GREMLIN Database
HCAE - 3-phenylpropionate/cinnamic acid dioxygenase subunit alpha
UniProt: P0ABR5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13456
Length: 453 (363)
Sequences: 3343 (2175)
Seq/√Len: 114.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_R112_Y5.7621.00
197_N332_Q4.9651.00
57_D99_N4.8681.00
49_E147_S4.5461.00
28_P32_Q4.5371.00
113_G117_E4.2551.00
146_E164_R4.0761.00
80_A145_V3.8271.00
73_Q79_K3.6461.00
79_K141_E3.4851.00
329_G332_Q3.3551.00
73_Q77_S3.2671.00
195_V332_Q3.1841.00
133_C136_H3.1771.00
331_D383_K3.1521.00
157_D160_A2.9881.00
32_Q35_L2.8701.00
47_A152_I2.8381.00
31_Y329_G2.7991.00
80_A154_G2.7441.00
146_E163_L2.7091.00
23_R27_D2.6631.00
58_F98_G2.6171.00
197_N376_C2.5931.00
71_V103_F2.5861.00
124_E134_K2.5201.00
91_R380_K2.5091.00
54_K57_D2.4151.00
41_R157_D2.3851.00
33_L37_R2.3801.00
52_I78_I2.3751.00
162_G165_D2.3591.00
60_N67_A2.3521.00
328_R332_Q2.3251.00
178_L184_G2.2941.00
155_N160_A2.2921.00
54_K99_N2.2761.00
143_P155_N2.2741.00
81_F141_E2.2381.00
46_L154_G2.1761.00
145_V152_I2.1691.00
184_G343_K2.1261.00
328_R334_E2.1101.00
107_Y206_Q2.0841.00
113_G119_I2.0631.00
28_P330_P2.0501.00
220_S370_D2.0371.00
163_L167_L2.0171.00
31_Y35_L1.9821.00
86_R140_N1.9561.00
53_P57_D1.9441.00
217_S374_N1.9291.00
55_P76_G1.8641.00
47_A59_F1.8501.00
35_L64_G1.8291.00
164_R171_A1.8261.00
51_Q59_F1.7991.00
211_Q214_A1.7901.00
161_P165_D1.7841.00
71_V79_K1.7611.00
93_S103_F1.7331.00
66_D385_H1.7201.00
195_V328_R1.7111.00
29_D32_Q1.7091.00
147_S152_I1.7021.00
102_A119_I1.6981.00
68_V80_A1.6681.00
52_I57_D1.6671.00
53_P72_R1.6651.00
49_E150_G1.6651.00
35_L65_E1.6631.00
68_V154_G1.6511.00
48_H151_L1.6171.00
70_V80_A1.5921.00
193_K336_W1.5611.00
52_I72_R1.5571.00
36_E40_G1.5571.00
62_Y67_A1.5481.00
90_M106_P1.5471.00
193_K334_E1.5451.00
94_Y377_E1.5431.00
186_E343_K1.5401.00
56_G114_I1.5311.00
91_R377_E1.5191.00
195_V334_E1.5161.00
109_G216_F1.4941.00
58_F95_A1.4911.00
92_V103_F1.4761.00
28_P331_D1.4631.00
143_P146_E1.4581.00
47_A70_V1.4571.00
32_Q36_E1.4481.00
143_P160_A1.4431.00
70_V152_I1.4361.00
62_Y65_E1.4151.00
153_F313_L1.4001.00
148_Y175_D1.3951.00
78_I147_S1.3711.00
331_D379_Q1.3691.00
78_I145_V1.3631.00
71_V114_I1.3511.00
121_V132_L1.3341.00
31_Y333_V1.3341.00
407_G411_I1.3311.00
73_Q115_N1.3081.00
115_N119_I1.2730.99
81_F142_V1.2620.99
328_R333_V1.2590.99
198_C375_W1.2450.99
325_W333_V1.2430.99
140_N388_R1.2350.99
58_F100_T1.2340.99
292_E297_E1.2290.99
31_Y328_R1.2240.99
38_I407_G1.2220.99
292_E295_L1.2200.99
102_A111_S1.1990.99
112_Y138_G1.1880.99
282_S286_E1.1850.99
237_G241_T1.1720.99
72_R78_I1.1720.99
288_Y292_E1.1670.99
35_L40_G1.1520.99
149_K175_D1.1500.99
117_E135_S1.1490.99
78_I152_I1.1490.99
30_I33_L1.1440.99
167_L309_I1.1430.99
77_S141_E1.1380.99
100_T114_I1.1330.99
199_N331_D1.1190.99
86_R138_G1.1050.98
51_Q97_C1.1040.98
236_L240_Q1.0960.98
