GREMLIN Database
COABC - Coenzyme A biosynthesis bifunctional protein CoaBC
UniProt: P0ABQ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10004
Length: 406 (388)
Sequences: 3578 (2449)
Seq/√Len: 124.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_N230_N3.5071.00
258_E313_G3.4791.00
201_P253_T3.3241.00
215_K365_D2.8861.00
7_K34_D2.8671.00
218_F235_S2.8261.00
185_D227_R2.7741.00
136_H144_R2.7151.00
340_Q344_R2.7031.00
288_E332_N2.6451.00
333_N336_E2.5161.00
369_L388_L2.4851.00
227_R394_D2.4151.00
44_K62_D2.4081.00
136_H140_V2.3991.00
25_V56_S2.3911.00
13_S94_L2.3791.00
224_A393_L2.3471.00
227_R393_L2.3251.00
190_N232_T2.3251.00
10_L25_V2.3031.00
281_R305_V2.2811.00
255_L259_A2.2801.00
283_A303_K2.2731.00
11_G107_V2.2451.00
36_R58_Y2.1871.00
152_D171_T2.1701.00
378_K395_E2.1591.00
335_E372_F2.1031.00
351_C369_L2.0981.00
194_T261_V2.0631.00
27_R30_D2.0601.00
5_G33_A2.0161.00
222_A386_E2.0121.00
86_I176_A1.9951.00
80_K160_D1.9911.00
22_P55_V1.9861.00
98_V120_V1.9811.00
22_P51_S1.9751.00
192_M268_Q1.9711.00
247_K264_S1.9641.00
84_L176_A1.9611.00
191_I270_I1.9591.00
149_W167_L1.9241.00
242_T248_R1.9231.00
12_V52_L1.8911.00
85_V114_T1.8511.00
38_A110_I1.8441.00
197_P237_P1.8411.00
193_I220_I1.8341.00
96_A134_T1.8331.00
230_N247_K1.8311.00
225_A246_V1.8011.00
331_T355_V1.7691.00
41_E45_A1.7681.00
232_T249_V1.7581.00
371_L395_E1.7521.00
34_D58_Y1.7441.00
258_E262_N1.7371.00
312_A316_A1.7361.00
281_R307_N1.7351.00
130_R163_P1.7151.00
262_N313_G1.7141.00
85_V111_C1.7121.00
194_T234_V1.7061.00
36_R81_W1.7041.00
338_A352_A1.6851.00
283_A305_V1.6501.00
223_A390_Q1.6421.00
98_V111_C1.6371.00
138_L148_I1.6231.00
31_R177_V1.6221.00
201_P211_H1.6191.00
218_F240_L1.5851.00
197_P236_G1.5801.00
261_V314_V1.5781.00
15_G91_T1.5741.00
95_I120_V1.5601.00
220_I392_L1.5491.00
119_A179_H1.5341.00
129_Y138_L1.5301.00
299_E303_K1.5121.00
349_L373_W1.5041.00
242_T250_D1.5021.00
270_I396_I1.4961.00
139_E143_S1.4881.00
260_A263_A1.4871.00
251_V257_M1.4871.00
189_L269_N1.4821.00
255_L308_P1.4781.00
39_M43_A1.4741.00
213_S363_N1.4741.00
249_V264_S1.4721.00
202_L208_I1.4681.00
150_G163_P1.4621.00
87_L111_C1.4561.00
150_G167_L1.4521.00
334_V352_A1.4491.00
366_N382_L1.4491.00
47_I52_L1.4451.00
94_L105_D1.3731.00
94_L108_S1.3721.00
191_I224_A1.3671.00
298_D306_K1.3611.00
199_R209_S1.3601.00
315_A324_V1.3411.00
136_H143_S1.3391.00
326_G347_L1.3331.00
201_P252_M1.3331.00
218_F238_V1.3291.00
271_F314_V1.3281.00
