YEAW - ECOLI - GREMLIN Contacts

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YEAW - Putative dioxygenase subunit alpha YeaW

UniProt:	P0ABR7	Sequences: MSNLSPDFVLPENFCANPQEAWTIPARFYTDQNAFEHEKENVFAKSWICVAHSSELANANDYVTREIIGESIVLVRGRDKVLRAFYNVCPHRGHQLLSGEGKAKNVITCPYHAWAFKLDGNLAHARNCENVANFDSDKAQLVPVRLEEYAGFVFINMDPNATSVEDQLPGLGAKVLEACPEVHDLKLAARFTTRTPANWKNIVDNYLECYHCGPAHPGFSDSVQVDRYWHTMHGNWTLQYGFAKPSEQSFKFEEGTDAAFHGFWLWPCTMLNVTPIKGMMTVIYEFPVDSETTLQNYDIYFTNEELTDEQKSLIEWYRDVFRPEDLRLVESVQKGLKSRGYRGQGRIMADSSGSGISEHGIAHFHNLLAQVFKD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG13509
Length:	374 (314)
Sequences:	5995 (4064)
Seq/√Len:	229.3

ECOLI - YEAW HCAE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
90_P	116_F	5.225	1.00
53_S	148_E	4.708	1.00
289_D	292_T	4.123	1.00
196_P	292_T	4.088	1.00
117_K	121_N	3.456	1.00
196_P	330_E	3.312	1.00
194_R	292_T	3.141	1.00
77_G	83_R	3.058	1.00
84_A	155_I	3.052	1.00
66_E	71_S	2.962	1.00
84_A	146_L	2.929	1.00
147_E	165_E	2.908	1.00
83_R	143_P	2.753	1.00
77_G	81_V	2.694	1.00
117_K	123_A	2.653	1.00
85_F	143_P	2.530	1.00
74_L	84_A	2.459	1.00
194_R	294_L	2.437	1.00
291_E	337_K	2.404	1.00
288_V	294_L	2.377	1.00
215_A	328_L	2.353	1.00
72_I	84_A	2.326	1.00
219_F	324_E	2.250	1.00
45_K	158_D	2.231	1.00
288_V	292_T	2.151	1.00
82_L	146_L	2.111	1.00
194_R	288_V	2.084	1.00
51_A	153_V	2.037	1.00
115_A	124_H	1.999	1.00
135_D	138_K	1.984	1.00
50_V	155_I	1.983	1.00
61_D	103_A	1.982	1.00
192_T	294_L	1.979	1.00
158_D	161_A	1.966	1.00
98_S	331_S	1.965	1.00
44_A	70_E	1.947	1.00
62_Y	107_I	1.944	1.00
146_L	153_V	1.932	1.00
75_V	83_R	1.828	1.00
53_S	76_R	1.821	1.00
111_Y	205_N	1.804	1.00
87_N	97_L	1.801	1.00
163_S	166_D	1.798	1.00
75_V	107_I	1.783	1.00
70_E	86_Y	1.782	1.00
82_L	153_V	1.774	1.00
233_H	236_W	1.759	1.00
147_E	164_V	1.756	1.00
95_Q	334_K	1.746	1.00
85_F	141_L	1.733	1.00
64_T	71_S	1.678	1.00
156_N	161_A	1.660	1.00
145_R	156_N	1.644	1.00
108_T	115_A	1.639	1.00
128_C	136_S	1.620	1.00
73_V	107_I	1.614	1.00
181_E	184_D	1.613	1.00
73_V	85_F	1.612	1.00
58_N	61_D	1.592	1.00
326_L	330_E	1.587	1.00
95_Q	331_S	1.585	1.00
234_G	237_T	1.575	1.00
236_W	239_Q	1.558	1.00
75_V	118_L	1.549	1.00
184_D	303_N	1.548	1.00
285_E	293_T	1.532	1.00
164_V	168_L	1.529	1.00
367_L	370_Q	1.521	1.00
312_S	316_W	1.500	1.00
57_A	61_D	1.493	1.00
56_L	76_R	1.479	1.00
197_A	329_V	1.478	1.00
218_G	324_E	1.475	1.00
72_I	155_I	1.464	1.00