118_L121_V1.0810.98
75_D115_N1.0790.98
346_S349_V1.0750.98
180_R184_G1.0720.98
49_E72_R1.0590.98
221_A370_D1.0580.98
172_W175_D1.0570.98
58_F93_S1.0560.98
143_P158_T1.0540.98
69_V81_F1.0340.97
106_P109_G1.0330.97
187_I340_I1.0330.97
237_G240_Q1.0320.97
46_L70_V1.0250.97
40_G66_D1.0240.97
104_T111_S1.0230.97
42_C410_G1.0120.97
358_T362_G1.0060.97
295_L298_V1.0030.97
324_V336_W1.0030.97
236_L239_G1.0010.97
373_E377_E0.9950.97
110_W212_Y0.9880.97
59_F70_V0.9790.97
143_P157_D0.9760.96
66_D82_L0.9760.96
146_E167_L0.9730.96
268_E271_D0.9670.96
69_V93_S0.9670.96
32_Q65_E0.9640.96
132_L137_W0.9640.96
169_D172_W0.9550.96
44_L63_M0.9490.96
47_A52_I0.9470.96
68_V142_V0.9440.96
51_Q61_T0.9420.96
30_I38_I0.9350.95
102_A113_G0.9330.95
397_G400_Q0.9270.95
98_G103_F0.9260.95
262_S265_F0.9240.95
26_T382_L0.9220.95
198_C203_P0.9200.95
267_T270_P0.9130.95
221_A224_V0.9110.95
292_E296_G0.9110.95
175_D179_D0.9060.95
121_V127_A0.9020.94
84_Q381_L0.8980.94
82_L386_R0.8970.94
155_N161_P0.8950.94
326_H336_W0.8900.94
348_E351_A0.8890.94
75_D79_K0.8850.94
294_R297_E0.8830.94
90_M378_I0.8820.94
142_V156_W0.8780.94
90_M374_N0.8770.94
205_E337_A0.8770.94
186_E350_K0.8700.93
191_V338_F0.8700.93
320_A340_I0.8690.93
86_R137_W0.8670.93
285_R288_Y0.8660.93
165_D168_G0.8650.93
37_R41_R0.8630.93
48_H148_Y0.8620.93
55_P74_K0.8610.93
69_V139_L0.8610.93
60_N69_V0.8580.93
204_A325_W0.8550.93
82_L142_V0.8490.93
20_V24_I0.8460.92
191_V336_W0.8460.92
45_F313_L0.8450.92
46_L61_T0.8440.92
24_I408_I0.8440.92
84_Q210_D0.8430.92
198_C202_F0.8410.92
290_E294_R0.8370.92
60_N96_D0.8370.92
33_L411_I0.8330.92
146_E162_G0.8330.92
121_V124_E0.8280.92
14_D17_N0.8270.92
170_I307_N0.8270.92
164_R167_L0.8250.91
198_C333_V0.8240.91
266_F269_K0.8230.91
206_Q390_S0.8220.91
206_Q210_D0.8210.91
81_F92_V0.8210.91
230_D234_K0.8200.91
143_P159_S0.8160.91
81_F139_L0.8140.91
15_T18_G0.8130.91
405_D409_P0.8100.91
31_Y65_E0.8080.91
24_I30_I0.8070.90
147_S150_G0.8050.90
289_A292_E0.8030.90
365_G369_Q0.8000.90
269_K272_A0.7990.90
46_L80_A0.7990.90
148_Y171_A0.7960.90
291_A295_L0.7930.90
308_N314_S0.7910.90
23_R26_T0.7840.89
26_T379_Q0.7840.89
93_S97_C0.7820.89
111_S120_D0.7810.89
60_N93_S0.7810.89
326_H334_E0.7800.89
267_T271_D0.7780.89
202_F378_I0.7730.89
111_S118_L0.7690.88
55_P73_Q0.7670.88
44_L326_H0.7510.87
98_G150_G0.7500.87
221_A306_H0.7480.87
33_L36_E0.7460.87
359_R362_G0.7460.87
79_K115_N0.7450.87
94_Y373_E0.7440.87
43_W206_Q0.7440.87
42_C166_Y0.7390.86
82_L384_G0.7350.86
69_V109_G0.7320.86
287_T295_L0.7320.86
117_E138_G0.7320.86
282_S285_R0.7270.85
60_N98_G0.7260.85
142_V154_G0.7250.85
76_G82_L0.7250.85
149_K171_A0.7230.85
291_A296_G0.7210.85
80_A142_V0.7210.85
51_Q338_F0.7200.85
310_F410_G0.7180.85
65_E383_K0.7150.84
292_E301_L0.7130.84
285_R289_A0.7070.84
171_A175_D0.7060.84
74_K134_K0.7050.83
369_Q373_E0.7020.83
74_K114_I0.7020.83