121_L149_W1.3271.00
199_R252_M1.3261.00
391_L394_D1.3241.00
319_D322_P1.3201.00
23_E27_R1.3151.00
97_R102_M1.3141.00
272_I393_L1.3131.00
202_L282_A1.3121.00
120_V146_L1.3091.00
24_L173_V1.3061.00
204_P288_E1.2951.00
96_A112_L1.2941.00
262_N317_L1.2901.00
255_L281_R1.2891.00
133_A144_R1.2871.00
10_L21_T1.2791.00
99_A140_V1.2781.00
383_E391_L1.2781.00
220_I272_I1.2771.00
84_L119_A1.2751.00
38_A107_V1.2731.00
139_E142_A1.2711.00
351_C392_L1.2711.00
273_G311_V1.2591.00
252_M256_E1.2571.00
337_Y340_Q1.2501.00
195_A218_F1.2491.00
339_R343_I1.2410.99
37_V56_S1.2320.99
125_N158_C1.2290.99
360_Q366_N1.2270.99
22_P47_I1.2260.99
336_E340_Q1.2240.99
129_Y151_P1.2200.99
314_V324_V1.2090.99
140_V144_R1.2070.99
184_N187_K1.1940.99
234_V261_V1.1900.99
225_A245_F1.1890.99
218_F242_T1.1870.99
115_P127_Q1.1860.99
254_A277_V1.1860.99
97_R104_N1.1820.99
23_E170_L1.1780.99
152_D167_L1.1760.99
235_S248_R1.1530.99
127_Q160_D1.1430.99
93_D104_N1.1410.99
318_K322_P1.1400.99
368_A382_L1.1350.99
313_G316_A1.1290.99
255_L258_E1.1270.99
8_I84_L1.1240.99
343_I374_Q1.1170.99
105_D108_S1.1170.99
311_V326_G1.1140.99
40_T107_V1.1110.99
373_W377_D1.1060.99
121_L167_L1.1050.99
265_V271_F1.1050.99
325_V396_I1.1000.99
232_T264_S1.0990.99
185_D397_V1.0970.99
45_A65_L1.0940.99
256_E259_A1.0880.99
98_V146_L1.0880.99
226_R390_Q1.0880.99
39_M44_K1.0860.99
96_A102_M1.0830.99
25_V52_L1.0800.99
112_L134_T1.0790.99
185_D394_D1.0790.99
192_M264_S1.0790.99
27_R173_V1.0750.99
260_A264_S1.0720.99
100_A140_V1.0640.98
243_P246_V1.0620.98
232_T247_K1.0600.98
142_A150_G1.0600.98
383_E388_L1.0580.98
152_D168_D1.0570.98
121_L166_M1.0480.98
313_G317_L1.0460.98
255_L307_N1.0450.98
192_M234_V1.0380.98
211_H363_N1.0350.98
253_T256_E1.0350.98
41_E63_S1.0330.98
211_H252_M1.0330.98
368_A379_V1.0300.98
265_V322_P1.0270.98
299_E306_K1.0180.98
148_I167_L1.0160.98
369_L392_L1.0100.98
61_S106_L1.0020.98
6_K83_D1.0000.98
266_Q317_L1.0000.98
199_R207_Y0.9980.98
111_C118_V0.9970.98
224_A272_I0.9900.97
90_A95_I0.9900.97
258_E308_P0.9850.97
202_L302_I0.9840.97
232_T268_Q0.9810.97
96_A100_A0.9770.97
8_I33_A0.9760.97
126_Q156_Q0.9720.97
131_A146_L0.9710.97
42_A93_D0.9690.97
28_L173_V0.9680.97
93_D102_M0.9680.97
167_L171_T0.9630.97
347_L350_I0.9630.97
257_M310_I0.9590.97
208_I304_M0.9580.97
166_M169_P0.9570.97
193_I224_A0.9560.97
223_A227_R0.9550.97
342_R374_Q0.9530.97
383_E387_L0.9520.97
149_W175_M0.9510.97
27_R169_P0.9470.97
323_Y349_L0.9460.97
