GREMLIN Database
GARR - 2-hydroxy-3-oxopropionate reductase
UniProt: P0ABQ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11176
Length: 294 (279)
Sequences: 11445 (7424)
Seq/√Len: 444.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_Y151_K3.6341.00
71_K103_E3.3691.00
140_K144_D3.3051.00
27_V47_A3.0071.00
114_D142_I2.9091.00
2_K25_S2.7891.00
40_I46_T2.7261.00
114_D145_K2.7211.00
17_K42_A2.7071.00
234_D274_T2.3291.00
48_S52_A2.2771.00
37_A41_A2.2261.00
144_D147_Y2.2121.00
36_I46_T2.1951.00
108_L113_I2.1241.00
89_V146_Y2.0511.00
20_L44_A2.0051.00
211_G216_D1.9971.00
13_K38_D1.9771.00
24_Y152_A1.9481.00
4_G53_I1.9461.00
140_K159_H1.9121.00
197_N200_L1.8911.00
105_S163_I1.8521.00
99_L249_G1.8431.00
49_T52_A1.8381.00
114_D139_D1.8371.00
81_I108_L1.8351.00
62_T90_L1.8341.00
22_A152_A1.7701.00
246_T249_G1.7671.00
18_N21_K1.7551.00
51_K55_E1.7321.00
25_S45_E1.7291.00
234_D268_R1.7211.00
2_K27_V1.7201.00
85_K88_T1.7111.00
32_N35_A1.6981.00
109_K139_D1.6961.00
34_E37_A1.6841.00
106_E110_A1.6811.00
191_A201_V1.6761.00
139_D142_I1.6421.00
134_V153_M1.6351.00
33_P37_A1.6241.00
74_A90_L1.6161.00
27_V56_Q1.5971.00
63_M93_M1.5901.00
89_V142_I1.5851.00
272_L275_A1.5761.00
107_A110_A1.5581.00
116_L138_G1.5521.00
105_S109_K1.5411.00
28_V44_A1.5251.00
84_A88_T1.5251.00
134_V154_A1.5181.00
143_F147_Y1.5011.00
103_E107_A1.4841.00
118_A134_V1.4791.00
61_I93_M1.4551.00
116_L146_Y1.4501.00
18_N130_G1.4431.00
143_F159_H1.4291.00
199_D203_Q1.4271.00
66_N69_H1.4261.00
220_P224_D1.4161.00
51_K83_G1.4151.00
27_V45_E1.4081.00
125_P129_D1.4051.00
124_E128_I1.4011.00
53_I57_C1.3991.00
37_A40_I1.3781.00
262_E265_Q1.3721.00
67_S100_A1.3701.00
179_L183_A1.3591.00
160_T169_T1.3461.00
258_A262_E1.3421.00
171_L242_N1.3371.00
233_I267_L1.3341.00
58_D85_K1.3211.00
101_S115_M1.3101.00
234_D273_G1.3091.00
131_T155_G1.3081.00
89_V145_K1.3071.00
192_T198_P1.3011.00
206_R216_D1.3001.00
259_A262_E1.3001.00
33_P48_S1.2991.00
21_K42_A1.2871.00
108_L115_M1.2801.00
79_G82_E1.2671.00
261_M265_Q1.2671.00
275_A282_C1.2501.00
17_K128_I1.2351.00
91_I146_Y1.2331.00
116_L143_F1.2301.00
14_P128_I1.2301.00
63_M120_V1.2291.00
237_I268_R1.2201.00
248_H258_A1.2171.00
21_K128_I1.2081.00
68_P72_E1.2071.00
4_G57_C1.2061.00
189_T193_K1.1991.00
59_V89_V1.1961.00
81_I111_K1.1891.00
39_V44_A1.1891.00
139_D162_E1.1851.00
247_S254_L1.1611.00
146_Y150_M1.1591.00
16_S26_L1.1591.00
38_D41_A1.1561.00
71_K107_A1.1541.00
47_A53_I1.1531.00
178_A240_L1.1531.00
50_A83_G1.1521.00
84_A113_I1.1521.00
194_A250_V1.1521.00
59_V149_L1.1431.00
245_D249_G1.1411.00
102_R168_V1.1391.00
178_A236_H1.1381.00
93_M134_V1.1341.00
82_E111_K1.1331.00
5_F15_M1.1201.00
88_T113_I1.1191.00
17_K21_K1.1111.00
5_F61_I1.1001.00
253_Q258_A1.1001.00
5_F16_S1.0941.00
97_A100_A1.0911.00
64_L73_V1.0901.00
102_R163_I1.0881.00
52_A55_E1.0801.00
90_L108_L1.0701.00
27_V57_C1.0651.00
244_L258_A1.0561.00
237_I265_Q1.0531.00
71_K100_A1.0501.00
67_S97_A1.0491.00
