GREMLIN Database
YEAW - Putative dioxygenase subunit alpha YeaW
UniProt: P0ABR7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13509
Length: 374 (314)
Sequences: 5995 (4064)
Seq/√Len: 229.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_P116_F5.2251.00
53_S148_E4.7081.00
289_D292_T4.1231.00
196_P292_T4.0881.00
117_K121_N3.4561.00
196_P330_E3.3121.00
194_R292_T3.1411.00
77_G83_R3.0581.00
84_A155_I3.0521.00
66_E71_S2.9621.00
84_A146_L2.9291.00
147_E165_E2.9081.00
83_R143_P2.7531.00
77_G81_V2.6941.00
117_K123_A2.6531.00
85_F143_P2.5301.00
74_L84_A2.4591.00
194_R294_L2.4371.00
291_E337_K2.4041.00
288_V294_L2.3771.00
215_A328_L2.3531.00
72_I84_A2.3261.00
219_F324_E2.2501.00
45_K158_D2.2311.00
288_V292_T2.1511.00
82_L146_L2.1111.00
194_R288_V2.0841.00
51_A153_V2.0371.00
115_A124_H1.9991.00
135_D138_K1.9841.00
50_V155_I1.9831.00
61_D103_A1.9821.00
192_T294_L1.9791.00
158_D161_A1.9661.00
98_S331_S1.9651.00
44_A70_E1.9471.00
62_Y107_I1.9441.00
146_L153_V1.9321.00
75_V83_R1.8281.00
53_S76_R1.8211.00
111_Y205_N1.8041.00
87_N97_L1.8011.00
163_S166_D1.7981.00
75_V107_I1.7831.00
70_E86_Y1.7821.00
82_L153_V1.7741.00
233_H236_W1.7591.00
147_E164_V1.7561.00
95_Q334_K1.7461.00
85_F141_L1.7331.00
64_T71_S1.6781.00
156_N161_A1.6601.00
145_R156_N1.6441.00
108_T115_A1.6391.00
128_C136_S1.6201.00
73_V107_I1.6141.00
181_E184_D1.6131.00
73_V85_F1.6121.00
58_N61_D1.5921.00
326_L330_E1.5871.00
95_Q331_S1.5851.00
234_G237_T1.5751.00
236_W239_Q1.5581.00
75_V118_L1.5491.00
184_D303_N1.5481.00
285_E293_T1.5321.00
164_V168_L1.5291.00
367_L370_Q1.5211.00
312_S316_W1.5001.00
57_A61_D1.4931.00
56_L76_R1.4791.00
197_A329_V1.4781.00
218_G324_E1.4751.00
72_I155_I1.4641.00
51_A55_E1.4591.00
113_A214_P1.4291.00
87_N95_Q1.4221.00
192_T296_N1.4111.00
106_V123_A1.3811.00
209_C212_C1.3611.00
121_N140_Q1.3531.00
56_L82_L1.3491.00
62_Y101_G1.3491.00
312_S315_E1.3451.00
235_N239_Q1.3431.00
51_A63_V1.3431.00
51_A74_L1.3301.00
323_P326_L1.3191.00
102_K108_T1.3161.00
186_K303_N1.3141.00
164_V167_Q1.3091.00
51_A56_L1.2881.00
106_V115_A1.2861.00
59_A80_K1.2841.00
119_D123_A1.2821.00
62_Y102_K1.2701.00
359_H363_H1.2581.00
367_L371_V1.2451.00
90_P142_V1.2331.00
86_Y142_V1.2271.00
86_Y144_V1.2211.00
66_E69_G1.2151.00
52_H152_F1.2141.00
82_L148_E1.2131.00
55_E63_V1.2121.00
45_K159_P1.2111.00
76_R82_L1.2091.00
202_I293_T1.2041.00
62_Y73_V1.2011.00
148_E153_V1.1941.00
97_L107_I1.1921.00
70_E339_R1.1901.00
94_H110_P1.1881.00
40_E44_A1.1881.00
83_R118_L1.1841.00
98_S327_R1.1821.00
169_P172_G1.1741.00