149_K179_D0.7010.83
378_I382_L0.7010.83
73_Q113_G0.7000.83
395_E399_G0.6940.83
40_G65_E0.6940.83
329_G333_V0.6930.82
88_R210_D0.6890.82
379_Q382_L0.6880.82
284_Y287_T0.6870.82
288_Y291_A0.6830.82
194_W335_V0.6830.82
402_K405_D0.6820.81
196_I372_S0.6810.81
347_D350_K0.6800.81
296_G300_A0.6790.81
40_G64_G0.6790.81
147_S163_L0.6760.81
72_R76_G0.6710.80
90_M377_E0.6690.80
42_C310_F0.6690.80
155_N158_T0.6680.80
92_V139_L0.6680.80
143_P161_P0.6670.80
294_R298_V0.6660.80
319_T360_A0.6650.80
77_S147_S0.6650.80
53_P71_V0.6650.80
284_Y288_Y0.6640.80
86_R118_L0.6640.80
347_D351_A0.6640.80
379_Q383_K0.6610.79
173_Y307_N0.6610.79
306_H316_L0.6590.79
62_Y91_R0.6570.79
69_V141_E0.6570.79
207_F314_S0.6550.79
68_V145_V0.6530.79
372_S376_C0.6530.79
238_D241_T0.6480.78
66_D384_G0.6480.78
111_S119_I0.6480.78
203_P333_V0.6460.78
377_E380_K0.6450.78
104_T109_G0.6440.78
293_Q298_V0.6430.78
63_M156_W0.6430.78
335_V372_S0.6420.77
22_P26_T0.6400.77
186_E344_A0.6400.77
86_R139_L0.6390.77
369_Q372_S0.6390.77
39_F296_G0.6380.77
153_F165_D0.6380.77
93_S136_H0.6370.77
202_F375_W0.6370.77
287_T291_A0.6360.77
133_C138_G0.6360.77
132_L136_H0.6330.76
26_T331_D0.6320.76
52_I101_R0.6310.76
406_D409_P0.6310.76
190_G365_G0.6300.76
19_R391_K0.6280.76
162_G168_G0.6270.76
362_G365_G0.6260.76
323_R337_A0.6250.76
22_P382_L0.6250.76
82_L140_N0.6240.75
148_Y164_R0.6240.75
264_F269_K0.6230.75
34_E201_K0.6230.75
45_F48_H0.6230.75
262_S266_F0.6210.75
286_E290_E0.6210.75
221_A368_E0.6210.75
226_G230_D0.6200.75
43_W155_N0.6190.75
293_Q296_G0.6180.75
207_F325_W0.6180.75
92_V112_Y0.6170.75
329_G383_K0.6150.74
210_D400_Q0.6080.74
52_I80_A0.6070.73
124_E127_A0.6070.73
112_Y212_Y0.6070.73
202_F376_C0.6060.73
82_L91_R0.6060.73
49_E164_R0.6060.73
56_G71_V0.6060.73
353_F360_A0.6030.73
31_Y330_P0.6020.73
194_W368_E0.6020.73
118_L200_W0.6010.73
47_A51_Q0.6000.73
203_P375_W0.6000.73
212_Y367_L0.5970.72
52_I70_V0.5970.72
22_P387_A0.5970.72
148_Y167_L0.5960.72
211_Q314_S0.5950.72
45_F153_F0.5940.72
194_W372_S0.5940.72
360_A363_P0.5940.72
21_T388_R0.5930.72
25_Y367_L0.5920.72
306_H310_F0.5910.71
151_L313_L0.5900.71
323_R368_E0.5900.71
348_E352_A0.5880.71
405_D408_I0.5880.71
188_V341_T0.5880.71
155_N162_G0.5860.71
48_H98_G0.5840.71
38_I42_C0.5830.70
44_L156_W0.5830.70
25_Y379_Q0.5810.70
211_Q360_A0.5810.70
49_E52_I0.5810.70
63_M154_G0.5810.70
141_E177_M0.5810.70
27_D330_P0.5810.70
25_Y329_G0.5800.70
298_V301_L0.5790.70
41_R388_R0.5790.70
392_L400_Q0.5770.70
187_I191_V0.5760.69
58_F103_F0.5760.69
48_H51_Q0.5760.69
207_F316_L0.5760.69
92_V109_G0.5750.69
47_A153_F0.5740.69
148_Y163_L0.5740.69
286_E289_A0.5740.69
265_F272_A0.5740.69
268_E272_A0.5730.69
266_F270_P0.5720.69
161_P166_Y0.5720.69
221_A318_G0.5720.69
380_K383_K0.5690.69
207_F363_P0.5680.68
310_F399_G0.5670.68
265_F269_K0.5670.68
74_K101_R0.5660.68
40_G385_H0.5660.68
203_P323_R0.5660.68