31_R173_V0.9440.97
223_A226_R0.9420.97
312_A344_R0.9420.97
282_A302_I0.9410.97
11_G85_V0.9390.97
119_A149_W0.9390.97
147_L179_H0.9380.97
6_K33_A0.9380.97
190_N268_Q0.9360.96
41_E44_K0.9360.96
191_I272_I0.9330.96
271_F324_V0.9330.96
333_N337_Y0.9330.96
235_S238_V0.9330.96
335_E339_R0.9320.96
121_L172_I0.9310.96
7_K81_W0.9270.96
185_D390_Q0.9270.96
227_R390_Q0.9250.96
218_F248_R0.9240.96
395_E398_T0.9190.96
195_A233_L0.9190.96
120_V148_I0.9180.96
315_A347_L0.9180.96
25_V37_V0.9170.96
315_A346_N0.9130.96
384_R387_L0.9130.96
357_Q368_A0.9120.96
323_Y396_I0.9090.96
24_L88_A0.9080.96
360_Q368_A0.9020.96
373_W376_G0.9000.96
249_V260_A0.8940.95
54_A73_M0.8820.95
378_K391_L0.8770.95
87_L98_V0.8770.95
349_L371_L0.8750.95
26_R155_S0.8720.95
114_T118_V0.8700.95
22_P52_L0.8600.94
118_V146_L0.8590.94
332_N337_Y0.8550.94
328_A338_A0.8520.94
265_V314_V0.8410.94
29_R57_G0.8410.94
92_A112_L0.8350.93
77_E81_W0.8320.93
294_A298_D0.8300.93
273_G314_V0.8300.93
7_K36_R0.8300.93
119_A176_A0.8240.93
380_L391_L0.8240.93
28_L176_A0.8230.93
235_S240_L0.8230.93
23_E169_P0.8210.93
153_S163_P0.8170.93
44_K49_P0.8160.93
218_F250_D0.8150.93
126_Q130_R0.8140.93
111_C131_A0.8130.93
340_Q343_I0.8120.92
329_A355_V0.8100.92
284_T303_K0.8100.92
27_R31_R0.8060.92
34_D81_W0.8050.92
9_V82_A0.8040.92
12_V18_A0.8030.92
265_V317_L0.7990.92
97_R108_S0.7960.92
150_G166_M0.7950.92
24_L86_I0.7940.92
259_A263_A0.7940.92
142_A148_I0.7930.92
22_P25_V0.7900.91
204_P331_T0.7890.91
111_C146_L0.7860.91
186_L397_V0.7850.91
227_R397_V0.7800.91
339_R372_F0.7790.91
140_V143_S0.7780.91
11_G87_L0.7760.91
286_A290_I0.7740.91
195_A217_G0.7740.91
220_I389_G0.7730.91
270_I323_Y0.7720.90
335_E370_H0.7700.90
393_L396_I0.7700.90
197_P209_S0.7690.90
152_D165_R0.7660.90
339_R342_R0.7600.90
80_K127_Q0.7590.90
280_Y300_L0.7590.90
291_K330_E0.7580.90
350_I372_F0.7560.90
21_T24_L0.7540.89
193_I272_I0.7530.89
100_A137_N0.7500.89
370_H379_V0.7490.89
174_D178_A0.7480.89
360_Q382_L0.7470.89
191_I393_L0.7470.89
311_V347_L0.7470.89
117_P147_L0.7460.89
28_L86_I0.7450.89
155_S161_I0.7430.89
360_Q364_S0.7410.89
339_R377_D0.7410.89
76_I158_C0.7400.89
361_G367_N0.7390.88
86_I172_I0.7380.88
10_L88_A0.7370.88
50_L54_A0.7340.88
21_T52_L0.7330.88
194_T273_G0.7310.88
118_V131_A0.7290.88
167_L172_I0.7290.88
351_C371_L0.7270.88
391_L395_E0.7230.87
369_L380_L0.7230.87
99_A136_H0.7210.87
192_M261_V0.7200.87
335_E379_V0.7180.87
21_T166_M0.7150.87
90_A141_L0.7150.87