121_N137_D1.1731.00
233_H237_T1.1701.00
245_P249_S1.1641.00
96_L107_I1.1641.00
75_V85_F1.1611.00
245_P248_Q1.1551.00
49_C152_F1.1331.00
58_N103_A1.1291.00
227_R230_H1.1251.00
85_F144_V1.1121.00
53_S151_G1.1101.00
57_A76_R1.1091.00
197_A202_I1.1061.00
56_L63_V1.1061.00
366_N370_Q1.1051.00
90_P140_Q1.0931.00
46_S371_V1.0891.00
145_R161_A1.0841.00
187_L300_Y1.0791.00
333_Q337_K1.0711.00
145_R160_N1.0521.00
165_E172_G1.0511.00
50_V74_L1.0471.00
313_L317_Y1.0471.00
116_F122_L1.0421.00
57_A60_N1.0381.00
311_K314_I1.0371.00
243_A247_E1.0371.00
147_E168_L1.0361.00
71_S95_Q1.0301.00
148_E151_G1.0301.00
195_T326_L1.0261.00
247_E251_K1.0251.00
327_R331_S1.0191.00
234_G239_Q1.0181.00
243_A246_S1.0121.00
94_H328_L1.0111.00
72_I144_V1.0111.00
76_R148_E1.0031.00
50_V84_A1.0031.00
69_G290_S0.9981.00
162_T166_D0.9941.00
166_D169_P0.9901.00
366_N369_A0.9891.00
100_E108_T0.9851.00
246_S249_S0.9801.00
52_H55_E0.9731.00
125_A134_F0.9671.00
71_S87_N0.9631.00
225_V230_H0.9611.00
48_I67_I0.9601.00
106_V117_K0.9601.00
230_H233_H0.9571.00
313_L316_W0.9531.00
247_E250_F0.9461.00
233_H238_L0.9441.00
232_M235_N0.9431.00
108_T124_H0.9421.00
197_A293_T0.9411.00
291_E333_Q0.9391.00
159_P162_T0.9361.00
99_G102_K0.9351.00
314_I317_Y0.9321.00
156_N159_P0.9291.00
201_N332_V0.9251.00
81_V148_E0.9231.00
127_N357_S0.9231.00
55_E65_R0.9171.00
232_M236_W0.9101.00
229_W232_M0.8830.99
79_D83_R0.8830.99
50_V65_R0.8810.99
134_F139_A0.8790.99
94_H332_V0.8780.99
310_Q313_L0.8760.99
331_S334_K0.8750.99
70_E144_V0.8730.99
315_E318_R0.8710.99
190_R298_D0.8660.99
235_N238_L0.8650.99
240_Y251_K0.8620.99
232_M237_T0.8590.99
226_D232_M0.8560.99
77_G118_L0.8500.99
225_V232_M0.8490.99
72_I157_M0.8470.99
319_D323_P0.8470.99
105_N115_A0.8450.99
167_Q170_G0.8390.99
242_F247_E0.8340.99
73_V97_L0.8320.99
116_F140_Q0.8300.99
62_Y99_G0.8280.99
66_E289_D0.8270.99
306_L309_E0.8230.99
345_G348_M0.8220.99
42_V368_L0.8190.99
198_N291_E0.8190.99
244_K249_S0.8160.99
102_K115_A0.8090.99
228_Y232_M0.8090.99
115_A123_A0.8050.99
90_P139_A0.8040.99
53_S82_L0.8020.99
240_Y246_S0.7960.99
243_A251_K0.7960.99
242_F246_S0.7960.99
362_A366_N0.7960.99
363_H366_N0.7950.99
244_K250_F0.7950.99
62_Y97_L0.7930.99
135_D139_A0.7930.99
197_A330_E0.7910.99
246_S250_F0.7910.99
64_T87_N0.7870.99
145_R158_D0.7840.99
244_K247_E0.7790.98
333_Q336_L0.7790.98
48_I268_C0.7750.98
56_L153_V0.7750.98
41_N45_K0.7750.98
232_M239_Q0.7730.98
227_R239_Q0.7710.98
81_V143_P0.7710.98
226_D231_T0.7700.98
311_K315_E0.7680.98
65_R72_I0.7680.98
