_Y213_Q0.8650.19
212_R223_F0.8610.19
20_A211_L0.8610.19
51_P159_G0.8600.18
103_I157_A0.8530.18
40_A67_L0.8470.18
55_N303_A0.8400.18
108_S142_A0.8360.18
47_V169_V0.8300.18
71_A288_W0.8300.18
254_D276_V0.8290.18
32_A210_E0.8290.18
108_S115_H0.8270.18
60_D256_V0.8260.18
14_V117_F0.8210.17
163_S168_R0.8200.17
252_E280_A0.8180.17
187_A220_A0.8180.17
8_L301_W0.8180.17
58_F302_I0.8170.17
51_P59_Y0.8170.17
105_L191_A0.8150.17
39_A247_Q0.8140.17
46_V125_L0.8120.17
138_I246_E0.8090.17
8_L31_I0.8040.17
93_A158_I0.8030.17
29_G89_E0.8020.17
118_A128_L0.8020.17
87_P97_A0.7980.17
101_S173_G0.7950.17
163_S283_S0.7950.17
76_D114_D0.7940.17
130_K301_W0.7920.17
50_A117_F0.7920.17
67_L280_A0.7920.17
41_F293_R0.7920.17
145_L261_L0.7900.17
51_P170_L0.7860.17
162_T301_W0.7840.17
42_S259_E0.7830.17
45_L133_V0.7810.17
77_F270_H0.7800.16
55_N184_P0.7790.16
59_Y237_W0.7790.16
19_P268_S0.7790.16
29_G218_S0.7780.16
159_G278_A0.7740.16
100_K177_L0.7730.16
4_Y47_V0.7720.16
105_L210_E0.7660.16
99_M288_W0.7650.16
105_L134_L0.7620.16
7_C269_T0.7600.16
47_V90_L0.7600.16
95_A274_T0.7570.16
228_R232_P0.7560.16
245_L265_A0.7550.16
51_P66_C0.7510.16
51_P108_S0.7490.16
13_L235_P0.7490.16
77_F192_H0.7490.16
215_R298_I0.7490.16
29_G36_E0.7470.16
100_K239_N0.7470.16
70_G156_E0.7470.16
68_G174_S0.7470.16
149_Q171_F0.7430.16
66_C137_F0.7420.16
103_I287_N0.7420.16
76_D116_G0.7410.16
172_L192_H0.7400.16
11_S303_A0.7390.16
165_L169_V0.7380.16
268_S296_R0.7320.15
70_G287_N0.7310.15
82_G114_D0.7310.15
77_F257_S0.7270.15
143_T267_K0.7270.15
76_D159_G0.7250.15
243_T249_R0.7250.15
22_E291_E0.7220.15
48_L121_L0.7200.15
109_Y256_V0.7180.15
36_E64_P0.7170.15
37_R147_G0.7160.15
33_S172_L0.7110.15
32_A133_V0.7110.15
90_L167_K0.7100.15
14_V61_V0.7100.15
54_Y183_V0.7090.15
108_S174_S0.7090.15
185_E267_K0.7080.15
28_N268_S0.7050.15
159_G170_L0.7040.15
191_A265_A0.7030.15
73_A117_F0.7010.15
13_L142_A0.6960.15
51_P119_Q0.6920.15
50_A307_S0.6910.14
141_V305_F0.6900.14
13_L184_P0.6870.14
18_D24_L0.6860.14
14_V120_P0.6840.14
67_L95_A0.6810.14
13_L56_G0.6800.14
59_Y116_G0.6790.14
298_I301_W0.6780.14
4_Y166_N0.6780.14
23_V103_I0.6770.14
151_T277_A0.6760.14
109_Y143_T0.6760.14
72_T239_N0.6750.14
60_D301_W0.6750.14
236_I306_G0.6730.14
46_V218_S0.6690.14
207_S214_Q0.6690.14
194_R301_W0.6660.14
9_S12_P0.6640.14
34_A46_V0.6630.14
138_I253_L0.6590.14
229_T240_Q0.6580.14
101_S245_L0.6570.14
16_Y44_E0.6570.14
29_G222_K0.6570.14
39_A44_E0.6570.14
244_L252_E0.6560.14
193_M261_L0.6540.14
98_V305_F0.6530.14
11_S142_A0.6520.14
48_L293_R0.6520.14
111_M120_P0.6510.14
36_E284_A0.6500.14
40_A221_E0.6470.14
37_R146_P0.6440.14
32_A236_I0.6440.14
39_A96_H0.6440.14
37_R166_N0.6440.14
195_D252_E0.6430.13
152_R184_P0.6420.13
141_V183_V0.6420.13
98_V105_L0.6390.13
45_L183_V0.6390.13
190_D220_A0.6380.13
222_K274_T0.6360.13
4_Y134_L0.6340.13
165_L171_F0.6330.13
117_F235_P0.6320.13
282_I288_W0.6310.13