51_A	55_E	1.459	1.00
113_A	214_P	1.429	1.00
87_N	95_Q	1.422	1.00
192_T	296_N	1.411	1.00
106_V	123_A	1.381	1.00
209_C	212_C	1.361	1.00
121_N	140_Q	1.353	1.00
56_L	82_L	1.349	1.00
62_Y	101_G	1.349	1.00
312_S	315_E	1.345	1.00
235_N	239_Q	1.343	1.00
51_A	63_V	1.343	1.00
51_A	74_L	1.330	1.00
323_P	326_L	1.319	1.00
102_K	108_T	1.316	1.00
186_K	303_N	1.314	1.00
164_V	167_Q	1.309	1.00
51_A	56_L	1.288	1.00
106_V	115_A	1.286	1.00
59_A	80_K	1.284	1.00
119_D	123_A	1.282	1.00
62_Y	102_K	1.270	1.00
359_H	363_H	1.258	1.00
367_L	371_V	1.245	1.00
90_P	142_V	1.233	1.00
86_Y	142_V	1.227	1.00
86_Y	144_V	1.221	1.00
66_E	69_G	1.215	1.00
52_H	152_F	1.214	1.00
82_L	148_E	1.213	1.00
55_E	63_V	1.212	1.00
45_K	159_P	1.211	1.00
76_R	82_L	1.209	1.00
202_I	293_T	1.204	1.00
62_Y	73_V	1.201	1.00
148_E	153_V	1.194	1.00
97_L	107_I	1.192	1.00
70_E	339_R	1.190	1.00
94_H	110_P	1.188	1.00
40_E	44_A	1.188	1.00
83_R	118_L	1.184	1.00
98_S	327_R	1.182	1.00
169_P	172_G	1.174	1.00
121_N	137_D	1.173	1.00
233_H	237_T	1.170	1.00
245_P	249_S	1.164	1.00
96_L	107_I	1.164	1.00
75_V	85_F	1.161	1.00
245_P	248_Q	1.155	1.00
49_C	152_F	1.133	1.00
58_N	103_A	1.129	1.00
227_R	230_H	1.125	1.00
85_F	144_V	1.112	1.00
53_S	151_G	1.110	1.00
57_A	76_R	1.109	1.00
197_A	202_I	1.106	1.00
56_L	63_V	1.106	1.00
366_N	370_Q	1.105	1.00
90_P	140_Q	1.093	1.00
46_S	371_V	1.089	1.00
145_R	161_A	1.084	1.00
187_L	300_Y	1.079	1.00
333_Q	337_K	1.071	1.00
145_R	160_N	1.052	1.00
165_E	172_G	1.051	1.00
50_V	74_L	1.047	1.00
313_L	317_Y	1.047	1.00
116_F	122_L	1.042	1.00
57_A	60_N	1.038	1.00
311_K	314_I	1.037	1.00
243_A	247_E	1.037	1.00
147_E	168_L	1.036	1.00
71_S	95_Q	1.030	1.00
148_E	151_G	1.030	1.00
195_T	326_L	1.026	1.00
247_E	251_K	1.025	1.00
327_R	331_S	1.019	1.00
234_G	239_Q	1.018	1.00
243_A	246_S	1.012	1.00
94_H	328_L	1.011	1.00
72_I	144_V	1.011	1.00
76_R	148_E	1.003	1.00
50_V	84_A	1.003	1.00
69_G	290_S	0.998	1.00
162_T	166_D	0.994	1.00
166_D	169_P	0.990	1.00
366_N	369_A	0.989	1.00
100_E	108_T	0.985	1.00
246_S	249_S	0.980	1.00
52_H	55_E	0.973	1.00
125_A	134_F	0.967	1.00
71_S	87_N	0.963	1.00
225_V	230_H	0.961	1.00
48_I	67_I	0.960	1.00
106_V	117_K	0.960	1.00
230_H	233_H	0.957	1.00
313_L	316_W	0.953	1.00
247_E	250_F	0.946	1.00
233_H	238_L	0.944	1.00
232_M	235_N	0.943	1.00
108_T	124_H	0.942	1.00
197_A	293_T	0.941	1.00
291_E	333_Q	0.939	1.00
159_P	162_T	0.936	1.00
99_G	102_K	0.935	1.00
314_I	317_Y	0.932	1.00
