GREMLIN Database
DYR - Dihydrofolate reductase
UniProt: P0ABQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10326
Length: 159 (155)
Sequences: 4706 (3649)
Seq/√Len: 293.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_V121_G3.1871.00
58_K73_T3.0671.00
36_L56_G2.8431.00
10_V116_D2.8041.00
135_S138_S2.2571.00
30_W34_N2.2331.00
4_L107_A2.2061.00
8_L12_R2.1611.00
78_V103_F2.1311.00
135_S154_E2.1291.00
38_K92_M2.0721.00
3_S111_Y1.9971.00
9_A13_V1.9911.00
114_H154_E1.9821.00
75_V84_A1.9441.00
110_L128_Y1.8731.00
77_S80_E1.8671.00
40_V59_N1.7771.00
31_F94_I1.7631.00
41_I91_I1.7051.00
109_K157_E1.7001.00
16_M120_E1.6851.00
136_V157_E1.6711.00
98_R101_E1.6641.00
64_S98_R1.6591.00
116_D152_C1.6521.00
13_V124_H1.6461.00
138_S152_C1.6241.00
129_E132_D1.5911.00
109_K155_I1.5891.00
6_A112_L1.5781.00
140_F152_C1.5691.00
10_V118_E1.5661.00
76_K80_E1.5511.00
48_E68_T1.5481.00
65_Q68_T1.5361.00
44_R48_E1.5221.00
26_A151_Y1.5181.00
30_W111_Y1.5031.00
62_L99_V1.4931.00
3_S90_E1.4881.00
93_V103_F1.4801.00
98_R102_Q1.4571.00
9_A119_V1.4551.00
30_W155_I1.4461.00
38_K90_E1.4451.00
29_A33_R1.4361.00
97_G101_E1.4321.00
5_I92_M1.4111.00
39_P58_K1.3861.00
8_L114_H1.3271.00
40_V94_I1.3231.00
79_D106_K1.3171.00
53_P59_N1.3011.00
60_I75_V1.2951.00
34_N111_Y1.2671.00
47_W72_V1.2501.00
11_D118_E1.2411.00
138_S154_E1.2141.00
3_S109_K1.2071.00
25_P29_A1.1971.00
111_Y155_I1.1521.00
20_M28_L1.1481.00
116_D150_S1.1451.00
8_L112_L1.1321.00
137_F155_I1.1271.00
59_N94_I1.1251.00
63_S68_T1.1041.00
26_A147_N1.1001.00
30_W153_F1.0941.00
4_L103_F1.0891.00
73_T84_A1.0841.00
135_S156_L1.0791.00
97_G123_T1.0761.00
62_L103_F1.0761.00
50_I59_N1.0731.00
63_S74_W1.0641.00
8_L110_L1.0611.00
81_A85_C1.0601.00
134_E157_E1.0571.00
80_E83_A1.0571.00
3_S92_M1.0561.00
90_E109_K1.0231.00
41_I81_A1.0231.00
63_S76_K1.0201.00
6_A125_F1.0171.00
141_H151_Y1.0021.00
85_C91_I0.9971.00
58_K88_V0.9891.00
5_I34_N0.9841.00
35_T57_R0.9701.00
32_K55_P0.9681.00
12_R127_D0.9641.00
32_K36_L0.9591.00
23_N28_L0.9551.00
45_H48_E0.9541.00
54_L57_R0.9521.00
66_P76_K0.9481.00
78_V102_Q0.9281.00
4_L125_F0.9161.00
142_D150_S0.9011.00
75_V81_A0.8931.00
60_I85_C0.8921.00
46_T49_S0.8901.00
6_A14_I0.8831.00
117_A149_H0.8831.00
112_L156_L0.8821.00
119_V149_H0.8791.00
42_M50_I0.8641.00
83_A86_G0.8611.00
114_H156_L0.8591.00
45_H98_R0.8581.00
25_P146_Q0.8571.00
18_N49_S0.8481.00
26_A146_Q0.8471.00
68_T74_W0.8451.00
24_L115_I0.8391.00
27_D153_F0.8371.00
81_A103_F0.8311.00
47_W53_P0.8191.00
84_A87_D0.8131.00
39_P60_I0.8051.00
37_N56_G0.8041.00