10_I124_E1.0411.00
162_E165_A1.0411.00
136_V143_F1.0381.00
107_A111_K1.0351.00
102_R106_E1.0351.00
93_M153_M1.0301.00
61_I149_L1.0261.00
159_H162_E1.0201.00
106_E109_K1.0171.00
54_A83_G1.0161.00
241_A261_M1.0121.00
105_S139_D1.0041.00
30_D35_A0.9941.00
47_A52_A0.9881.00
176_I187_A0.9871.00
245_D248_H0.9871.00
151_K157_V0.9841.00
38_D42_A0.9721.00
56_Q85_K0.9691.00
116_L136_V0.9681.00
200_L203_Q0.9671.00
8_L39_V0.9631.00
78_N82_E0.9601.00
84_A90_L0.9571.00
78_N107_A0.9561.00
20_L43_G0.9501.00
45_E56_Q0.9491.00
61_I91_I0.9451.00
172_A191_A0.9381.00
233_I268_R0.9331.00
188_L202_Y0.9321.00
69_H72_E0.9311.00
117_D164_G0.9301.00
231_F235_L0.9231.00
127_A132_L0.9201.00
241_A245_D0.9191.00
213_T217_A0.9171.00
34_E38_D0.9131.00
74_A80_I0.9131.00
70_V96_I0.9111.00
31_R69_H0.9101.00
172_A187_A0.9061.00
160_T165_A0.9061.00
74_A108_L0.9031.00
144_D159_H0.8991.00
138_G143_F0.8971.00
50_A54_A0.8961.00
89_V114_D0.8961.00
52_A56_Q0.8951.00
121_S173_N0.8921.00
33_P46_T0.8871.00
179_L256_L0.8861.00
18_N153_M0.8851.00
268_R273_G0.8811.00
135_M204_A0.8801.00
97_A245_D0.8791.00
275_A279_A0.8781.00
13_K17_K0.8781.00
51_K79_G0.8781.00
71_K104_I0.8771.00
265_Q269_A0.8741.00
241_A265_Q0.8721.00
121_S135_M0.8711.00
86_P112_G0.8691.00
59_V145_K0.8681.00
100_A103_E0.8671.00
206_R215_L0.8621.00
101_S167_N0.8591.00
5_F26_L0.8511.00
202_Y219_A0.8481.00
168_V246_T0.8471.00
272_L282_C0.8451.00
237_I261_M0.8441.00
53_I56_Q0.8441.00
96_I100_A0.8411.00
160_T204_A0.8411.00
8_L28_V0.8351.00
168_V194_A0.8341.00
35_A38_D0.8331.00
15_M153_M0.8261.00
103_E106_E0.8261.00
148_D151_K0.8251.00
142_I145_K0.8241.00
193_K252_A0.8181.00
228_K275_A0.8171.00
206_R211_G0.8161.00
265_Q268_R0.8131.00
19_L61_I0.8131.00
91_I118_A0.8121.00
202_Y206_R0.8071.00
267_L279_A0.8051.00
232_R274_T0.8031.00
62_T70_V0.8021.00
182_A256_L0.7981.00
140_K162_E0.7941.00
199_D224_D0.7941.00
180_N212_S0.7921.00
65_P69_H0.7911.00
117_D166_G0.7911.00
169_T196_V0.7881.00
2_K58_D0.7831.00
50_A53_I0.7801.00
60_I80_I0.7781.00
99_L102_R0.7751.00
219_A222_V0.7751.00
256_L260_V0.7731.00
27_V53_I0.7721.00
175_V257_T0.7721.00
137_G166_G0.7701.00
232_R235_L0.7671.00
266_A283_Y0.7641.00
102_R164_G0.7631.00
59_V91_I0.7581.00
180_N184_M0.7561.00
15_M93_M0.7551.00
246_T250_V0.7511.00
143_F157_V0.7471.00
114_D141_A0.7451.00
266_A270_D0.7421.00
116_L142_I0.7391.00
3_V24_Y0.7391.00
15_M132_L0.7381.00
142_I146_Y0.7371.00
92_D115_M0.7351.00
150_M157_V0.7351.00
6_I50_A0.7331.00
95_S242_N0.7331.00
81_I113_I0.7281.00
175_V243_A0.7281.00
31_R35_A0.7261.00
28_V36_I0.7221.00
191_A196_V0.7221.00
24_Y149_L0.7211.00
6_I29_A0.7201.00
20_L42_A0.7181.00
244_L261_M0.7131.00
147_Y157_V0.7121.00
176_I184_M0.7111.00
184_M215_L0.7111.00
5_F63_M0.7091.00
81_I107_A0.7051.00
123_G126_K0.7041.00
64_L69_H0.7031.00
13_K42_A0.7011.00
193_K250_V0.7011.00
270_D283_Y0.6981.00
62_T74_A0.6981.00
248_H261_M0.6971.00
266_A269_A0.6941.00
3_V19_L0.6921.00
104_I115_M0.6891.00
15_M63_M0.6881.00