156_N	159_P	0.929	1.00
201_N	332_V	0.925	1.00
81_V	148_E	0.923	1.00
127_N	357_S	0.923	1.00
55_E	65_R	0.917	1.00
232_M	236_W	0.910	1.00
229_W	232_M	0.883	0.99
79_D	83_R	0.883	0.99
50_V	65_R	0.881	0.99
134_F	139_A	0.879	0.99
94_H	332_V	0.878	0.99
310_Q	313_L	0.876	0.99
331_S	334_K	0.875	0.99
70_E	144_V	0.873	0.99
315_E	318_R	0.871	0.99
190_R	298_D	0.866	0.99
235_N	238_L	0.865	0.99
240_Y	251_K	0.862	0.99
232_M	237_T	0.859	0.99
226_D	232_M	0.856	0.99
77_G	118_L	0.850	0.99
225_V	232_M	0.849	0.99
72_I	157_M	0.847	0.99
319_D	323_P	0.847	0.99
105_N	115_A	0.845	0.99
167_Q	170_G	0.839	0.99
242_F	247_E	0.834	0.99
73_V	97_L	0.832	0.99
116_F	140_Q	0.830	0.99
62_Y	99_G	0.828	0.99
66_E	289_D	0.827	0.99
306_L	309_E	0.823	0.99
345_G	348_M	0.822	0.99
42_V	368_L	0.819	0.99
198_N	291_E	0.819	0.99
244_K	249_S	0.816	0.99
102_K	115_A	0.809	0.99
228_Y	232_M	0.809	0.99
115_A	123_A	0.805	0.99
90_P	139_A	0.804	0.99
53_S	82_L	0.802	0.99
240_Y	246_S	0.796	0.99
243_A	251_K	0.796	0.99
242_F	246_S	0.796	0.99
362_A	366_N	0.796	0.99
363_H	366_N	0.795	0.99
244_K	250_F	0.795	0.99
62_Y	97_L	0.793	0.99
135_D	139_A	0.793	0.99
197_A	330_E	0.791	0.99
246_S	250_F	0.791	0.99
64_T	87_N	0.787	0.99
145_R	158_D	0.784	0.99
244_K	247_E	0.779	0.98
333_Q	336_L	0.779	0.98
48_I	268_C	0.775	0.98
56_L	153_V	0.775	0.98
41_N	45_K	0.775	0.98
232_M	239_Q	0.773	0.98
227_R	239_Q	0.771	0.98
81_V	143_P	0.771	0.98
226_D	231_T	0.770	0.98
311_K	315_E	0.768	0.98
65_R	72_I	0.768	0.98
205_N	345_G	0.768	0.98
242_F	245_P	0.764	0.98
44_A	69_G	0.764	0.98
244_K	248_Q	0.762	0.98
286_F	294_L	0.761	0.98
160_N	163_S	0.757	0.98
143_P	146_L	0.755	0.98
67_I	157_M	0.753	0.98
64_T	73_V	0.750	0.98
248_Q	251_K	0.747	0.98
206_Y	285_E	0.746	0.98
136_S	139_A	0.745	0.98
195_T	329_V	0.743	0.98
145_R	159_P	0.743	0.98
198_N	333_Q	0.742	0.98
78_R	103_A	0.741	0.98
122_L	125_A	0.736	0.98
184_D	302_T	0.734	0.98
211_H	216_H	0.731	0.98
56_L	61_D	0.727	0.98
70_E	142_V	0.726	0.98
260_F	264_W	0.723	0.97
65_R	84_A	0.722	0.97
246_S	251_K	0.721	0.97
182_V	185_L	0.720	0.97
97_L	101_G	0.718	0.97
60_N	118_L	0.715	0.97
227_R	231_T	0.714	0.97
205_N	211_H	0.714	0.97
314_I	318_R	0.714	0.97
115_A	122_L	0.710	0.97
73_V	141_L	0.707	0.97
150_A	181_E	0.705	0.97
286_F	296_N	0.703	0.97
154_F	269_T	0.702	0.97
61_D	102_K	0.700	0.97
310_Q	317_Y	0.696	0.97
193_T	322_R	0.694	0.97
147_E	167_Q	0.692	0.97
45_K	156_N	0.691	0.97
311_K	317_Y	0.690	0.97