61_I72_V0.8010.99
4_L100_Y0.7950.99
12_R114_H0.7950.99
6_A110_L0.7870.99
114_H130_P0.7850.99
82_I106_K0.7820.99
18_N45_H0.7740.99
22_W115_I0.7640.99
50_I53_P0.7530.99
9_A118_E0.7500.99
24_L147_N0.7480.99
93_V99_V0.7420.99
47_W50_I0.7400.99
148_S151_Y0.7390.99
129_E133_W0.7380.99
9_A117_A0.7370.99
53_P71_R0.7360.99
38_K89_P0.7300.99
10_V117_A0.7240.99
8_L125_F0.7190.99
28_L32_K0.7140.99
139_E142_D0.7140.99
21_P119_V0.7120.99
34_N92_M0.7100.99
2_I91_I0.7080.99
9_A121_G0.7080.99
53_P61_I0.7060.99
2_I107_A0.6850.98
78_V106_K0.6790.98
10_V114_H0.6760.98
51_G59_N0.6760.98
39_P59_N0.6720.98
39_P88_V0.6710.98
115_I119_V0.6700.98
146_Q149_H0.6700.98
99_V102_Q0.6690.98
53_P72_V0.6620.98
41_I60_I0.6570.98
63_S66_P0.6480.98
84_A88_V0.6470.98
18_N122_D0.6420.98
25_P148_S0.6390.98
110_L125_F0.6370.97
21_P121_G0.6350.97
8_L128_Y0.6330.97
20_M23_N0.6280.97
13_V21_P0.6260.97
62_L102_Q0.6170.97
16_M20_M0.6140.97
141_H150_S0.6100.97
114_H152_C0.6070.97
21_P100_Y0.6060.97
140_F150_S0.6030.96
128_Y156_L0.6000.96
30_W137_F0.5930.96
66_P69_D0.5930.96
79_D83_A0.5920.96
47_W51_G0.5910.96
75_V80_E0.5890.96
18_N123_T0.5860.96
132_D135_S0.5830.96
141_H152_C0.5830.96
136_V155_I0.5810.96
42_M46_T0.5800.96
62_L81_A0.5780.96
22_W119_V0.5770.96
4_L104_L0.5750.95
101_E126_P0.5750.95
65_Q69_D0.5730.95
85_C88_V0.5720.95
41_I103_F0.5670.95
58_K84_A0.5650.95
92_M111_Y0.5640.95
42_M94_I0.5600.95
8_L21_P0.5600.95
39_P89_P0.5590.95
26_A29_A0.5580.95
135_S152_C0.5570.95
90_E111_Y0.5560.95
141_H147_N0.5540.94
104_L128_Y0.5500.94
20_M49_S0.5480.94
80_E84_A0.5480.94
94_I100_Y0.5420.94
13_V119_V0.5420.94
7_A22_W0.5400.94
27_D30_W0.5360.93
110_L133_W0.5360.93
147_N150_S0.5330.93
28_L49_S0.5320.93
60_I73_T0.5320.93
100_Y125_F0.5320.93
28_L40_V0.5300.93
83_A87_D0.5250.93
103_F106_K0.5240.93
32_K46_T0.5220.93
145_A148_S0.5130.92
145_A150_S0.5120.92
100_Y123_T0.5110.92
121_G124_H0.5080.91
12_R128_Y0.5070.91
14_I121_G0.5070.91
19_A23_N0.5050.91
99_V103_F0.5050.91
50_I94_I0.5020.91
107_A110_L0.5010.91
82_I85_C0.5010.91
65_Q76_K0.5010.91
36_L40_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bl9A 1 0.9874 100 0.263 Contact Map
4eilA 3 0.9874 100 0.264 Contact Map
1j3kA 1 0.9874 100 0.27 Contact Map
3ia4A 1 1 100 0.271 Contact Map
3irmA 4 0.9937 100 0.276 Contact Map
3rg9A 1 1 100 0.279 Contact Map
2w9hA 1 0.9811 100 0.287 Contact Map
3tq8A 1 0.9874 100 0.289 Contact Map
1zdrA 1 1 100 0.29 Contact Map
4pssA 1 0.7107 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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