126_Q158_C0.7150.87
235_S250_D0.7140.87
94_L111_C0.7130.87
95_I138_L0.7110.87
261_V273_G0.7110.87
219_A222_A0.7090.86
186_L189_L0.7080.86
218_F233_L0.7080.86
13_S91_T0.7080.86
167_L175_M0.7080.86
235_S242_T0.7070.86
126_Q160_D0.7010.86
41_E105_D0.7000.86
37_V52_L0.7000.86
361_G364_S0.6990.86
373_W395_E0.6980.85
174_D177_V0.6930.85
359_T368_A0.6930.85
96_A137_N0.6900.85
354_D357_Q0.6900.85
33_A177_V0.6890.85
98_V131_A0.6860.84
39_M60_V0.6850.84
324_V347_L0.6780.84
288_E333_N0.6750.84
29_R34_D0.6750.84
64_L106_L0.6740.83
386_E390_Q0.6720.83
79_G116_A0.6710.83
273_G324_V0.6710.83
88_A166_M0.6700.83
192_M271_F0.6690.83
281_R308_P0.6670.83
226_R386_E0.6660.83
119_A147_L0.6660.83
357_Q360_Q0.6660.83
103_A112_L0.6630.82
370_H377_D0.6630.82
291_K337_Y0.6600.82
329_A354_D0.6600.82
254_A278_A0.6580.82
48_T51_S0.6580.82
42_A45_A0.6570.82
222_A226_R0.6570.82
13_S87_L0.6560.82
234_V257_M0.6540.82
262_N314_V0.6530.81
73_M158_C0.6510.81
220_I393_L0.6510.81
135_Q139_E0.6500.81
25_V29_R0.6500.81
251_V256_E0.6490.81
264_S267_Q0.6470.81
16_I51_S0.6470.81
292_K311_V0.6450.81
292_K306_K0.6450.81
119_A175_M0.6450.81
338_A350_I0.6450.81
26_R30_D0.6430.80
225_A242_T0.6420.80
265_V268_Q0.6410.80
387_L390_Q0.6410.80
233_L240_L0.6380.80
12_V21_T0.6370.80
9_V78_L0.6350.80
125_N160_D0.6330.79
388_L391_L0.6320.79
367_N388_L0.6310.79
254_A307_N0.6300.79
27_R170_L0.6300.79
115_P130_R0.6280.79
380_L383_E0.6230.78
213_S274_C0.6220.78
251_V260_A0.6210.78
186_L393_L0.6190.78
259_A262_N0.6150.78
282_A285_V0.6150.78
71_A77_E0.6130.77
70_E74_G0.6110.77
6_K180_F0.6110.77
26_R158_C0.6110.77
204_P286_A0.6100.77
371_L392_L0.6100.77
354_D360_Q0.6100.77
38_A106_L0.6090.77
111_C120_V0.6090.77
236_G257_M0.6080.77
175_M178_A0.6070.77
129_Y150_G0.6060.76
199_R237_P0.6020.76
113_A125_N0.6020.76
309_D345_K0.6010.76
36_R61_S0.6000.76
133_A140_V0.5980.76
199_R211_H0.5970.75
14_G42_A0.5970.75
200_E307_N0.5960.75
268_Q271_F0.5960.75
86_I121_L0.5950.75
97_R105_D0.5950.75
48_T52_L0.5950.75
346_N374_Q0.5930.75
39_M52_L0.5930.75
240_L248_R0.5900.75
372_F377_D0.5890.74
366_N384_R0.5890.74
294_A306_K0.5880.74
30_D155_S0.5870.74
281_R285_V0.5870.74
79_G127_Q0.5860.74
355_V361_G0.5840.74
24_L166_M0.5820.74
265_V324_V0.5800.73
39_M49_P0.5800.73
72_A77_E0.5790.73
119_A180_F0.5780.73
24_L27_R0.5780.73
380_L388_L0.5760.73
190_N264_S0.5750.73
186_L191_I0.5730.72
138_L142_A0.5700.72
356_S359_T0.5700.72
111_C114_T0.5690.72
28_L33_A0.5690.72
237_P240_L0.5680.72