341_Y	345_G	0.689	0.97
346_R	349_A	0.688	0.97
195_T	330_E	0.688	0.97
94_H	331_S	0.686	0.97
64_T	97_L	0.685	0.97
78_R	104_K	0.683	0.96
211_H	325_D	0.678	0.96
310_Q	314_I	0.678	0.96
172_G	175_V	0.677	0.96
313_L	318_R	0.676	0.96
228_Y	233_H	0.675	0.96
162_T	167_Q	0.674	0.96
146_L	155_I	0.674	0.96
144_V	155_I	0.673	0.96
77_G	119_D	0.666	0.96
230_H	236_W	0.663	0.96
234_G	238_L	0.662	0.96
59_A	78_R	0.661	0.96
79_D	119_D	0.661	0.96
242_F	250_F	0.661	0.96
226_D	230_H	0.659	0.96
243_A	248_Q	0.658	0.96
110_P	113_A	0.655	0.96
98_S	110_P	0.653	0.95
204_D	365_H	0.652	0.95
345_G	349_A	0.651	0.95
90_P	141_L	0.650	0.95
237_T	240_Y	0.649	0.95
228_Y	231_T	0.648	0.95
323_P	327_R	0.647	0.95
108_T	113_A	0.647	0.95
205_N	208_E	0.646	0.95
47_W	205_N	0.646	0.95
245_P	250_F	0.643	0.95
149_Y	154_F	0.641	0.95
65_R	286_F	0.641	0.95
202_I	285_E	0.639	0.95
217_P	324_E	0.639	0.95
283_I	322_R	0.637	0.95
86_Y	340_G	0.636	0.95
288_V	293_T	0.636	0.95
266_W	367_L	0.635	0.95
216_H	325_D	0.634	0.95
197_A	201_N	0.629	0.94
88_V	93_G	0.626	0.94
231_T	235_N	0.625	0.94
67_I	155_I	0.625	0.94
256_T	259_A	0.624	0.94
114_W	210_Y	0.623	0.94
186_K	310_Q	0.622	0.94
230_H	239_Q	0.622	0.94
50_V	67_I	0.621	0.94
125_A	128_C	0.620	0.94
190_R	296_N	0.619	0.94
220_S	262_G	0.618	0.94
186_K	304_E	0.617	0.94
49_C	284_Y	0.617	0.94
191_F	319_D	0.616	0.94
253_E	256_T	0.616	0.94
175_V	180_P	0.615	0.94
208_E	361_I	0.615	0.94
164_V	171_L	0.615	0.94
125_A	131_V	0.613	0.94
225_V	228_Y	0.612	0.94
310_Q	316_W	0.611	0.94
229_W	233_H	0.611	0.94
225_V	229_W	0.610	0.94
204_D	297_Y	0.609	0.93
147_E	163_S	0.608	0.93
48_I	157_M	0.607	0.93
44_A	68_I	0.607	0.93
229_W	237_T	0.606	0.93
142_V	342_R	0.606	0.93
334_K	337_K	0.605	0.93
243_A	250_F	0.604	0.93
158_D	162_T	0.603	0.93
226_D	229_W	0.602	0.93
74_L	153_V	0.601	0.93
87_N	141_L	0.600	0.93
69_G	289_D	0.600	0.93
231_T	236_W	0.597	0.93
266_W	371_V	0.596	0.93
128_C	131_V	0.594	0.93
125_A	212_C	0.594	0.93
65_R	74_L	0.593	0.93
219_F	222_S	0.592	0.92
77_G	104_K	0.590	0.92
229_W	238_L	0.588	0.92
245_P	251_K	0.588	0.92
230_H	238_L	0.585	0.92
92_R	111_Y	0.584	0.92
305_E	308_D	0.582	0.92
348_M	357_S	0.578	0.92
191_F	297_Y	0.578	0.92
217_P	223_V	0.577	0.92
164_V	170_G	0.576	0.91
85_F	142_V	0.576	0.91
260_F	274_T	0.576	0.91
49_C	154_F	0.576	0.91
183_H	186_K	0.575	0.91
206_Y	262_G	0.574	0.91
66_E	292_T	0.573	0.91
207_L	361_I	0.573	0.91
282_V	285_E	0.573	0.91