205_N345_G0.7680.98
242_F245_P0.7640.98
44_A69_G0.7640.98
244_K248_Q0.7620.98
286_F294_L0.7610.98
160_N163_S0.7570.98
143_P146_L0.7550.98
67_I157_M0.7530.98
64_T73_V0.7500.98
248_Q251_K0.7470.98
206_Y285_E0.7460.98
136_S139_A0.7450.98
195_T329_V0.7430.98
145_R159_P0.7430.98
198_N333_Q0.7420.98
78_R103_A0.7410.98
122_L125_A0.7360.98
184_D302_T0.7340.98
211_H216_H0.7310.98
56_L61_D0.7270.98
70_E142_V0.7260.98
260_F264_W0.7230.97
65_R84_A0.7220.97
246_S251_K0.7210.97
182_V185_L0.7200.97
97_L101_G0.7180.97
60_N118_L0.7150.97
227_R231_T0.7140.97
205_N211_H0.7140.97
314_I318_R0.7140.97
115_A122_L0.7100.97
73_V141_L0.7070.97
150_A181_E0.7050.97
286_F296_N0.7030.97
154_F269_T0.7020.97
61_D102_K0.7000.97
310_Q317_Y0.6960.97
193_T322_R0.6940.97
147_E167_Q0.6920.97
45_K156_N0.6910.97
311_K317_Y0.6900.97
341_Y345_G0.6890.97
346_R349_A0.6880.97
195_T330_E0.6880.97
94_H331_S0.6860.97
64_T97_L0.6850.97
78_R104_K0.6830.96
211_H325_D0.6780.96
310_Q314_I0.6780.96
172_G175_V0.6770.96
313_L318_R0.6760.96
228_Y233_H0.6750.96
162_T167_Q0.6740.96
146_L155_I0.6740.96
144_V155_I0.6730.96
77_G119_D0.6660.96
230_H236_W0.6630.96
234_G238_L0.6620.96
59_A78_R0.6610.96
79_D119_D0.6610.96
242_F250_F0.6610.96
226_D230_H0.6590.96
243_A248_Q0.6580.96
110_P113_A0.6550.96
98_S110_P0.6530.95
204_D365_H0.6520.95
345_G349_A0.6510.95
90_P141_L0.6500.95
237_T240_Y0.6490.95
228_Y231_T0.6480.95
323_P327_R0.6470.95
108_T113_A0.6470.95
205_N208_E0.6460.95
47_W205_N0.6460.95
245_P250_F0.6430.95
149_Y154_F0.6410.95
65_R286_F0.6410.95
202_I285_E0.6390.95
217_P324_E0.6390.95
283_I322_R0.6370.95
86_Y340_G0.6360.95
288_V293_T0.6360.95
266_W367_L0.6350.95
216_H325_D0.6340.95
197_A201_N0.6290.94
88_V93_G0.6260.94
231_T235_N0.6250.94
67_I155_I0.6250.94
256_T259_A0.6240.94
114_W210_Y0.6230.94
186_K310_Q0.6220.94
230_H239_Q0.6220.94
50_V67_I0.6210.94
125_A128_C0.6200.94
190_R296_N0.6190.94
220_S262_G0.6180.94
186_K304_E0.6170.94
49_C284_Y0.6170.94
191_F319_D0.6160.94
253_E256_T0.6160.94
175_V180_P0.6150.94
208_E361_I0.6150.94
164_V171_L0.6150.94
125_A131_V0.6130.94
225_V228_Y0.6120.94
310_Q316_W0.6110.94
229_W233_H0.6110.94
225_V229_W0.6100.94
204_D297_Y0.6090.93
147_E163_S0.6080.93
48_I157_M0.6070.93
44_A68_I0.6070.93
229_W237_T0.6060.93
142_V342_R0.6060.93
334_K337_K0.6050.93
243_A250_F0.6040.93
158_D162_T0.6030.93
226_D229_W0.6020.93
74_L153_V0.6010.93
87_N141_L0.6000.93
69_G289_D0.6000.93
231_T236_W0.5970.93
266_W371_V0.5960.93
128_C131_V0.5940.93
125_A212_C0.5940.93
65_R74_L0.5930.93