288_Y298_V0.5650.68
403_R407_G0.5640.68
314_S325_W0.5630.68
58_F101_R0.5620.68
245_V264_F0.5620.68
153_F163_L0.5620.68
29_D282_S0.5620.68
390_S394_L0.5610.67
35_L39_F0.5600.67
92_V386_R0.5600.67
163_L166_Y0.5600.67
68_V156_W0.5600.67
83_N93_S0.5580.67
101_R104_T0.5580.67
123_L126_R0.5580.67
20_V390_S0.5570.67
118_L138_G0.5570.67
349_V352_A0.5560.67
18_G137_W0.5560.67
194_W375_W0.5550.67
101_R114_I0.5550.67
21_T24_I0.5540.66
358_T361_F0.5540.66
67_A72_R0.5540.66
190_G361_F0.5520.66
50_S148_Y0.5520.66
397_G403_R0.5510.66
151_L190_G0.5500.66
30_I407_G0.5500.66
101_R111_S0.5490.66
74_K120_D0.5480.66
50_S186_E0.5470.66
167_L171_A0.5470.66
48_H150_G0.5460.65
198_C379_Q0.5460.65
106_P374_N0.5460.65
37_R414_Y0.5460.65
342_D345_A0.5450.65
285_R290_E0.5430.65
210_D364_A0.5430.65
376_C379_Q0.5420.65
314_S319_T0.5420.65
38_I41_R0.5410.65
295_L304_A0.5410.65
290_E297_E0.5410.65
406_D410_G0.5410.65
235_R238_D0.5400.65
226_G229_D0.5400.65
73_Q114_I0.5390.64
81_F140_N0.5390.64
216_F219_A0.5380.64
364_A367_L0.5380.64
127_A132_L0.5370.64
192_Q339_C0.5370.64
155_N159_S0.5370.64
61_T326_H0.5370.64
284_Y290_E0.5360.64
353_F357_A0.5360.64
207_F211_Q0.5350.64
93_S96_D0.5350.64
61_T154_G0.5350.64
198_C363_P0.5330.64
164_R168_G0.5310.63
227_A234_K0.5310.63
210_D220_S0.5300.63
316_L367_L0.5290.63
95_A101_R0.5270.63
222_V227_A0.5260.63
174_L179_D0.5250.62
52_I59_F0.5250.62
90_M94_Y0.5250.62
341_T345_A0.5230.62
210_D214_A0.5220.62
25_Y394_L0.5200.62
82_L385_H0.5200.62
316_L321_T0.5190.62
123_L396_M0.5190.62
41_R159_S0.5190.62
65_E68_V0.5170.61
209_S214_A0.5170.61
201_K212_Y0.5170.61
58_F104_T0.5170.61
94_Y106_P0.5170.61
345_A348_E0.5150.61
59_F152_I0.5150.61
337_A368_E0.5150.61
211_Q367_L0.5140.61
54_K100_T0.5140.61
238_D245_V0.5140.61
22_P378_I0.5130.61
316_L323_R0.5120.60
157_D162_G0.5120.60
206_Q375_W0.5110.60
103_F106_P0.5100.60
83_N312_T0.5090.60
29_D33_L0.5090.60
180_R342_D0.5090.60
376_C380_K0.5090.60
25_Y205_E0.5080.60
209_S318_G0.5080.60
81_F115_N0.5080.60
127_A205_E0.5070.60
31_Y302_R0.5070.60
67_A91_R0.5070.60
134_K138_G0.5070.60
368_E374_N0.5070.60
387_A390_S0.5070.60
103_F152_I0.5060.60
39_F368_E0.5040.59
211_Q339_C0.5040.59
207_F306_H0.5040.59
84_Q91_R0.5040.59
174_L317_N0.5030.59
100_T122_P0.5020.59
289_A298_V0.5020.59
70_V130_Q0.5010.59
300_A305_G0.5000.59
207_F318_G0.5000.59
316_L360_A0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gbwA 3 0.9558 100 0.351 Contact Map
3gzxA 3 0.9426 100 0.353 Contact Map
2bmoA 3 0.9404 100 0.364 Contact Map
1uliA 3 0.9161 100 0.364 Contact Map
3vcaA 3 0.8521 100 0.369 Contact Map
3n0qA 3 0.8587 100 0.374 Contact Map
2b1xA 3 0.9227 100 0.38 Contact Map
1z01A 4 0.8609 100 0.504 Contact Map
4qdfB 3 0.7373 100 0.541 Contact Map
3gkeA 3 0.713 100 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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