130_N	133_N	0.572	0.91
231_T	239_Q	0.571	0.91
262_G	266_W	0.566	0.91
203_V	270_M	0.564	0.91
208_E	273_V	0.564	0.91
156_N	160_N	0.563	0.91
280_M	300_Y	0.563	0.91
285_E	295_Q	0.561	0.90
144_V	157_M	0.560	0.90
201_N	329_V	0.557	0.90
43_F	368_L	0.556	0.90
48_I	286_F	0.556	0.90
293_T	327_R	0.555	0.90
210_Y	358_E	0.553	0.90
105_N	117_K	0.553	0.90
301_F	307_T	0.552	0.90
242_F	249_S	0.549	0.89
240_Y	244_K	0.549	0.89
334_K	338_S	0.548	0.89
90_P	122_L	0.548	0.89
149_Y	165_E	0.547	0.89
335_G	338_S	0.547	0.89
223_V	264_W	0.545	0.89
240_Y	243_A	0.544	0.89
122_L	139_A	0.543	0.89
240_Y	249_S	0.543	0.89
330_E	334_K	0.541	0.89
94_H	335_G	0.540	0.89
108_T	126_R	0.539	0.89
281_T	324_E	0.538	0.88
154_F	206_Y	0.538	0.88
265_L	269_T	0.536	0.88
283_I	295_Q	0.536	0.88
206_Y	270_M	0.536	0.88
303_N	307_T	0.535	0.88
47_W	348_M	0.534	0.88
97_L	138_K	0.534	0.88
126_R	214_P	0.534	0.88
58_N	165_E	0.533	0.88
235_N	312_S	0.532	0.88
77_G	117_K	0.532	0.88
78_R	118_L	0.532	0.88
44_A	157_M	0.531	0.88
76_R	153_V	0.530	0.88
70_E	157_M	0.530	0.88
149_Y	170_G	0.529	0.88
70_E	338_S	0.526	0.87
231_T	238_L	0.524	0.87
301_F	305_E	0.524	0.87
182_V	208_E	0.523	0.87
227_R	233_H	0.522	0.87
242_F	248_Q	0.522	0.87
49_C	52_H	0.521	0.87
229_W	234_G	0.521	0.87
332_V	360_G	0.520	0.87
231_T	240_Y	0.520	0.87
201_N	333_Q	0.520	0.87
203_V	285_E	0.519	0.87
227_R	234_G	0.518	0.87
100_E	103_A	0.517	0.86
102_K	107_I	0.517	0.86
231_T	237_T	0.516	0.86
86_Y	338_S	0.515	0.86
156_N	162_T	0.515	0.86
200_K	368_L	0.513	0.86
63_V	153_V	0.513	0.86
205_N	216_H	0.511	0.86
188_A	301_F	0.511	0.86
145_R	162_T	0.511	0.86
96_L	340_G	0.509	0.86
220_S	264_W	0.508	0.85
67_I	286_F	0.508	0.85
164_V	169_P	0.508	0.85
93_G	332_V	0.506	0.85
60_N	82_L	0.505	0.85
252_F	258_A	0.504	0.85
284_Y	296_N	0.503	0.85
47_W	156_N	0.503	0.85
243_A	249_S	0.502	0.85
227_R	232_M	0.502	0.85
66_E	95_Q	0.501	0.85
150_A	154_F	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3vcaA	3	0.9412	100	0.233	Contact Map
3n0qA	3	0.9492	100	0.237	Contact Map
3gzxA	3	0.9679	100	0.297	Contact Map
2gbwA	3	0.9465	100	0.301	Contact Map
2b1xA	3	0.992	100	0.301	Contact Map
2bmoA	3	0.9519	100	0.309	Contact Map
1uliA	3	0.9599	100	0.314	Contact Map
1z01A	4	0.9011	100	0.336	Contact Map
3gkeA	3	0.8422	100	0.341	Contact Map
4qdfB	3	0.7995	100	0.362	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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