219_F222_S0.5920.92
77_G104_K0.5900.92
229_W238_L0.5880.92
245_P251_K0.5880.92
230_H238_L0.5850.92
92_R111_Y0.5840.92
305_E308_D0.5820.92
348_M357_S0.5780.92
191_F297_Y0.5780.92
217_P223_V0.5770.92
164_V170_G0.5760.91
85_F142_V0.5760.91
260_F274_T0.5760.91
49_C154_F0.5760.91
183_H186_K0.5750.91
206_Y262_G0.5740.91
66_E292_T0.5730.91
207_L361_I0.5730.91
282_V285_E0.5730.91
130_N133_N0.5720.91
231_T239_Q0.5710.91
262_G266_W0.5660.91
203_V270_M0.5640.91
208_E273_V0.5640.91
156_N160_N0.5630.91
280_M300_Y0.5630.91
285_E295_Q0.5610.90
144_V157_M0.5600.90
201_N329_V0.5570.90
43_F368_L0.5560.90
48_I286_F0.5560.90
293_T327_R0.5550.90
210_Y358_E0.5530.90
105_N117_K0.5530.90
301_F307_T0.5520.90
242_F249_S0.5490.89
240_Y244_K0.5490.89
334_K338_S0.5480.89
90_P122_L0.5480.89
149_Y165_E0.5470.89
335_G338_S0.5470.89
223_V264_W0.5450.89
240_Y243_A0.5440.89
122_L139_A0.5430.89
240_Y249_S0.5430.89
330_E334_K0.5410.89
94_H335_G0.5400.89
108_T126_R0.5390.89
281_T324_E0.5380.88
154_F206_Y0.5380.88
265_L269_T0.5360.88
283_I295_Q0.5360.88
206_Y270_M0.5360.88
303_N307_T0.5350.88
47_W348_M0.5340.88
97_L138_K0.5340.88
126_R214_P0.5340.88
58_N165_E0.5330.88
235_N312_S0.5320.88
77_G117_K0.5320.88
78_R118_L0.5320.88
44_A157_M0.5310.88
76_R153_V0.5300.88
70_E157_M0.5300.88
149_Y170_G0.5290.88
70_E338_S0.5260.87
231_T238_L0.5240.87
301_F305_E0.5240.87
182_V208_E0.5230.87
227_R233_H0.5220.87
242_F248_Q0.5220.87
49_C52_H0.5210.87
229_W234_G0.5210.87
332_V360_G0.5200.87
231_T240_Y0.5200.87
201_N333_Q0.5200.87
203_V285_E0.5190.87
227_R234_G0.5180.87
100_E103_A0.5170.86
102_K107_I0.5170.86
231_T237_T0.5160.86
86_Y338_S0.5150.86
156_N162_T0.5150.86
200_K368_L0.5130.86
63_V153_V0.5130.86
205_N216_H0.5110.86
188_A301_F0.5110.86
145_R162_T0.5110.86
96_L340_G0.5090.86
220_S264_W0.5080.85
67_I286_F0.5080.85
164_V169_P0.5080.85
93_G332_V0.5060.85
60_N82_L0.5050.85
252_F258_A0.5040.85
284_Y296_N0.5030.85
47_W156_N0.5030.85
243_A249_S0.5020.85
227_R232_M0.5020.85
66_E95_Q0.5010.85
150_A154_F0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vcaA 3 0.9412 100 0.233 Contact Map
3n0qA 3 0.9492 100 0.237 Contact Map
3gzxA 3 0.9679 100 0.297 Contact Map
2gbwA 3 0.9465 100 0.301 Contact Map
2b1xA 3 0.992 100 0.301 Contact Map
2bmoA 3 0.9519 100 0.309 Contact Map
1uliA 3 0.9599 100 0.314 Contact Map
1z01A 4 0.9011 100 0.336 Contact Map
3gkeA 3 0.8422 100 0.341 Contact Map
4qdfB 3 0.7995 100 0.362 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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