96_H263_A0.6300.13
30_V294_Y0.6300.13
109_Y145_L0.6290.13
32_A247_Q0.6260.13
261_L269_T0.6240.13
148_F226_D0.6240.13
93_A164_T0.6220.13
127_G289_R0.6220.13
113_V167_K0.6180.13
56_G152_R0.6140.13
72_T83_E0.6130.13
140_G198_L0.6120.13
72_T93_A0.6110.13
154_L251_Q0.6100.13
14_V31_I0.6090.13
32_A65_F0.6090.13
164_T168_R0.6080.13
107_V253_L0.6060.13
90_L161_F0.6060.13
67_L93_A0.6040.13
169_V241_F0.6040.13
19_P234_N0.6020.13
120_P124_L0.6010.13
38_I218_S0.6010.13
73_A148_F0.6000.13
125_L147_G0.5990.13
239_N246_E0.5980.13
260_E263_A0.5980.13
188_K236_I0.5960.13
134_L160_R0.5940.13
277_A288_W0.5940.13
36_E39_A0.5940.13
192_H198_L0.5930.13
180_Q226_D0.5920.12
34_A95_A0.5920.12
86_V280_A0.5900.12
40_A166_N0.5890.12
166_N265_A0.5890.12
57_F137_F0.5880.12
38_I42_S0.5840.12
87_P208_E0.5840.12
100_K263_A0.5810.12
222_K240_Q0.5810.12
90_L94_C0.5800.12
36_E44_E0.5780.12
51_P55_N0.5780.12
55_N76_D0.5770.12
107_V136_V0.5750.12
55_N209_R0.5740.12
218_S228_R0.5730.12
115_H275_W0.5730.12
197_L301_W0.5720.12
85_P223_F0.5710.12
256_V265_A0.5680.12
164_T259_E0.5680.12
97_A101_S0.5670.12
258_N261_L0.5670.12
32_A255_A0.5670.12
166_N236_I0.5630.12
204_L257_S0.5630.12
178_S295_Y0.5590.12
190_D193_M0.5560.12
242_M309_S0.5550.12
125_L198_L0.5530.12
42_S210_E0.5520.12
6_H242_M0.5510.12
32_A96_H0.5510.12
112_Q301_W0.5510.12
42_S213_Q0.5510.12
242_M288_W0.5500.12
81_A307_S0.5490.12
192_H226_D0.5490.12
203_D301_W0.5490.12
256_V308_L0.5470.12
7_C80_A0.5470.12
99_M194_R0.5470.12
66_C174_S0.5470.12
46_V100_K0.5460.12
147_G220_A0.5450.12
4_Y161_F0.5450.12
77_F231_H0.5450.12
107_V186_L0.5410.12
252_E297_P0.5400.12
138_I276_V0.5380.12
114_D184_P0.5380.12
60_D112_Q0.5370.11
120_P309_S0.5350.11
240_Q257_S0.5330.11
244_L249_R0.5330.11
156_E164_T0.5310.11
245_L294_Y0.5310.11
158_I168_R0.5290.11
147_G270_H0.5260.11
93_A98_V0.5260.11
93_A240_Q0.5260.11
195_D202_K0.5230.11
226_D309_S0.5220.11
83_E88_V0.5210.11
7_C112_Q0.5200.11
203_D298_I0.5190.11
117_F148_F0.5190.11
36_E41_F0.5130.11
32_A89_E0.5130.11
236_I243_T0.5120.11
70_G89_E0.5120.11
143_T249_R0.5110.11
192_H264_I0.5110.11
138_I245_L0.5100.11
7_C87_P0.5100.11
240_Q253_L0.5090.11
120_P137_F0.5090.11
171_F200_S0.5080.11
57_F120_P0.5080.11
141_V223_F0.5070.11
125_L146_P0.5050.11
151_T273_K0.5040.11
39_A251_Q0.5040.11
274_T284_A0.5030.11
102_G105_L0.5030.11
183_V233_L0.5020.11
17_V204_L0.5010.11
231_H307_S0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b4uB 2 0.8471 100 0.646 Contact Map
3wraA 2 0.8408 100 0.653 Contact Map
3vsjB 2 0.8599 100 0.701 Contact Map
3vsjA 1 0.8312 100 0.736 Contact Map
2pw6A 2 0.7389 100 0.758 Contact Map
3bczA 1 0.8121 100 0.785 Contact Map
3menA 3 0.3599 72.2 0.969 Contact Map
1c3pA 1 0.535 72 0.969 Contact Map
1zz1A 4 0.449 56.3 0.972 Contact Map
4zurA 2 0.3471 29.1 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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