265_V318_K0.5680.72
9_V85_V0.5680.72
223_A393_L0.5680.72
200_E254_A0.5670.72
190_N267_Q0.5670.72
197_P238_V0.5670.72
11_G40_T0.5670.72
98_V112_L0.5650.71
334_V337_Y0.5650.71
261_V310_I0.5630.71
117_P179_H0.5630.71
100_A136_H0.5610.71
171_T244_P0.5610.71
94_L107_V0.5600.71
88_A172_I0.5600.71
126_Q163_P0.5600.71
44_K48_T0.5590.71
356_S360_Q0.5590.71
102_M109_T0.5580.70
315_A322_P0.5580.70
249_V263_A0.5560.70
290_I300_L0.5560.70
12_V37_V0.5540.70
197_P235_S0.5530.70
39_M47_I0.5530.70
23_E168_D0.5520.70
136_H139_E0.5520.70
85_V110_I0.5520.70
368_A388_L0.5490.69
390_Q394_D0.5480.69
315_A318_K0.5480.69
19_Y23_E0.5460.69
14_G43_A0.5460.69
218_F239_S0.5450.69
272_I396_I0.5450.69
308_P313_G0.5440.69
165_R168_D0.5430.68
357_Q361_G0.5420.68
351_C388_L0.5420.68
336_E339_R0.5410.68
84_L180_F0.5410.68
29_R56_S0.5410.68
284_T287_P0.5400.68
7_K83_D0.5400.68
67_P74_G0.5370.68
14_G18_A0.5370.68
335_E377_D0.5360.67
392_L396_I0.5360.67
264_S268_Q0.5350.67
24_L172_I0.5350.67
238_V242_T0.5350.67
87_L94_L0.5350.67
14_G46_F0.5350.67
186_L224_A0.5330.67
243_P248_R0.5330.67
189_L270_I0.5330.67
318_K346_N0.5320.67
121_L148_I0.5320.67
155_S158_C0.5310.67
59_P68_A0.5310.67
29_R58_Y0.5300.67
169_P173_V0.5300.67
199_R363_N0.5300.67
349_L395_E0.5290.66
90_A120_V0.5280.66
328_A341_K0.5280.66
325_V349_L0.5280.66
201_P285_V0.5280.66
342_R350_I0.5280.66
222_A246_V0.5270.66
22_P39_M0.5270.66
86_I119_A0.5230.66
93_D97_R0.5230.66
23_E30_D0.5230.66
66_D71_A0.5210.65
223_A386_E0.5190.65
105_D109_T0.5190.65
45_A50_L0.5190.65
258_E261_V0.5180.65
74_G77_E0.5160.64
25_V55_V0.5150.64
300_L304_M0.5150.64
43_A52_L0.5130.64
26_R29_R0.5120.64
79_G110_I0.5110.64
80_K126_Q0.5090.63
73_M80_K0.5080.63
215_K219_A0.5080.63
197_P240_L0.5070.63
88_A121_L0.5060.63
171_T175_M0.5050.63
158_C161_I0.5050.63
130_R135_Q0.5040.63
76_I125_N0.5030.63
18_A52_L0.5020.62
342_R347_L0.5010.62
18_A47_I0.5010.62
261_V268_Q0.5000.62
317_L322_P0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjiA 2 0.5025 100 0.532 Contact Map
1p9oA 2 0.5345 100 0.593 Contact Map
2gk4A 2 0.5049 100 0.635 Contact Map
1mvlA 3 0.4113 100 0.637 Contact Map
1p3y1 6 0.4163 100 0.64 Contact Map
1u7zA 2 0.5443 100 0.643 Contact Map
3qjgA 5 0.4089 100 0.645 Contact Map
1qzuA 3 0.3768 100 0.65 Contact Map
1g63A 6 0.4187 100 0.661 Contact Map
3mcuA 5 0.4409 100 0.668 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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