60_I84_A0.6871.00
267_L283_Y0.6851.00
141_A144_D0.6831.00
3_V149_L0.6821.00
19_L26_L0.6821.00
233_I279_A0.6811.00
33_P36_I0.6801.00
55_E83_G0.6791.00
2_K56_Q0.6771.00
185_S280_L0.6771.00
115_M163_I0.6751.00
227_F282_C0.6741.00
189_T192_T0.6721.00
51_K54_A0.6681.00
47_A56_Q0.6681.00
20_L26_L0.6651.00
199_D223_M0.6611.00
279_A282_C0.6551.00
267_L272_L0.6531.00
156_S207_G0.6521.00
100_A104_I0.6491.00
219_A223_M0.6470.99
180_N214_V0.6440.99
36_I40_I0.6430.99
169_T201_V0.6420.99
70_V94_S0.6420.99
158_V204_A0.6380.99
118_A136_V0.6380.99
176_I183_A0.6360.99
172_A190_L0.6350.99
196_V201_V0.6330.99
64_L70_V0.6300.99
176_I180_N0.6280.99
137_G159_H0.6250.99
13_K39_V0.6240.99
202_Y223_M0.6240.99
156_S203_Q0.6220.99
136_V150_M0.6200.99
168_V196_V0.6200.99
72_E78_N0.6200.99
262_E269_A0.6180.99
68_P71_K0.6130.99
46_T49_T0.6120.99
171_L243_A0.6120.99
262_E266_A0.6060.99
30_D33_P0.6060.99
70_V92_D0.6040.99
97_A242_N0.6030.99
213_T216_D0.6010.99
86_P111_K0.6000.99
205_I210_A0.5990.99
181_I277_H0.5990.99
57_C60_I0.5980.99
241_A248_H0.5980.99
96_I167_N0.5970.99
16_S28_V0.5960.99
72_E79_G0.5960.99
126_K131_T0.5950.99
176_I205_I0.5950.99
263_M266_A0.5930.99
190_L254_L0.5910.99
70_V100_A0.5910.99
118_A150_M0.5890.99
9_G65_P0.5890.99
96_I101_S0.5890.99
244_L248_H0.5850.99
179_L260_V0.5840.99
11_M15_M0.5840.99
136_V157_V0.5840.99
51_K82_E0.5830.99
147_Y159_H0.5830.99
237_I241_A0.5810.99
150_M154_A0.5800.99
80_I84_A0.5790.99
46_T50_A0.5770.99
14_P124_E0.5700.99
62_T92_D0.5680.99
101_S163_I0.5670.99
17_K20_L0.5650.99
70_V104_I0.5590.99
51_K78_N0.5590.99
59_V146_Y0.5570.98
73_V79_G0.5490.98
226_N229_P0.5480.98
85_K113_I0.5470.98
149_L152_A0.5470.98
175_V190_L0.5440.98
126_K129_D0.5430.98
99_L103_E0.5420.98
60_I88_T0.5420.98
140_K143_F0.5400.98
8_L16_S0.5390.98
91_I150_M0.5380.98
17_K38_D0.5340.98
18_N22_A0.5340.98
98_P168_V0.5340.98
268_R271_G0.5330.98
37_A46_T0.5330.98
30_D69_H0.5320.98
36_I39_V0.5310.98
189_T252_A0.5300.98
84_A87_G0.5280.98
236_H264_M0.5260.98
256_L259_A0.5230.98
74_A104_I0.5200.98
185_S222_V0.5190.98
30_D36_I0.5190.98
221_M226_N0.5190.98
148_D152_A0.5180.98
165_A168_V0.5180.98
253_Q266_A0.5180.98
4_G27_V0.5170.98
177_V214_V0.5140.97
6_I53_I0.5130.97
61_I153_M0.5120.97
160_T200_L0.5100.97
217_A221_M0.5070.97
218_K222_V0.5070.97
92_D101_S0.5060.97
14_P130_G0.5050.97
29_A50_A0.5040.97
31_R72_E0.5030.97
158_V207_G0.5030.97
170_K174_Q0.5020.97
16_S39_V0.5010.97
47_A54_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vpdA 1 1 100 0.353 Contact Map
3ckyA 4 1 100 0.354 Contact Map
3obbA 4 0.9762 100 0.354 Contact Map
3pefA 5 0.9728 100 0.358 Contact Map
3dojA 3 0.9796 100 0.358 Contact Map
3pduA 4 0.9728 100 0.36 Contact Map
1yb4A 4 0.9898 100 0.366 Contact Map
3g0oA 3 0.9592 100 0.369 Contact Map
2uyyA 3 0.9728 100 0.37 Contact Map
4gbjA 2 0.9864 100 0.372 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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