GREMLIN Database
DINI - DNA-damage-inducible protein I
UniProt: P0ABR1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12670
Length: 81 (77)
Sequences: 136 (69)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_L17_A4.2620.98
8_A11_S3.2780.91
8_A64_S2.5580.77
20_A24_E2.5140.75
3_I18_I1.7960.49
27_R53_I1.7440.46
27_R62_R1.6580.43
35_D42_V1.6570.43
19_D26_S1.6520.43
17_A25_L1.6170.41
22_A36_N1.6060.41
51_S64_S1.6010.41
52_V63_I1.5930.40
22_A40_V1.5710.40
67_L76_D1.5500.39
5_V42_V1.5430.39
11_S29_I1.5290.38
9_K23_G1.5270.38
52_V60_K1.4670.36
43_R63_I1.4420.35
46_A64_S1.3970.33
35_D39_H1.3540.32
23_G46_A1.3490.31
67_L70_T1.3450.31
19_D22_A1.3260.31
7_I59_D1.2690.29
12_P15_A1.2660.29
70_T73_S1.2620.28
5_V27_R1.2030.26
55_A68_Q1.1810.26
18_I65_E1.1370.24
52_V70_T1.1210.24
72_E77_W1.0870.23
32_A59_D1.0850.23
33_F60_K1.0750.23
33_F62_R1.0690.22
17_A43_R1.0610.22
11_S46_A1.0430.22
6_T25_L1.0430.22
49_N57_K1.0390.22
5_V32_A1.0370.22
3_I63_I1.0220.21
26_S42_V1.0090.21
27_R31_Y1.0000.21
22_A44_Y0.9560.19
59_D69_E0.9560.19
30_Q51_S0.9540.19
74_A77_W0.9120.18
54_G76_D0.9010.18
15_A43_R0.8970.18
56_T61_Q0.8830.18
35_D46_A0.8810.18
54_G57_K0.8780.18
19_D61_Q0.8730.17
2_R44_Y0.8710.17
30_Q58_E0.8690.17
23_G40_V0.8660.17
33_F39_H0.8510.17
35_D56_T0.8490.17
11_S64_S0.8450.17
24_E78_F0.8310.16
40_V49_N0.8270.16
19_D42_V0.8180.16
7_I11_S0.8160.16
22_A42_V0.7900.16
21_L25_L0.7890.16
27_R58_E0.7680.15
20_A78_F0.7630.15
3_I29_I0.7570.15
32_A35_D0.7560.15
3_I55_A0.7500.15
1_M17_A0.7350.14
50_L64_S0.7340.14
29_I42_V0.7150.14
54_G58_E0.7130.14
72_E78_F0.7080.14
9_K15_A0.6940.14
39_H55_A0.6930.14
29_I66_I0.6930.14
33_F59_D0.6900.14
47_A54_G0.6780.13
26_S40_V0.6730.13
29_I73_S0.6670.13
23_G31_Y0.6620.13
53_I62_R0.6620.13
66_I70_T0.6530.13
21_L24_E0.6510.13
45_A69_E0.6470.13
44_Y48_N0.6350.13
31_Y35_D0.6180.12
7_I10_T0.6100.12
63_I69_E0.6060.12
61_Q65_E0.5940.12
3_I7_I0.5940.12
8_A46_A0.5760.12
59_D73_S0.5740.11
29_I62_R0.5720.11
14_P21_L0.5720.11
55_A66_I0.5690.11
13_L66_I0.5670.11
11_S27_R0.5640.11
17_A70_T0.5640.11
59_D63_I0.5420.11
44_Y64_S0.5410.11
5_V23_G0.5400.11
1_M13_L0.5360.11
18_I52_V0.5220.11
34_P63_I0.5210.11
2_R9_K0.5180.11
28_R77_W0.5170.11
32_A47_A0.5150.11
69_E78_F0.5040.10
8_A16_G0.5020.10
25_L43_R0.5010.10
48_N57_K0.5000.10
18_I32_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ghhA 1 1 100 0.229 Contact Map
1lq9A 2 0.8148 31.3 0.92 Contact Map
1eyhA 1 0.5432 25.1 0.923 Contact Map
1xg8A 1 0.8519 17.5 0.929 Contact Map
4dn9A 3 0.7901 17.2 0.929 Contact Map
1yxbA 4 0.6667 13.5 0.932 Contact Map
3e9vA 1 0.963 13.2 0.933 Contact Map
3aqpA 1 0.9506 12.8 0.933 Contact Map
3h90A 3 0.5926 12.3 0.934 Contact Map
2gffA 2 0.7901 12 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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